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The human nasal cavity develops from birth with size anatomical changes. This study aims to evaluate the flow parameters and particle deposition parameters. Neonatal and infant nasal cavities are developed using MIMICS 21.0, and the flow is evaluated by ANSYS 2021 R2 using CFD to evaluate velocity, pressure, micro- and nanoparticle depositions under sedentary breathing conditions. Neonatal nasal valve velocity was recorded 3.5 times higher compared to the infant for 1.8 LPM and 2.7 times for 3 LPM. Neonatal vestibular depositions up to 10 µm were 6.6%, which increased to 76% for 60 µm for 1.8 LPM and increased to 21.3% for 10 µm and 79% for 60 µm for 1.8 LPM. The neonatal nasal valve showed maximum depositions of around 35% for 20 µm for both flow rates. Maximum depositions of nanoparticles are in the mid-nasal region. Infant nasal cavities deposit around 1% to 2% for nanoparticles below 20 nm for both flow rates. Neonatal overall microparticle depositions doubled with an increase in flow rate up to 10 µm. The overall deposition efficiency of nanoparticles increases 1.5 times with increasing flow rate. This study will help with the medical administration of aerosol-based medications in the patient and age-specific nasal cavity. [ABSTRACT FROM AUTHOR]

Objective: The nasal cavity effectively captures the particles present in inhaled air, thereby preventing harmful and toxic pollutants from reaching the lungs. This filtering ability of the nasal cavity can be effectively utilized for targeted nasal drug delivery applications. This study aims to understand the particle deposition patterns in three age groups: neonate, infant, and adult. Materials and methods: The CT scans are built using MIMICS 21.0, followed by CATIA V6 to generate a patient-specific airway model. Fluid flow is simulated using ANSYS FLUENT 2021 R2. Spherical monodisperse microparticles ranging from 2 to 60 µm and a density of 1100 kg/m3 are simulated at steady-state and sedentary inspiration conditions. Results: The highest nasal valve depositions for the neonate are 25% for 20 µm, for infants, 10% for 50 µm, 15% for adults, and 15% for 15 µm. At mid nasal region, deposition of 15% for 20 µm is observed for infant and 8% for neonate and adult nasal cavities at a particle size of 10 and 20 µm, respectively. The highest particle deposition at the olfactory region is about 2.7% for the adult nasal cavity for 20 µm, and it is <1% for neonate and infant nasal cavities. Discussion and conclusions: The study of preferred nasal depositions during natural sedentary breathing conditions is utilized to determine the size that allows medication particles to be targeted to specific nose regions. [ABSTRACT FROM AUTHOR]

The selection of abrasive material and parameters of the Air-Abrasion device for a particular application is a crucial detail. However, there are no standard recommendations or manuals for choosing these details; the operator must depend on his experience and knowledge of the procedure to select the best possible material and set of parameters. This short review attempts to identify some of the effects that the selection of material and parameters could have on the performance of the Air-Abrasion procedure for a particular application. The material and parameter data are collected from various studies and categorized according to the most popular materials in use right now. These studies are then analyzed to arrive at some inferences on the performance of Air-Abrasion materials and parameters. This review arrives at a few conclusions on the effectiveness of a material and parameter set, and that there is potential for developments in the area of standardizing parameter selection; also, there is scope for further studies on Bio-Active Glass as an alternative to the materials currently used in Air-Abrasion. [ABSTRACT FROM AUTHOR]

Renal transplantation is the treatment of choice for improved survival and quality of life in patients with end-stage renal disease. However, perirenal fluid collections are common surgical complications after renal transplant, with about 0.6 to 18% of patients developing a lymphocele. Conventional treatments include percutaneous aspiration and drainage, laparoscopic fenestration, and open surgical decompression stepwise. Recently, a new image-guided percutaneous transperitoneal balloon fenestration technique has been described as an alternative to the laparoscopic or surgical technique. We present the case of a 25-year-old male patient diagnosed with a lymphocele after 2 months of transplantation and no resolution of the lymphocele with percutaneous aspiration and drainage. We used this new technique under ultrasound and fluoroscopy guidance, which resulted in the resolution of the lymphocele at 1 month postprocedure. This case report highlights this new technique's potential role in successfully managing the posttransplant lymphocele in a minimally invasive manner. [ABSTRACT FROM AUTHOR]

