13 results on '"Yurdakul G"'
Search Results
2. Discordant performance of assays for free and total prostate-specific antigen in relation to the early detection of prostate cancer
- Author
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Blijenberg, B.G., Yurdakul, G., Van Zelst, B.D., Bangma, C.H., Wildhagen, M.F., and Schröder, F.H.
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- 2001
3. Different PSA Assays Lead to Detection of Prostate Cancers with Identical Histological Features
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Yurdakul, G, Bangma, C.H, Blijenberg, B.G, van Zelst, B.D, Wildhagen, M.F, van der Kwast, Th.H, and Schröder, F.H
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- 2002
- Full Text
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4. What is an acceptable false negative rate in the detection of prostate cancer?
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Verbeek, J. F., Roobol, Monique J., Bangma, C. H., Kirkels, W. J., Rietbergen, J. B.W., van der Cruijsen, I. W., Raaijmakers, R., de Vries, S. H., Roemeling, S., Gosselaar, C., Wolters, T., van den Bergh, R. C.N., van Leeuwen, P. J., Bul, M., Zhu, Y., van Vugt, H. A., Yurdakul, G., Boeken-Kruger, A., Wijburg, C., Forouzanfor, M., de Boer, M., Vis, A. N., Venderbos, L. D.F., Schröder, Fritz H., Postma, R., van der Kwast, T. H., Hoedemaeker, R., van Leenders, A. G.J.L.H., Blijenberg, B. G., van Schaik, R. H.N., de Koning, H. J., Heijnsdijk, E., van der Maas, P. J., Beemsterboer, P., Otto, S. J., Essink-Bot, M., Korfage, I., Alberts, A. R., Bokhorst, L. P., Drost, F. H., Osses, D. F., Salman, J., Boer, R., Wildhagen, M., Draisma, G., Merkelbach, W., Hoekstra, W., van den Berg, E., Smit, A., Urology, Public Health, Pathology, CCA - Imaging and biomarkers, CCA - Cancer biology and immunology, CCA - Cancer Treatment and quality of life, and Radiation Oncology
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Oncology ,medicine.medical_specialty ,Prostate biopsy ,False negative ,Survival ,Urology ,030232 urology & nephrology ,urologic and male genital diseases ,Negative predictive value ,Metastasis ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Internal medicine ,Biopsy ,medicine ,Mortality ,Previous negative biopsy ,Prostate cancer (PCa) ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Multi-parametric magnetic resonance imaging (mpMRI) ,Prostate specific antigen (PSA) ,Prostate-specific antigen ,ERSPC ,Reproductive Medicine ,030220 oncology & carcinogenesis ,Risk stratification ,Screening ,Population study ,Original Article ,business - Abstract
Background: In prostate cancer (PCa) screening men and their physicians aim to rule out the presence of potentially life threatening PCa. To date, prostate specific antigen (PSA) testing and systematic prostate biopsy (Bx)-in case of an elevated PSA-are still the main modes of PCa detection. Often uncertainty remains when a PSA-test is < 3.0 ng/mL or a Bx shows a benign result, leading to the continuous repeating of procedures. Here we assess the potential consequences of false negatives by studying follow-up data of a purely PSA-based approach with applying sextant Bx, an approach considered to have a high risk of missing PCa diagnosis. Methods: Our study population consisted of 19,970 men from the ERSPC project section Rotterdam, initially screened in 1993-1999. We assessed clinically significant Gleason ≥3+4 PCa (csPCa) diagnosis within the 4-year screening interval and subsequent screening round 4 years later in men having a PSA < 3.0 ng/mL at initial screening (no Bx) and men with Bx (PSA > 3.0 ng/mL), but no PCa detected at that time. In addition, we addressed PCa mortality and PCa diagnosis for men with a negative PSA test and negative Bx, who were retested every 4 years covering a 15-year follow-up. Results: A total of 14,935 men had PSA < 3.0 ng/mL in the initial screening round, of whom 75 (0.5%) were diagnosed with csPCa at a subsequent screening examination and 2 ( < 0.1%) in the 4-year screening interval. For 2,260 men with a previously negative Bx at first screening, the figures were 17 (0.8%) and 2 (0.1%) respectively. Indolent PCa (Gleason ≥3+3) was diagnosed in 312 (2%) men with PSA < 3.0 ng/mL initially and 115 (5%) men with initial negative Bx. After a 15-year follow-up, 45 (0.3%) PCa deaths occurred in men with initially low PSA, and 29 men (0.2%) had metastasis. For men with negative Bx, 11 (0.5%) PCa deaths occurred and 4 (0.2%) experienced metastasis. Conclusions: The false negative rates for men with PSA < 3.0 ng/mL and negative sextant Bx are extremely low but not negligible. Proper risk stratification before deciding to biopsy is expected to hardly miss any clinical significant PCa diagnosis. This is especially relevant with the increased use of the relatively expensive multi-parametric magnetic resonance imaging (mpMRI) guided targeted Bx procedures.
