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Aqueous rechargeable nickel//bismuth batteries have surfaced as a prospective energy storage and conversion system because of their merits of good safety, high power density, and low cost. Their electrochemical performances, however, are heavily dependent on the electrode active materials. Herein, high-performance aqueous rechargeable nickel//bismuth batteries were assembled with Bi2MoO6@reduced graphene oxide (rGO) as the anode active material and Co0.5Ni0.5MoO4@rGO as the cathode active material. Introducing rGO could effectively enhance the utilization of the electrode active materials, improving the specific capacity and rate performance. The Bi2MoO6@rGO delivered a specific capacity of 198.0 mA h g−1 at the current density of 1 A g−1 and rate property of 75.9% in 1–20 A g−1. Additionally, the Co0.5Ni0.5MoO4@rGO exhibited specific capacities of 150.5 and 110.8 mA h g−1 at 1 and 15 A g−1, respectively. Accordingly, the nickel//bismuth batteries afforded a maximum energy density of 53.1 W h kg−1 with a power density of 351.6 W kg−1 at 0.5 A g−1. This research demonstrates the great prospects for aqueous nickel//bismuth batteries and enriches the field of battery electrochemical systems. [ABSTRACT FROM AUTHOR]

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Multimodal operation is an efficient form of transportation organization. By integrating various modes of transport, the advantages of each mode are fully exerted, and the efficiency and quality of transportation are improved to meet the demand for personalized transport. This article first analyzes the status of multimodal transport development in various regions of Shandong Province; through the analysis of the external environment in which Jinan City is located, it proposes the layout of the Jinan Multimodal Transport Center; finally, it proposes various solutions based on the actual development status.

With the development of economy, efficient organization and transportation are increasingly sought after by people. The comprehensive freight system is the direction of future development. Multimodal transport is a large system composed of a combination of multiple modes of transport. It is a new form of transport organization. In the context of economic globalization, multimodal transport has become one of the most efficient ways to improve efficiency in transportation. This paper uses SWOT analysis to analyze the development of multimodal transportation in Jinan; expounds the internal functional areas of Jinan multimodal transport center; and conducts a detailed analysis of the multimodal transport center planning in Jinan.

Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague–Dawley (SD) pregnant rat model of chronic hypoxia was established. Plasma and urine metabolite profiles at different stages of the pregnancy were detected by 1H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders. [ABSTRACT FROM AUTHOR]

Systemic inflammatory response syndrome (SIRS) is characterized by dysregulated cytokine release, immune responses and is associated with organ dysfunction. IL‐6R blockade indicates promising therapeutic effects in cytokine release storm but still remains unknown in SIRS. To address the issue, we generated the human il‐6r knock‐in mice and a defined epitope murine anti‐human membrane‐bound IL‐6R (mIL‐6R) mAb named h‐mIL‐6R mAb. We found that the h‐mIL‐6R and the commercial IL‐6R mAb Tocilizumab significantly improved the survival rate, reduced the levels of TNF‐α, IL‐6, IL‐1β, IFN‐γ, transaminases and blood urea nitrogen of LPS‐induced SIRS mice. Besides, the h‐mIL‐6R mAb could also dramatically reduce the levels of inflammatory cytokines in LPS‐treated THP‐1 cells in vitro. RNA‐seq analysis indicated that the h‐mIL‐6R mAb could regulate LPS‐induced activation of NF‐κB/Ccl2 and NOD‐like receptor signaling pathways. Furthermore, we found that the h‐mIL‐6R mAb could forwardly inhibit Ccl2 expression and NLRP3‐mediated pyroptosis by suppressing NF‐κB in combination with the NF‐κB inhibitor. Collectively, mIL‐6R mAbs suppressed NF‐κB/Ccl2 signaling and inflammasome activation. IL‐6R mAbs are potential alternative therapeutics for suppressing excessive cytokine release, over‐activated inflammatory responses and alleviating organ injuries in SIRS. [ABSTRACT FROM AUTHOR]