119 results on '"Zorbas H"'
Search Results
2. Factors predictive of immediate breast reconstruction following mastectomy for invasive breast cancer in Australia
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Roder, D., Zorbas, H., Kollias, J., Pyke, C., Walters, D., Campbell, I., Taylor, C., and Webster, F.
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- 2013
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3. Survival and Degree of Spread for Female Breast Cancers in New South Wales from 1980 to 2003: Implications for Cancer Control
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Tracey, E., Roder, D., Zorbas, H., Villanueva, E., Jelfs, P., and Bishop, J.
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- 2008
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4. Sharing the challenge of cancer control for Indigenous Australians: a national agenda
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Zorbas, H. and Elston, J.
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- 2016
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5. Managing mastalgia: fact or fiction?
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Zorbas, H and Ung, OA
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- 2000
6. Use of complementary therapies by Australian women with breast cancer
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Kremser, T., Evans, A., Moore, A., Luxford, K., Begbie, S., Bensoussan, A., Marigliani, R., and Zorbas, H.
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- 2008
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7. An Australian first guideline: Recommendations for the management of early breast cancer in women with an identified BRCA1 or BRCA2 gene mutation or at high risk of a gene mutation
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Kenny, L, Toohey, J, Kirk, J, Nelson, A, Dalton, T, Webster, F, Care, O, and Zorbas, H
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- 2014
8. PATTERN OF SURGICAL TREATMENT FOR WOMEN WITH BREAST CANCER: DOES AGE MAKE A DIFFERENCE?: BS13
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Kollias, J., Wang, J., Boult, M., Babidge, W, Zorbas, H., and Maddern, G.
- Published
- 2008
9. SENTINEL NODE BIOPSY IN EARLY BREAST CANCER - GUIDELINES FOR BEST PRACTICE: BS08
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Wetzig, N., Pearce, A., Wilcoxon, H., Vagg, R., Anderson, K., and Zorbas, H.
- Published
- 2008
10. Ovarian cancer in the Centre - what's in a name?
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Zorbas, H
- Published
- 2008
11. MULTIDISCIPLINARY CANCER CARE IN AUSTRALIA: AN AUDIT OF CURRENT UPTAKE: SO16P
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WILCOXON, H., EVANS, A., GOODWIN, H., OʼBRIEN, J., ZORBAS, H., and LUXFORD, K.
- Published
- 2007
12. SYNOPTIC REPORTING OF BREAST IMAGING: AN OPPORTUNITY TO IMPROVE BREAST CANCER CARE: SO02
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MANN, B., ZORBAS, H., GOODWIN, H., and NEHILL, C.
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- 2007
13. FACILITATING NATIONAL CONSISTENCY IN BREAST CANCER DATA COLLECTION: BS15P
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RODER, D., KOLLIAS, J., GILLETT, D., PYKE, C., CARE, O., and ZORBAS, H.
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- 2007
14. Investigating Symptoms of Lung Cancer - An evidence-based guide for general practitioners
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Mazza, D., Chakraborty, S., Jones, K., Sinclair, S., King, L., and Zorbas, H.
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Background: Lung cancer is the leading cause of cancer deaths in Australia. Late detection and extended delays in referral contribute to high mortality rates. Consequently, the Australian Government agency, Cancer Australia, sought to develop guidance for general practitioners about the early investigation[for full text, please go to the a.m. URL], G-I-N Conference 2012
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- 2012
15. A systematic review of inequalities in psychosocial outcomes for women with breast cancer according to residential location and Indigenous status in Australia.
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Youl, PH, Dasgupta, P, Youlden, D, Aitken, JF, Garvey, G, Zorbas, H, Chynoweth, J, Wallington, I, and Baade, PD
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PSYCHOSOCIAL factors ,CANCER patients -- Social conditions ,SERVICES for breast cancer patients ,SOCIAL support ,QUALITY of life - Abstract
Background The aim of this systematic review was to examine variations in psychosocial outcomes by residential location and Indigenous status in women diagnosed with breast cancer (BC) in Australia. Methods Systematic searches were undertaken using multiple databases covering articles between 1 January 1990 and 1 March 2015 focusing on adult women with BC in an Australian setting and measuring quality of life (QOL), psychological distress or psychosocial support. Results Thirteen quantitative and three qualitative articles were included. Two quantitative and one qualitative article were rated high quality, seven moderate and the remaining were low quality. No studies examining inequalities by Indigenous status were identified. Non-metropolitan women were more likely to record lower QOL relating to breast cancer-specific concerns and reported a lack of information and resources specific to their needs. Continuity of support, ongoing care and access to specialist and allied health professionals were major concerns for non-metropolitan women. Non-metropolitan women identified unmet needs in relation to travel, fear of cancer recurrence and lack of psychosocial support. Conclusions Overall, there was a lack of evidence relating to variations in psychosocial outcomes for women with BC according to residential status or Indigenous status. While the review identified some specific concerns for non-metropolitan women with BC, it was limited by the lack of good quality studies using standardised measures. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2016
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16. 549 Exploring new approaches to follow-up care for early breast cancer in Australia
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Zorbas, H., Giles, C., and Marr, G.
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- 2010
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17. Sustainable models for multidisciplinary cancer care
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Zorbas, H., Evans, A., Luxford, K., and Nehill, C.
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- 2006
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18. A National Priority: Improving Outcomes for Aboriginal and Torres Strait Islander People With Cancer Through an Optimal Care Pathway.
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Chynoweth, J., Daveson, B., McCambridge, M., Coutts, J., Zorbas, H., and Whitfield, K.
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TORRES Strait Islanders ,NATIONAL interest ,INDIGENOUS Australians ,HEALTH literacy ,BUSINESSWOMEN - Abstract
Background and context: Cancer survival rates in Australia are among the best in the world, yet Aboriginal and Torres Strait Islander (indigenous) people continue to experience disparities in the distribution and burden of cancer, and unwarranted variations in outcomes. Indigenous Australians are 40% more likely to die of cancer than non-Indigenous Australians. Cancer Australia developed the National Aboriginal and Torres Strait Islander Cancer Framework (the framework), which identified 7 national priorities to address disparities in cancer outcomes experienced by indigenous Australians. An ongoing collaboration with indigenous Australians was integral to developing this shared agenda. Priority 5 in the framework highlights the need to ensure indigenous Australians affected by cancer receive optimal and culturally appropriate treatment, services, and supportive and palliative care. Aim: To improve cancer outcomes for indigenous Australians through the development and national endorsement of a population-specific Optimal Care Pathway (OCP) to guide the delivery of consistent, safe, high-quality, culturally appropriate and evidence-based care. Strategy/Tactics: Cancer Australia formed a partnership with the Victorian Department of Health and Human Services (DHHS) to address Priority 5 and develop the OCP. The approach to development was underpinned by Cancer Australia's Model of Engagement for Aboriginal and Torres Strait Islander People and guided by the national Leadership Group on Aboriginal and Torres Strait Islander Cancer Control (Leadership Group). Program/Policy process: Cancer Australia, in collaboration with DHHS: • reviewed experiences of care and the framework's comprehensive evidence base • developed a draft OCP to complement tumor-specific pathways • facilitated an Expert Working Group, comprising indigenous health sector leaders and consumers to refine and validate the draft OCP • undertook national public consultation, including with the indigenous health sector and community, health professionals and professional colleges • received an indication of support to proceed to endorsement from the Leadership Group. Outcomes: The first population-specific OCP for Aboriginal and Torres Strait Islander people with cancer received national endorsement. It will guide the delivery of consistent, safe, high-quality, culturally appropriate and evidence-based care. What was learned: Key elements of optimal care include: addressing the cultural appropriateness of the healthcare environment; improving cross-cultural communication; relationship building with local community; optimizing health literacy; recognition of men's and women's business; and the need to use culturally appropriate resources. The national priority in the framework informed and unified high-level direction, which was integral to effective OCP development and endorsement. The evidence-based, step-wise development approach contributed to its relevance, utility and quality. [ABSTRACT FROM AUTHOR]
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- 2018
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19. Improving Outcomes Through Principles of Best Practice Management: Australia's National Lung Cancer Framework.
