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Abstract Background Ferroptosis is a newly discovered type of programmed cell death that participates in the biological processes of various cancers. However, the mechanism by which ferroptosis modulates acute myeloid leukemia (AML) remains unclear. This study aimed to investigate the role of ferroptosis-related long non-coding RNAs (lncRNAs) in AML and establish a corresponding prognostic model. Methods RNA-sequencing data and clinicopathological characteristics were obtained from The Cancer Genome Atlas database, and ferroptosis-related genes were obtained from the FerrDb database. The “limma” R package, Cox regression, and the least absolute shrinkage and selection operator were used to determine the ferroptosis-related lncRNA signature with the lowest Akaike information criteria (AIC). The risk score of ferroptosis-related lncRNAs was calculated and patients with AML were divided into high- and low-risk groups based on the median risk score. The Kaplan–Meier curve and Cox regression were used to evaluate the prognostic value of the risk score. Finally, gene set enrichment analysis (GSEA) and single-sample gene set enrichment analysis (ssGSEA) were performed to explore the biological functions of the ferroptosis-related lncRNAs. Results Seven ferroptosis-related lncRNA signatures were identified in the training group, and Kaplan–Meier and Cox regression analyses confirmed that risk scores were independent prognostic predictors of AML in both the training and validation groups (All P

In this article, we propose to learn shared semantic space with correlation alignment (S³CA) for multimodal data representations, which aligns nonlinear correlations of multimodal data distributions in deep neural networks designed for heterogeneous data. In the context of cross-modal (event) retrieval, we design a neural network with convolutional layers and fully connected layers to extract features for images, including images on Flickr-like social media. Simultaneously, we exploit a fully connected neural network to extract semantic features for text documents, including news articles from news media. In particular, nonlinear correlations of layer activations in the two neural networks are aligned with correlation alignment during the joint training of the networks. Furthermore, we project the multimodal data into a shared semantic space for cross-modal (event) retrieval, where the distances between heterogeneous data samples can be measured directly. In addition, we contribute a Wiki-Flickr Event dataset, where the multimodal data samples are not describing each other in pairs like the existing paired datasets, but all of them are describing semantic events. Extensive experiments conducted on both paired and unpaired datasets manifest the effectiveness of S³CA, outperforming the state-of-the-art methods. [ABSTRACT FROM AUTHOR]