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Your search keyword '"Yaggi, Klar"' showing total 16 results
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16 results on '"Yaggi, Klar"'

13. Reducing Cardiovascular Risk through Treatment of Obstructive Sleep Apnea: Two Methodological Approaches

Author

Yaggi, Klar, Mittleman, Murray A, Bravata, Dawn M., Concato, John, Ware, James, Stoney, Catherine M., and Redline, Susan

Subjects
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Cardiovascular Diseases, Risk Factors, Incidence, Humans, Patient Compliance, Global Health, Article, Randomized Controlled Trials as Topic
Abstract

Obstructive sleep apnea (OSA) significantly impacts cardiovascular health, demonstrated by observational investigations showing an independently increased risk of ischemic heart disease, diabetes, hypertension, congestive heart failure, acute coronary syndrome, stroke, cardiovascular mortality, and all-cause mortality. Positive airway pressure (PAP), a medical therapy for sleep apnea, reverses airway obstruction and may help reduce cardiovascular risk. Prior to planning large Phase III randomized controlled trials to test the impact of PAP on cardiovascular outcomes, several gaps in knowledge need to be addressed. This paper describes two independent studies that worked collaboratively to fill these gaps. The populations, design features, and relative benefits/challenges of the two studies (SleepTight and BestAIR) are described. Both studies were encouraged to have multidisciplinary teams with expertise in behavioral interventions to improve PAP compliance. Both studies provide key information that will be useful to the research community in future large-scale, event-driven, randomized trials to evaluate the efficacy and/or effectiveness of strategies to identify and treat significant obstructive sleep apnea for decreasing risk of major adverse cardiovascular events in high-risk patients.

Published
2015

15. Abstract W P129.

Author

Stahl, Stephanie M, Taylor, Stanley, Ofner, Susan, Qin, Li, Yaggi, Klar, Ivan, C. Simona, and Bravata, Dawn M

Published
2014

16. Experiences of Stigma and Discrimination Compounded by Intersecting Identities among Individuals Receiving Medication for Opioid Use Disorder.

Author

Nwanaji-Enwerem U, Redeker NS, O'Connell M, Barry D, Iheanacho T, Knobf TM, Scheinost D, Wang K, Yaggi K, and Sadler LS

Subjects
Humans, Male, Female, Adult, Middle Aged, Qualitative Research, Opiate Substitution Treatment psychology, New England, Social Discrimination, Interviews as Topic, Social Stigma, Opioid-Related Disorders psychology, Opioid-Related Disorders drug therapy
Abstract

Stigma and discrimination create barriers to care among people receiving medication for opioid use disorder (MOUD). We report qualitative findings from a mixed methods study guided by three aims: to explore (1) intersecting identities of people receiving MOUD (2) how individuals experience stigma and discrimination and (3) helpful resources in addressing cumulative experiences of multiple forms of disadvantage. We conducted interviews with 25 individuals in three treatment centers in the Northeast United States and identified six themes: (1) Living with multiple socially marginalized identities and addiction; (2) Loss; (3) "It's everywhere": Discrimination and stigma; (4) A "damaged" identity, (5) Positive responses to negative experiences: Facing reality and becoming accountable, and (6) Experiencing treatment and identifying supportive interventions. Findings highlight the complexity of intersecting, marginalized social positions. Future work should look beyond one-size-fits-all approaches to care and recognize individual vulnerabilities and strengths for improving outcomes among those experiencing OUD.

Published
2024

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