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To promote the achievement of low-carbon goals in the power industry, rational and effective power system planning is essential. The participation of demand response in power system planning is an important means to reduce carbon emissions. To this end, a dual-layer low-carbon planning model for power systems considering carbon emission flow and demand response was designed. The upper layer investment planning model minimizes investment and operational costs, using an annual 8760-h operation simulation model and unit clustering linearization of the coal-fired units, coordinating the optimized investment and construction capacity of traditional units, new energy, and storage. The lower layer model forms a demand response model based on carbon emission flow theory and a load-side stepped carbon price mechanism, using the unit output and line flow data calculated by the upper layer model. This model reasonably adjusts the load distribution to reduce both the amount and cost of carbon emissions. Finally, the proposed model was analyzed and verified on the improved IEEERTS-24 node system. [ABSTRACT FROM AUTHOR]

To investigate Mandarin Tone 2 production of disyllabic words of prelingually deafened children with a cochlear implant (CI) and a contralateral hearing aid (HA) and to evaluate the relationship between their demographic variables and tone-production ability. Thirty prelingually Mandarin-speaking preschoolers with CI+HA and 30 age-matched normal-hearing (NH) children participated in the study. Fourteen disyllabic words were recorded from each child. A total of 840 tokens (14 × 60) were then used in tone-perception tests in which four speech therapists participated. The production of T2-related disyllabic words of the bimodal group was significantly worse than that of the NH group, as reflected in the overall accuracy (88.57% ± 16.31% vs 99.29% ± 21.79%, p < 0.05), the accuracy of T1+T2 (93.33% vs 100%), the accuracy of T2+T1 (66.67 ± 37.91% vs 98.33 ± 9.13%), and the accuracy of T2+T4 (78.33 ± 33.95% vs 100%). In addition, the bimodal group showed significantly inferior production accuracy of T2+T1 than T2+T2 and T3+T2, p < 0.05. Both bimodal age and implantation age were significantly negatively correlated with the overall production accuracy, p < 0.05. For the error patterns, bimodal participants experienced more errors when T2 was in the first position of the tone combination, and T2 was most likely to be mispronounced as T1 and T3. Bimodal patients aged 3–5 have T2-related disyllabic lexical tone production defects, and their performances are related to tone combination, implantation age, and bimodal age. [ABSTRACT FROM AUTHOR]

In order to study the standard security access authentication mechanism of intelligent sensing terminals of massive power Internet of Things, In order to study the standard secure access authentication mechanism of intelligent sensing terminal of massive power Internet of Things, a new privacy protection method widely used in block chain is proposed to prove identity. The traditional power IoT cloud-side interaction security access MQTT protocol still has a lot of room for adaptation and optimization. First, the proposed non-interactive zero-knowledge proof identity authentication method reduces the time of traditional standard secure access authentication process; Second, it reduced the computing resources consumed in a large number of intelligent sensors access authentication. The comparison results show that, the access authentication time of this method is 30% ∼ 50% less than that of the traditional secure access authentication process. The computing resources consumed during authentication are reduced by 20% to 30% compared with traditional security and secrecy mechanisms. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the efficacy and safety of DBPR108 (prusogliptin), a novel dipeptidyl peptidase‐4 (DPP‐4) inhibitor, as an add‐on therapy in patients with type 2 diabetes (T2D) that is inadequately controlled with metformin. Materials and Methods: In this 24‐week, multi‐centre, randomized, double‐blind, placebo‐controlled, superiority, phase III study, adult T2D patients with HbA1c levels ranging from 7.0% to 9.5% on stable metformin were enrolled and randomized (2:1) into the DBPR108 + metformin and placebo + metformin groups. The primary endpoint was the change from baseline in HbA1c at week 24 of DBPR108 versus placebo as an add‐on therapy to metformin. Results: At week 24, the least‐square mean (standard error) change from baseline in HbA1c was significantly greater in the DBPR108 group (−0.70% [0.09%]) than in the placebo group (−0.07% [0.11%]) (P <.001), with a treatment difference of −0.63% (95% confidence interval: −0.87%, −0.39%) on the full analysis set. A higher proportion of patients achieved an HbA1c of 6.5% or less (19.7% vs. 8.5%) and an HbA1c of 7.0% or less (50.0% vs. 21.1%) at week 24 in the DBPR108 + metformin group. Furthermore, add‐on DBPR108 produced greater reductions from baseline in fasting plasma glucose and 2‐hour postprandial plasma glucose without causing weight gain. The overall frequency of adverse events was similar between the two groups. Conclusions: DBPR108 as add‐on therapy to metformin offered a significant improvement in glycaemic control, was superior to metformin monotherapy (placebo) and was safe and well‐tolerated in patients with T2D that is inadequately controlled with metformin. [ABSTRACT FROM AUTHOR]

