38 results on '"Yu-Ting Lee"'
Search Results
2. Exploring the spatial association between the distribution of temperature and urban morphology with green view index.
- Author
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Ta-Chien Chan, Ping-Hsien Lee, Yu-Ting Lee, and Jia-Hong Tang
- Subjects
Medicine ,Science - Abstract
Urban heat islands will occur if city neighborhoods contain insufficient green spaces to create a comfortable environment, and residents' health will be adversely affected. Current satellite imagery can only effectively identify large-scale green spaces and cannot capture street trees or potted plants within three-dimensional building spaces. In this study, we used a deep convolutional neural network semantic segmentation model on Google Street View to extract environmental features at the neighborhood level in Taipei City, Taiwan, including the green vegetation index (GVI), building view factor, and sky view factor. Monthly temperature data from 2018 to 2021 with a 0.01° spatial resolution were used. We applied a linear mixed-effects model and geographically weighted regression to explore the association between pedestrian-level green spaces and ambient temperature, controlling for seasons, land use information, and traffic volume. Their results indicated that a higher GVI was significantly associated with lower ambient temperatures and temperature differences. Locations with higher traffic flows or specific land uses, such as religious or governmental, are associated with higher ambient temperatures. In conclusion, the GVI from street-view imagery at the community level can improve the understanding of urban green spaces and evaluate their effects in association with other social and environmental indicators.
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- 2024
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3. Assessing the Impact of the COVID-19 Pandemic on Pediatric Emergency Department Visits in Taiwan
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Yu-Ting Lee, Yen-Wen Lai, Jiann-Hwa Chen, Wei-Lung Chen, Meng-Yu Wu, and Jui-Yuan Chung
- Subjects
COVID-19 ,pandemic ,pediatric ,emergency department visits ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted healthcare systems worldwide. To assess the effects of the pandemic on pediatric emergency department (ED) visits in Taiwan, we conducted a study to evaluate changes in pediatric ED visits during the COVID-19 pandemic. Materials and Methods: This retrospective study included pediatric patients (age ≤ 18) who visited the ED between 21 January 2019 and 30 April 2019, at three hospitals of the Cathay Health System, and compared them with a corresponding period in 2020. Basic information, including mode of arrival, triage level, disposition, chief complaints, and incidence rates, were analyzed before and during the pandemic. Results: A total of 10,116 patients, with 6009 in the pre-pandemic group and 4107 in the pandemic group, were included in this study. The mean number of daily pediatric ED visits decreased from 60.09 before the pandemic to 40.66 during the pandemic, while ambulance use increased significantly by 2.56%. The percentage of patients with high acuity triage levels (levels 1 and 2) was significantly lower during the pandemic period (0.63% and 10.18%, respectively) than the pre-pandemic period (0.7% and 10.9%, respectively). Additionally, a significantly higher proportion of patients were discharged during the pandemic period (89.36%) than during the pre-pandemic period (88.33%). The proportion of COVID-19-related complaints, such as fever and respiratory tract infections, as well as other complaints including gastrointestinal issues, trauma, and psychological problems, significantly increased during the pandemic. Conclusions: In preparation for future pandemics, we recommend increasing emergency medical service capacity, establishing a non-contagious route for obtaining chronic medication prescriptions, optimizing staff allocation in pediatric emergency departments, and increasing the number of hospital social workers for enhanced support.
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- 2024
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4. Parathyroidectomy Improves the Consumption of Erythropoiesis-Stimulating Agents in Hemodialysis Patients
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Yu-Ting Lee, Chi-Wen Tu, Kam-Hong Kam, Tsung-Liang Ma, Chin-Ho Kuo, Ming-Yang Lee, Chih-Yen Hsiao, Michael W. Y. Chan, and Peir-Haur Hung
- Subjects
end-stage renal disease ,anemia ,parathyroidectomy ,secondary hyperparathyroidism ,hemoglobin ,TAST ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Secondary hyperparathyroidism (SHPT) is common in end-stage renal disease (ESRD) patients, and it can suppress erythropoiesis. We aimed to investigate the relationship between the consumption of erythropoiesis-stimulating agents (ESAs) and parathyroidectomy (PTX) in ESRD patients with SHPT and to determine the predictors for anemia improvement. The current standard of chronic kidney disease anemia therapy relies on the prescription of iron supplementation, and ESA. We retrospectively analyzed 81 ESRD patients with PTX at Ditmanson Medical Foundation Chiayi Christian Hospital from July 2004 to Dec 2018. The requirement of ESA therapy markedly declined from a dose of 41.6 (interquartile range [IQR], 0–91.2) to 10.3 (IQR, 0–59.5, p = 0.001) unit/kg/week. In addition, 63.7% of patients required iron replacement therapy preoperatively and the proportion reduced to 52.5% after PTX (p < 0.001). The hemoglobin (Hb) level showed an insignificant change from a median value of 10.7 g/dL (9.5–11.6 g/dL) before PTX to 10.5 g/dL (9.6–11.2 g/dL) at 6 months after PTX. A preoperative Hb level ≤ 10 mg/dL (odds ratio [OR], 20.1; 95% confidence interval [CI], 4.71–125, p < 0.001) and transferrin saturation (TSAT) < 25% (OR, 12.8; 95% CI, 2.51–129, p < 0.001) were predictors for anemia improvement. Our study demonstrated that PTX markedly decreased the requirement of ESA. Patients with a low preoperative Hb level or low TSAT showed an increase in the Hb level after PTX. PTX may be considered not only for SHPT with refractory anemia but also for high ESA-dependent patients.