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Daveson, B., Milch, V., Chynoweth, J., Kable, L., Austen, M., Basrai, H., Salvestrin, D., Wade, R., Andereisz, C., and Zorbas, H.
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LUNG cancer ,BEST practices ,PSYCHOLOGICAL distress ,CONTINUUM of care ,PATIENT-centered care - Abstract
Background and context: Lung cancer is estimated to be the fifth most commonly diagnosed cancer and leading cause of cancer death in Australia, representing 9.2% of all new cancer cases (n = 138,321) diagnosed and 18.9% of all cancer deaths (n = 48,586). The 5-year survival rate for those with lung cancer is 16%, compared with 68% for all cancers combined (between 2009 and 2013). Lung cancer is also the leading cause of cancer burden in Australia and patients affected by lung cancer may experience high levels of unmet need with associated psychological distress and decreased quality of life. Cancer Australia, Australia's national cancer control agency, developed the national Lung Cancer Framework: Principles for Best Practice Lung Cancer Care (Framework) to provide evidence-based, best practice information, strategies, tools and resources to support local adoption of the 5 principles for best practice management of lung cancer (principles): patient-centered care; multidisciplinary care; timely access to evidence-based care; coordination, communication and continuity of care; and data-driven improvements. Aim: The framework aims to improve the outcomes and experiences of people affected by lung cancer in Australia by supporting national uptake of the principles. Strategy/Tactics: Cancer Australia: • established a Lung Cancer Advisory Group to advise on strategies for national implementation of the framework and its principles • conducted a national lung cancer demonstration project, with advice from an Expert Steering Group, to demonstrate the delivery of lung cancer care according to the principles across a range of service delivery settings, and identify key factors contributing to ongoing delivery of best practice cancer care • completed systematic reviews for each principle to determine the effectiveness of the principles in improving lung cancer care processes and outcomes. Program/Policy process: To support national adoption of the framework and its principles, Cancer Australia: • developed a promotion and communication strategy for widespread national dissemination • convened a National Summit to bring together policy makers, clinical stakeholders and consumers to support local application of the principles, and drive optimal care for people affected by lung cancer • identified and communicated consumer, service, and system-level approaches to aid sustainable use of the principles. Outcomes: The evidence-based approach to the development of the framework and its principles identified ways to improve the healthcare system to achieve better outcomes for those affected by lung cancer in Australia. A coordinated approach to the delivery of the National Summit supported those involved in lung cancer care to share and adopt innovative and multilevel strategies for best practice care. What was learned: Embedding strategies to support implementation of the principles, responsive to local context, was key to enabling sustainable improvements in national lung cancer control. [ABSTRACT FROM AUTHOR]
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- 2018
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20. Collection and Reporting of System-Wide Cancer Treatment Activity Data As Part of the Stage, Treatment and Recurrence (STaR) Project.
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Long, R., Luzuriaga, J., Biondi, C., Woods, A., Jackson, P., Anderiesz, C., Giles, C., and Zorbas, H.
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THERAPEUTICS ,CANCER treatment ,PUBLIC hospitals ,ONCOLOGIC surgery ,PALLIATIVE treatment - Abstract
Background: The need for high quality, comprehensive national data on the treatments applied to cancers is widely recognized within the Australian cancer control community. The analysis and reporting of cancer treatment data will greatly enhance our ability to better understand cancer care activity and outcomes - and in particular the treatments being applied across population groups. Aim: To collect and report national data on cancer treatments, as part of Cancer Australia's Stage, Treatment and Recurrence (STaR) project. The linking of this data with national data on stage at diagnosis, survival and recurrence, will help inform policy and practice and ultimately improve cancer outcomes. Methods: Cancer Australia developed a dataset of selected surgical procedures for the treatment of the top five incidence cancers (prostate, breast, colorectal, lung, and melanoma). A dataset of key selected radiotherapy, and systemic therapies for the treatment of all cancer types was also developed. Data for reporting system-wide treatment activity were extracted from existing national health administrative datasets, including: the Pharmaceutical Benefits Scheme (PBS), the Medicare Benefits Schedule (MBS) and the National Hospital Morbidity Database (NHMD). The scope of the analysis was selected surgical procedures, radiotherapy procedures, or pharmaceutical agents administered with the general intent to change the outcome of the cancer and/or provide symptom relief/ palliative care. Results: The data reported provide a high-level national system-wide overview of cancer treatments applied, including: • More than 1 million radiotherapy services were provided for all cancers combined in Australia (as indicated by MBS reimbursement claims data) for the years 2013 to 2015 inclusive; • The number of people receiving systemic anticancer therapies in Australia for all cancers combined (as indicated by PBS reimbursement claims data) increased from 198,756 in 2012 to 247,939 in 2016; and • The number of hospital separations recorded in the NHMD (i.e., episodes of admitted patient care) for patients with a principal diagnosis of cancer undergoing surgery for the treatment of the top five high incidence cancers in Australia increased from 53,516 in 2010 to 57,651 in 2015. Conclusion: National cancer treatment data were successfully collected and reported. Australia is one of very few countries in the world to collect and report national system-wide treatment data with a specific focus on cancer. These data will be linked to cancer incidence, stage at diagnosis, survival and recurrence data to help inform for population-level reporting of cancer outcomes. [ABSTRACT FROM AUTHOR]
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- 2018
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21. Collection and Reporting of National Cancer Stage at Diagnosis Data in Australia (STaR Project).
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Long, R., Woods, A., Biondi, C., Luzuriaga, J., Anderiesz, C., Jackson, P., Giles, C., and Zorbas, H.
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CANCER diagnosis ,MELANOMA ,CANCER relapse ,CHILDHOOD cancer ,THERAPEUTICS ,CANCER-related mortality - Abstract
Background: Stage at diagnosis is an important prognostic factor for cancer, providing contextual information for interpreting population health indicators such as mortality from cancer and cancer survival. Australian population-based cancer registries (PBCRs) routinely collect information on cancer incidence and mortality. The need for high quality, comprehensive national data on stage at diagnosis to supplement these data are widely recognized in Australia. The collection and dissemination of quality national stage data will enhance the: • ability to better monitor cancer outcomes, inform cancer control policy; • understand variations across different populations; and • identify where further research and targeted strategies may be required to improve cancer outcomes. Linking data on cancer stage at diagnosis with other administrative cancer data will also allow for a better understanding of the relationship between stage at diagnosis, treatments received, patterns of cancer recurrence, and survival outcomes. Aim: To strengthen national data capacity by collecting and reporting cancer stage at diagnosis for Cancer Australia's Stage, Treatment and Recurrence (STaR) project. Methods: Working with state and territory population-based cancer registries (PBCRs) and the Australian Pediatric Cancer Registry, Cancer Australia supported the development and testing of Business Rules for the collection of national cancer stage at diagnosis for: • The top 5 incident cancers based on the Tumor, Node, and Metastasis (TNM) staging system. These rules were endorsed by the Australasian Association of Cancer Registries (AACR) as a national standard in May 2016; and • Childhood cancers, with a separate set of Business Rules for 16 childhood cancer types based on the Toronto Pediatric Cancer Stage Guidelines. These rules were supported by the AACR as a national standard. Results: Using the AACR-endorsed Business Rules, comprehensive national cancer stage at diagnosis data for the top 5 incident cancers (for 2011) have been collected in Australia for the first time. Over 90% of incidence cases were able to be assigned a value for registry-derived (RD) stage at diagnosis for melanoma (97%), prostate (97%), and female breast (94%) cancers. Lower staging completeness was found for colorectal cancers (88%), and for lung cancers (72%). Business Rules for the collection of stage at diagnosis data for pediatric cancers have also been developed; 93% of sample cases diagnosed in the period 2006-2010 were able to be staged, ranging from 84% for nonrhabdomyosarcoma to 100% for hepatoblastoma. Conclusion: The Business Rules enabled the uniform collection of cancer stage at diagnosis data for the first time in Australia. The collection of these data will allow for the linkage of stage at diagnosis to other sources of information, including patterns of treatments applied, and enable reporting of survival and recurrence outcomes by stage. [ABSTRACT FROM AUTHOR]
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- 2018
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22. 'Bridging the Continuum' - Reporting Population-Level Trends Across the Continuum of Care: The Australian National Cancer Control Indicator (NCCI) Web Site.
