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6 results on '"Yuriy, Sirenko"'

1. Pulmonary Vascular Research Institute GoDeep: A meta‐registry merging deep phenotyping datafrom international PH reference centers

Author

Raphael W. Majeed, Martin R. Wilkins, Luke Howard, Paul M. Hassoun, Anastasia Anthi, Hector R. Cajigas, John Cannon, Stephen Y. Chan, Victoria Damonte, Jean Elwing, Kai Förster, Robert Frantz, Stefano Ghio, Imad Al Ghouleh, Anne Hilgendorff, Arun Jose, Ernesto Juaneda, David G. Kiely, Allan Lawrie, Stylianos E. Orfanos, Antonella Pepe, Joanna Pepke‐Zaba, Yuriy Sirenko, Andrew J. Swett, Olena Torbas, Roham T. Zamanian, Kurt Marquardt, Achim Michel‐Backofen, Tobiah Antoine, Jochen Wilhelm, Stephanie Barwick, Phillipp Krieb, Meike Fuenderich, Patrick Fischer, Henning Gall, Hossein‐Ardeschir Ghofrani, Friedrich Grimminger, Khodr Tello, Manuel J. Richter, and Werner Seeger

Subjects
deep phenotyping, meta‐registry, outcome, pulmonary hypertension, risk assessment, worldwide outreach, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Abstract The Pulmonary Vascular Research Institute GoDeep meta‐registry is a collaboration of pulmonary hypertension (PH) reference centers across the globe. Merging worldwide PH data in a central meta‐registry to allow advanced analysis of the heterogeneity of PH and its groups/subgroups on a worldwide geographical, ethnical, and etiological landscape (ClinTrial. gov NCT05329714). Retrospective and prospective PH patient data (diagnosis based on catheterization; individuals with exclusion of PH are included as a comparator group) are mapped to a common clinical parameter set of more than 350 items, anonymized and electronically exported to a central server. Use and access is decided by the GoDeep steering board, where each center has one vote. As of April 2022, GoDeep comprised 15,742 individuals with 1.9 million data points from eight PH centers. Geographic distribution comprises 3990 enrollees (25%) from America and 11,752 (75%) from Europe. Eighty‐nine perecent were diagnosed with PH and 11% were classified as not PH and provided a comparator group. The retrospective observation period is an average of 3.5 years (standard error of the mean 0.04), with 1159 PH patients followed for over 10 years. Pulmonary arterial hypertension represents the largest PH group (42.6%), followed by Group 2 (21.7%), Group 3 (17.3%), Group 4 (15.2%), and Group 5 (3.3%). The age distribution spans several decades, with patients 60 years or older comprising 60%. The majority of patients met an intermediate risk profile upon diagnosis. Data entry from a further six centers is ongoing, and negotiations with >10 centers worldwide have commenced. Using electronic interface‐based automated retrospective and prospective data transfer, GoDeep aims to provide in‐depth epidemiological and etiological understanding of PH and its various groups/subgroups on a global scale, offering insights for improved management.

Published
2022
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2. Axial-Symmetric Diffraction Radiation Antenna with a Very Narrow Funnel-Shaped Directional Diagram

Author

Yuriy Sirenko, Seil Sautbekov, Merey Sautbekova, Nataliya Yashina, Nursaule Burambayeva, and Assel Begimova

Subjects
wave analog of Smith–Purcell radiation, axially symmetric radiators, radial dielectric waveguide, concentric grating, very narrow throat funnel-shaped radiation pattern, rigorous electrodynamic modeling, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

The paper is focused on reliable modeling and analysis of axially symmetric radiators with a very narrow (throat) funnel-shaped radiation pattern. When such a diagram is formed, a wave analogue of Smith–Purcell coherent radiation is realized—the surface wave of a radial dielectric waveguide ‘sweeps out’ with its exponentially decaying part a concentric periodic grating, the fundamental spatial harmonic of which, propagating without attenuation in a direction close to the symmetry axis of the structure, generates a radiation field with the required characteristics.

