14 results on '"de Araújo, Dayane Pessoa"'
Search Results
2. L-linalool exerts a neuroprotective action on hemiparkinsonian rats
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de Lucena, Jalles Dantas, Gadelha-Filho, Carlos Vinicius Jataí, da Costa, Roberta Oliveira, de Araújo, Dayane Pessoa, Lima, Francisco Arnaldo Viana, Neves, Kelly Rose Tavares, and de Barros Viana, Glauce Socorro
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- 2020
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3. Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats.
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de Araújo, Dayane Pessoa, Camboim, Thaisa Gracielle Martins, Silva, Ana Patrícia Magalhães, Silva, Caio da Fonseca, de Sousa, Rebeca Canuto, Barbosa, Mabson Delâno Alves, Oliveira, Lucidio Clebeson, Cavalcanti, José Rodolfo Lopes de Paiva, Lucena, Eudes Euler de Souza, and Guzen, Fausto Pierdoná
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TARDIVE dyskinesia , *DYSKINESIAS , *ANTIPSYCHOTIC agents , *BASAL ganglia , *HYPERKINESIA - Abstract
Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omega-3 (ω-3) are antioxidants acting as enzyme cofactors, regenerating antioxidant enzymes. This study aimed to investigate behavioral and neurochemical effects of supplementation with LA (100 mg/kg) and ω-3 (1 g/kg) in the treatment of TD induced by chronic use of haloperidol (HAL) (1 mg/kg) in rats. Wistar male rats were used, weighing between 180-200 g. The animals were treated chronically (31 days) with LA alone or associated with HAL or ω-3. Motor behavior was assessed by open-field test, the catalepsy test, and evaluation of orofacial dyskinesia. Oxidative stress was accessed by determination of lipid peroxidation and concentration of nitrite. LA and ω-3 alone or associated caused an improvement in motor performance by increasing locomotor activity in the open-field test and decreased the permanence time on the bar in the catalepsy test and decreased the orofacial dyskinesia. LA and ω-3 showed antioxidant effects, decreasing lipid peroxidation and nitrite levels. Thus, the use of LA associated with ω-3 reduced the extrapyramidal effects produced by chronic use of HAL. [ABSTRACT FROM AUTHOR]
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- 2017
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4. Effect of FGF-2 and sciatic nerve grafting on ChAT expression in dorsal root ganglia neurons of spinal cord transected rats.
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Guzen, Fausto Pierdoná, de Araújo, Dayane Pessoa, de Souza Lucena, Eudes Euler, de Morais, Hécio Henrique Araújo, de Paiva Cavalcanti, José Rodolfo Lopes, Jr.do Nascimento, Expedito Silva, de Oliveira Costa, Miriam Stela Maris, and Cavalcante, Jeferson Sousa
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SPINAL cord surgery , *DORSAL root ganglia , *SCIATIC nerve , *NEUROTROPHINS , *GENE expression , *LABORATORY rats , *FIBROBLAST growth factor 2 - Abstract
Neurotrophic factors and peripheral nerves are known to be good substrates for bridging CNS trauma. The involvement of fibroblast growth factor-2 (FGF-2) activation in the dorsal root ganglion (DRG) was examined following spinal cord injury in the rat. We evaluated whether FGF-2 increases the ability of a sciatic nerve graft to enhance neuronal plasticity, in a gap promoted by complete transection of the spinal cord. The rats were subjected to a 4 mm-long gap at low thoracic level and were repaired with saline (Saline or control group, n = 10), or fragment of the sciatic nerve (Nerve group, n = 10), or fragment of the sciatic nerve to which FGF-2 (Nerve + FGF-2 group, n = 10) had been added immediately after lesion. The effects of the FGF-2 and fragment of the sciatic nerve grafts on neuronal plasticity were investigated using choline acetyl transferase (ChAT)-immunoreactivity of neurons in the dorsal root ganglion after 8 weeks. Preservation of the area and diameter of neuronal cell bodies in dorsal root ganglion (DRG) was seen in animals treated with the sciatic nerve, an effect enhanced by the addition of FGF-2. Thus, the addition of exogenous FGF-2 to a sciatic nerve fragment grafted in a gap of the rat spinal cord submitted to complete transection was able to improve neuroprotection in the DRG. The results emphasized that the manipulation of the microenvironment in the wound might amplify the regenerative capacity of peripheral neurons. [ABSTRACT FROM AUTHOR]
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- 2016
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5. Central effects of lipoic Acid associated with paroxetine in mice.
