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Objective We carried out this study to explore the possibility of initiating goserelin therapy during the non-menstrual period in patients diagnosed with adenomyosis.Methods 115 premenopausal adenomyosis patients were enrolled and divided into three groups based on their menstrual cycle phase during the initial outpatient visit: menstrual, follicular, and luteal. Each received a 3.6 mg subcutaneous dose of goserelin monthly for three months. The endpoints encompassed alterations in uterine volume, dysmenorrhea Numerical Rating Scale (NRS) score, CA125 level, hemoglobin (HGB) after a 12-week treatment course, and the occurrence and duration of uterine hemorrhage during the first treatment cycle.Results Analysis revealed that the timing of goserelin therapy initiation in the menstrual cycle did not significantly impact its effectiveness in reducing uterine size, alleviating pain, lowering CA125 levels, or improving hemoglobin concentrations. However, patients starting treatment during the luteal phase experienced increased uterine bleeding (reference: menstrual period, OR = 4.33, 95% CI 1.23–15.25, p = .023).Conclusions The results suggested non-inferiority of goserelin therapy initiated during the non-menstrual period, but the uterine bleeding rate was higher in the luteal phase group. Therefore, goserelin treatment for outpatient adenomyosis patients should not be limited to starting during the menstrual period; it can also be initiated outside the menstrual period, providing more convenience for patients as most consultations occur outside the menstrual period. However, the use of goserelin during the luteal phase should be avoided to reduce the risk of exacerbated bleeding, especially in anemic patients with heavy menstrual bleeding. This study highlights the importance of individualizing treatment initiation based on the patient’s health profile to optimize therapeutic outcomes and minimize adverse effects.Trial registration ChiCTR2200059548

Abstract Background Diabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The first-line drugs recommended by clinical guidelines fail to achieve satisfactory effects for people with DKD. A Chinese herbal medicine Tangshen Qushi Formula (TQF) shows preliminary efficacy and safety in preserving renal function for people with DKD, but the effects on comprehensive renal outcomes remain unclear. We will conduct a systematic review and meta-analysis to evaluate the effects of TQF herbs and their compounds identified from ultra-high performance liquid chromatography-MS/MS in diabetic animal models with renal outcomes. Methods This protocol complies with the guideline Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. We will include studies investigating the effects of TQF herbs and compounds on diabetic rats or mice with renal outcomes. Six electronic databases will be searched from their inception to February 2023. Quality assessment will be conducted using SYRCLE’s risk of bias tool. Standardized or weighted mean differences will be estimated for renal outcomes (creatinine, urea, proteinuria, histological changes, oxidative stress, inflammation, and kidney fibrosis). Data will be pooled using random-effects models. Heterogeneity across studies will be expressed as I 2. Sensitivity analyses will explore treatment effects in adjusted models and within subgroups. Funnel plots and Egger’s test will be used to explore publication bias. Discussion The results of this review will provide valuable insights into the potential effects of TQF in managing DKD. The limitation is that the included studies will be animal studies from specific databases, and the interpretation of the findings must be cautious. Systematic review registration PROSPERO CRD42023432895. Registered on 19 July 2023 ( https://www.crd.york.ac.uk/PROSPERO/#recordDetails ).

Tb3+ doped BaAl2O4 phosphors (0–9.0 mol%) were prepared through sol–gel combustion method. The crystal structure, morphology, chemical composition, photoluminescence (PL), afterglow and thermoluminescence (TL) glow curve of Tb3+ doped BaAl2O4 were investigated by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, PL spectroscopy, afterglow spectroscopy, and TL dosimetry. Characterizations of the PL and afterglow spectra indicate that both Tb3+ doping species and oxygen vacancies act as the luminescence center of PL whereas only Tb3+ dopant works as the luminescence center of afterglow for Tb3+ doped BaAl2O4. The green afterglow of Tb3+ doped BaAl2O4 lasts for about 214 min at the optimal doping concentration of about 1.0 mol%. The profile of TL glow curve of Tb3+ doped BaAl2O4 heavily depends on the doping concentration, and the evolution of the TL glow curve with doping concentration reveals that doping BaAl2O4 with Tb3+ can significantly modify the distribution of carrier traps in the phosphor. The effects of Tb3+ doping on the PL, afterglow, and TL glow curve of Tb3+ doped BaAl2O4 are discussed in terms of the creation, recombination, and neutralization of defects in BaAl2O4. This work proves that doing with Tb3+ species is a general and robust strategy for endowing BaAl2O4 with highly efficient green afterglow. This “defect engineering” approach enables ultra-long afterglow for Tb3+ doped BaAl2O4 when defect centers in the phosphors are optimized.