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- 2018
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5. The use of Tc-99m sestamibi imaging in patients with breast masses: A complementary adjunct to ultrasonography and mammography
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Yurdakul G., Kibar M., Alparslan A., Boga H., and Çukurova Üniversitesi
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Technetium-99m sestamibi ,Breast masses ,skin and connective tissue diseases ,Mammography ,Ultrasonography - Abstract
Purpose: The aim of this study was to investigate the value of Tc-99m sestamibi breast scintigraphy in the tumor detection in comparison with mammography and ultrasonography (US), and to determine whether it could be used to differentiate malignancies from benign lesions. Methods: Thirty-one patients with palpable breast masses underwent Tc-99m sestamibi breast scintigraphy, mammography and US. Results: On histological diagnosis, there were 19 malignant tumors (18 infiltrative ductal carcinoma, one infiltrative lobular carcinoma) and 12 benign lesions (10 ductal hyperplasia, one chronic inflammation, one granulomatous mastitis). All of the 19 breast cancers were detected using Tc-99m sestamibi scintigraphy. Eight of the 12 patients with histologically proven benign breast lesions did not demonstrate any Tc-99m sestamibi accumulation. But, two patients with ductal hyperplasia, one patient with chronic inflammation, and one patient with granulomatous mastitis showed Tc-99m sestamibi uptake. Tc-99m sestamibi activity within malign breast tumors, calculated as tumor/background (T/B) ratio, ranged between 1.21 and 4.27 with a mean value 1.82. However, in patients with benign breast lesions, except one patient, T/B ratio was not more than 1.29. The overall sensitivity, specificity and accuracy rate of Tc-99m sestamibi breast scintigraphy for the detection of breast cancer was 100%, 67%, and 87%, respectively. The accuracy rate of Tc-99m sestamibi was slightly better than that of both mammography (sensitivity 94%, specificity 75%, and accuracy 86%) and US (sensitivity 95%, specificity 67%, and accuracy 84%). Conclusion: Tc-99m sestamibi scintigraphy may provide additional information in differentiating malignant and benign lesions in patients with palpable breast masses. And as a simple, non-invasive and low-cost imaging technique, Tc-99m sestamibi scintigraphy may be helpful in the selection of patients for biopsy without delay, in association with mammography and US.
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- 1997
6. Technetiumm-99m-N,N-ethylenedicysteine scintigraphy in the detection of renal parenchymal abnormalities: A comparative study with Tc-99m DMSA
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Kibar M., Noyan A., Paydas S., Tutus A., Anarat A., Yurdakul G., Reyhan M., and Çukurova Üniversitesi
- Subjects
Technetium-99m-N,N-ethylenedicysteine ,Technetium-99m-dimercaptosuccinic acid - Abstract
Purpose: Technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) is currently the most important agent in the detection of renal parenchymal defect, and allows calculation of differential renal function (DRF). But this agent has some important disadvantages such as high radiation dose and time consumption. In this study, we investigated the value of technetium-99m-N,N-ethylenedicysteine (Tc-99m EC) scintigraphy in the detection of a renal focal defect and estimation of DRF, and compared the results with Tc-99m DMSA. Methods: Twenty-seven patients (12 children and 15 adults) with various renal disorders underwent both Tc-99m DMSA and Tc-99m EC scintigraphy. Posterior Tc-99m DMSA and summed first 45-120 sec Tc-99m EC images were used to calculate the DRF and renal parenchymal defects. Results: In children and adult patients, the correlation coefficient between the two methods was 0.99. The sensitivity and specificity of Tc-99m EC summed images in the detection of parenchymal focal abnormalities was calculated as 89% and 98%, respectively. In addition, regional relative renal parenchymal uptake of the three parts of the kidney (upper, middle portion, lower) with two agents showed good correlation (r = 0.97). Conclusion: These results show that Tc-99m EC scintigraphy provides accurate DRF and allows reliably detection of parenchymal abnormalities, and may be used instead of Tc-99m DMSA for this purpose in routine clinical practice.
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- 1997
7. Association Between Motor Imagery Ability and Pain, Functional Status, Neck Awareness, and Depression in Individuals with Chronic Neck Pain.
