1. The correlation between trajectories of serum C3 variability and clinical course in Pediatric-onset systemic lupus erythematosus
- Author
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Yun-chuan Chen, Yung-chieh Huang, Jun-peng Chen, Ming-chin Tsai Mc, and Lin-shien Fu
- Subjects
Trajectory ,Pediatric systemic lupus erythematosus(pSLE) ,Longitudinal ,Remission ,Corticosteroid ,Microbiology ,QR1-502 - Abstract
Objective: The aim of this study is to investigate the usefulness which 2-year trajectories of C3 variability have in predicting clinical remission and systemic corticosteroids (SCS) use in pediatric patients with systemic lupus erythematosus (pSLE). Methods: We recruited 189 confirmed pSLE patients from the electronic database of our hospital, all had undergone SCS treatment. The follow up period was 4.17–14.83 years. We used Group-Based Trajectory modeling to divide the patients into four different trajectory groups by their initial 2-year C3 variability. We divided the patients into groups A, B or C by their clinical course and SCS use. Statistical methods included Kruskal–Wallis and Chi-square tests and logic regression test. Results: There were 4 separate trajectories. The distribution of groups A, B and C in these 4 trajectories showed a significant difference (p = 0.005). Initial C3 and C4 levels in these 4 revealed significant differences (p ≦ 0.001, p ≦ 0.016). When compared to other trajectories, trajectory1 showed a higher risk for persistent SCS use (p
- Published
- 2023
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