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Silva, Márcia Calheiros Chaves, Sampaio, Luis Rafael Leite, de Araújo, Dayane Pessoa, Araújo, Paulo Victor Pontes, Monte, Aline Santos, Rodrigues, Francisca Taciana Sousa, Woods, David John, de Sousa, Francisca Cléa Florenço, Fonteles, Marta Maria França, and Vasconcelos, Silvânia Maria Mendes
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- 2014
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6. The Contributions Of Antioxidant Activity Of Lipoic Acid In Reducing Neurogenerative Progression Of Parkinson's Disease: A Review.
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De Araújo, Dayane Pessoa, Lobato, Rodrigo De Freitas Guimarães, Cavalcanti, José Rodolfo Lopes De Paiva, Sampaio, Luis Rafael Leite, Araújo, Paulo Victor Pontes, Silva, Marcia Calheiros Chaves, Neves, Kelly Rose Tavares, Fonteles, Marta Maria De França, Sousa, Francisca Clea Florenço De, and Vasconcelos, Silvania Maria Mendes
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ANTIOXIDANTS , *LIPOIC acid , *PARKINSON'S disease treatment , *NEUROPROTECTIVE agents , *OXIDATIVE stress , *DOPAMINERGIC neurons , *NEURODEGENERATION - Abstract
This work reviews the evidence of the mechanism of neuronal degeneration in Parkinson's disease (PD) and the neuroprotective effect of lipoic acid and its use in the treatment of PD. PD is characterized by slow and progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta, leading to reduction of the striatal dopaminergic terminals. It is known that several factors influence neuronal damage. Among these factors, oxidative stress, immune system activity, microglial cells, and apoptotic mechanisms are of major importance. Currently, several antioxidants have been studied with the aim of reducing/slowing the progression of neurodegenerative processes. Lipoic acid is considered a universal antioxidant because it is an amphipathic substance. Lipoic acid and its reduced form, dihidrolipoic acid, act against reactive oxygen species, reducing oxidative stress. Therefore, this antioxidant has been used in the treatment of many diseases, including a new perspective for the treatment of Parkinson's disease. [ABSTRACT FROM AUTHOR]
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- 2011
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7. NURSING AND HEAD INJURY: LITERATURE SYSTEMATIC REVIEW STUDY.
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Cavalcanti, José Rodolfo Lopes de Paiva, de Oliveira, Felipe Cesar Chaves, de Araújo, Dayane Pessoa, and Guzen, Fausto Pierdoná
- Abstract
Copyright of Journal of Nursing UFPE / Revista de Enfermagem UFPE is the property of Revista de Enfermagem UFPE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2011
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8. Corrigendum to “The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats”.
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da Costa, Roberta Oliveira, Gadelha-Filho, Carlos Vinicius Jataí, da Costa, Ayane Edwiges Moura, Feitosa, Mariana Lima, de Araújo, Dayane Pessoa, de Lucena, Jalles Dantas, de Aquino, Pedro Everson Alexandre, Lima, Francisco Arnaldo Viana, Neves, Kelly Rose Tavares, and de Barros Viana, Glauce Socorro
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- 2018
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9. Expansion and Phenotypic Changes of Mouse Bone Marrow Mesenchymal Cells Cultured with FGF-2 and Facial Nerve-Conditioned Medium.