With the increasing proportion of wind power connected to grid, power system dispatching is facing more and more challenges from uncertainty. To cope with this uncertainty, robust optimization has been applied in unit commitment (UC) problem. In this paper, a multi‐band uncertainty set considering the temporal correlation (MBUSCTC) of wind/load prediction error is proposed firstly, which has two characteristics: (1) The MBUSCTC rigorously and realistically reflect the distribution characteristics of uncertainties in uncertainty intervals, thereby effectively reducing the conservatism of the traditional singe‐band uncertainty set; (2) the temporal correlation constraints of wind power/load prediction errors in MBUSCTC could limit the realization of uncertainties fluctuating frequently in uncertain intervals, thereby eliminating scenarios with lower probability in uncertainty sets. Then the proposed MBUSCTC is applied to UC problem, leading a robust UC model based on MBUSCTC, which is solved by Benders decomposition method and C&CG method. Finally, case studies based on the modified IEEE‐118 bus system and an actual power system of China demonstrate that the proposed method can effectively reduce the conservativeness of the robust UC model and ensure the robustness of the unit commitment solution. [ABSTRACT FROM AUTHOR]

Thioglycolic acid (TGA)-coated colloidal AgS quantum dots (QDs) emitting in the near-infrared (NIR) region upon excitation by an 808 nm diode laser were synthesized. The observed photoluminescence (PL) was attributed to the presence of ligand-modified AgS on the QD surfaces and could be easily controlled by a simple dilution process due to the concentration-dependent surface structure of the colloidal QDs. Upon dilution of the solution, the PL intensity initially increased before later decreasing, with a blueshift being observed in the PL spectra. These phenomena can be accounted for by the aggregation of QDs due to a decrease in the content of ligand-modified AgS on the QD surfaces upon dilution, which in turn affected the fluorescence resonance energy transfer (FRET), and re-emission of the surface energy level. [ABSTRACT FROM AUTHOR]

The floating ring bearing (FRB) has been widely used in the field of high-speed rotating machinery such as turbochargers, aviation engines and so on, because of its simple structure, high efficiency and low power consumption. In order to obtain the best ratio between inter-oil clearance and shaft radius of the floating ring bearing necessitates the design reference of dimensional parameters for the design of floating ring bearings. This study, based on the transfer-matrix method, developed the dynamic model of the floating ring bearing-rotor system, and, using the Runge–Kutta analysis method for floating ring bearings, the influence of oil film relative clearance ratio of floating rings on rotor system stability was analyzed and studied. The optimum clearance ratio between inner oil film and the shaft of floating ring bearings is λ = 0.01. This research can provide some theoretical support for the design of parameters and fault diagnosis of rotor floating ring bearing systems. [ABSTRACT FROM AUTHOR]

Background: Centromere protein U (CENPU) is key for mitosis in the carcinogenesis of cancers. However, the roles of CENPU have not been inspected in nasopharyngeal carcinoma (NPC). Thus, we aimed to explore the functions and mechanisms of CENPU in NPC., Methods: Expression of CENPU was evaluated by real-time quantitative polymerase chain reaction, western blotting and immunohistochemistry. The biological functions of CENPU were evaluated in vitro and in vivo . Gene chip analysis, ingenuity pathway analysis, and coimmunoprecipitation experiments were used to explore the mechanisms of CENPU., Results: CENPU was highly expressed in NPC. High expression of CENPU was associated with advanced tumor, node and metastasis (TNM) stage and poor overall survival. Cox regression analysis demonstrated that CENPU expression was an independent prognostic factor in NPC. Knockdown of CENPU inhibited proliferation and migration in vitro and in vivo . Knockdown of CENPU upregulated dual specificity phosphatase 6 (DUSP6) expression. The expression of CNEPU was inversely correlated with the expression of DUSP6 in NPC tissues. Mechanistic studies confirmed that CENPU increased the activation of the ERK1/2 and p38 signaling pathways by suppressing the expression of DUSP6., Conclusions: CENPU acts as an oncogene in NPC by interacting with DUSP6, and may represent a promising prognostic biomarker for patients with NPC., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-2395/coif). The authors have no conflicts of interest to declare., (2024 Translational Cancer Research. All rights reserved.)