Search

Lung cancer is the common malignant tumor with the highest death rate in the world. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a potential anticancer agent induces selective apoptotic death of human cancer cells. Unfortunately, approximately half of lung cancer cell lines are intrinsically resistant to TRAIL-induced cell death. In this study, we identified RuvBL1 as a repressor of c-Jun/AP-1 activity, contributing to TRAIL resistance in lung cancer cells. Knocking down RuvBL1 effectively sensitized resistant cells to TRAIL, and overexpression of RuvBL1 inhibited TRAIL-induced apoptosis. Moreover, there was a negative correlation expression between RuvBL1 and c-Jun in lung adenocarcinoma by Oncomine analyses. High expression of RuvBL1 inversely with low c-Jun in lung cancer was associated with a poor overall prognosis. Taken together, our studies broaden the molecular mechanisms of TRAIL resistance and suggest the application of silencing RuvBL1 synergized with TRAIL to be a novel therapeutic strategy in lung cancer treatment. [ABSTRACT FROM AUTHOR]

The three-dimensional vibration of a functionally graded sandwich rectangular plate on an elastic foundation with normal boundary conditions was analyzed using a semi-analytical method based on three-dimensional elasticity theory. The material properties of the sandwich plate varied with thickness according to the power law distribution. Two types of functionally graded material (FGM) sandwich plates were investigated in this paper: one with a homogeneous core and FGM facesheets, and another with homogeneous panels and an FGM core. Various displacements of the plates were created using an improved Fourier series consisting of a standard Fourier cosine series along with a certain number of closed-form auxiliary functions satisfying the essential boundary conditions. The vibration behavior of the FGM sandwich plate, including the natural frequencies and mode shapes, was obtained using the Ritz method. The effectiveness and accuracy of the suggested technique were fully verified by comparing the natural frequencies of sandwich plates with results from investigations of other functionally graded sandwich rectangular plates in the literature. A parametric study, including elastic parameters, foundation parameters, power law exponents, and layer thickness ratios, was performed, and some new results are presented. [ABSTRACT FROM AUTHOR]