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de Souza Lucena, Eudes Euler, de Morais, Hécio Henrique Araújo, de Araújo, Dayane Pessoa, de Paiva Cavalcanti, José Rodolfo Lopes, de Azevedo, Eduardo Pereira, de Queiroz, Dinalva Brito, Botelho, Marco Antônio, do Rêgoa, Amália Cinthia Meneses, Filho, Irami Araújo, Barboza, Carlos Augusto Galvão, do Nascimento Júnior, Expedito Silva, de Oliveira Costa, Miriam Stela Maris, de Sousa Cavalcante, Jeferson, and Guzen, Fausto Pierdoná
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MESENCHYMAL stem cells , *IMMUNOCYTOCHEMISTRY , *GENE expression , *FIBROBLAST growth factor 2 , *PARACRINE mechanisms - Abstract
Mesenchymal cells (MCs) exhibit great regenerative potential due to their intrinsic properties and ability to restore tissue function, either directly through transdifferentiation or indirectly through paracrine effects. This study aimed to evaluate morphometric and phenotypic changes in MCs grown with facial nerve-conditioned medium in the presence or absence of fibroblast growth factor 2 (FGF-2). For quantitative phenotypic analysis, the expression of GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200 was analyzed by immunocytochemistry. Cells cultured with facial nerve-conditioned medium in the presence of FGF-2 expressed GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200. On average, the area and perimeter of GFAP-positive cells were higher in the group cultured with facial nerve-conditioned medium compared to the group cultured with conditioned medium and FGF-2 (p=0.0001). This study demonstrated the plasticity of MCs for neuronal and glial lineages and opens up new research perspectives in cell therapy and trans.differentiation. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Neurobiological effects of forced swim exercise on the rodent hippocampus: a systematic review.
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Oliveira RF, Paiva KM, da Rocha GS, de Moura Freire MA, de Araújo DP, de Oliveira LC, Guzen FP, de Gois Morais PLA, and de Paiva Cavalcanti JRL
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- Animals, Rodentia, Time Factors, Antioxidants metabolism, Hippocampus physiology, Physical Conditioning, Animal physiology, Swimming physiology
- Abstract
Forced swimming is a common exercise method used for its low cost and easy management, as seen in studies with the hippocampus. Since it is applied for varied research purposes many protocols are available with diverse aspects of physical intensity, time and periodicity, which produces variable outcomes. In the present study, we performed a systematic review to stress the neurobiological effects of forced swim exercise on the rodent hippocampus. Behavior, antioxidant levels, neurotrophins and inflammatory markers were the main topics examined upon the swimming effects. Better results among these analyses were associated with forced exercise at moderate intensity with an adaptation period and the opposite for continuous exhausting exercises with no adaptation. On further consideration, a standard swimming protocol is necessary to reduce variability of results for each scenario investigated about the impact of the forced swimming on the hippocampus., Forced swimming is a common exercise method used for its low cost and easy management, as seen in studies with the hippocampus. Since it is applied for varied research purposes many protocols are available with diverse aspects of physical intensity, time and periodicity, which produces variable outcomes. In the present study, we performed a systematic review to stress the neurobiological effects of forced swim exercise on the rodent hippocampus. Behavior, antioxidant levels, neurotrophins and inflammatory markers were the main topics examined upon the swimming effects. Better results among these analyses were associated with forced exercise at moderate intensity with an adaptation period and the opposite for continuous exhausting exercises with no adaptation. On further consideration, a standard swimming protocol is necessary to reduce variability of results for each scenario investigated about the impact of the forced swimming on the hippocampus.
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- 2021
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11. Haloperidol-Induced Preclinical Tardive Dyskinesia Model in Rats.