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Long, R., Cooper, K., Woods, A., Biondi, C., Luzuriaga, J., Jackson, P., Anderiesz, C., Giles, C., and Zorbas, H.
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WEBSITES ,CONTINUUM of care ,CANCER-related mortality ,NATURAL resources ,CONTINUITY - Abstract
Background: High-quality data can assist the development of policy and cancer strategies, stimulate lines of research, and inform the provision of care leading to better cancer outcomes. In November 2017 Cancer Australia launched the National Cancer Control Indicators (NCCI) Web site (https://ncci.canceraustralia.gov.au), Australia's first interactive Web site of cancer-specific, national population-based data across the continuum of care. The NCCI Web site presents a set of indicators for monitoring national cancer trends and benchmarking internationally across seven key aspects of cancer control; prevention, screening, diagnosis, treatment, psychosocial care, research and outcomes. Aim: By presenting a set of indicators using seven domains from the cancer care continuum, the NCCI Web site presents the most current Australian national data for a range of cancer control indicators in an accessible and interactive format. The primary aim of the NCCI Web site (hosted as part of the Cancer Australia Web site) is to monitor and report the most recent population-level trends to drive improvements across the cancer control continuum in Australia, and to facilitate international benchmarking of Australia's cancer control efforts. Methods: National data level on 33 individual measures across the seven cancer continuum domains was accessed from both government and nongovernment data custodians. Where applicable and available for measures, data were disaggregated and presented by age, sex, indigenous status, remoteness area of residence and socioeconomic status. Review of the data analysis was undertaken by 46 external reviewers including data custodians and subject matter experts. Results: Example summary data from several indicators across the NCCI Web site, including demographic disaggregation by age, sex, remoteness area of residence and socioeconomic status (where available) will be provided. e.g., • Smoking prevalence has decreased substantially over the past 30 years, and smoking rates among both adolescents and adults in Australia are among the lowest in the world. • Cancer mortality rates have been falling steadily since 1995, across most cancer types. Australia has lower mortality rates from cancer when compared with most other similar developed countries, about 6% lower than the estimated global average in 2012. National population-level data showing incidence by stage at diagnosis for the top five most common cancers has also been reported on the Web site - making Australia one of the few countries in the world where these data are available. Conclusion: The NCCI Web site is a flagship data Web site providing, for the first time, an evolving high-level national data resource to monitor Australian population-level trends in cancer control across the continuum. As one of the very few cross-continuum cancer reporting resources in the world, this is a valuable resource for use by those within the international cancer control community. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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23. A systematic review of inequalities in psychosocial outcomes for women with breast cancer according to residential location and Indigenous status in Australia.
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Ernst, Jochen, Youl, P H, Dasgupta, P, Youlden, D, Aitken, J F, Garvey, G, Zorbas, H, Chynoweth, J, Wallington, I, and Baade, P D
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- 2016
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24. The 2003 Australian Breast Health Survey: survey design and preliminary results
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Favelle Simone, Nehill Caroline, Jones Sandra, Villanueva Elmer V, Steel David, Iverson Donald, and Zorbas Helen
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The Breast Health Surveys, conducted by the National Breast Cancer Centre (NBCC) in 1996 and 2003, are designed to gain insight into the knowledge, attitudes and behaviours of a nationally representative sample of Australian women on issues relevant to breast cancer. In this article, we focus on major aspects of the design and present results on respondents' knowledge about mammographic screening. Methods The 2003 BHS surveyed English-speaking Australian women aged 30–69 without a history of breast cancer using computer-assisted telephone interviewing. Questions covered the following themes: knowledge and perceptions about incidence, mortality and risk; knowledge and behaviour regarding early detection, symptoms and diagnosis; mammographic screening; treatment; and accessibility and availability of information and services. Respondents were selected using a complex sample design involving stratification. Sample weights against Australian population benchmarks were used in all statistical analyses. Means and proportions for the entire population and by age group and area of residence were calculated. Statistical tests were conducted using a level of significance of 0.01. Results Of the 3,144 respondents who consented to being interviewed, 138 (4.4%) had a previous diagnosis of breast cancer and were excluded leaving 3,006 completed interviews eligible for analysis. A majority of respondents (61.1%) reported ever having had a mammogram and 29.1% identified mammography as being the best way of finding breast cancer. A majority of women (85.9%) had heard of the BreastScreen Australia (BSA) program, the national mammographic screening program providing free biennial screening mammograms, with 94.5% believing that BSA attendance was available regardless of the presence or absence of symptoms. There have been substantial gains in women's knowledge about mammographic screening over the seven years between the two surveys. Conclusion The NBCC Breast Health Surveys provide a valuable picture of the knowledge of Australian women about a range of issues. The present analysis shows significant gains in knowledge and behaviours relating to mammographic screening, while identifying additional areas for targeted improvement, as in the need to better communicate with women about screening and diagnostic services. Further analysis of additional core topic areas (eg., incidence, mortality, risk and treatment) will provide equally noteworthy insight.
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- 2008
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25. BS10 POST-SURGICAL CARE IN BREAST CANCER – PROCESS MAPPING CURRENT MODELS IN AUSTRALIA.
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Giles, C., Buckingham, J., Delaney, G., Pearce, A., Wilcoxon, H., and Zorbas, H.
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BREAST cancer surgery ,CANCER in women ,LENGTH of stay in hospitals ,POSTOPERATIVE period ,SURGERY ,HEALTH facilities - Abstract
Purpose: Evidence collated by National Breast and Ovarian Cancer Centre (NBOCC) suggests that recent reductions in length of stay (LOS) following early breast cancer surgery are influencing the care women receive. Process mapping (PM) identifies steps involved in a patient's pathway. This project utilises PM to identify successful components and gaps in current models related to LOS and highlight opportunities to improve the post-surgical (PS) care of women with breast cancer in Australia. Methodology: Nine Australian hospitals were selected for high level PM using seven criteria; public/private, metropolitan/regional, services (diagnostic, treatment and follow up), surgical caseload, patient management protocols, multidisciplinary care, information and support. PM includes a workshop with the multidisciplinary team and consumers, as well as interviews with key clinical informants from the PS care pathway. Results: PM results in a series of flowcharts of the PS pathway. These inform a report on current models of care and their successful aspects, together with stakeholder perceptions. Differences between public/private and metropolitan/regional facilities are highlighted, along with the impact of different delivery models on the provision of information, clinical and supportive care for women. Conclusion: PM allows a representation of the impact of LOS on women's PS care, and the extent to which information, clinical and supportive care are available within current models. These results, combined with other NBOCC collated data (including AIHW statistics, surveys of women and breast care nurses, and literature reviews) will inform recommendations on new delivery models. [ABSTRACT FROM AUTHOR]
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- 2009
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26. BS09 STAGING AND MANAGING THE AXILLA IN EARLY BREAST CANCER – GUIDELINES FOR BEST PRACTICE.
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O'brien, J., Wilcoxon, H., Pearce, A., Luxford, K., Nelson, A., and Zorbas, H.