- Author
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Dere T, Yurdakul G, Buğra Kılınç S, and Alemdaroğlu-Gürbüz İ
- Abstract
Background: Pain-related symptoms are thought to affect motor imagery abilities adversely., Primer Study Objective: The study aimed to examine motor imagery ability and its association with pain, functional status, neck awareness, and depression in individuals with chronic neck pain., Design and Setting: A cross-sectional study, single-center., Participants: 60 individuals with chronic neck pain, aged between 18 and 65 years, were recruited., Intervention: Demographic data was recorded, pain and disability were evaluated using the Visual Analogue Scale and Neck Disability Index, motor imagery ability using Kinesthetic and Visual Imagery Questionnaire-20, and mental chronometry. Grip strength, cervical muscle endurance, upper limbs' functionality, neck awareness, and depression levels were assessed using a hydraulic hand dynamometer, cervical muscle endurance tests, Upper Extremity Functional Index-15, Fremantle Neck Awareness Questionnaire, and Beck Depression Inventory, respectively., Primary Outcome Measures: Motor imagery ability, neck pain, functional status, neck awareness, and depression levels., Results: Of the 60 individuals (mean age 51.60 ± 11.70 years), 83% (n = 50) were female. The Kinesthetic and Visual Imagery Questionnaire-20 score (mean 68.62 ± 27.02) was weakly correlated with Visual Analogue Scale-night (r = 0.332), duration of pain (r = -0.264), cervical extensor muscle endurance (r = -0.270) and Fremantle Neck Awareness Questionnaire (r = -0.295) (P < .05). Weak to moderate correlations were found between the individuals' mental chronometry task scores and Neck Disability Index, Fremantle Neck Awareness Questionnaire, Beck Depression Inventory, and grip strength (P < .05). The regression analysis indicates that motor imagery ability can explain pain intensity, cervical extensor endurance, neck awareness, and depression level (P < .05)., Conclusion: Individuals with chronic neck pain showed an impaired motor imagery ability which was associated with pain, functional status, neck awareness, and depression levels. Thus improving motor imagery ability may contribute to better functional outcomes and psychosocial status in these individuals., Clinical Trial Number: NCT06502236.
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- 2024
8. Resettlement, Employment, and Mental Health Among Syrian Refugee Men in Canada: An Intersectional Study Using Photovoice.
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Clark N, Yurdakul G, Hilario C, Elgharbawy H, Izzden N, Moses E, and Zaidalkilani M
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- Humans, Male, Canada, Syria ethnology, Adult, Middle Aged, Masculinity, Young Adult, Community-Based Participatory Research, Photography, Refugees psychology, Mental Health, Employment psychology
- Abstract
Context: The impact of forced migration on the mental health of refugee men is far-reaching and compounded by gendered masculinity, which shapes men's access to employment and other resources. A gap in knowledge exists on the broader determinants of refugee men's mental health., Methodology: Using community-based participatory action research and the arts-based method of photovoice, this study advances knowledge about the gendered impacts of forced migration from the perspective of ( n = 11) Syrian refugee men in the Canadian context. Theoretical approaches of intersectionality and masculinity were applied to understand how power relations shape Syrian men's identities, their access to employment, and impacts on their mental health., Analysis and Results: Syrian men's identities were marginalized by working in low-wage jobs because of inequitable policies that favored Canadian experience and credentialing assessment processes that devalued their knowledge. Multiple and overlapping factors shaped Syrian men's mental health including language and literacy barriers, time and stage of life, isolation and loneliness, belonging and identity, and gender-based stress. Caring masculinities performed through fathering, cultural connection, and service-based work promoted agency, hope, and resilience., Conclusions: Public health and community-based pathways must adopt gender-responsive and intersectional approaches to policy and practice. Peer-based programs may mitigate harmful forms of masculinity and promote transformative change to support refugee men's mental health.
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- 2024
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9. Computational Mechanical Analysis of AO 44A1, 44B1, and 44C1 Fractures with Finite Element Modeling: Evaluation of Screw, Plate, and Kirschner Wire Fixation.