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Guzen FP, Cavalcanti JRLP, Cavalcanti DMLP, de Sales LGP, da Silva MSM, da Silva ANA, Pinheiro FI, and de Araújo DP
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- Animals, Drug Evaluation, Preclinical methods, Male, Mastication physiology, Rats, Rats, Wistar, Tardive Dyskinesia physiopathology, Antipsychotic Agents toxicity, Disease Models, Animal, Haloperidol toxicity, Mastication drug effects, Tardive Dyskinesia chemically induced
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Haloperidol is a first-generation antipsychotic used in the treatment of psychoses, especially schizophrenia. This drug acts by blocking dopamine D2 receptors, reducing psychotic symptoms. Notwithstanding its benefits, haloperidol also produces undesirable impacts, in particular extrapyramidal effects such as tardive dyskinesia (TD), which limit the use of this and related drugs. TD is characterized by repetitive involuntary movements occurring after chronic exposure therapy with haloperidol. Symptoms most commonly manifest in the orofacial area and include involuntary movements, tongue protrusion, pouting lips, chewing in the absence of any object to chew, and facial grimacing. The most serious aspect of TD is that it may persist for months or years after drug withdrawal and is irreversible in some patients. This unit, aimed at facilitating the study of TD, describes methods to induce TD in rats using haloperidol, as well as procedures for evaluating the animals's TD-related symptoms. © 2019 by John Wiley & Sons, Inc., (© 2019 John Wiley & Sons, Inc.)
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- 2019
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12. Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review.
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da Costa IM, Freire MAM, de Paiva Cavalcanti JRL, de Araújo DP, Norrara B, Moreira Rosa IMM, de Azevedo EP, do Rego ACM, Filho IA, and Guzen FP
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- Alzheimer Disease metabolism, Alzheimer Disease pathology, Alzheimer Disease prevention & control, Amyloid beta-Peptides metabolism, Animals, Curcuma chemistry, Curcumin pharmacology, Dietary Supplements, Humans, Neurofibrillary Tangles metabolism, Neuroprotective Agents pharmacology, Plant Extracts pharmacology, Randomized Controlled Trials as Topic, Alzheimer Disease drug therapy, Curcumin administration & dosage, Neuroprotective Agents administration & dosage, Plant Extracts administration & dosage
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Background: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases., Objective: The aim of the present work is to review studies that addressed the effects of curcumin in experimental models (in vivo and in vitro) for AD., Method: This study is a systematic review conducted between January and June 2017, in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (PubMed), Cochrane Library and Scielo databases, using the following descriptors: "Curcuma longa", "Curcumin" and "Alzheimer's disease"., Results: A total of 32 studies were analyzed, which indicated that curcumin supplementation reverses neurotoxic and behavioral damages in both in vivo and in vitro models of AD., Conclusion: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2019
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13. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats.
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da Costa RO, Gadelha-Filho CVJ, da Costa AEM, Feitosa ML, de Araújo DP, de Lucena JD, de Aquino PEA, Lima FAV, Neves KRT, and de Barros Viana GS
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- Animals, Humans, Male, Oxidative Stress, Rats, Rats, Wistar, Brain pathology, Dopaminergic Neurons metabolism, Exercise Test methods, Parkinson Disease therapy
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Parkinson's disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays. The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for p < 0.05. The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests. The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress. In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise. We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals. The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.
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- 2017
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14. Behavioral and neurochemical effects of alpha-lipoic Acid in the model of Parkinson's disease induced by unilateral stereotaxic injection of 6-ohda in rat.
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de Araújo DP, De Sousa CN, Araújo PV, Menezes CE, Sousa Rodrigues FT, Escudeiro SS, Lima NB, Patrocínio MC, Aguiar LM, Viana GS, and Vasconcelos SM
- Abstract
This study aimed to investigate behavioral and neurochemical effects of α -lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson's disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity. α -Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test. α -lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity. Therefore, α -lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that α -lipoic could be a new therapeutic target for Parkinson's disease prevention and treatment.
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- 2013
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