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BREAST cancer ,CANCER in women ,LYMPH nodes ,DISEASES -- Management ,MEDICAL literature ,CLINICAL medicine - Abstract
Purpose: Evidence-based guidelines assist clinicians to integrate research into practice. National Breast and Ovarian Cancer Centre (NBOCC) has systematically reviewed current evidence and developed recommendations for staging and managing the axilla in early breast cancer (EBC). NBOCC guidelines for sentinel node biopsy (SNB) were presented at RACS in 2008, supporting SNB as an alternative to axillary dissection (AD) in suitable women with EBC. However, guidelines for non-SNB-based axillary management are also required. Methodology: A multidisciplinary working group including consumers oversaw the systematic review addressing: AD versus 4-node sampling in axillary staging; AD versus non-surgical methods in axillary staging; the optimal extent of AD; the prognostic significance of the number of nodes retrieved and the proportion of involved nodes identified at AD; long-term outcomes of AD; and axillary irradiation (with or without AD) following breast surgery. Evaluation of the evidence informed the development of guideline recommendations by the working group. Results: Eleven randomised trials were identified, however the majority of evidence was from non-randomised trials. Imaging alone is not recommended for routine staging, and for most patients, surgical staging of the axilla is required. For women undergoing AD, level I or II AD is recommended. For women in whom axillary dissection is contraindicated, radiotherapy of the axilla is recommended. Implications and further recommendations for clinical practice will be discussed. Conclusion: Guidance for clinical practice is vital where evidence is inconsistent. Axilla management in EBC is once such area, emphasising the importance of new NBOCC guidelines. [ABSTRACT FROM AUTHOR]
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- 2009
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27. SO02 SYNOPTIC REPORTING OF BREAST IMAGING: AN OPPORTUNITY TO IMPROVE BREAST CANCER CARE.
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Mann, B., Zorbas, H., Goodwin, H., and Nehill, C.
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- *
BREAST cancer , *MEDICAL imaging systems , *DIAGNOSTIC imaging , *SURGEONS ,ABSTRACTS - Abstract
A scoping study of breast imaging reporting in July 2006 by the National Breast Cancer Centre (NBCC) revealed that synoptic reporting has not been widely implemented in Australia. The 2002 NBCC publication Breast imaging: a guide for practice recommended the use of a breast imaging synoptic report. A synoptic report contains a summary of essential information in a checklist format with standard language, descriptions and classification system (i). Synoptic reporting may improve the content and completeness of reports, reduce the risk of misinterpretation of findings, improve communication between referring clinicians and radiologists and facilitate the transfer of information to databases for quality improvement activities and audit (i). A breast imaging synoptic report helps clinicians and patients by assisting in tracking individual lesions, ensuring the inclusion of mammographic and ultrasound characteristics of lesions, offering one classification per lesion and a combined imaging diagnosis. As a result of the scoping study, the breast imaging synoptic report has been revised by a multidisciplinary working group to ensure acceptability and applicability to radiologists, referring clinicians and end users. A number of strategies have been identified to assist the implementation of the revised NBCC breast imaging synoptic report and standard classification system. Surgeons as referrers and end users, play an integral role in advocating and promoting the use of synoptic reporting in breast imaging. (i) National Breast Cancer Centre. Breast imaging: a guide for practice. Camperdown, NSW: National Breast Cancer Centre, 2002. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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28. BS15P FACILITATING NATIONAL CONSISTENCY IN BREAST CANCER DATA COLLECTION.
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Roder, D., Kollias, J., Gillett, D., Pyke, C., Care, O., and Zorbas, H.
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BREAST cancer ,CANCER patients ,LYMPH nodes ,TUMORS ,NATIONAL health services - Abstract
In Australia there is currently no consistent approach to collecting breast cancer specific data. The National Health Data Dictionary (NHDD) recommends a core set of generic data items for clinical cancer registration. However this list does not include the more detailed items required by specific tumour streams. The NBCC has developed a supplementary set of Breast Specific Data Items and definitions to serve as a guide for specialist breast cancer data collection in Australia. A multidisciplinary Working Group comprising clinical and consumer representation, including three breast surgeons, identified 16 breast specific data items for collection. The items are designed to align with items collected through the RACS National Breast Cancer Audit and leading cancer centres. A range of items from patient data (menopausal status), diagnostic data (HER2 status, sentinel lymph node), treatment (surgical margin clearance and involvement), and breast reconstruction are included. The data items are recommended as best practice for breast cancer specific data collection and aim to facilitate national consistency in defining, recording, and monitoring information about patients with breast cancer. This national approach will contribute to improved patient outcomes by informing planning, quality improvement and evaluation strategies for cancer services. The items are currently being piloted in two sites in NSW and will be available nationally in late 2007. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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29. SO16P MULTIDISCIPLINARY CANCER CARE IN AUSTRALIA: AN AUDIT OF CURRENT UPTAKE.
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Wilcoxon, H., Evans, A., Goodwin, H., O'Brien, J., Zorbas, H., and Luxford, K.
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ABSTRACTS ,CANCER patients ,TUMORS ,MEDICAL care ,HEALTH surveys - Abstract
Multidisciplinary care (MDC) has been shown to improve care and outcomes for cancer patients and is incorporated into national and state/territory clinical practice guidelines, frameworks and plans across Australia. The National Breast Cancer Centre Principles of Multidisciplinary Care provide a flexible framework for the implementation of MDC. However, while there has been a considerable focus on MDC in breast cancer there is anecdotal evidence that the wider uptake of MDC is limited. The NBCC has undertaken a national audit of MDC activity across five tumour streams: breast, gynaecological, lung, colorectal and prostate cancers. The aim of the audit was to provide a snapshot of MDC activity in Australia across a range of health service delivery settings, to identify areas or gaps where implementation strategies could be targeted to increase MDC uptake. The audit was timed to precede the introduction of a Medicare Benefit Schedule item to support specialists attending MDC meetings. A random sample of 420 hospitals, stratified by state/territory, hospital type (public/private) and geographic area (metropolitan/regional) were invited to nominate hospital staff to participate in a telephone survey about MDC activity for each of the five tumour streams. The survey investigated both practical and qualitative aspects of MDC practice based on the Principles of Multidisciplinary Care. Within two states the survey was administered through collaboration with state-based health departments. The national data was analysed by tumour stream, hospital type and geographical area. Key results and outcomes relevant to surgeons will be presented. [ABSTRACT FROM AUTHOR]
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- 2007
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30. Novel bis-platinum-complexes and their interaction with DNA
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Büning, H. and Zorbas, H.
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- 1995
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31. Variations in outcomes for Indigenous women with breast cancer in Australia: A systematic review
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Gail Garvey, Danny R. Youlden, Jennifer Chynoweth, Joanne F. Aitken, Helen Zorbas, Paramita Dasgupta, Philippa H. Youl, David Roder, Isabella Wallington, Peter D. Baade, Dasgupta, P, Baade, PD, Youlden, DR, Garvey, G, Aitken, JF, Wallington, I, Chynoweth, J, Zorbas, H, Roder, D, and Youl, PH
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medicine.medical_specialty ,Native Hawaiian or Other Pacific Islander ,Geographical isolation ,Referral ,Breast Neoplasms ,Comorbidity ,Indigenous ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,breast cancer ,systematic review ,Medicine ,Humans ,030212 general & internal medicine ,Registries ,Healthcare Disparities ,variations ,indigenous ,Disadvantage ,Early Detection of Cancer ,Mastectomy ,Gynecology ,Adult female ,business.industry ,Age Factors ,Australia ,Health Status Disparities ,medicine.disease ,Disadvantaged ,Survival Rate ,Treatment Outcome ,Oncology ,Social Class ,030220 oncology & carcinogenesis ,Female ,business ,Demography ,Qualitative research ,Mammography - Abstract
This systematic review examines variations in outcomes along the breast cancer continuum for Australian women by Indigenous status. Multiple databases were systematically searched for peer-reviewed articles published from 1 January 1990 to 1 March 2015 focussing on adult female breast cancer patients in Australia and assessing survival, patient and tumour characteristics, diagnosis and treatment by Indigenous status. Sixteen quantitative studies were included with 12 rated high, 3 moderate and 1 as low quality. No eligible studies on referral, treatment choices, completion or follow-up were retrieved. Indigenous women had poorer survival most likely reflecting geographical isolation, advanced disease, patterns of care, comorbidities and disadvantage. They were also more likely to be diagnosed when younger, have advanced disease or comorbidities, reside in disadvantaged or remote areas, and less likely to undergo mammographic screening or surgery. Despite wide heterogeneity across studies, an overall pattern of poorer survival for Indigenous women and variations along the breast cancer continuum of care was evident. The predominance of state-specific studies and small numbers of included Indigenous women made forming a national perspective difficult. The review highlighted the need to improve Indigenous identification in cancer registries and administrative databases and identified key gaps notably the lack of qualitative studies in current literature. Refereed/Peer-reviewed
- Published
- 2017
32. Multidisciplinary care in Australia
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Redman, S., Rainbird, K., Luxford, K., and Zorbas, H.
