1. A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming.
- Author
-
Chew SC, Choo SY, and Chow PK
- Subjects
- Animals, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular immunology, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic immunology, Cellular Reprogramming genetics, Cellular Reprogramming immunology, Fetal Development genetics, Fetal Development immunology, Folate Receptor 2 physiology, Humans, Liver Neoplasms genetics, Liver Neoplasms immunology, Macrophages pathology, Macrophages physiology, Membrane Proteins genetics, Membrane Proteins physiology, Mice, Signal Transduction genetics, Signal Transduction immunology, Tumor Microenvironment genetics, Tumor Microenvironment immunology, Vascular Endothelial Growth Factor Receptor-2 genetics, Vascular Endothelial Growth Factor Receptor-2 physiology, alpha-Fetoproteins genetics, alpha-Fetoproteins physiology, Carcinoma, Hepatocellular pathology, Liver Neoplasms pathology, Tumor Escape genetics, Tumor Escape immunology
- Abstract
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.
- Published
- 2021
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