Published
2021
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3. Resonances in Reverse Vavilov-Cherenkov Radiation Produced by Electron Beam Passage over Periodic Interface

Author

Gerard Granet, Petr Melezhik, Anatoliy Poyedinchuk, Seil Sautbekov, Yuriy Sirenko, and Nataliya Yashina

Subjects
Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Cellular telephone services industry. Wireless telephone industry, HE9713-9715
Abstract

Resonances in reverse Vavilov-Cherenkov radiation produced by the charged particles beam passage over periodic boundary of dispersive left-handed medium are found out and studied. Analysis and modeling are performed on the base of rigorous mathematical approaches. For the first time, several physical peculiarities owing to these effects are considered in the conditions of possible resonant scattering of electromagnetic waves.

Published
2015
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4. Analysis of pulmonary hypertension patient survival after treatment in referral center (data of first Ukrainian register)

Author

Yuriy Sirenko, Iryna O Zhyvylo, and Ganna D. Radchenko

Subjects
Pulmonary and Respiratory Medicine, lcsh:RC705-779, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, business.industry, Ukrainian, Patient survival, lcsh:Diseases of the respiratory system, medicine.disease, Pulmonary hypertension, survival, language.human_language, predictors, lcsh:RC666-701, Internal medicine, pulmonary hypertension, medicine, language, Referral center, Chronic thromboembolic pulmonary hypertension, In patient, one referral center cohort study, business, After treatment, Research Article
Abstract

The aims of the study were: (1) to evaluate the Ukrainian reality of survival in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH); and (2) to determine predictors of death. A total of 281 patients were enrolled (52 [18.5%] with CTEPH, 229 [81.5%] with PAH). Long-term survival (Kaplan–Meier) and its predictors (Stepwise binary logistic regression and Cox's proportional hazards analyses) were evaluated in adult patients with PH (diagnosed by right heart catheterization [RHC]) within a prospective registry at a single referral center in Kyiv, Ukraine. Follow-up period was up to 51 months. The Kaplan–Meier survival rate for the total cohort was 93.3%, 86.8%, and 81.5% at one, two, and three years, respectively. Survival was better in patients with congenital heart diseases (CHD) in comparison with idiopathic PAH (long rank P = 0.002), connective tissue diseases (CTD; long rank P = 0.001) and CTEPH (long rank P = 0.04). Univariate Cox's predictors of death were: functional class IV (odds ratio [OR] = 4.94; 95% confidence interval [CI] = 2.12–11.48), presence of ascites (OR = 4.52; 95% CI = 2.21–9.24), PAH-CTD (OR = 3.07; 95% CI = 1.07–8.87), PAH-CHD (OR = 0.28; 95% CI = 0.11–0.68), HR on treatment > 105 beats per min (OR = 7.85; 95% CI = 1.83–33.69), office systolic BP 300 pg/mL (OR = 4.98; 95% CI = 1.49–16.6), right atrium square > 22 cm 2 (OR = 14.2; 95% CI = 1.92–104.89), right ventricular square in diastole (OR = 1.08; 95% CI = 1.03–1.14), right ventricular square in systole (OR = 1.08; 95% CI = 1.02–1.11), mean pressure in right atrium per each 1-mmHg increase (OR = 1.02; 95% CI = 1.02–1.19). In multivariate Cox regression analyses only presence of ascites, office systolic BP 300 pg/mL were associated with survival.

Published
2019

5. Electromagnetic Waves in Complex Systems : Selected Theoretical and Applied Problems

Author

Yuriy Sirenko, Lyudmyla Velychko, Yuriy Sirenko, and Lyudmyla Velychko

Subjects
Electromagnetic waves--Mathematical models
Abstract

This book gives guidance to solve problems in electromagnetics, providing both examples of solving serious research problems as well as the original results to encourage further investigations. The book contains seven chapters on various aspects of resonant wave scattering, each solving one original problem. All of them are unified by the authors'desire to show advantages of rigorous approaches at all stages, from the formulation of a problem and the selection of a method to the interpretation of results. The book reveals a range of problems associated with wave propagation and scattering in natural and artificial environments or with the design of antennas elements. The authors invoke both theoretical (analytical and numerical) and experimental techniques for handling the problems. Attention is given to mathematical simulations, computational efficiency, and physical interpretation of the experimental results. The book is written for students, graduate students and young researchers.