BackgroundDiabetic kidney disease (DKD) has become the leading cause of kidney failure, causing a significant socioeconomic burden worldwide. The usual care for DKD fails to achieve satisfactory effects in delaying the persistent loss of renal function. A Chinese herbal medicine, Tangshen Qushi Formula (TQF), showed preliminary clinical benefits with a sound safety profile for people with stage 2-4 DKD. We present the protocol of an ongoing clinical trial investigating the feasibility, efficacy, and safety of TQF compared to placebo in delaying the progressive decline of renal function for people with stage 2-4 DKD.MethodsA mixed methods research design will be used in this study. A randomized, double-blind, placebo-controlled pilot trial will evaluate the feasibility, efficacy, and safety of TQF compared to placebo on kidney function for people with stage 2-4 DKD. An embedded semi-structured interview will explore the acceptability of TQF granules and trial procedures from the participant’s perspective. Sixty eligible participants with stage 2-4 DKD will be randomly allocated to the treatment group (TQF plus usual care) or the control group (TQF placebo plus usual care) at a 1:1 ratio for 48-week treatment and 12-week follow-up. Participants will be assessed every 12 weeks. The feasibility will be assessed as the primary outcome. The changes in the estimated glomerular filtration rate, urinary protein/albumin, renal function, glycemic and lipid markers, renal composite endpoint events, and dampness syndrome of Chinese medicine will be assessed as the efficacy outcomes. Safety outcomes such as liver function, serum potassium, and adverse events will also be evaluated. The data and safety monitoring board will be responsible for the participants’ benefits, the data’s credibility, and the results’ validity. The intent-to-treat and per-protocol analysis will be performed as the primary statistical strategy.DiscussionConducting a rigorously designed pilot trial will be a significant step toward establishing the feasibility and acceptability of TQF and trial design. The study will also provide critical information for future full-scale trial design to further generate new evidence supporting clinical practice for people with stage 2-4 DKD.Trial registration numberhttps://www.chictr.org.cn/, identifier ChiCTR2200062786.

Introduction Colorectal adenoma (CRA) is a precancerous lesion for colorectal cancer. Endoscopic resection is the first-line treatment for CRA. However, CRA recurrence rate is high. This proposed study aims to determine if Chinese herbal medicine (CHM) reduces CRA recurrence.Methods and analysis This project encompasses an observational, registry-based, cohort study and a nested qualitative study. The cohort study aims to include 364 postpolypectomy CRA participants at Guangdong Provincial Hospital of Chinese Medicine (GPHCM), China, with a follow-up phase of up to 1 year. In addition to routine care, these participants will receive a CHM treatment prescribed by experienced Chinese medicine (CM) clinicians. The CHM treatment encompasses CHM products and CHM formulae according to CM syndromes. The primary outcome is CRA recurrence rate at 1 year after enrolment. Secondary outcomes include characteristics of recurrent CRA, incidence of colorectal polyp (except for CRA), incidence of advanced CRA, incidence of colorectal cancer, improvement of gastrointestinal symptoms commonly seen in CRA patients, faecal occult blood test result, lipid level, fasting plasma glucose level, uric acid level, carcinoembryonic antigen, carbohydrate antigen 19-9, quality of life and safety evaluations. Logistic regression analysis will be used to explore the correlation between exposure and outcome. Qualitative interviews will be conducted among approximate 30 CRA patients from the cohort study and 10 CM practitioners in Department of Gastroenterology at GPHCM. Thematic analysis will be used to analyse qualitative data.Ethics and dissemination Ethical approval has been obtained from the Human Research Ethics Committee (HREC) of GPHCM (YF2022-320-02) and registered at Royal Melbourne Institute of Technology (RMIT) HREC. The results will be disseminated in peer-reviewed journals and international academic conferences.Trial registration number ChiCTR2200065713.

