188 results on '"Yusa, Kosuke"'
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2. Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia
3. RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations
4. B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors
5. Sphingomyelin synthase 1 supports two steps of rubella virus life cycle
6. Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma
7. AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors
8. Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin
9. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11
10. Author Correction: Pooled extracellular receptor-ligand interaction screening using CRISPR activation
11. KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements
12. ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
13. Minimal genome-wide human CRISPR-Cas9 library
14. Genome-wide CRISPR-Cas9 screening in mammalian cells
15. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation
16. Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution
17. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
18. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
19. Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia
20. Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
21. Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells.
22. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
23. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening
24. Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
25. Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
26. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
27. SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
28. Pooled extracellular receptor-ligand interaction screening using CRISPR activation
29. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
30. A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention
31. Nuclear Wave1 Is Required for Reprogramming Transcription in Oocytes and for Normal Development
32. The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
33. Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells
34. A hyperactive piggyBac transposase for mammalian applications
35. PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice
36. Seamless genome editing in human pluripotent stem cells using custom endonuclease–based gene targeting and the piggyBac transposon
37. Inhibition of Lysine Acetyltransferases p300/CBP Overcomes BTK Inhibitor Resistance in Mantle Cell Lymphoma Cells
38. CNOT4 Knockout Induces Proteasome Inhibitor Resistance in Multiple Myeloma Cells
39. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
40. Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene
41. Mobilization of giant piggyBac transposons in the mouse genome
42. Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development
43. Rad54 is dispensable for the ALT pathway
44. A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
45. Genetic Vulnerabilities of DNMT3AR882H in Myeloid Malignancies
46. SRPK1 Is a Therapeutic Vulnerability in Acute Myeloid Leukemia through Its Effects on Alternative Isoforms of Epigenetic Regulators Including BRD4
47. Chapter Twelve - Genome-Wide Forward Genetic Screens in Mouse ES Cells
48. Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.
49. piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
50. A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia
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