Published
2016

6. Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient : design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial

Author

Nieves Martell-Claros, Alberto Zanchetti, Fernando Pinto, Yuqing Zhang, Michel Burnier, Krzysztof Narkiewicz, Stéphane Laurent, Serap Erdine, Peter M. Nilsson, Antonella Zambon, Giovanni Corrao, Grzegorz Bilo, Anna F. Dominiczak, Enrico Agabiti-Rosei, Maciej Banach, Josep Redon, Chengbin Xu, Hengge Xie, Athanasios J. Manolis, Vincenzo Silani, Lisheng Liu, Xuezhong Zhang, Marco Stramba-Badiale, Bojan Jelaković, Dingliang Zhu, Luis M. Ruilope, John T. O'Brien, Guido Grassi, Gangzhi Wei, Ting Rui Guan, Dror Dicker, Dragan Lovic, Roland E. Schmieder, Csaba Farsang, Antonio Coca, Yuriy Sirenko, Zhaosu Wu, Rok Accetto, Gianfranco Parati, Gary A. Ford, Lorenza Scotti, Hayyan Wang, Xin-Hua Zhang, Arman Postadzhiyan, Jose L. Rodicio, Alexandra Konradi, Eivind Berge, Margus Viigimaa, Renata Cifkova, Giuseppe Mancia, Philippos Stylianou, Irina Lazareva, Maria Dorobantu, Zanchetti, A, Liu, L, Mancia, G, Parati, G, Grassi, G, Stramba Badiale, M, Silani, V, Bilo, G, Corrao, G, Zambon, A, Scotti, L, Zhang, X, Wang, H, Zhang, Y, Guan, T, Berge, E, Redon, J, Narkiewicz, K, Dominiczak, A, Nilsson, P, Viigimaa, M, Laurent, S, Agabiti Rosei, E, Wu, Z, Zhu, D, Rodicio, J, Ruilope, L, Martell Claros, N, Pinto, F, Schmieder, R, Burnier, M, Banach, M, Cifkova, R, Farsang, C, Konradi, A, Lazareva, I, Sirenko, Y, Dorobantu, M, Postadzhiyan, A, Accetto, R, Jelakovic, B, Lovic, D, Manolis, A, Stylianou, P, Erdine, S, Dicker, D, Wei, G, Xu, C, Xie, H, Coca, A, O'Brien, J, and Ford, G

Subjects
Male, medicine.medical_specialty, China, Physiology, Blood Pressure, law.invention, chemistry.chemical_compound, Cognition, Randomized controlled trial, law, Recurrence, Internal medicine, Internal Medicine, medicine, Secondary Prevention, blood pressure, cognitive decline, low-density lipoprotein cholesterol, randomized controlled trial, secondary prevention, stroke, Dementia, Humans, Prospective Studies, Cognitive decline, Prospective cohort study, Stroke, Antihypertensive Agents, Aged, Ldl cholesterol, Cholesterol, business.industry, Blood Pressure Determination, Cholesterol, LDL, lipoprotein cholesterol, randomized controlled trial, secondary prevention, stroke, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, blood pressure, cognitive decline, low-density, Europe, Blood pressure, chemistry, Ischemic Attack, Transient, Hypertension, Physical therapy, Cardiology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, Cognition Disorders
Abstract

BACKGROUND AND OBJECTIVES:: The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. PROTOCOL DESIGN:: The European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment trial is a prospective multinational, randomized trial with a 3×2 factorial design comparing: three different SBP targets (1

Published
2014

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