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- 2022
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5. Association between health behaviors and mood disorders among the elderly: a community-based cohort study
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Tzu-Jung Tseng, Yi-Syuan Wu, Jia-Hong Tang, Yen-Hui Chiu, Yu-Ting Lee, I-Chun Fan, and Ta-Chien Chan
- Subjects
Elderly health examination database ,Socio-economic status ,Health behaviors ,Mental health ,Mood disorders ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background According to a WHO report, nearly 15% of adults aged 60 and over suffer from a mental disorder, constituting 6.6% of the total disability for this age group. Taipei City faces rapid transformation towards an aging society, with the proportion of elderly in the total population rising from 12% in 2008 to 16% in 2016. The aim of this study is to identify the prevalence of mental disorders among the elderly in Taipei City and to elucidate risk factors contributing to mental disorders. Methods The elderly health examination database was obtained from the Department of Health, Taipei City government, from 2005 to 2012. A total of 86,061 people underwent publicly funded health examinations, with 348,067 visits. Each year, there are around 43,000 elderly persons in Taipei City using this service. We used a mental health questionnaire including five questions to estimated relative risks among potential risk factors with the generalized estimating equations (GEE) model to measure the mental health status of the elderly. Mood disorders were measured with the Brief Symptom Rating Scale (BSRS-5) questionnaire. Age, education level, gender, marital status, living alone, drinking milk, eating vegetables and fruits, long-term medication, smoking status, frequency of alcohol consumption, frequency of physical activity, BMI, and number of chronic diseases were included as covariates. Results The results show that being male (odds ratio (OR) 0.57; 95% CI = 0.56, 0.59), higher education (OR 0.88; 95% CI = 0.82, 0.95), no long-term medication (OR 0.57; 95% CI = 0.56, 0.58), and exercising three or more times per week (OR 0.94; 95% CI = 0.91, 0.98) were all positively correlated with better emotional status. However, being divorced (OR = 1.22, 95% CI = 1.09, 1.36), not drinking milk (OR = 1.12, 95% CI = 1.09, 1.14), not eating enough vegetables and fruits every day (OR = 1.78, 95% CI = 1.73, 1.83), daily smoking (OR = 1.15, 95% CI = 1.01, 1.32), and having more chronic diseases (OR = 1.02, 95% CI = 1.01, 1.03) were all correlated with poor mental status among the elderly. Conclusions The findings of this research can both estimate the prevalence of mood disorders at the community level, and identify risk factors of mood disorders at the personal level.
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- 2019
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6. Methylomic analysis identifies C11orf87 as a novel epigenetic biomarker for GI cancers.
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Mita T M T Tran, Kun-Tu Yeh, Yu-Ming Chuang, Po-Yen Hsu, Jie-Ting Low, Himani Kumari, Yu-Ting Lee, Yin-Chen Chen, Wan-Hong Huang, Hongchuan Jin, Shu-Hui Lin, and Michael W Y Chan
- Subjects
Medicine ,Science - Abstract
Gastric cancer is one of the leading causes of cancer death worldwide. Previous studies demonstrated that activation of STAT3 is crucial for the development and progression of gastric cancer. However, the role of STAT3 in neuronal related gene methylation in gastric cancer has never been explored. In this study, by using DNA methylation microarray, we identified a potential STAT3 target, C11orf87, showing promoter hypomethylation in gastric cancer patients with lower STAT3 activation and AGS gastric cancer cell lines depleted with STAT3 activation. Although C11orf87 methylation is independent of its expression, ectopic expression of a constitutive activated STAT3 mutant upregulated its expression in gastric cancer cell line. Further bisulfite pyrosequencing demonstrated a progressive increase in DNA methylation of this target in patient tissues from gastritis, intestinal metaplasia, to gastric cancer. Intriguingly, patients with higher C11orf87 methylation was associated with better survival. Furthermore, hypermethylation of C11orf87 was also frequently observed in other GI cancers, as compared to their adjacent normal tissues. These results suggested that C11orf87 methylation may serve as a biomarker for diagnosis and prognosis of GI cancers, including gastric cancer. We further postulated that constitutive activation of STAT3 might be able to epigenetically silence C11orf87 as a possible negative feedback mechanism to protect the cells from the overactivation of STAT3. Targeted inhibition of STAT3 may not be appropriate in gastric cancer patients with promoter hypermethylation of C11orf87.
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- 2021
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7. Older Age and High Serum Ferritin Levels Associated With the Risk of Chronic Cytopenia in Hemodialysis Patients
- Author
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Yu-Ting Lee, Wei-Yu Wang, Chin-Ho Kuo, Ming-Yang Lee, Yin-Che Lu, Chih-Yen Hsiao, Yueh-Han Hsu, and Peir-Haur Hung
- Subjects
end stage renal disease ,leucopenia ,thrombocytopenia ,hemodialysis ,risk factors ,Medicine (General) ,R5-920 - Abstract
Leukopenia or thrombocytopenia is sometimes observed in end-stage renal disease (ESRD) patients, but the association between chronic leukopenia or thrombocytopenia and hemodialysis (HD) is still unclear. We aimed to investigate the incidence of chronic leukopenia or thrombocytopenia in patients with ESRD who received HD and to determine the risk factors of this complication. We retrospectively analyzed ESRD patients treated with HD at Ditmanson Medical Foundation Chia-Yi Christian Hospital in 2018. The risk factors for the occurrence of chronic leukopenia and thrombocytopenia were analyzed by Cox regression models. Of the 473 patients in our study cohort, 46 (9.7%) patients had a hematologic abnormality, including 18 patients with chronic leukopenia, 18 with chronic thrombocytopenia, and 10 with pancytopenia. Multivariate analysis revealed that patient age ≥60 years at the initiation of dialysis was a significant predictor for both chronic leukopenia [adjusted hazard ratio (aHR), 2.71; 95% confidence interval (CI), 1.06-6.89] and chronic thrombocytopenia (aHR, 2.83; 95% CI, 1.08–7.35). Chronic liver disease (aHR, 3.31; 95% CI, 1.27–8.61) and serum ferritin levels >800 mg/dl (aHR, 3.29; 95% CI, 1.29–8.39) were risk factors for chronic thrombocytopenia. A trend showed that vitamin D from intravenous supplementation (aHR, 0.13; 95% CI, 0.01–1.16, P = 0.066) and serum phosphorous level (aHR, 0.73; 95% CI, 0.53–1.02, P = 0.068) may be associated with chronic thrombocytopenia. Our study demonstrated that hematological abnormality was a long-term complication of HD. These results reveal that older patients with HD and high serum ferritin levels are at an elevated risk for chronic cytopenia. Healthcare professionals should be aware of this risk when treating HD patients in order to improve their prognosis.
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- 2020
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8. Interplay between doping and size effects on Y1-xEuxMn2O5 nanorods
- Author
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Ting-Wei Hsu, Chun-Chuen Yang, Yung-Hsiang Tung, Cheng-Wei Kao, Wei-Chun Wu, Yu-Ting Lee, and Kuen-Song Lin
- Subjects
Physics ,QC1-999 - Abstract
Y1-xEuxMn2O5 nanorod samples (x = 0, 0.5, and 1) were prepared and crystallized in an orthorhombic structure with the Pbam space group. Magnetic susceptibility experiments revealed that the size effect reduced the effective magnetic moment and interaction among magnetic moments. All six samples exhibited AFM ordering and canted AFM domain below 50 K, and adjustable by varying the size of the nanorods. Hysteresis experiments revealed the size effect induced exchange bias. Room-temperature Raman spectra revealed a red-shift in all of x = 0 and x = 1 samples in an applied magnetic field, indicating that a spin-phonon interaction existed at room temperature.
