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Abstract Compared to transition metal dichalcogenide (TMD) monolayers, rhombohedral-stacked (R-stacked) TMD bilayers exhibit remarkable electrical performance, enhanced nonlinear optical response, giant piezo-photovoltaic effect and intrinsic interfacial ferroelectricity. However, from a thermodynamics perspective, the formation energies of R-stacked and hexagonal-stacked (H-stacked) TMD bilayers are nearly identical, leading to mixed stacking of both H- and R-stacked bilayers in epitaxial films. Here, we report the remote epitaxy of centimetre-scale single-crystal R-stacked WS2 bilayer films on sapphire substrates. The bilayer growth is realized by a high flux feeding of the tungsten source at high temperature on substrates. The R-stacked configuration is achieved by the symmetry breaking in a-plane sapphire, where the influence of atomic steps passes through the lower TMD layer and controls the R-stacking of the upper layer. The as-grown R-stacked bilayers show up-to-30-fold enhancements in carrier mobility (34 cm2V−1s−1), nearly doubled circular helicity (61%) and interfacial ferroelectricity, in contrast to monolayer films. Our work reveals a growth mechanism to obtain stacking-controlled bilayer TMD single crystals, and promotes large-scale applications of R-stacked TMD.

Abstract Controllable growth of two-dimensional (2D) single crystals on insulating substrates is the ultimate pursuit for realizing high-end applications in electronics and optoelectronics. However, for the most typical 2D insulator, hexagonal boron nitride (hBN), the production of a single-crystal monolayer on insulating substrates remains challenging. Here, we propose a methodology to realize the facile production of inch-sized single-crystal hBN monolayers on various insulating substrates by an atomic-scale stamp-like technique. The single-crystal Cu foils grown with hBN films can stick tightly (within 0.35 nm) to the insulating substrate at sub-melting temperature of Cu and extrude the hBN grown on the metallic surface onto the insulating substrate. Single-crystal hBN films can then be obtained by removing the Cu foil similar to the stamp process, regardless of the type or crystallinity of the insulating substrates. Our work will likely promote the manufacturing process of fully single-crystal 2D material-based devices and their applications.

Recent studies have reported the growth of 2D non-centrosymmetric single crystals on substrates with surface steps, but the mechanisms are still unclear. Here, the authors demonstrate a method to grow unidirectionally aligned transition metal dichalcogenide grains on various types of substrates, showing the importance of the simultaneous formation of grain nuclei and substrate steps.

A collinear backscattering Mueller matrix (CBMM) imaging system has clear advantages in the detection of bulk biological tissues, which are highly scattering and depolarizing. Due to the double-pass configuration and noise in the system, the calibration of a collinear backscattering Mueller matrix imaging system is usually complex and of poor accuracy. In this work, we propose an alternative modified eigenvalue calibration method (ECM) based on the equivalent standard sample. For better noise suppression and higher calibration accuracy, we design the distribution of polarization states over the Poincaré sphere and solve for the parameters of equivalent standard samples by means of an optimization. Compared to other variants of the eigenvalue calibration method used in the double-pass system, the accuracy of the proposed method is improved by more than 40 times. The comparison results with the error model-based calibration methods indicate that the modified eigenvalue calibration method generally gives the best accuracy and precision, as well as the best reliability.

Abstract The low‐energy layer edge states (LESs) from quasi 2D hybrid perovskite single crystals have shown great potential because of their nontrivial photoelectrical properties. However, the underlying formation mechanism of the LESs still remains controversial. Also, the presence or creation of the LESs is of high randomness due to the lack of proper techniques to manually generate these LESs. Herein, using a single crystals platform of quasi‐2D (BA)2(MA)n−1PbnI3n+1 (n > 1) perovskites, the femtosecond laser ablation approach to design and write the LESs with a high spatial resolution is reported. Fundamentally, these LESs are of smaller bandgap 3D MAPbI3 nanocrystals which are formed by the laser‐induced BA escaping from the lattice and thus the lattice shrinkage from quasi‐2D to 3D structures. Furthermore, by covering the crystal with tape, an additional high‐energy emission state corresponding to the reformation of (BA)2PbI4 (n = 1) within the irradiation region is generated. This work presents a simple and efficient protocol to manually write LESs on single crystals and thus lays the foundation for utilizing these LESs to further enhance the performance of future photoelectronic devices.

Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs) are incorporated into cysteine-based poly-(disulfide amide) (Cys-PDSA) to form stable and biodegradable nanoagent. The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles (NPs) as a novel contrast agent for high-resolution PT-OCT bioimaging. The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo. And the obtained NPs exhibit excellent near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform, with very low chemo drug dosage and side effects. Both of the polymer and BPQD are degradable, indicating this platform is a rare PT-OCT agent that is completely biodegradable. Overall, our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy.

The lateral imaging characteristic of an acoustic lens is similar to the well-known object-image relationship of an optical lens. In this paper, axial signal analysis is carried on and reconstruction methods for a sample's axial photoacoustic (PA) image are researched based on the acoustic-lens PA imaging system. The integral and envelope methods are both proposed to reconstruct a sample's axial PA image, which has only been achieved approximately by the PA signals' peak values obtained by a peak-holding circuit in previous reports. And the envelope method is proposed for the first time. Hilbert transform was used to obtain the envelope of the sample's PA signals and axial PA images. Simulation results show that the integral method is appropriate for low frequency samples, and that the envelope reconstruction method can provide low frequency information of the PA images of samples. So for a sample, it would be best to combine the two methods together.

Soluble microneedles (MNs) have recently become an efficient and minimally invasive tool in transdermal drug delivery because of their excellent biocompatibility and rapid dissolution. However, direct monitoring of structural and functional changes of MNs in vivo to estimate the efficiency of insulin delivery is difficult. We monitored the dissolution of MNs to obtain structural imaging of MNs’ changes by using optical coherence tomography (OCT). We also observed the effect of MNs on microvascular conditions with laser speckle contrast imaging (LSCI) and measured the blood perfusion of skin to obtain functional imaging of MNs. We determined the performance of two soluble MN arrays made from polyvinyl alcohol (PVA) and polyvinyl alcohol/polyvinylpyrolidone (PVA/PVP) by calculating the cross-sectional areas of the microchannels in mouse skin as a function of time. Moreover, the change in blood glucose before and after using MNs loaded with insulin was evaluated as an auxiliary means to demonstrate the ability of the soluble MNs to deliver insulin. Results showed that the structural imaging of these MNs could be observed in vivo via OCT in real time and the functional imaging of MNs could be showed using LSCI. OCT and LSCI are potential tools in monitoring MNs structural and functional changes.

In a single quantum dot (QD) system connected with ferromagnetic electrodes, the electron transport properties, assisted by the thermal and Fock state optical fields, are theoretically studied by the Keldysh nonequilibrium Green’s function approach. The results show that the evolution properties of the density of state and tunneling current assisted by the Fock state optical field, are quite different from those of the thermal state. The photon sideband shift decreases monotonously with the increase in the electron−photon coupling strength for the case of the thermal state, while the shift is oscillatory for the case of the Fock state. Negative differential conductance (NDC) appears obviously in a QD system contacted with parallel (P) and antiparallel (AP) magnetization alignment of the ferromagnetic electrode leads, assisted by the Fock state optical field in a wide range of electron−photon interaction parameters. Evident NDC usually only arises in an AP configuration QD system assisted by the thermal state optical field. The results have the potential to introduce a new way to actively manipulate and control the single-electron tunneling transport on a QD system by the quantum states of the optical field.

In this paper, using the particle-number-resolved master equation, the properties of full counting statistics (FCS) are investigated for a single quantum dot (QD) system interacting with optical fields in the thermal state, Fock state, coherent state, and coherent state with random phase. In these diverse quantum states of optical fields, average tunneling currents have different step shoulder heights at a lower bias voltage with the same light intensity, and a staircase-shaped current can be induced unexpectedly in vacuum state optical field. The characteristics of the Fano factor and skewness in the coherent state differ from those in all of the other cases. For avalanche-like transport at a lower bias voltage, the mechanism is a dynamical channel blockade in a moderate electron–photon interaction regime. There is a pronounced negative differential conductance that results from tuning the phase of the coherent state optical field in a symmetric QD system.

