1. Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity
- Author
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Masanori Sugiyama, Toshihiro Yamase, Tetsuya Yoshida, Yoshio Inouye, and Yasuhiro Fujimoto
- Subjects
Vanadium Compounds ,Stereochemistry ,Human immunodeficiency virus (HIV) ,Pharmaceutical Science ,medicine.disease_cause ,Antiviral Agents ,Immunodeficiency virus ,Structure-Activity Relationship ,Viral Proteins ,Cytopathogenic Effect, Viral ,Species Specificity ,polyoxometalate ,medicine ,Humans ,syncytium formation ,Cells, Cultured ,Pharmacology ,Molybdenum ,human immunodeficiency virus ,Chemistry ,virus diseases ,strain specificity ,General Medicine ,Tungsten Compounds ,Strain specificity ,cytopathogenicity ,Fluorescent Antibody Technique, Direct ,Polyoxometalate ,HIV-1 - Abstract
The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB and HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLVIIIB activity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIB activity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2 to a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIB activity and the specificity for HIV-1SF-2H might result from differential structural requirements in these functions.
- Published
- 1995