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- 2020
- Full Text
- View/download PDF
9. Conversion of a Thiol Precursor into Aroma Compound 4-mercapto-4-methyl-2-pentanone Using Microbial Cell Extracts
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Hao-Kai Li, Chi-Fon Chang, Hsuan-Ju Lin, Jung-Lee Lin, Yu-Ting Lee, Yu-Hsuan Wu, Chiao-Yen Liu, Tze-Chia Lin, Pang-Hung Hsu, and Hong-Ting Victor Lin
- Subjects
aroma compounds ,4-mercapto-4-methyl-2-pentanone ,β-lyase ,precursors ,fermentation ,Shewanella putrefaciens ,Fermentation industries. Beverages. Alcohol ,TP500-660 - Abstract
4-Mercapto-4-methyl-2-pentanone (4MMP), a high-impact aroma compound with the box tree and black currant flavors was first identified in wines and could be released by microbial cysteine-S-conjugate β-lyases from its precursors. In this study, various yeasts and bacteria encoding β-lyases were selected to examine their β-lyase activities. A thiol precursor of 4MMP, cysteine-conjugate of 4MMP (cys-4MMP), was synthesized with a purity of >95% in a relatively environmentally friendly approach, and its chemical structure was confirmed by nuclear magnetic resonance spectroscopy. The β-lyase activities of the crude cell extract from the bacteria and yeast strains for different substrates were examined using a colorimetric method. Shewanella putrefaciens cell extract exhibited the highest β-lyase activity for all tested substrates. Additionally, the optimum pH and temperature for their β-lyase activities were determined. To monitor the conversion efficiency of precursor cys-4MMP to 4MMP, liquid chromatography-mass spectrometry was used. Our data indicate that selected bacteria and yeasts could convert cys-4MMP into 4MMP, and S. putrefaciens exhibited the best conversion yield. This study demonstrated the potential use of microbial cell extracts to produce sulfur-containing aroma compounds such as 4MMP.
- Published
- 2021
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10. Combinatorial Epigenetic and Immunotherapy in Breast Cancer Management: A Literature Review
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Yu-Ting Lee, Yu-Ming Chuang, and Michael W. Y. Chan
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immune checkpoint inhibitors ,epi-drug ,combination therapy ,breast cancer ,Genetics ,QH426-470 ,Biotechnology ,TP248.13-248.65 - Abstract
Breast cancer is one of the leading causes of death among cancer patients worldwide. To date, there are several drugs that have been developed for breast cancer therapy. In the 21st century, immunotherapy is considered a pioneering method for improving the management of malignancies; however, breast cancer is an exception. According to the immunoediting model, many immunosuppressive cells contribute to immunological quiescence. Therefore, there is an urgent need to enhance the therapeutic efficacy of breast cancer treatments. In the last few years, numerous combinatorial therapies involving immune checkpoint blockade have been demonstrated that effectively improve clinical outcomes in breast cancer and combining these with methods of targeting epigenetic regulators is also an innovative strategy. Nevertheless, few studies have discussed the benefits of epi-drugs in non-cancerous cells. In this review, we give a brief overview of ongoing clinical trials involving combinatorial immunotherapy with epi-drugs in breast cancer and discuss the role of epi-drugs in the tumor microenvironment, including the results of recent research.
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- 2020
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11. Concurrent chemoradiotherapy in elderly patients with muscle-invasive bladder cancer: A single-center experience
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Yu-Ting Lee, Yi-Tsui Wu, Cheuh-Chuan Yen, Mu-Hsin Chang, Yen-Hwa Chang, Hsiao-Jen Chung, Tzu-Ping Lin, Chia-Jen Liu, and Jin-Hwang Liu
- Subjects
Bladder cancer ,Elderly ,Radiation therapy ,Concurrent chemoradiation ,Bladder preservation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Bladder cancer is a disease frequently seen in the elderly. Frail and elderly patients with muscle-invasive bladder cancer (MIBC) are often unfit for surgery. While concurrent chemoradiotherapy (CCRT) is a well-established alternative treatment modality, only a small proportion of elderly patients receive CCRT. The purpose of this article is to review our experience with CCRT in elderly MIBC patients. Methods: Between January 1, 2007 and December 31, 2013, we retrospectively reviewed patients aged >75 who were treated with CCRT at Taipei Veterans General Hospital. Patients' characteristics, therapeutic strategy, clinical outcomes, and treatment-related toxicities were assessed. Results: Nineteen patients (4 females and 15 males) were identified. The median age was 79.5 years (range, 78.5–84.0 years) and the median follow-up was 33.7 months (interquartile range, 19.1–51.8 months). The major adverse event was grade 3 or grade 4 neutropenia, which developed in 10 of the 19 patients. No treatment-related mortality occurred. We found no association between prognosis and the chemotherapy regimen. Chemotherapy with a conventional dose of gemcitabine (800–1000 mg/m2) was well tolerated. The two-year and three-year estimated overall survival rates were 74% and 60%, respectively. Conclusion: CCRT after complete transurethral resection of the bladder tumor is feasible for elderly patients with MIBC. The conventional dose of gemcitabine as a chemosensitizer is adequate in the elderly population, but further investigation is needed.
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- 2016
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12. Tandem Three-Component Reactions of Aldehyde, Alkyl Acrylate, and Dialkylmalonate Catalyzed by Ethyl Diphenylphosphine
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Utpal Das, Ko-Wei Chen, Chia-Jui Lee, Yu-Ting Lee, Yi-Wun Jhang, Siang-En Syu, Yeong-Jiunn Jang, and Wenwei Lin
- Subjects
multicomponent reaction ,Morita-Baylis-Hillman ,chemoselectivity ,Michael addition ,aldehyde ,Organic chemistry ,QD241-441 - Abstract
A new highly efficient three-component reaction of alkyl acrylate, aldehyde and dialkyl malonate using ethyl diphenylphosphine as organocatalyst has been described. Various highly functional compounds bearing hydroxyl groups and the ester functions can be easily prepared in moderate to good yields according to our one-step procedure. The reactions are believed to proceed via Morita-Baylis-Hillman reactions of alkyl acrylate and aldehydes, followed by the Michael addition reactions of dialkyl malonates. Our reactions indicated that the intermediate species formed in the phosphine-catalyzed MBH reaction are an effective organic base to catalyze the Michael addition reactions of dialkyl malonates to the preformed MBH adducts.
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- 2012
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13. Genome-phenome wide association study of broadly defined headache.