We demonstrate the feasibility of simultaneous multi-probe detection for an optical-resolution photoacoustic microscopy (OR-PAM) system. OR-PAM has elicited the attention of biomedical imaging researchers because of its optical absorption contrast and high spatial resolution with great imaging depth. OR-PAM allows label-free and noninvasive imaging by maximizing the optical absorption of endogenous biomolecules. However, given the inadequate absorption of some biomolecules, detection sensitivity at the same incident intensity requires improvement. In this study, a modulated continuous wave with power density less than 3 mW/cm2 (1/4 of the ANSI safety limit) excited the weak photoacoustic (PA) signals of biological cells. A microcavity transducer is developed based on the bulk modulus of gas five orders of magnitude lower than that of solid; air pressure variation is inversely proportional to cavity volume at the same temperature increase. Considering that a PA wave expands in various directions, detecting PA signals from different positions and adding them together can increase detection sensitivity and signal-to-noise ratio. Therefore, we employ four detectors to acquire tiny PA signals simultaneously. Experimental results show that the developed OR-PAM system allows the label-free imaging of cells with weak optical absorption.

Several methodologies are used to study the theory of the imaging property of photoacoustic (PA) Fourier imaging, as well as tomography. The analysis shows that the method described can be widely used to provide PA tomography images of even the biological tissue with extremely clear images and sharp backgrounds.

Photoacoustic (PA) signals carry much information related to the physical parameters of a sample, such as its optical, thermal, acoustic, and elastic properties. These physical parameters synchronously make their own contributions to PA signals. It is difficult to distinguish the contributions of different physical parameters to the mixed PA signals. To separate these parameters and to extract the featured information, we report herein a means of dissecting the transient PA signal using time-frequency analysis in a forward detection model. The simulated and experimental results indicate that the features of different physical parameters related to the sample can be qualitatively extracted from the mixed PA signals. [ABSTRACT FROM AUTHOR]

In this paper, we propose a simultaneous multiple-slice photoacoustic (PA) imaging technique by utilizing an acoustic lens with parallel imaging ability. Our method can directly image multiple slices of the three-dimensional (3D) PA images in real-time without utilizing special reconstruction algorithms. Combining the advantages of an acoustic lens with long focal depth and a fast data acquisition system with high sampling rate, the new system can acquire all slices of a 3D object simultaneously. This is achieved by utilizing the time-resolved technique that allows to distinguish PA signals from different object planes. According to the experiment results, the reconstructed sectional images match the original samples well. The proposed technique provides a fast and reliable approach to multiple-section PA imaging. Our study can be applied to noninvasive imaging and medical diagnosis. [ABSTRACT FROM AUTHOR]

Photoacoustic (PA) method is used for measuring the viscoelasticity of red blood cells (RBCs) in order to determine whether it might elucidate mechanical characteristic at a cellular level. The PA method is a simple, real-time and noninvasive way to obtain the viscoelastic properties at a cellular level.

The article explains a newly developed analytical method of photoacoustic (PA) spectroscopy, which employs wavelet transform (WT) and the first-derivative PA spectrum for the sensitive detection of weak absorption signals. The technique is shown to be extremely sensitive and accurate for the spectral analysis.

We designed, fabricated, and tested a rapid and noncontact photoacoustic tomography (PAT) imaging system using a low-coherence interferometer with high-speed phase modulation technique. Such a rapid and noncontact probing system can greatly decrease the time of imaging. The proposed PAT imaging system is experimentally verified by capturing images of a simulated tissue sample and the blood vessels within the ear flap of a mouse (pinna) in vivo. The axial and lateral resolutions of the system are evaluated at 45 and ~15 µm, respectively. The imaging depth of the system is 1 mm in a special phantom. Our results show that the proposed system opens a promising way to realize noncontact, real-time PAT. [ABSTRACT FROM AUTHOR]

A simultaneous photoacoustic (PA) tomography imaging technique in multilayer samples was developed. Instead of using the PA image reconstruction methods on the basis of complex algorithms, obtaining a two-dimensional PA image in real time is available by using an acoustic lens that has the ability of parallel imaging. The imaging system can acquire the complete PA signals of high signal-to-noise ratio from all the object planes by utilizing the advantages of the acoustic lens with long focal depth and a fast data acquisition system with a high sampling rate. With the time-resolved technique, the PA signals from different object planes can be distinguished and then the high optical contrast multilayer PA images can be reconstructed simultaneously without any algorithms. The experimental results show that the reconstructed sections agree well with the original samples. [ABSTRACT FROM AUTHOR]