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Background The 21st -century is a paradigm shift of learning in which the curriculum developed at this time requires educational institutions to change their instructional approach. This study aimed to assess the level of satisfaction with integrated E-learning among staff members & medical students at Zagazig University during academic year 2023-2024. Methods: A cross-sectional study was performed on 264 staff members & 248 undergraduate medical students of Faculty of Medicine, Zagazig University. The level of satisfaction with integrated e-learning among staff members and medical students was assessed using self-administered Arabic semi-structured questionnaire which involved questions about demographic data, level of satisfaction with integrated e-learning and drawbacks present in this new approach application. Results: About 53% of staff members were found to be satisfied with integrated e-learning, however the remaining were not satisfied at all. As regarding students, 78.6% of them were found to be satisfied with integrated e-learning, however the remaining were not satisfied at all. A highly significant relation was revealed between overall satisfaction about integrated e-learning and the age of staff. Satisfaction was noticed to be higher among younger age staff compared to older ones (p<0.001). However, there was no significant relation between overall satisfaction and other baseline characteristics. According to students, a significant relation was revealed between overall satisfaction about integrated e-learning and the age of students. Satisfaction was noticed to be higher among third year students compared to others (p<0.001). Conclusions: The level of satisfaction with the integrated e-learning was higher among medical students compared to staff members. There was no relation between overall satisfaction and baseline data of both students and staff members except the age of the later ones. The negative feedback among those who were dissatisfied needs to work on improving the educational system, put their needs in concern as a priority and working on the infrastructure. [ABSTRACT FROM AUTHOR]