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Wan-Ting Hsu, Yu-Ting Lee, Jasmine Tan, Yung-Han Chang, Frank Qian, Kuei-Yu Liu, Jo-Ching Hsiung, Chia-Hung Yo, Sung-Chun Tang, Xia Jiang, and Chien-Chang Lee
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- 2023
- Full Text
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14. Analysis of COVID-19 pandemic impact on the presenting complaints of the emergency department visits
- Author
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Yen-Wen Lai, Ching-Tang Hsu, Yu-Ting Lee, Wei-Lung Chen, Jiann-Hwa Chen, Chien-Cheng Huang, and Jui-Yuan Chung
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emergency visits ,coronavirus disease 2019 ,emergency department ,Observational Study ,COVID-19 ,Humans ,General Medicine ,Emergency Service, Hospital ,Pandemics ,presenting complaints ,Research Article ,Retrospective Studies - Abstract
The impact of coronavirus disease 2019 (COVID-19) on economic and medical systems is significant, especially in the emergency department (ED). The patterns of ED visits have also changed significantly and may play a crucial role in rearranging medical resources to the most needed departments during the pandemic. This was a retrospective study conducted in hospitals of the Cathay Health System. All patients presented to the EDs between January 21, 2020 to April 30, 2020 (pandemic stage) and January 21, 2019 to April 30, 2019 (before the pandemic stage). Basic demographics, including visit characteristics, disposition, and chief complaints, of the patients visiting the ED between these 2 periods of time will be compared and analyzed. A total of 71,739 patients were included in the study. A reduction in ED visits was noted in 15.1% (32,950 ED visits) during the pandemic stage. ED visiting patients with the chief complaints of upper respiratory infection and social problems increased by 14.23% and 1.86%, respectively, during the pandemic period. Critical chief complaints such as cardiac arrest, chest pain and altered mental status decreased to less than the ED visits difference (−15.1%) between the pandemic and prepandemic stages, for 0%, −7.67%, and −13.8% respectively. Rearrangement of the ED pediatric staff to the COVID-19 special units and recruiting more social workers to the ED should be performed to respond to the COVID-19 pandemic.
- Published
- 2021
15. Conversion of a Thiol Precursor into Aroma Compound 4-mercapto-4-methyl-2-pentanone Using Microbial Cell Extracts
- Author
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Chiao-Yen Liu, Hsuan-Ju Lin, Yu-Hsuan Wu, Pang-Hung Hsu, Yu-Ting Lee, Tze-Chia Lin, Hong-Ting Victor Lin, Jung-Lee Lin, Hao-Kai Li, and Chi-Fon Chang
- Subjects
0301 basic medicine ,aroma compounds ,4-mercapto-4-methyl-2-pentanone ,β-lyase ,precursors ,fermentation ,Shewanella putrefaciens ,Chemical structure ,Fermentation industries. Beverages. Alcohol ,030106 microbiology ,Plant Science ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,03 medical and health sciences ,chemistry.chemical_compound ,Aroma compound ,Aroma ,chemistry.chemical_classification ,TP500-660 ,Chromatography ,biology ,Chemistry ,food and beverages ,biology.organism_classification ,Yeast ,030104 developmental biology ,Thiol ,Fermentation ,Bacteria ,Food Science - Abstract
4-Mercapto-4-methyl-2-pentanone (4MMP), a high-impact aroma compound with the box tree and black currant flavors was first identified in wines and could be released by microbial cysteine-S-conjugate β-lyases from its precursors. In this study, various yeasts and bacteria encoding β-lyases were selected to examine their β-lyase activities. A thiol precursor of 4MMP, cysteine-conjugate of 4MMP (cys-4MMP), was synthesized with a purity of >95% in a relatively environmentally friendly approach, and its chemical structure was confirmed by nuclear magnetic resonance spectroscopy. The β-lyase activities of the crude cell extract from the bacteria and yeast strains for different substrates were examined using a colorimetric method. Shewanella putrefaciens cell extract exhibited the highest β-lyase activity for all tested substrates. Additionally, the optimum pH and temperature for their β-lyase activities were determined. To monitor the conversion efficiency of precursor cys-4MMP to 4MMP, liquid chromatography-mass spectrometry was used. Our data indicate that selected bacteria and yeasts could convert cys-4MMP into 4MMP, and S. putrefaciens exhibited the best conversion yield. This study demonstrated the potential use of microbial cell extracts to produce sulfur-containing aroma compounds such as 4MMP.
- Published
- 2021
16. Association between health behaviors and mood disorders among the elderly: a community-based cohort study
- Author
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Yu-Ting Lee, Jia-Hong Tang, I-Chun Fan, Tzu-Jung Tseng, Yi-Syuan Wu, Ta-Chien Chan, and Yen-Hui Chiu
- Subjects
Male ,Health Behavior ,Socio-economic status ,lcsh:Geriatrics ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Prevalence of mental disorders ,Elderly health examination database ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,Longitudinal Studies ,Health behaviors ,Socioeconomic status ,Aged ,Retrospective Studies ,Aged, 80 and over ,Marital Status ,business.industry ,Smoking ,Odds ratio ,medicine.disease ,Mental health ,Community Mental Health Services ,lcsh:RC952-954.6 ,Mood disorders ,Relative risk ,Marital status ,Female ,Geriatrics and Gerontology ,Diet, Healthy ,business ,030217 neurology & neurosurgery ,Demography ,Cohort study ,Research Article ,Follow-Up Studies - Abstract
Background According to a WHO report, nearly 15% of adults aged 60 and over suffer from a mental disorder, constituting 6.6% of the total disability for this age group. Taipei City faces rapid transformation towards an aging society, with the proportion of elderly in the total population rising from 12% in 2008 to 16% in 2016. The aim of this study is to identify the prevalence of mental disorders among the elderly in Taipei City and to elucidate risk factors contributing to mental disorders. Methods The elderly health examination database was obtained from the Department of Health, Taipei City government, from 2005 to 2012. A total of 86,061 people underwent publicly funded health examinations, with 348,067 visits. Each year, there are around 43,000 elderly persons in Taipei City using this service. We used a mental health questionnaire including five questions to estimated relative risks among potential risk factors with the generalized estimating equations (GEE) model to measure the mental health status of the elderly. Mood disorders were measured with the Brief Symptom Rating Scale (BSRS-5) questionnaire. Age, education level, gender, marital status, living alone, drinking milk, eating vegetables and fruits, long-term medication, smoking status, frequency of alcohol consumption, frequency of physical activity, BMI, and number of chronic diseases were included as covariates. Results The results show that being male (odds ratio (OR) 0.57; 95% CI = 0.56, 0.59), higher education (OR 0.88; 95% CI = 0.82, 0.95), no long-term medication (OR 0.57; 95% CI = 0.56, 0.58), and exercising three or more times per week (OR 0.94; 95% CI = 0.91, 0.98) were all positively correlated with better emotional status. However, being divorced (OR = 1.22, 95% CI = 1.09, 1.36), not drinking milk (OR = 1.12, 95% CI = 1.09, 1.14), not eating enough vegetables and fruits every day (OR = 1.78, 95% CI = 1.73, 1.83), daily smoking (OR = 1.15, 95% CI = 1.01, 1.32), and having more chronic diseases (OR = 1.02, 95% CI = 1.01, 1.03) were all correlated with poor mental status among the elderly. Conclusions The findings of this research can both estimate the prevalence of mood disorders at the community level, and identify risk factors of mood disorders at the personal level.