BackgroundColorectal adenoma (CRA) is a significant precancerous lesion of sporadic colorectal cancer (CRC). CRA is likely to recur after polypectomy, increasing the risk of CRC. Chinese herbal medicine (CHM) has been used to reduce CRA recurrence. This review aims to evaluate the effectiveness and safety of oral CHM in reducing CRA recurrence compared to other treatments (placebo, routine care, no treatment, and conventional medicine).MethodsWe will search for randomised controlled trials (RCTs) from nine major biomedical databases in English and Chinese from their inception to July 2023. The RCTs that investigate the effects of oral CHM in reducing CRA recurrence compared to other treatments will be involved. We will exclude trials using CHM extract or external application of CHM, cohort study and cross-section study. The Cochrane Risk of Bias Tool version 2 will be used to assess the quality of included studies. Data will be analysed using Review Manager software 5.4 and STATA. The random effect model will be used. The heterogeneity of intervention effects will be tested by Chi2 (Cochrane Q) and I2 statistics. Funnel plots will assess publication bias if more than ten studies are included. Subgroup and sensitivity analysis will be conducted when possible.DiscussionThis review will discuss the effectiveness and safety of oral CHM in reducing CRA recurrence. It will show the critical information for clinicians in the decision-making process and countries to develop clinical guidelines on CRA management. Systematic review registration PROSPERO CRD42023324197.

BackgroundPoria cocos (Schw.) Wolf or Fuling is one of the top 10 most frequently prescribed herbs in China for the treatment of type 2 diabetes mellitus (T2DM).ObjectiveThe purpose of this systematic review is to determine the additional benefit of Fuling formulae use in addition to hypoglycaemic agents for T2DM in randomised clinical trials.MethodsEnglish (5) and Chinese (4) medical databases were searched from their inception to August 2021. RCTs that included Fuling in herbal formulae for T2DM were included. Risk of bias were assessed using the Cochrane Collaboration's procedures. Stata software (13.0) was used for data analysis.ResultsSeventy-three RCTs (6,489 participants) with herbal formulae containing Fuling were included. Most studies were at risk of bias and strength of the evidence were low to moderate. Meta-analysis findings showed that the addition of formulae containing Fuling to hypoglycaemic agent-treatments could benefit people with T2DM by reducing fasting blood glucose (MD -0.82 [-0.93, -0.71]; I2 = 79.6%, P = 0.00), 2-hour postprandial blood glucose (MD-1.15 [-1.31, -0.98], I2 = 80%, P = 0.00) and haemoglobin A1c (MD-0.64 [-0.75, -0.53], I2 = 84.7%, P = 0.00). Adverse events were also significantly lower in the integrative group than in the hypoglycaemic alone group (RR 0.99 [0.93, 1.06], P = 0.87).ConclusionEvidence from this study supports the use of Fuling formulae combined with hypoglycaemic agents for T2DM. The combined therapies appear to be well tolerated.Trail registrationThis review is registered with the PROSPERO international prospective register of systematic reviews (CRD42020214635).

Polymer materials are widely used in medical materials, food packaging, coatings, and other fields. However, the surface of the materials is easily contaminated by microorganisms, resulting in serious problems. To solve this issue, a new type of antibacterial polymer fluorescent coating was successfully synthesized by copolymerization of divinylbenzene with 7-methacryloxy-4-methyl coumarin, dodecafluoroheptyl methacrylate, and other monomers. The surface structure and thermal stability of the coating were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Fluorine was polymerized into the polymer, improving the thermal stability compared to polystyrene and polydivinylbenzene. The bactericidal and antibacterial adhesion properties of the coating materials were studied by a contact germicidal test and antibacterial adhesion test. The polymer had a strong inhibitory effect on Staphylococcus aureus. After immersion in room temperature water, the film maintained its strong inhibitory effect on S. aureus fluorescence intensity and had high fluorescence stability.

Dy3+ and Mn4+ codoped SrAl2O4 (SrAl2O4:Dy3+,Mn4+) phosphors were obtained by diffusing Mn4+ ions into Dy3+-doped SrAl2O4 via the constant-source diffusion technique. The influences of diffusion temperature and diffusion time on the emissions of SrAl2O4:Dy3+,Mn4+ were investigated. It was found that: (i) efficient red emission peaking at 651 nm can be readily achieved for SrAl2O4:Dy3+ by simply diffusing Mn4+ into SrAl2O4:Dy3+ at 800 °C and above; (ii) the red emission of Mn4+ becomes dominant over the characteristic emissions of Dy3+ when the diffusion temperature is 900 °C or higher; and (iii) the intensity of the red emission of SrAl2O4:Dy3+,Mn4+ is far more sensitive to diffusion temperature than to diffusion time. Our results have demonstrated that full-color tunable emissions can be realized for SrAl2O4:Dy3+, Mn4+ by tuning the parameters of diffusion temperature and diffusion time, which opens up a space for realizing easy color control of Dy3+-doped inorganic materials.

