1. Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France
- Author
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Yves Dorleans, Jérôme Jacques, Laurent Varesi, F. Agostini, Clément Turbelin, Alessandra Falchi, Laurent Andreoletti, G. Spadoni, Bruno Lina, Thierry Blanchon, Jean Pierre Amoros, Christophe Arena, Antoine Flahault, Nicolas Lévêque, Sciences pour l'environnement (SPE), Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP), Service maladies infectueuses, Université de Reims Champagne-Ardenne (URCA)-Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), Laboratoire Paul Painlevé - UMR 8524 (LPP), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Virologie et pathogenèse virale (VPV), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pascal Paoli (UPP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Male ,medicine.disease_cause ,France/epidemiology ,MESH: Aged, 80 and over ,Influenza A Virus, H1N1 Subtype ,MESH: Reverse Transcriptase Polymerase Chain Reaction ,MESH: Child ,Influenza A virus ,Prevalence ,Child ,MESH: Influenza B virus ,MESH: Aged ,Aged, 80 and over ,Influenza B virus/classification/genetics/*isolation & purification ,0303 health sciences ,MESH: Middle Aged ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,MESH: Influenza, Human ,virus diseases ,Middle Aged ,3. Good health ,Infectious Diseases ,Child, Preschool ,Human mortality from H5N1 ,Influenza A Virus, H1N1 Subtype/classification/genetics/*isolation & purification ,Female ,Viral disease ,France ,Seasons ,Adult ,Virus Cultivation ,Adolescent ,Orthomyxoviridae ,Hemagglutinin (influenza) ,H5N1 genetic structure ,MESH: Influenza A Virus, H3N2 Subtype ,MESH: Virus Cultivation ,MESH: Influenza A Virus, H1N1 Subtype ,03 medical and health sciences ,Virology ,Influenza, Human ,medicine ,Humans ,Influenza A Virus, H3N2 Subtype/classification/genetics/*isolation & purification ,MESH: Prevalence ,030304 developmental biology ,Aged ,MESH: Adolescent ,MESH: Humans ,[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] ,030306 microbiology ,Influenza A Virus, H3N2 Subtype ,MESH: Child, Preschool ,MESH: Adult ,Influenza, Human/*diagnosis/epidemiology/*virology ,biology.organism_classification ,Influenza A virus subtype H5N1 ,MESH: Male ,MESH: France ,Influenza B virus ,Immunology ,biology.protein ,Neuraminidase ,MESH: Seasons ,MESH: Female - Abstract
International audience; BACKGROUND: The investigation of dual influenza infection human cases is of major interest specifically for the control of new emerging influenza strains. OBJECTIVES: Using RT-PCR assays, we retrospectively assessed the prevalence of dual influenza virus infections that occurred in patients during the 2006-2007 winter season in Corsica Island (France). STUDY DESIGN: One hundred and thirty-four nasal swabbing samples taken from patients suffering from influenza-like illness between February and March 2007 were analysed using a rapid influenza antigen detection test, cell culture and RT-PCR assays. RESULTS AND CONCLUSION: Influenza viruses were detected in 93 (69.4%) of 134 patients with influenza-like illness using the combination of classical and molecular assays. Dual respiratory infections by influenza viruses were detected in 3 (3.2%) of the 93 influenza positive patients, including two cases of infection by influenza A/H3N2 and B viruses and one case of dual infection by influenza A/H3N2 and A/H1N1 viruses. In the present report, human co-infection cases by two influenza viruses appeared as a rare event in symptomatic patients. However, the virological and epidemiological mechanisms that determine the occurrence of dual influenza infections remain to be fully investigated in further prospective multicentric studies.
- Published
- 2008