- Published
- 2019
17. NTHU-route 2.0: a robust global router for modern designs
- Author
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Yen-Jung Chang, Yu-Ting Lee, Jhih-Rong Gao, Pei-Ci Wu, and Ting-Chi Wang
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Standard IC ,Bridge/router ,Internetworking device ,ISDN router ,Integrated circuits -- Design and construction ,Semiconductor chips -- Design and construction ,Bridge/routers -- Innovations ,Bridge/routers -- Usage ,Very-large-scale integration -- Usage - Published
- 2010
18. Interplay between doping and size effects on Y1-xEuxMn2O5 nanorods
- Author
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Cheng-Wei Kao, Yung-Hsiang Tung, Kuen-Song Lin, Yu-Ting Lee, Ting-Wei Hsu, Chun-Chuen Yang, and Wei-Chun Wu
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010302 applied physics ,Materials science ,Magnetic moment ,Analytical chemistry ,General Physics and Astronomy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Magnetic susceptibility ,lcsh:QC1-999 ,Magnetic field ,symbols.namesake ,Hysteresis ,Condensed Matter::Materials Science ,Exchange bias ,0103 physical sciences ,symbols ,Orthorhombic crystal system ,Nanorod ,Condensed Matter::Strongly Correlated Electrons ,0210 nano-technology ,Raman spectroscopy ,lcsh:Physics - Abstract
Y1-xEuxMn2O5 nanorod samples (x = 0, 0.5, and 1) were prepared and crystallized in an orthorhombic structure with the Pbam space group. Magnetic susceptibility experiments revealed that the size effect reduced the effective magnetic moment and interaction among magnetic moments. All six samples exhibited AFM ordering and canted AFM domain below 50 K, and adjustable by varying the size of the nanorods. Hysteresis experiments revealed the size effect induced exchange bias. Room-temperature Raman spectra revealed a red-shift in all of x = 0 and x = 1 samples in an applied magnetic field, indicating that a spin-phonon interaction existed at room temperature.
- Published
- 2020
19. Tandem Three-Component Reactions of Aldehyde, Alkyl Acrylate, and Dialkylmalonate Catalyzed by Ethyl Diphenylphosphine
- Author
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Siang En Syu, Yu‐Ting Lee, Utpal Das, Yeong Jiunn Jang, Wenwei Lin, Yi Wun Jhang, Ko Wei Chen, and Chia Jui Lee
- Subjects
multicomponent reaction ,Phosphines ,Pharmaceutical Science ,Aldehyde ,Article ,aldehyde ,Catalysis ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Michael addition ,Drug Discovery ,Organic chemistry ,Physical and Theoretical Chemistry ,Chemoselectivity ,Alkyl ,chemistry.chemical_classification ,Acrylate ,Aldehydes ,Diphenylphosphine ,Molecular Structure ,Morita-Baylis-Hillman ,Organic Chemistry ,Stereoisomerism ,Malonates ,Malonate ,chemistry ,Acrylates ,Chemistry (miscellaneous) ,chemoselectivity ,Michael reaction ,Molecular Medicine - Abstract
A new highly efficient three-component reaction of alkyl acrylate, aldehyde and dialkyl malonate using ethyl diphenylphosphine as organocatalyst has been described. Various highly functional compounds bearing hydroxyl groups and the ester functions can be easily prepared in moderate to good yields according to our one-step procedure. The reactions are believed to proceed via Morita-Baylis-Hillman reactions of alkyl acrylate and aldehydes, followed by the Michael addition reactions of dialkyl malonates. Our reactions indicated that the intermediate species formed in the phosphine-catalyzed MBH reaction are an effective organic base to catalyze the Michael addition reactions of dialkyl malonates to the preformed MBH adducts.
- Published
- 2012
20. Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
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Garcia, Mario D., Chua, Sheena M. H., Yu-Shang Low, Yu-Ting Lee, Agnew-Francis, Kylie, Jian-Guo Wang, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A., and Guddat, Luke W.
- Subjects
TRIAZOLES ,ANTIFUNGAL agents ,PATHOGENIC microorganisms ,DRUG resistance ,CRYPTOCOCCUS neoformans - Abstract
The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat to global human health. Thus, new drugs are urgently required to combat these infections. Here, we demonstrate that acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway, is a promising new target for antifungal drug discovery. First, we show that several AHAS inhibitors developed as commercial herbicides are powerful accumulative inhibitors of Candida albicans AHAS (K
i values as low as 800 pM) and have determined high-resolution crystal structures of this enzyme in complex with several of these herbicides. In addition, we have demonstrated that chlorimuron ethyl (CE), a member of the sulfonylurea herbicide family, has potent antifungal activity against five different Candida species and Cryptococcus neoformans (with minimum inhibitory concentration, 50% values as low as 7 nM). Furthermore, in these assays, we have shown CE and itraconazole (a P450 inhibitor) can act synergistically to further improve potency. Finally, we show in Candida albicans-infected mice that CE is highly effective in clearing pathogenic fungal burden in the lungs, liver, and spleen, thus reducing overall mortality rates. Therefore, in view of their low toxicity to human cells, AHAS inhibitors represent a new class of antifungal drug candidates. [ABSTRACT FROM AUTHOR]- Published
- 2018
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21. Pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma in an Asian population.
- Author
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Wen-Chun Chen, Pen-Yuan Chu, Yu-Ting Lee, Wen-Bin Lu, Chun-Yu Liu, Peter Mu-Hsin Chang, Muh-Hwa Yang, Chen, Wen-Chun, Chu, Pen-Yuan, Lee, Yu-Ting, Lu, Wen-Bin, Liu, Chun-Yu, Chang, Peter Mu-Hsin, and Yang, Muh-Hwa
- Published
- 2017
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22. Enterovesical fistula caused by regressive change of non-Hodgkin's lymphoma: A case report.