The transmission mechanism of artificial flapping-wing drones generally needs low weight and the fewest interconnecting components, making their development challenging. The four-bar Linkage mechanism for flapping actuation has generally been used till now with complex and heavy connecting designs, but our proposed novel perpendicularly organized 3-cylindrical joint mechanism is designed to be unique and lighter weight with smooth functioning performance. The proposed prototype transforms the rotary motion of the motor into a specific angle of flapping movement, where the dimensions and specifications of the design components are proportional to the obtained flapping angle. Power consumption and flapping actuation can be monitored by adjusting the motor's rotational speed to control the individual wing in this mechanism. The proposed mechanism consists of a crank with three slightly slidable cylindrical joints perpendicularly arranged to each other with a specified distance in a well-organized pattern to produce a flapping movement at the other end. In order to examine the kinematic attributes, a mathematical process approach is formulated, and kinematic simulations are performed using SIMSCAPE multibody MATLAB, PYTHON programming and COMPMECH GIM software. The proposed invention's real-time test bench prototype model is designed, tested and analyzed for flapping validation. [ABSTRACT FROM AUTHOR]

Aim and background: Maternal mortality is one of the nightmares for obstetricians and also for the patient's family. There are many causes, but disseminated intravascular coagulation (DIC) with acute renal failure is one of the challenging cases, which requires a multidisciplinary approach. Case description: A 29-year-old second para patient with two live births, was presented in the emergency department with septic shock and DIC. She had gross hemoperitoneum with massive rectus sheath hematoma. Initially her blood pressure was stabilized by giving blood products and supportive treatment. As soon as her blood pressure became stable, she underwent computed tomographic angiography-guided embolization of right inferior epigastric artery. After 24 hours of embolization, she underwent laparotomy for abdominal compartment syndrome. Conclusion: Although primary treatment of DIC is to treat underlying cause, but transarterial embolization in addition to primary treatment, is also equally effective in controlling the on-going bleeding which in turn results in DIC. Clinical significance: Maternal mortality represents health state of a country and one should try to be safe as many near miss as possible with a multidisciplinary approach. [ABSTRACT FROM AUTHOR]

The airflow behaviour and particle deposition before and after the maxillary expansion are evaluated using the computational fluid dynamics method. A pediatric patient was subjected to maxillary expansion and the CT scans of pre and post were recorded. The procured CT scans were developed into 3D models using Materialise MIMICS 21.0 (Materialise, Ann Arbor, MI). The analysis was performed using ANSYS FLUENT 2020 R2 with three different flow rates defined at the nostril inlet as 5, 10, and 15 LPM. The surface area and nasal volume increased by 5.1% and 16.5%, respectively, for the post-maxillary expansion case. The velocity profiles show a maximum value at the nasal valve regions followed by a decreased velocity in the mid-nasal region with an 85% lower velocity observed at the nasal valve for the post-maxillary expansion case. The nasal resistance and pressure drop decrease by 46% to 66% in post-maxillary expansion cases. The maximum WSS at the nasal valve region is observed which is reduced by around 47% for postmaxillary expansion cases. Particle deposition studies show a reduction in particle depositions in post cases indicating a greater number of inhaled particles reaching the lungs. The pressure drop and the nasal resistance values were reduced by more than 50% for post-maxillary expansion. The particle deposition studies show increased depositions at higher flow rates for both cases. [ABSTRACT FROM AUTHOR]

Insect RoboFlyers are interesting and active focuses of study but producing high-quality flapping robots that replicate insect flight is challenging., due to the dual requirement of both a sophisticated transmission mechanism with light weight and minimal intervening connections. This innovative mechanism was created to address the need for a producible structure that is small in size, small in mass, and has reduced design linkages. The proposed Single Crank-Slotted Dual Lever (SC-SDL) mechanism transforms rotational motion into specific angular motion at different velocities for each of its two strokes, i.e., the forward stroke and the return stroke. The discovery of a lag between the left and right lever motions in our design mechanism-I leads us to the conclusion that the flapping is asymmetric. To eliminate the position lag, the design has been altered, and a new design mechanism-II has been developed. Comparative kinematic analysis of both design systems is performed using simulations. Two-dimensional analysis of the base ornithopter configuration using ANSYS FLUENT yielded deeper insights regarding the influence of varying flapping frequency on critical flow metrics regarding adequate lift and thrust. For a flapping frequency of 24 Hz, adequate lift generation was achieved with minimal flow disturbances and wake interactions. Averaged dual wing estimations were made as part of the CFD study, which showed similar agreements. To validate the estimations, experimental tests were performed over the design mechanism-II configuration. [ABSTRACT FROM AUTHOR]

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