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Olçar HA, Özer A, Mutu HB, Yurdakul G, Kuru T, Aydın D, and Korkmaz M
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- Humans, Finite Element Analysis, Fracture Fixation, Internal methods, Bone Screws, Bone Plates, Biomechanical Phenomena, Bone Wires, Fractures, Bone diagnostic imaging, Fractures, Bone surgery
- Abstract
Background: The aim of this study was to create AO 44A1, 44B1, and 44C1 fractures using finite element analysis to determine the stability of Kirschner wire, intramedullary screw, and plate-screw fixation methods in fracture., Methods: Using finite element analysis, the postreduction behavior of AO 44A1, 44B1, and 44C1 fractures with Kirschner wire, intramedullary screw, and plate-screw fixation methods was analyzed and compared in terms of displacement and stress., Results: The lowest amount of displacement was provided with the intramedullary screw method in AO 44A1 and 44B1 fractures and with the 4-mm Kirschner wire method in AO 44C1 fractures. The total displacement of the intramedullary screw system used for fixation in AO 44A1, 44B1, and 44C1 fractures was lower., Conclusions: According to finite element analysis results, the lowest amount of displacement was obtained with intramedullary screw fixation in AO 44A1 and 44B1 fractures, and 4-mm Kirschner wire fixation was achieved in AO 44C1 fractures.
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- 2024
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10. Assessing countries' performances against COVID-19 via WSIDEA and machine learning algorithms.
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Aydin N and Yurdakul G
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The COVID-19 pandemic, which first spread to the People of Republic of China and then to other countries in a short time, affected the whole world by infecting millions of people and have been increasing its impact day by day. Hundreds of researchers in many countries are in search of a solution to end up this pandemic. This study aims to contribute to the literature by performing detailed analyses via a new three-staged framework constructed based on data envelopment analysis and machine learning algorithms to assess the performances of 142 countries against the COVID-19 outbreak. Particularly, clustering analyses were made using k-means and hierarchic clustering methods. Subsequently, efficiency analysis of countries were performed by a novel model, the weighted stochastic imprecise data envelopment analysis. Finally, parameters were analyzed with decision tree and random forest algorithms. Results have been analyzed in detail, and the classification of countries are determined by providing the most influential parameters. The analysis showed that the optimum number of clusters for 142 countries is three. In addition, while 20 countries out of 142 countries were fully effective, 36% of them were found to be effective at a rate of 90%. Finally, it has been observed that the data such as GDP, smoking rates, and the rate of diabetes patients do not affect the effectiveness level of the countries., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2020 Elsevier B.V. All rights reserved.)
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- 2020
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11. Twin reversed arterial perfusion syndrome in a monochorionic monoamniotic twin pregnancy.
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Yapıcıoğlu-Yıldızdaş H, Ece Ü, Sucu M, Yurdakul G, Şimşek H, and Özlü F
- Abstract
Yapıcıoğlu-Yıldızdaş H, Ece Ü, Sucu M, Yurdakul G, Şimşek H, Özlü F. Twin reversed arterial perfusion syndrome in a monochorionic monoamniotic twin pregnancy. Turk J Pediatr 2017; 59: 724-727. Twin reversed arterial perfusion syndrome is mostly seen in monochorionic diamniotic twin pregnancies with an estimated incidence of 1/9500-11000 pregnancies. One of the twins is acardiac with various abnormalities especially with upper part of the body, and mortality is 100%. The other twin functions as a pump twin and mostly has polyhydramnios and heart failure; and mortality rate is high due to prematurity and heart failure. Herein we report a TRAP syndrome and the prognosis of pump twin who was born at 30 weeks gestational age.
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- 2017
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12. Rectal squamous cell carcinoma 11 years after brachytherapy for carcinoma of the prostate.
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Yurdakul G, de Reijke TM, Blank LE, and Rauws EA
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- Aged, Fistula diagnosis, Fistula etiology, Humans, Iodine Radioisotopes adverse effects, Iodine Radioisotopes therapeutic use, Male, Prostatic Diseases diagnosis, Prostatic Diseases etiology, Radiation Injuries diagnosis, Radiation Injuries etiology, Rectal Fistula diagnosis, Rectal Fistula etiology, Adenocarcinoma radiotherapy, Brachytherapy adverse effects, Carcinoma, Squamous Cell etiology, Neoplasms, Radiation-Induced diagnosis, Neoplasms, Radiation-Induced etiology, Neoplasms, Second Primary diagnosis, Neoplasms, Second Primary etiology, Prostatic Neoplasms radiotherapy, Rectal Neoplasms etiology
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- 2003
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13. Comparison of HPLC and derivative spectrophotometric methods for the determination of paracetamol and caffeine in tablets.
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Yurdakul G, Ersoy L, and Sungur S
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- Chromatography, High Pressure Liquid, Quality Control, Spectrophotometry, Ultraviolet, Tablets, Acetaminophen analysis, Caffeine analysis
- Published
- 1991
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