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- 2002
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33. Development of a National Aboriginal and Torres Strait Islander Cancer Framework: A Shared Process to Guide Effective Policy and Practice.
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Brands J, Garvey G, Anderson K, Cunningham J, Chynoweth J, Wallington I, Morris B, Knott V, Webster S, Kinsella L, Condon J, and Zorbas H
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- Australia, Health Policy, Health Services, Indigenous, Humans, Native Hawaiian or Other Pacific Islander, Neoplasms ethnology, Neoplasms therapy
- Abstract
Indigenous Australians experience a substantially higher cancer mortality rate than non-Indigenous Australians. While cancer outcomes are improving for non-Indigenous Australians, they are worsening for Indigenous Australians. Reducing this disparity requires evidence-based and culturally-appropriate guidance. The purpose of this paper is to describe an initiative by Cancer Australia and Menzies School of Health Research (Menzies) to develop Australia’s first National Aboriginal and Torres Strait Islander Cancer Framework using a process of co-design with relevant stakeholders. The initiative was guided by three core principles: achieving policy-relevant evidence-based outcomes; engaging and maintaining trust with Indigenous Australians at every phase; and employing best-practice and appropriate research methods. Four components of research comprised the Framework development: evidence review; multifaceted stakeholder consultation and input; triangulation of findings; and direct stakeholder input in drafting and refining the Framework. The evidence review confirmed the increasing burden of cancer on Indigenous Australians, while stakeholder consultations facilitated comprehensive input from those with lived experience. The consultations revealed issues not identified in existing literature, and gave different emphases of priority, thus reinforcing the value of including stakeholder perspectives. This paper focuses primarily on documenting the methods used; findings are presented only in order to illustrate the results of the process. The published Framework is available at www.canceraustralia.gov.au; further description and analyses of findings from the consultations will be published elsewhere. The logistics inherent in large-scale consultation are considerable. However, the quality of data and the foundation for sustained partnership with stakeholders and knowledge translation vastly outweighed the challenges. The process of wide-ranging stakeholder consultation described in this paper offers a model for other areas of national and international Indigenous priority setting and policy and practice development that meets the needs of those most affected. The Framework, through the establishment of an agreed, shared and evidence-based agenda, provides guidance for jurisdictional cancer plans, optimal care pathways, and program and service planning for the multiple players across all levels of the health system.
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- 2018
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34. Variations in outcomes by residential location for women with breast cancer: a systematic review.
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Dasgupta P, Baade PD, Youlden DR, Garvey G, Aitken JF, Wallington I, Chynoweth J, Zorbas H, and Youl PH
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- Australia epidemiology, Continuity of Patient Care, Female, Humans, Outcome Assessment, Health Care, Qualitative Research, Socioeconomic Factors, Treatment Outcome, Breast Neoplasms epidemiology, Residence Characteristics
- Abstract
Objectives: To systematically assess the evidence for variations in outcomes at each step along the breast cancer continuum of care for Australian women by residential location., Design: Systematic review., Methods: Systematic searches of peer-reviewed articles in English published from 1 January 1990 to 24 November 2017 using PubMed, EMBASE, CINAHL and Informit databases. Inclusion criteria were: population was adult female patients with breast cancer; Australian setting; outcome measure was survival, patient or tumour characteristics, screening rates or frequencies, clinical management, patterns of initial care or post-treatment follow-up with analysis by residential location or studies involving non-metropolitan women only. Included studies were critically appraised using a modified Newcastle-Ottawa Scale., Results: Seventy-four quantitative studies met the inclusion criteria. Around 59% were considered high quality, 34% moderate and 7% low. No eligible studies examining treatment choices or post-treatment follow-up were identified. Non-metropolitan women consistently had poorer survival, with most of this differential being attributed to more advanced disease at diagnosis, treatment-related factors and socioeconomic disadvantage. Compared with metropolitan women, non-metropolitan women were more likely to live in disadvantaged areas and had differing clinical management and patterns of care. However, findings regarding geographical variations in tumour characteristics or diagnostic outcomes were inconsistent., Conclusions: A general pattern of poorer survival and variations in clinical management for Australian female patients with breast cancer from non-metropolitan areas was evident. However, the wide variability in data sources, measures, study quality, time periods and geographical classification made direct comparisons across studies challenging. The review highlighted the need to promote standardisation of geographical classifications and increased comparability of data systems. It also identified key gaps in the existing literature including a lack of studies on advanced breast cancer, geographical variations in treatment choices from the perspective of patients and post-treatment follow-up., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
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- 2018
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35. Stating best practice in breast cancer care.
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Zorbas H
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- Australia, Female, Government Agencies, Humans, Breast Neoplasms therapy, Practice Guidelines as Topic
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- 2016
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36. Healthy lifestyles and the primary prevention of cancer summed up.
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Zorbas H
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- Australia, Humans, Life Style, Neoplasms prevention & control, Primary Prevention
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- 2016
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37. Psychological distress and quality of life in lung cancer: the role of health-related stigma, illness appraisals and social constraints.
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Chambers SK, Baade P, Youl P, Aitken J, Occhipinti S, Vinod S, Valery PC, Garvey G, Fong KM, Ball D, Zorbas H, Dunn J, and O'Connell DL
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- Adaptation, Psychological, Aged, Anxiety epidemiology, Cross-Sectional Studies, Depression epidemiology, Female, Humans, Lung Neoplasms therapy, Male, Middle Aged, New South Wales epidemiology, Queensland epidemiology, Shame, Lung Neoplasms psychology, Quality of Life psychology, Social Stigma, Stress, Psychological epidemiology
- Abstract
Objective: Health-related stigma is associated with negative psychological and quality of life outcomes in lung cancer patients. This study describes the impact of stigma on lung cancer patients' psychological distress and quality of life and explores the role of social constraints and illness appraisal as mediators of effect., Methods: A self-administered cross-sectional survey examined psychological distress and quality of life in 151 people (59% response rate) diagnosed with lung cancer from Queensland and New South Wales. Health-related stigma, social constraints and illness appraisals were assessed as predictors of adjustment outcomes., Results: Forty-nine percent of patients reported elevated anxiety; 41% were depressed; and 51% had high global distress. Health-related stigma was significantly related to global psychological distress and quality of life with greater stigma and shame related to poorer outcomes. These effects were mediated by illness appraisals and social constraints., Conclusions: Health-related stigma appears to contribute to poorer adjustment by constraining interpersonal discussions about cancer and heightening feelings of threat. There is a need for the development and evaluation of interventions to ameliorate the negative effects of health-related stigma among lung cancer patients., (© 2015 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd.)
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- 2015
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38. Breast cancer survival in New Zealand women.
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Campbell ID, Scott N, Seneviratne S, Kollias J, Walters D, Taylor C, Webster F, Zorbas H, and Roder DM
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- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Female, Humans, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, New Zealand epidemiology, Poverty, Registries, Risk Factors, Survival Analysis, Breast Neoplasms ethnology, Breast Neoplasms mortality
- Abstract
Background: The Quality Audit (BQA) of Breast Surgeons of Australia and New Zealand includes a broad range of data and is the largest New Zealand (NZ) breast cancer (BC) database outside the NZ Cancer Registry. We used BQA data to compare BC survival by ethnicity, deprivation, remoteness, clinical characteristic and case load., Methods: BQA and death data were linked using the National Health Index. Disease-specific survival for invasive cases was benchmarked against Australian BQA data and NZ population-based survivals. Validity was explored by comparison with expected survival by risk factor., Results: Compared with 93% for Australian audit cases, 5-year survival was 90% for NZ audit cases overall, 87% for Maori, 84% for Pacific and 91% for other., Conclusions: BC survival in NZ appears lower than in Australia, with inequities by ethnicity. Differences may be due to access, timeliness and quality of health services, patient risk profiles, BQA coverage and death-record methodology., (© 2014 Royal Australasian College of Surgeons.)
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- 2015
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39. Risk factors for poorer breast cancer outcomes in residents of remote areas of Australia.
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Roder D, Zorbas H, Kollias J, Pyke C, Walters D, Campbell I, Taylor C, and Webster F
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- Adult, Aged, Aged, 80 and over, Analysis of Variance, Australia, Breast Neoplasms diagnosis, Chemotherapy, Adjuvant statistics & numerical data, Female, Health Services Accessibility, Hospitals, Rural statistics & numerical data, Hospitals, Urban statistics & numerical data, Humans, Middle Aged, Multivariate Analysis, Practice Patterns, Physicians' statistics & numerical data, Radiotherapy, Adjuvant statistics & numerical data, Referral and Consultation statistics & numerical data, Risk Factors, Social Class, Statistics, Nonparametric, Breast Neoplasms therapy, Mastectomy, Segmental statistics & numerical data, Rural Population
- Abstract
To investigate patient, cancer and treatment characteristics in females with breast cancer from more remote areas of Australia, to better understand reasons for their poorer outcomes, bi-variable and multivariable analyses were undertaken using the National Breast Cancer Audit database of the Society of Breast Surgeons of Australia and New Zealand. Results indicated that patients from more remote areas were more likely to be of lower socio- economic status and be treated in earlier diagnostic epochs and at inner regional and remote rather than major city centres. They were also more likely to be treated by low case load surgeons, although this finding was only of marginal statistical significance in multivariable analysis (p=0.074). Patients from more remote areas were less likely than those from major cities to be treated by breast conserving surgery, as opposed to mastectomy, and less likely to have adjuvant radiotherapy when having breast conserving surgery. They had a higher rate of adjuvant chemotherapy. Further monitoring will be important to determine whether breast conserving surgery and adjuvant radiotherapy utilization increase in rural patients following the introduction of regional cancer centres recently funded to improve service access in these areas.
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- 2013
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40. Factors predictive of treatment by Australian breast surgeons of invasive female breast cancer by mastectomy rather than breast conserving surgery.
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Roder D, Zorbas H, Kollias J, Pyke C, Walters D, Campbell I, Taylor C, and Webster F
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- Adult, Aged, Aged, 80 and over, Analysis of Variance, Australia, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Female, Health Services Accessibility statistics & numerical data, Humans, Logistic Models, Mastectomy statistics & numerical data, Middle Aged, Multivariate Analysis, Rural Population statistics & numerical data, Statistics, Nonparametric, Tumor Burden, Urban Population statistics & numerical data, Breast Neoplasms surgery, Carcinoma, Ductal, Breast surgery, Mastectomy, Segmental statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Background: The National Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand is used by surgeons to monitor treatment quality and for research. About 60% of early invasive female breast cancers in Australia are recorded. The objectives of this study are: (1) to investigate associations of socio-demographic, health-system and clinical characteristics with treatment of invasive female breast cancer by mastectomy compared with breast conserving surgery; and (2) to consider service delivery implications., Materials and Methods: Bi-variable and multivariable analyses of associations of characteristics with surgery type for cancers diagnosed in 1998-2010., Results: Of 30,299 invasive cases analysed, 11,729 (39%) were treated by mastectomy as opposed to breast conserving surgery. This proportion did not vary by diagnostic year (p>0.200). With major city residence as the reference category, the relative rate (95% confidence limits) of mastectomy was 1.03 (0.99, 1.07) for women from inner regional areas and 1.05 (1.01, 1.10) for those from more remote areas. Low annual surgeon case load (<10) was predictive of mastectomy, with a relative rate of 1.08 (1.03, 1.14) when compared with higher case loads. Tumour size was also predictive, with a relative rate of 1.05 (1.01, 1.10) for large cancers (40+ mm) compared with smaller cancers (<30 mm). These associations were confirmed in multiple logistic regression analysis., Conclusions: Results confirm previous studies showing higher mastectomy rates for residents of more remote areas, those treated by surgeons with low case loads, and those with large cancers. Reasons require further study, including possible effects of surgeon and woman's choice and access to radiotherapy services.
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- 2013
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41. Evaluation of implementation of sentinel node biopsy in Australia.
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Morris T, Wetzig N, Sinclair S, Kollias J, and Zorbas H
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- Australia, Female, Humans, Practice Guidelines as Topic, Breast Neoplasms pathology, Guideline Adherence statistics & numerical data, Sentinel Lymph Node Biopsy standards
- Abstract
Background: Sentinel node biopsy (SNB) has been a major change in surgical technique for the management of early breast cancer. In June 2008, the National Breast and Ovarian Cancer Centre (NBOCC) released evidence-based guidelines for the use of SNB in Australia. During 2010, NBOCC undertook a cohort study to identify the extent to which clinical practice in Australia reflected the recommendations for use of SNB in the 6 months after release of the guidelines., Methods: Records obtained from four datasets, Royal Australasian College of Surgeons National Breast Cancer Audit, New South Wales Central Cancer Registry, Victorian Cancer Registry and Medicare Benefits Schedule records, were analysed to determine the extent to which the four key guideline recommendations had been implemented. This was supplemented by an audit of written SNB protocols of a sample of pathology laboratories in Australia., Results: ACROSS all cohorts, between 78 and 83% of women in Australia with tumours ≤3 cm had an SNB. Data were not available to indicate whether nodes were clinically negative. The likelihood of women having an SNB decreased outside the metropolitan regions, for women treated as public patients compared with private patients and as the size of the tumour increased. In 90% of procedures both preoperative lymphoscintigraphy with isotope and blue dye were used., Conclusion: The findings from the study confirm that best practice recommendations from the NBOCC guidelines for SNB were largely being implemented for women with early breast cancer in Australia within 6 months of their release., (© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.)
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- 2012
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42. Use of trastuzumab in Australia and New Zealand: results from the National Breast Cancer Audit.
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Whitfield R, Kollias J, De Silva P, Zorbas H, and Maddern G
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- Adult, Breast Neoplasms metabolism, Female, Humans, Middle Aged, Receptor, ErbB-2 metabolism, Trastuzumab, Antibodies, Monoclonal, Humanized therapeutic use, Antineoplastic Agents therapeutic use, Breast Neoplasms drug therapy
- Abstract
Background: Trastuzumab increases disease-free and overall survival in HER-2-positive, early breast cancer. In 2007, the National Breast and Ovarian Cancer Centre recommended that patients with HER-2 positive cancers (node positive or node negative tumours >1 cm) be offered adjuvant trastuzumab with chemotherapy. The aim of this study was to evaluate recent trends in trastuzumab therapy in Australia and New Zealand., Methods: Following data were obtained from the National Breast Cancer Audit for patients treated between 2006 and 2008: tumour size, number of cases recorded per surgeon per year, location of hospital, HER-2 receptor status, age, lymph node status, chemotherapy and trastuzumab treatment., Results: Data were available from 23,290 patients. During the study period, the percentage of breast cancers tested for HER-2 rose from 77% to 91%. Patients over 70 had fewer HER-2 tests than their younger counterparts. Fourteen percent of tumours were HER-2 positive; the proportion treated with trastuzumab in 2006, 2007 and 2008 was 50%, 66% and 74%, respectively. Significantly more node-positive patients (77%) were given trastuzumab than node-negative patients (52%). All the patients prescribed trastuzumab also received chemotherapy. Patients under 70 years, patients treated in Australia and patients treated by higher caseload surgeons were more likely to be prescribed trastuzumab than those over 70, patients in New Zealand and patients treated by lower caseload surgeons., Conclusions: Trastuzumab-prescribing trends conform to the published guidelines. However, older patients and those with HER-2 positive, node-negative tumours >1 cm may be undertreated in some cases., (© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.)
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- 2012
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43. Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand.
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Roder D, de Silva P, Zorbas H, Kollias J, Malycha P, Pyke C, Campbell I, and Webster F
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- Adult, Aged, Aged, 80 and over, Australia epidemiology, Female, Humans, Middle Aged, Multivariate Analysis, Neoplasm Staging, Neoplasms, Multiple Primary epidemiology, New Zealand epidemiology, Prevalence, Prognosis, Proportional Hazards Models, Breast Neoplasms mortality, Breast Neoplasms pathology, Neoplasms, Multiple Primary mortality, Neoplasms, Multiple Primary pathology
- Abstract
Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand were investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries., Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken., Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). After adjusting for favourable prognostic factors more common in SBBC cases (i.e., histology type, grade, lymphatic/ vascular invasion, and oestrogen receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common in SBBC cases (i.e., older age and large tumour diameter), the relative risk of breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26)., Conclusions: Results confirm previous findings of an equivalent or moderately poorer survival for SBBC but indicate that SBBC status is likely to be an important prognostic indicator for some cases.
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- 2012
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44. Breast screening and breast cancer survival in Aboriginal and Torres Strait Islander women of Australia.
- Author
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Roder D, Webster F, Zorbas H, and Sinclair S
- Subjects
- Adult, Aged, Australia epidemiology, Breast Neoplasms epidemiology, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Ductal, Breast epidemiology, Carcinoma, Ductal, Breast mortality, Carcinoma, Intraductal, Noninfiltrating diagnosis, Carcinoma, Intraductal, Noninfiltrating epidemiology, Carcinoma, Intraductal, Noninfiltrating mortality, Carcinoma, Lobular diagnosis, Carcinoma, Lobular epidemiology, Carcinoma, Lobular mortality, Female, Follow-Up Studies, Health Services, Indigenous, Humans, Lymph Nodes pathology, Mammography, Middle Aged, Native Hawaiian or Other Pacific Islander, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Registries, Socioeconomic Factors, Survival Rate, Breast Neoplasms diagnosis, Breast Neoplasms mortality, Early Detection of Cancer
- Abstract
Unlabelled: Aboriginal and Torres Strait Islander people comprise about 2.5% of the Australian population. Cancer registry data indicate that their breast cancer survivals are lower than for other women but the completeness and accuracy of Indigenous descriptors on registries are uncertain. We followed women receiving mammography screening in BreastScreen to determine differences in screening experiences and survivals from breast cancer by Aboriginal and Torres Strait Islander status, as recorded by BreastScreen. This status is self-reported and used in BreastScreen accreditation, and is considered to be more accurate. The study included breast cancers diagnosed during the period of screening and after leaving the screening program., Design: Least square regression models were used to compare screening experiences and outcomes adjusted for age, geographic remoteness, socio-economic disadvantage, screening period and round during 1996-2005. Survival of breast cancer patients from all causes and from breast cancer specifically was compared for the 1991-2006 diagnostic period using linked cancer-registry data. Cox proportional hazards regression was used to adjust for socio-demographic differences, screening period, and where available, tumour size, nodal status and proximity of diagnosis to time of screen., Results: After adjustment for socio-demographic differences and screening period, Aboriginal and Torres Strait Islander women participated less frequently than other women in screening and re-screening although this difference appeared to be diminishing; were less likely to attend post-screening assessment within the recommended 28 days if recalled for assessment; had an elevated ductal carcinoma in situ but not invasive cancer detection rate; had larger breast cancers; and were more likely than other women to be treated by mastectomy than complete local excision. Linked cancer registry data indicated that five-year year survivals of breast cancer cases from all causes of death were 81% for Aboriginal and Torres Strait Islander women, compared with 90% for other women, and that the former had larger breast cancers that were more likely to have nodal spread at diagnosis. After adjusting for socio-demographic factors, tumour size, nodal spread and time from last screen to diagnosis, Aboriginal and Torres Strait Islander women had approximately twice the risk of death from breast cancer as other women., Conclusions: Aboriginal and Torres Strait Islander women have less favourable screening experiences and those diagnosed with breast cancer (either during the screening period or after leaving the screening program) have lower survivals that persist after adjustment for socio-demographic differences, tumour size and nodal status.
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- 2012
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45. A specialist breast care nurse role for women with metastatic breast cancer: enhancing supportive care.
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Watts K, Meiser B, Conlon H, Rovelli S, Tiller K, Zorbas H, Lewis C, Neil G, and Friedlander M
- Subjects
- Adult, Aged, Breast Neoplasms pathology, Breast Neoplasms psychology, Female, Humans, Middle Aged, Nursing Evaluation Research, Patient Satisfaction, Breast Neoplasms nursing, Nurse's Role, Nurse-Patient Relations, Oncology Nursing, Social Support
- Published
- 2011
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46. Reducing time to diagnosis does not improve outcomes for women with symptomatic ovarian cancer: a report from the Australian Ovarian Cancer Study Group.
- Author
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Nagle CM, Francis JE, Nelson AE, Zorbas H, Luxford K, de Fazio A, Fereday S, Bowtell DD, Green AC, and Webb PM
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- Australia, Case-Control Studies, Female, Humans, Middle Aged, Neoplasm Staging, Proportional Hazards Models, Early Detection of Cancer, Ovarian Neoplasms diagnosis, Ovarian Neoplasms mortality
- Abstract
Purpose: To determine if time to diagnosis is associated with stage of disease at diagnosis or survival among women with symptomatic ovarian cancer., Methods: A representative sample of Australian women (n = 1,463) with ovarian cancer diagnosed between 2002 and 2005 who participated in a population-based case-control study were interviewed regarding the events leading to their diagnosis and were observed for mortality for 5 years., Results: Of the 1,318 women (90%) who presented to a medical practitioner with symptoms, 55% presented within 1 month, 70% in less than 2 months, and 92% within 6 months of symptom onset. There were no significant differences in the time from symptom onset to first medical practitioner consultation (P = .19) or symptom onset to diagnosis (P = .64) among women with borderline, early (International Federation of Gynecology and Obstetrics [FIGO] stages I to II) or late (FIGO stages III to IV) disease. There was also no association between time to diagnosis and survival; adjusted hazard ratio for long delay (> 12 months from symptom onset to diagnosis) versus short delay (≤ 1 month) was 0.94 (95% CI, 0.68 to 1.30). Women who had asymptomatic cancers diagnosed incidentally (n = 145) were younger and were more likely to have borderline or stage I disease compared with women who had symptomatic ovarian cancer., Conclusion: The results of this study suggest that, once ovarian cancer is symptomatic, reducing the time to diagnosis would not greatly alter stage of disease at diagnosis or survival.
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- 2011
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47. It's now or never: fertility-related knowledge, decision-making preferences, and treatment intentions in young women with breast cancer--an Australian fertility decision aid collaborative group study.
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Peate M, Meiser B, Friedlander M, Zorbas H, Rovelli S, Sansom-Daly U, Sangster J, Hadzi-Pavlovic D, and Hickey M
- Subjects
- Adult, Australia, Breast Neoplasms drug therapy, Conflict, Psychological, Female, Humans, Patient Participation, Breast Neoplasms psychology, Decision Making, Fertility, Health Knowledge, Attitudes, Practice
- Abstract
Purpose: For many young women with early breast cancer, fertility is a priority. Interventions to retain fertility options generally need to be accessed before chemotherapy, but many women do not receive information regarding these options in a timely fashion. Knowledge about fertility and decisional conflict has not previously been measured in young patients with breast cancer considering future pregnancies., Methods: One hundred eleven young women with early breast cancer who had not yet completed their families were recruited around the time of diagnosis. Knowledge regarding fertility-related information, decisional conflict, and preferences regarding fertility information and decision making was measured., Results: From a potential fertility-related knowledge score of 10, the mean was 5.2 (standard deviation = 2.3; range, 0 to 10). Decreased knowledge was associated with increased decisional conflict about pursuing fertility preserving interventions (odds ratio [OR] = 0.57; 95% CI, 0.44 to 0.73; P < .001). Thirty-one percent of women reported that they would consider undertaking in vitro fertilization (IVF) as a method to conserve their fertility, whereas 38% were uncertain. Consideration of IVF was not related to whether subjects were in a committed relationship (OR = 1.20; P = .716) or a definite desire for more children (OR = 1.54; P = .513)., Conclusion: Around diagnosis, many young patients with breast cancer have low levels of knowledge about fertility issues. Further, low knowledge is associated with increased decisional conflict, which is likely to undermine the quality of decision making. These findings suggest that targeted and timely fertility information may reduce decisional conflict and increase informed choice. Neither relationship status nor firm plans regarding future children reliably predict desire to pursue fertility preservation.
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- 2011
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48. Multidisciplinary cancer care in Australia: a national audit highlights gaps in care and medico-legal risk for clinicians.
- Author
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Wilcoxon H, Luxford K, Saunders C, Peterson J, and Zorbas H
- Subjects
- Cancer Care Facilities, Case Management, Delivery of Health Care organization & administration, Humans, Patient Care Planning ethics, Patient Care Planning standards, Delivery of Health Care standards, Interdisciplinary Communication, Medical Audit statistics & numerical data, Neoplasms therapy, Patient Care Planning organization & administration, Patient Care Team organization & administration, Practice Patterns, Physicians' legislation & jurisprudence
- Abstract
Aim: Multidisciplinary care (MDC) is accepted as best practice in cancer treatment planning and care. Despite recognition of the importance of a team approach, limited data are available about the extent to which MDC has been implemented in Australia. The aim of the audit was to investigate the implementation of MDC for five main cancer types across Australia in line with best practice., Methods: A sample of 155 hospitals was surveyed to investigate the status of MDC for cancer treatment planning in Australia across five cancer types (breast, gynecological, lung, prostate and colorectal). The survey investigated team structure, meetings, patient consent, documentation of team recommendations and communication with the patient., Results: Two-thirds of hospitals surveyed did not have a multidisciplinary team. Of those with such a team; in one-third patients were not informed their case would be discussed by the team, in half patient consent was not sought for all cases discussed by the team, in one-quarter the team's recommended treatment plan was not noted in the patient record. Less than 1% of teams reported routine attendance by the tumour-specific minimum core team., Conclusion: MDC is not being implemented in line with best practice or applied consistently across Australia. This audit has highlighted gaps in care delivery, despite national recommendations about MDC. Areas being neglected can affect the quality of care provided and may put clinicians at medico-legal risk. Recommendations to improve uptake and effectiveness of MDC are provided., (© 2011 Blackwell Publishing Asia Pty Ltd.)
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- 2011
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49. Australian women's awareness of ovarian cancer symptoms, risk and protective factors, and estimates of own risk.
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Jones SC, Magee CA, Francis J, Luxford K, Gregory P, Zorbas H, and Iverson DC
- Subjects
- Adult, Aged, Australia epidemiology, Carcinoma epidemiology, Carcinoma prevention & control, Female, Health Knowledge, Attitudes, Practice, Humans, Middle Aged, Ovarian Neoplasms epidemiology, Ovarian Neoplasms prevention & control, Patient Education as Topic, Perception, Primary Prevention education, Risk Factors, Statistics as Topic, Awareness physiology, Carcinoma diagnosis, Carcinoma etiology, Ovarian Neoplasms diagnosis, Ovarian Neoplasms etiology, Self-Assessment
- Abstract
Objective: To examine Australian women's perceived risk of ovarian cancer, reasons for perceived risk levels, and knowledge of ovarian cancer symptoms at two timepoints (2003 and 2007)., Methods: A computer-assisted telephone (CATI) survey of 2,954 Australian women with no history of ovarian cancer was conducted., Results: Approximately 60% of women perceived their risk of ovarian cancer was similar to other women of their age; 10% indicated an increased risk, and 30% indicated a lower risk. These figures were similar in 2003 and 2007. Logistic regression found that lower income, increased age, being born overseas, and being retired were significantly associated with lower perceived risk (accounted for only 7.5% of the variance). Common reasons for higher perceived risk included family history of ovarian/other cancers, increasing age, and having had other types of cancer or health problems. Reasons for lower than average risk included absence of family history, having a hysterectomy, and having regular Pap smears (indicating confusion between ovarian and cervical cancer). There appeared to be substantial confusion in women's understanding of ovarian cancer symptoms; this was similar in 2003 and 2007., Conclusion: The observed misperceptions and confusion regarding ovarian cancer symptoms and risk factors suggest ongoing public education campaigns are needed to improve knowledge and awareness.
- Published
- 2010
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50. Survival from breast cancers managed by surgeons participating in the National Breast Cancer Audit of the Royal Australasian College of Surgeons.
- Author
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Roder D, Wang JX, Zorbas H, Kollias J, and Maddern G
- Subjects
- Adult, Age Factors, Aged, Australia, Breast Neoplasms pathology, Disease-Free Survival, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Mastectomy methods, Middle Aged, Neoplasm Invasiveness pathology, Neoplasm Staging, Pilot Projects, Prognosis, Registries, Risk Assessment, SEER Program, Societies, Medical, Survival Analysis, Time Factors, Breast Neoplasms mortality, Breast Neoplasms surgery, Cause of Death, Mastectomy mortality
- Abstract
Background: he National Breast Cancer Audit (NBCA) of the Royal Australasian College of Surgeons has collected data on early breast cancer since 1998. In this project, deaths were traced by linkage of NBCA patient identifiers (first three digits of surname and date of birth) with the National Death Index that covers all deaths in Australia., Methods: Death data were traced to 31 December 2007. Invasive cancers diagnosed in 1998-2005 were included in survival analyses to allow enough follow-up for assessment. Survivals were compared with survivals for similar stages recorded by the New South Wales (NSW) Cancer Registry and USA Surveillance Epidemiology and End Results (SEER) programme. Survivals were analysed by conventional clinical risk factors to see if expected differences presented., Results: The 5-year survival from breast cancer of 93% for NBCA cases was the same as the SEER figure for local and regional cases combined in 1996-2004. The NBCA figure for localized cases was 97%, which was the same as for NSW. Node-positive NBCA cancers had a 5-year survival of 89%, which was slightly higher than the corresponding 86% for NSW, which may reflect exclusion from the NBCA of some cases with a poorer prognosis, including those with positive fixed nodes. As expected, lower survivals presented for older cases and those with conventional clinical risk factors., Conclusions: These survivals are credible both overall and by clinical risk factor. Opportunities present to use these data for survival monitoring and to investigate survival by socio-demographic characteristic, treatment protocol, case volume and provider characteristics., (© 2010 The Authors. ANZ Journal of Surgery © 2010 Royal Australasian College of Surgeons.)
- Published
- 2010
- Full Text
- View/download PDF
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