1. Brain transcriptomes of honey bees (Apis mellifera) experimentally infected by two pathogens: Black queen cell virus and Nosema ceranae
- Author
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Robin F. A. Moritz, Yves Le Conte, Cédric Alaux, Robert J. Paxton, Cynthia McDonnell, Sabine Nidelet, Vincent Doublet, Emeric Dubois, Doublet, Vincent, Institut für Biologie, Martin-Luther-Universität Halle Wittenberg (MLU), German Centre for Integrative Biodiversity Research (iDiv), Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Martin-Luther-University Halle-Wittenberg, Abeilles & Environnement (UR 406 ), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), European Project: 244956,EC:FP7:KBBE,FP7-KBBE-2009-3,BEE DOC(2010), University of Exeter, Abeilles et environnement (AE), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, and BEES IN EUROPE AND THE DECLINE OF HONEYBEE COLONIES - BEE DOC - - EC:FP7:KBBE2010-03-01 - 2013-02-28 - 244956 - VALID
- Subjects
[SDE] Environmental Sciences ,0106 biological sciences ,0301 basic medicine ,lcsh:QH426-470 ,infection expérimentale ,media_common.quotation_subject ,[SDV]Life Sciences [q-bio] ,Honeybee ,Insect ,Biology ,01 natural sciences ,Biochemistry ,Virus ,03 medical and health sciences ,apis carnica ,Data in Brief ,Genetics ,Disease ,analyse du transcriptome ,Pathogen ,media_common ,Regulation of gene expression ,abeille ouvrière ,fungi ,food and beverages ,RNA virus ,Honey bee ,biology.organism_classification ,Virology ,Nosema ceranae ,3. Good health ,[SDV] Life Sciences [q-bio] ,Parasite ,lcsh:Genetics ,010602 entomology ,030104 developmental biology ,BQCV ,Microsporidia ,[SDE]Environmental Sciences ,Molecular Medicine ,cerveau ,varroa ,RNA-seq ,Biotechnology - Abstract
International audience; Regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli. However, both can be severely affected by environmental factors, such as parasites and pathogens. In honey bees, the emergence and re-emergence of pathogens and potential for pathogen co-infection and interaction have been suggested as major components that significantly impaired social behavior and survival. To understand how the honey bee is affected and responds to interacting pathogens, we co-infected workers with two prevalent pathogens of different nature, the positive single strand RNA virus Black queen cell virus (BQCV), and the Microsporidia Nosema ceranae, and explored gene expression changes in brains upon single infections and co-infections. Our data provide an important resource for research on honey bee diseases, and more generally on insect host-pathogen and pathogen-pathogen interactions. Rawand processed data are publicly available in the NCBI/GEO database: (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE81664.
- Published
- 2016
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