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16. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78

Author

Yan Zi, Liu Yufeng, Yang Bowen, Zhao Wenhui, Wang Yan, Wang Deping, Li Jianguo, Jiao Xiangying, and Cao Jimin

Subjects
acetylation, apoptosis, cardiomyocytes, GRP78, trauma, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Cardiomyocyte apoptosis is an important cause of trauma-induced secondary cardiac injury (TISCI), in which the endoplasmic reticulum stress (ERS)-mediated apoptosis signaling pathway is known to be first activated, but the mechanism remains unclear. In this study, rat models of traumatic injury are established by using the Noble-Collip trauma device. The expression of glucose-regulating protein 78 (GRP78, a molecular chaperone of the cardiomyocyte ER), acetylation modification of GRP78 and apoptosis of cardiomyocytes are determined. The results show that ERS-induced GRP78 elevation does not induce cardiomyocyte apoptosis in the early stage of trauma. However, with prolonged ERS, the GRP78 acetylation level is elevated, and the apoptosis of cardiomyocytes also increases significantly. In addition, in the early stage of trauma, the expression of histone acetyl-transferase (HAT) P300 is increased and that of histone deacetylase 6 (HDAC6) is decreased in cardiomyocytes. Inhibition of HDAC function could induce the apoptosis of traumatic cardiomyocytes by increasing the acetylation level of GRP78. Our present study demonstrates for the first time that post-traumatic protracted ERS can promote cardiomyocyte apoptosis by increasing the acetylation level of GRP78, which may provide an experimental basis for seeking early molecular events of TISCI.

Published
2023
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17. Formation of a two-dimensional helical square tube ice in hydrophobic nanoslit using the TIP5P water model.

Author

Li, Jiaxian, Zhu, Chongqin, Zhao, Wenhui, Gao, Yurui, Bai, Jaeil, Jiang, Jian, and Zeng, Xiao Cheng

Subjects
NANOTUBES, WATER use, MOLECULAR dynamics, ICE, HYDROGEN bonding, HYDROGEN analysis, TUBES
Abstract

In extreme and nanoconfinement conditions, the tetrahedral arrangement of water molecules is challenged, resulting in a rich and new phase behavior unseen in bulk phases. The unique phase behavior of water confined in hydrophobic nanoslits has been previously observed, such as the formation of a variety of two-dimensional (2D) ices below the freezing temperature. The primary identified 2D ice phase, termed square tube ice (STI), represents a unique arrangement of water molecules in 2D ice, which can be viewed as an array of 1D ice nanotubes stacked in the direction parallel to the confinement plane. In this study, we report the molecular dynamics (MD) simulations evidence of a novel 2D ice phase, namely, helical square tube ice (H-STI). H-STI is characterized by the stacking of helical ice nanotubes in the direction parallel to the confinement plane. Its structural specificity is evident in the presence of helical square ice nanotubes, a configuration unseen in both STI and single-walled ice nanotubes. A detailed analysis of the hydrogen bonding strength showed that H-STI is a 2D ice phase diverging from the Bernal–Fowler–Pauling ice rules by forming only two strong hydrogen bonds between adjacent molecules along its helical ice chain. This arrangement of strong hydrogen bonds along ice nanotube and weak bonds between the ice nanotube shows a similarity to quasi-one-dimensional van der Waals materials. Ab initio molecular dynamics simulations (over a 30 ps) were employed to further verify H-STI's stability at 1 GPa and temperature up to 200 K. [ABSTRACT FROM AUTHOR]

Published
2024
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23. China Anti-Cancer Association (CACA) guidelines for holistic integrative management of lymphoma (version 2022)

Author

Zhang, Qingyuan, Feng, Jifeng, Wang, Huaqing, Huang, Huiqiang, Zhang, Huilai, Li, Xiaoqiu, Gao, Yuhuan, Song, Yongping, Li, Zhiming, Bai, Ou, Cao, Junning, Zhou, Hui, Gu, Kangsheng, Zhao, Shu, Zhao, Wenhui, Qin, Yan, Li, Yajun, Ma, Guangyu, Wen, Shujuan, Wang, Yu, Zhao, Peiqi, Guo, Wei, Lv, Fangfang, Tian, Yuyang, Chen, Xinrui, Xie, Zucheng, and Shi, Yuankai

Published
2023
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26. An Empirical Study on Blended Learning in Higher Education in 'Internet + ' Era

Author

Zhao, Wenhui

Abstract

In order to investigate the overall cognition of blended learning, we made a questionnaire survey and interviews with students and teachers of 10 universities and colleges in Anhui Province. Based on this investigation, we design a Rain class blended learning model which fully utilizes the modern network technology and mobile terminals to closely link pre-class and after-class learning to classroom teaching by using Wechat terminal. In order to validate the application effect of the model, a quasi-experiment is conducted between two groups of students. We used SPSS 23.0 in recording and analyzing the data for inferential statistics, two independent samples T-test, variance analysis and descriptive statistical analysis. The difference was statistically significant with P < 0.05. The study found that students have higher interest and acceptance to blended learning, but miscellaneous online resources and excessive interference information have negative impacts on students' online learning participation behavior. The hypothesis about the influencing factors of blended learning has been verified empirically, that is, perceived ease of use, perceived usefulness, a learning atmosphere are important factors affecting learners' acceptance of blended learning. A teaching practice proved that the new learning model has achieved remarkable results in improving learning efficiency and quality of students in large classroom, cultivating students' learning initiative and stimulating their interest in learning.

Published
2022
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