BackgroundChinese medicine has been used to treat diabetes symptoms for thousands of years. Dioscoreae rhizome or Shanyao is a Chinese medicinal herb that is routinely used in the treatment of diabetes mellitus (DM).ObjectiveThe purpose of this study is to evaluate the evidence of the added benefits and safety of herbal formulae containing Shanyao in clinical studies and the possible mechanisms of Shanyao in the prevention and treatment of DM in experimental studies.MethodsWe searched nine databases for randomized controlled trials (RCTs) that included Shanyao in the formulae in the treatment of type 2 DM. Furthermore, experimental studies on the prevention and treatment of DM by Shanyao in English- and Chinese-language databases were identified.ResultsFifty-three moderate quality RCTs with herbal formulae containing Shanyao were identified. Results from meta-analysis indicated that Shanyao alone or formulae containing Shanyao in addition to conventional treatments could benefit people with type 2 DM in lowering blood glucose, blood lipids and reducing insulin resistance. Moreover, adverse events were significantly lower in the CHM plus conventional group than those in the conventional group. Shanyao may exert the benefit through various mechanisms including inhibition of α-glucosidase and DPP-IV activity, increase of endogenous GLP-1 and immune regulating activities.ConclusionEvidence from this review suggested that there appeared to be added clinical benefits associated with the use of Shanyao for DM, whether as a food supplement or as a CHM combined with hypoglycemic agents with a good safety profile.

The traditional online teaching adopts the single architecture to develop and implement the system, which facilitates the data sharing and testing of the system. However, due to the increasing complexity of the system's business functions, the system based on monolithic architecture has become increasingly complex, its scalability has deteriorated, and its concurrency performance has decreased. Based on these problems, this paper puts forward combining microservice architecture and online teaching platform, using microservice architecture independent deployment, concurrent performance characteristics such as high technology selection and flexible, the complex business function is divided into several small service module, solve the challenges faced by the traditional system, at the same time improve the efficiency of the use of online teaching platform and students' learning autonomy, The system function design, architecture design, safety design and so on are expounded to build an efficient and perfect online teaching platform.

With the rapid development of copyright industry, people’s copyright awareness of their own creation of software and works is constantly improving, the number of applications for software copyright registration and works copyright is increasing. Therefore, how to make copyright registration business becomes more convenient and efficient is imminent. Existing copyright registration system need to first fill through PC and then make an appointment through the phone to deal with relevant business. This model is not only complicated operations, but also poor user experience. Therefore, based on the analysis of multiple needs of users and enterprises, this paper proposes to use Vue,SpringBoot, MyBatis and other technologies to develop a copyright appointment registration system based on microplatform. The development of this system can not only for the user to create a more convenient way of operation, give users a better experience, but also can change, rich business approach, bring more profits.

Tb3+ doped pentazinc bimolybdate pentahydrate (Zn5Mo2O11·5H2O) was synthesized via the precipitation method. Thermal gravimetric analysis and differential scanning calorimetric analysis indicate that Zn5Mo2O11·5H2O is decomposed into ZnMoO4 at the phase transition temperature 267 °C. The photoluminescence characterization shows that the characteristic emissions of Tb3+ at 488, 544, 586 and 613 nm are superimposed over a broad emission band of Zn5Mo2O11·5H2O. The characteristic emissions of Tb3+ ions get weakened in intensity as the calcination temperature increases from 150 to 267 °C. Our results have demonstrated that Tb3+ can be used as an effective and direct probe in the spectroscopic studies on the phase transition of Zn5Mo2O11·5H2O. Keywords: Pentazinc bimolybdate pentahydrate, Photoluminescence, Phase transition, Dehydration, Calcination

This study aimed to modify chitosan microspheres to have large specific surface area as cathode catalysts in microbial fuel cell. Nitrogen-rich chitosan microspheres were first prepared and were used as precursors to prepare the activated carbon materials. The activation effects of KOH and activation temperature on the graphitization degree, specific surface area and electrochemical performance were investigated. The materials were characterised through various microscopic analyses and the electrochemical properties of the materials as cathode catalyst were also investigated. