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In this paper, a novel p-type junctionless field effect transistor (PJLFET) based on a partially depleted silicon-on-insulator (PD-SOI) is proposed and investigated. The novel PJLFET integrates a buried N+-doped layer under the channel to enable the device to be turned off, leading to a special work mechanism and optimized performance. Simulation results show that the proposed PJLFET demonstrates an Ion/Ioff ratio of more than seven orders of magnitude, with Ion reaching up to 2.56 × 10−4 A/μm, Ioff as low as 3.99 × 10−12 A/μm, and a threshold voltage reduced to −0.43 V, exhibiting excellent electrical characteristics. Furthermore, a new CMOS inverter comprising a proposed PJLFET and a conventional NMOSFET is designed. With the identical geometric dimensions and gate electrode, the pull-up and pull-down driving capabilities of the proposed CMOS are equivalent, showing the potential for application in high-performance chips in the future.

In order to improve the cleaning effect of the castor shelling mixture, an air-sieve castor cleaning device was developed. The structure of the cleaning device was optimized by experiment and simulation based on the discrete element method. The results show that the sieving efficiency of the square distribution is 98.23% and the loss rate is 2.39%, both of which are better than the triangular distribution. The sieving efficiency in the condition of a 14 mm sieve hole diameter is 98.23%. For the conditions of 15 mm and 16 mm sieve hole diameters, the sieving efficiencies are 96.64% and 96.69%, respectively. Therefore, a sieve hole diameter of 14 mm is more beneficial for the sieving of castor capsules. The sieving efficiency is 94.0–99.5%, and the loss rate is 0.5–3.0% under 5–9° sieve inclination. The cleaning effect is better through comprehensive analysis when the sieve surface inclination is 8°. The parameters of maximum sieving efficiency combination, minimum loss rate combination, and optimal cleaning effect were obtained by optimizing the operating parameters of the cleaning device. The operating parameters were adjusted, and then the three combinations of parameters were tested. It is found that the impurity content of castor seeds is within 1%, which meets the requirements of the device design. This study can provide a reference for developing high-efficiency castor cleaning devices.

This paper develops a new class of nonlinear acceleration algorithms based on extending conjugate residual-type procedures from linear to nonlinear equations. The main algorithm has strong similarities with Anderson acceleration as well as with inexact Newton methods--depending on which variant is implemented. We prove theoretically and verify experimentally, on a variety of problems from simulation experiments to deep learning applications, that our method is a powerful accelerated iterative algorithm. The code is available at https://github.com/Data-driven-numericalmethods/Nonlinear-Truncated-Conjugate-Residual. [ABSTRACT FROM AUTHOR]

The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain reaction analysis, we demonstrated in the present study that miR-198 was downregulated in breast cancer tissues and cell lines, and that downregulation of miR-198 was significantly correlated with lymph node metastasis. Functional studies revealed that miR-198 inhibited cell proliferation and migration and promoted cell adhesion in aggressive breast cancer cells in vitro. In addition, we observed that CUB domain-containing protein 1 (CDCP1) was a direct target of miR-198, and that knockdown of CDCP1 inhibited cell proliferation and migration, and promoted cell adhesion, which was similar to the effects of overexpression of miR-198. Taken together, we provide evidence to characterize the role of miR-198/CDCP1 interaction in breast cancer, which may be useful in breast cancer therapy. [ABSTRACT FROM AUTHOR]