- Author
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YU-TING LEE, YING-YUAN CHEN, CHIA-0YUN WU, HUNG-MING CHEN, CHENG-HWAI TZENG, and TZEON-JYE CHIOU
- Subjects
- *
DIVERTICULITIS , *CROHN'S disease , *RADIOTHERAPY , *INFLAMMATION , *LYMPHOMAS - Abstract
Enterovesical fistula (EVF) is a rare complication of diverticulitis, as well as Crohn's disease, intestinal malignancy, radiotherapy and trauma. EVF formation is associated with inflammation of the involved bowel segments. The current study presents the case of a 35-year-old man with non-Hodgkin's lymphoma who developed pneumaturia, fecaluria and recurrent urinary tract infections following chemotherapy, accompanied by regressive change of the lymphoma. Abdominal computed tomography scans revealed that the terminal ileum had adhered to the bladder wall. The patient underwent exploratory laparotomy and partial resection of the terminal ileum, and EVF was confirmed. Histological examination revealed an inflammatory response but no evidence of residual lymphoma. The diagnosis of EVF is occasionally difficult and requires appropriate radiographic examination. Surgical treatment is recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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23. EAST ASIA AND HUMAN KNOWLEDGE-A PERSONAL QUEST.
- Author
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Yu‐Ting, Lee
- Subjects
- *
EAST Asian history , *THEORY of knowledge , *INTELLECTUAL history , *CONFUCIANISM ,EAST Asian civilization - Abstract
This essay is a reflection on the ways we understand East Asia, as well as how East Asia is related to our knowledge construction. In spite of the personal tone, which I use strategically to formulate arguments in a carefully designed narrative flow, the article remains critical throughout and its conclusion is clear: exploration of the essence of East Asian civilization can constitute a meaningful effort to reevaluate and even restructure our current world of knowledge. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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24. The polymorphism of CAG repeats in the androgen receptor gene and breast cancer mortality.
- Author
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Yu-Ting Lee, Hsueng-Mei Liu, Li-Hsuan Lee, Chia-Jen Liu, Jeong-Shi Lin, Ta-Chung Chao, Woan-Fang Tzeng, and Tzeon-Jye Chiou
- Subjects
- *
GENETIC polymorphisms , *ANDROGEN receptors , *BREAST cancer diagnosis , *LOGISTIC regression analysis , *CLINICAL prediction rules - Abstract
BACKGROUND: The polymorphic CAG repeats of the androgen receptor (AR) gene have been suggested to affect the risk of breast cancer, but the results are controversial. In addition, the relationship between patients' CAG genotype and the prognosis has not been investigated. OBJECTIVE: The purpose of this study is to access the association between the polymorphic CAG repeats and the incidence and prognosis of breast cancer. METHODS: One hundred and fifty-six breast cancer cases and 108 healthy controls from Taipei Veteran General Hospital were enrolled. The length of CAG repeats was analyzed among by means of PCR amplification. The logistic regression model was used for cross-sectional analyses of prevalent breast cancer. Furthermore, we categorized the cases according to the average length of both CAG alleles (CAGn ≥ 23 versus < 23). Outcomes were disease-free survival and mortality. The Cox proportional hazards model and Kaplan-Meier estimate were used for survival analysis. RESULTS: The median age was 56 (51-64) and 46 (37-52) in breast cancer patients and healthy controls, respectively. The median of CAGn was 22.5 (21.5-24) in study group and 23 (21.5-24) in controls. Our study showed the length of CAG repeats did not contribute to breast cancer or benign breast tumors (HR 1.01; 95% CI, 0.90-1.13). In the median follow-up of 6.59 years, we found the CAGn ≥ 23 (n = 75) could be a poor prognosis (adjust HR, 3.08; 95% CI, 1.42-6.67, p = 0.004). CONCLUSION: The CAG polymorphism is not associated with development of breast cancer, but patients with more CAG repeats of the AR gene are prone to poor prognoses. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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25. Incidence of Second Primary Malignancies Following Colorectal Cancer: A Distinct Pattern of Occurrence Between Colon and Rectal Cancers and Association of Co-Morbidity with Second Primary Malignancies in a Population-Based Cohort of 98,876 Patients in Taiwan
- Author
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Yu-Ting Lee, Chia-Jen Liu, Yu-Wen Hu, Chung-Jen Teng, Cheng-Hwai Tzeng, Chiu-Mei Yeh, Tzeng-Ji Chen, Jen-Kou Lin, Chun-Chi Lin, Yuan-Tzu Lan, Huann-Sheng Wang, Shung-Haur Yang, Jeng-Kai Jiang, Wei-Shone Chen, Tzu-Chen Lin, Shih-Ching Chang, Ming-Huang Chen, Hao-Wei Teng, Jin-Hwang Liu, and Chueh-Chuan Yen
- Published
- 2015
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- View/download PDF
26. Outcome Disparities Between Medical Personnel and Nonmedical Personnel Patients Receiving Definitive Surgery for Colorectal Cancer.
- Author
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Chia-Jen Liu, Nicole Huang, Chun-Chi Lin, Yu-Ting Lee, Yu-Wen Hu, Chiu-Mei Yeh, Tzeng-Ji Chen, and Yiing-Jenq Chou
- Published
- 2015
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- View/download PDF
27. A temperature-aware global router.
- Author
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Yu-Ting Lee, Yen-Jung Chang, and Ting-Chi Wang
- Published
- 2010
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28. NTHU-Route 2.0: A fast and stable global router.
- Author
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Yen-Jung Chang, Yu-Ting Lee, and Ting-Chi Wang
- Published
- 2008
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29. Simplifying the Manager Competency Model by Using the Rough Set Approach.
- Author
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Ślezak, Dominik, JingTao Yao, Peters, James F., Ziarko, Wojciech, Xiaohua Hu, Wei-Wen Wu, Yu-Ting Lee, and Gwo-Hshiung Tzeng
- Abstract
It is now a leading company strategy to apply competency models for identifying and developing capabilities of their managers. However, a competency model usually contains too many intended competencies to be implemented. Recently, some scholars and experts argue that eight is the maximum for managers to assess. Hence, how to simplify the manager competency model is becoming an important issue. Well known as data mining techniques, the rough sets theory is a relatively new approach and good at data reduction in qualitative analysis, so that the rough set approach is suitable for dealing with the qualitative problem in simplifying the competency model. The aim of this paper is to mining the minimal set of competencies through using the rough set approach to help companies for better utilizing the competency model. The results show that the "self-management" competency is the most indispensable portion to a manager competency model. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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- View/download PDF
30. Tagore and Orientalism: Tagore Studies as a Focus for East-West Debate.
- Author
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Yu-ting LEE
- Subjects
ORIENTALISM ,EAST-West divide ,INDIC literature -- History & criticism ,INTELLECTUAL life - Abstract
This essay adopts a critical approach to the making of Tagore's (1861-1941) public image and the concomitant studies of him. By exploring the ideological premises that have undergirded the historical and interpretive narratives of the Indian poet for nearly a century, this paper demonstrates that many of the regional, temporal, and thematic ramifications of the topic are, on a deeper theoretical level, closely related to the different ways of conceiving and projecting the East, which constitute different types of Orientalism. The introduction discusses and lays the methodological groundwork for this Orientalism. Section 1 critically reviews the process of Tagore's rise to fame in the West, which by way of the 1913 Nobel Prize in Literature elevated him to the position of "Eastern messenger." Section 2 juxtaposes India's and the West's contrasting attitudes towards Tagore's cultural legacies; while relevant studies develop in different directions in the two parts of the world, the thread of "East- West civilizations" is common to their problematics. Section 3 depicts Tagore's interaction with Japanese and Chinese intellectuals, and indicates how the conventions of Tagore studies in the two countries have been shaped by their respective identifications with "Asia." The conclusion delves into how Orientalism as an ideology permeates the three levels of "the mythologizing of Tagore," "the crystallization of Tagore studies," and "the emergence of the East as an issue." [ABSTRACT FROM AUTHOR]
- Published
- 2013
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- View/download PDF
31. Tandem Three-Component Reactions of Aldehyde, Alkyl Acrylate, and Dialkylmalonate Catalyzed by Ethyl Diphenylphosphine.
- Author
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Yeong-Jiunn Jang, Siang-En Syu, Yi-Wun Jhang, Yu-Ting Lee, Chia-Jui Lee, Ko-Wei Chen, Das, Utpal, and Wenwei Lin
- Subjects
ALDEHYDES ,CHEMICAL reactions ,DIPHENYLPHOSPHINE ,HYDROXYL group ,ORGANOCATALYSIS - Abstract
A new highly efficient three-component reaction of alkyl acrylate, aldehyde and dialkyl malonate using ethyl diphenylphosphine as organocatalyst has been described. Various highly functional compounds bearing hydroxyl groups and the ester functions can be easily prepared in moderate to good yields according to our one-step procedure. The reactions are believed to proceed via Morita-Baylis-Hillman reactions of alkyl acrylate and aldehydes, followed by the Michael addition reactions of dialkyl malonates. Our reactions indicated that the intermediate species formed in the phosphine-catalyzed MBH reaction are an effective organic base to catalyze the Michael addition reactions of dialkyl malonates to the preformed MBH adducts. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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32. Preparation of Functional Benzofurans, Benzothiophenes, and Indoles Using Ester, Thioester, and Amide via Intramolecular Wittig Reactions.
- Author
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Siang-en Syu, Yu-Ting Lee, Yeong-Jiunn Jang, and Wenwei Lin
- Subjects
- *
BENZOFURAN , *THIOPHENES , *INDOLE , *ESTERS , *AMIDES , *WITTIG reaction , *INTERMEDIATES (Chemistry) - Abstract
Preparation of new types of highly functional benzofurans, benzothiophenes, and indoles is realized via intramolecular Wittig reactions with the corresponding ester, thioester, and amide functionalities. The key intermediates, phosphorus ylides, presumably result from the addition of Bu3P toward aldehydes followed by acylation and deprotonation. Synthesis of functional benzofurans directly starting from salicylic aldehyde derivatives with acid chlorides in a one-step procedure is also developed. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
33. Structure-activity relationships for a new family of sulfonylurea herbicides.
- Author
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Jian-Guo Wang, Zheng-Ming Li, Ning Ma, Bao-Lei Wang, Lin Jiang, Siew Siew Pang, Yu-Ting Lee, Guddat, Luke W., and Duggleby, Ronald G.
- Subjects
STRUCTURE-activity relationships ,HERBICIDES ,BRANCHED chain amino acids ,BIOSYNTHESIS ,MOLECULAR structure ,CHEMICAL structure ,COMPUTER-aided design ,COMPUTER-aided engineering - Abstract
Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyzes the first common step in branched-chain amino acid biosynthesis. The enzyme is inhibited by several chemical classes of compounds and this inhibition is the basis of action of the sulfonylurea and imidazolinone herbicides. The commercial sulfonylureas contain a pyrimidine or a triazine ring that is substituted at both meta positions, thus obeying the initial rules proposed by Levitt. Here we assess the activity of 69 monosubstituted sulfonylurea analogs and related compounds as inhibitors of pure recombinant Arabidopsis thaliana AHAS and show that disubstitution is not absolutely essential as exemplified by our novel herbicide, monosulfuron (2-nitro- N-(4′-methyl-pyrimidin−2′-yl) phenyl-sulfonylurea), which has a pyrimidine ring with a single meta substituent. A subset of these compounds was tested for herbicidal activity and it was shown that their effect in vivo correlates well with their potency in vitro as AHAS inhibitors. Three-dimensional quantitative structure–activity relationships were developed using comparative molecular field analysis and comparative molecular similarity indices analysis. For the latter, the best result was obtained when steric, electrostatic, hydrophobic and H-bond acceptor factors were taken into consideration. The resulting fields were mapped on to the published crystal structure of the yeast enzyme and it was shown that the steric and hydrophobic fields are in good agreement with sulfonylurea-AHAS interaction geometry. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
34. Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site.
- Author
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Tyagi, Rajiv, Yu-Ting Lee, Guddat, Luke W., and Duggleby, Ronald G.
- Subjects
- *
ISOMERASES , *ENZYMES , *MUTAGENESIS , *BINDING sites , *AMINO acids , *ISOMERIZATION , *BIOCHEMISTRY - Abstract
Ketol-acid reductoisomerase (EC 1.1.1.86) is involved in the biosynthesis of the branched-chain amino acids. It is a bifunctional enzyme that catalyzes two quite different reactions at a common active site; an isomerization consisting of an alkyl migration, followed by an NADPH-dependent reduction of a 2-ketoacid. The 2-ketoacid formed by the alkyl migration is not released. Using the pure recombinantEscherichia colienzyme, we show that the isomerization reaction has a highly unfavourable equilibrium constant. The reductase activity is shown to be relatively nonspecific and is capable of utilizing a variety of 2-ketoacids. The active site of the enzyme contains eight conserved polar amino acids and we have mutated each of these in order to dissect their contributions to the isomerase and reductase activities. Several mutations result in loss of the isomerase activity with retention of reductase activity. However, none of the 17 mutants examined have the isomerase activity only. We suggest a reason for this, involving direct reduction of a transition state formed during the isomerization, which is necessitated by the unfavourable equilibrium position of the isomerization. Our mechanism explains why the two activities must occur in a single active site without release of a 2-ketoacid and provides a rationale for the requirement for NADPH by the isomerase. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
35. Identification of the Regulatory Subunit of Arabidopsis thaliana Acetohydroxyacid Synthase and....
- Author
-
Yu-Ting Lee and Duggleby, Ronald G.
- Subjects
- *
CATALYSIS , *BRANCHED chain amino acids , *HYDROXY acids - Abstract
Focuses on the catalysis of acetohydroxyacid synthase for the formation of branched amino acids. Combination of protein with the catalytic subunit of Arabidopsis thaliana; Reconstitution of catalytic subunit; Synergical effects of leucine and valine.
- Published
- 2001
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36. Effect of mutagenesis at serine 653 of Arabidopsis thaliana acetohydroxyacid synthase on the sensitivity to imidazolinone and sulfonylurea herbicides
- Author
-
Ronald G. Duggleby, Alan K. Chang, and Yu-Ting Lee
- Subjects
medicine.drug_class ,Restriction Mapping ,Arabidopsis ,Biophysics ,Phenylalanine ,Acetohydroxyacid synthase ,Niacin ,Biochemistry ,Serine ,Structure-Activity Relationship ,Structural Biology ,Enzyme kinetic ,Genetics ,medicine ,Arabidopsis thaliana ,Asparagine ,Arylsulfonates ,Threonine ,Site-directed mutagenesis ,Molecular Biology ,Alanine ,Sulfonamides ,biology ,Herbicides ,Triazines ,Imidazoles ,Herbicide-resistance ,Cell Biology ,biology.organism_classification ,Sulfonylurea ,Recombinant Proteins ,Acetolactate Synthase ,Kinetics ,Enzyme inhibition ,Pyrimidines ,Sulfonylurea Compounds ,Amino Acid Substitution ,Mutagenesis, Site-Directed - Abstract
Resistance to sulfonylurea and imidazolinone herbicides can occur by mutations in acetohydroxyacid synthase (EC 4.1.3.18). Changing serine 653 to asparagine is known to cause insensitivity to imidazolinones but not to sulfonylureas. Here, S-653 of the Arabidopsis thaliana enzyme was mutated to alanine, threonine and phenylalanine. The purified mutated enzymes resemble wild-type in their enzymatic properties. The threonine and phenylalanine mutants are imidazolinone-resistant and the latter is also slightly sulfonylurea-resistant. The alanine mutant remains sensitive to both herbicides. The results suggest that the β-hydroxyl group is not required for imidazolinone binding and that the size of the side-chain determines resistance.
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- View/download PDF
37. Organocatalytic Tandem Three-Component Reaction of Imine, Alkyl Vinyl Ketone, and Imide via aza-Baylis--Hillman Reaction.
- Author
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Siang-en Syu, Yu Ting Lee, Yeong-Jiunn Jang, and Wenwei Lin
- Subjects
- *
IMINES , *ORGANONITROGEN compounds , *ALKYLATION , *KETONES , *IMIDES - Abstract
A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita--Baylis--Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
38. Fluid balance correlates with clinical course of multiple organ dysfunction syndrome and mortality in patients with septic shock.
- Author
-
Allen Chung-Cheng Huang, Tim Yu-Ting Lee, Meng-Cheng Ko, Chih-Hsien Huang, Tsai-Yu Wang, Ting-Yu Lin, and Shu-Min Lin
- Subjects
Medicine ,Science - Abstract
IntroductionPositive fluid balance is a prognostic factor for mortality in patients with sepsis; however, the association between cumulated fluid balance (CFB) and sepsis-induced multi-organ dysfunction syndrome (MODS) has yet to be elucidated. In this study, we sought to determine whether CFB is correlated with MODS and mortality in cases of septic shock.MethodsThe study retrospectively recruited patients with septic shock from the intensive care unit of a tertiary care hospital. Multiple organ dysfunction syndrome (MODS) was identified as sequential organ failure assessment (SOFA) score ≥ 2 in more than one organ system. The CFB is the sum of all daily intake and output. An independent t-test, single and multivariate logistic regression, the receiver operating characteristic (ROC) curves, and the Pearson correlation coefficient were used to determine whether a relationship exists between CFB and the development of MODS and mortality.ResultsAmong the 104 patients enrolled in the study, 58 (55.8%) survived more than 28 days, and 73 (70.2%) developed MODS on day 3. The values of CFB in the first 24 hours and 72 hours after diagnosis of septic shock in patients with MODS were higher than these in patients without MODS (1086.6 ± 176.3 vs. 325.5 ± 205.7 ml, p = 0.013 and 2408 ± 361 vs. 873.1 ± 489 ml, p < 0.0001). In a multivariate logistic regression, the independent factors associated with the development of MODS on day 3 were APACHE II score at ICU admission (27.6 ± 7.6 in patients with MODS vs. 20.5 ± 6.4 in those without; O.R. 1.18; 95% C.1 I. 1.08-1.30; p < 0.001), disseminated intravascular coagulopathy (DIC) (n = 28; 38.4% vs. n = 2; 6.5%; O.R. 23.67; 95% C.I. 3.58-156.5; p = 0.001), and CFB in the first 72 hours (72-hr CFB) > median (1767.50ml) (n = 41; 56.2% vs. n = 11; 35.5%; O.R. 3.67; 95% C.I., 1.18-11.40; p = 0.024). Moreover, a multivariate logistic regression also identified neoplasm (n = 25; 54.3% vs. n = 17; 29.3%; O.R. 3.45; 95% C.I. 1.23-10.0; p = 0.019) and 72-hr CFB > median (n = 30; 65.2% vs. n = 21; 36.2%; O.R. 4.13; 95% C.I. 1.34-12.66; p = 0.013) as independent factors associated with 28-day mortality. 72-hr CFB values were strongly correlated with the SOFA score (r = 0.445, p < 0.0001). The area under the ROC curve revealed that 72-hr CFB has good discriminative power in associating the development of MODS (0.644, p = 0.002) and predicting subsequent 28-day mortality (0.704, p < 0.0001).Conclusions72-hr CFB appears to be correlated with the likelihood of developing MODS and mortality in patients with septic shock. Thus, it appears that 72-hr CFB could perhaps be used as an indicator for MODS and a predictor for mortality in those patients.
- Published
- 2019
- Full Text
- View/download PDF
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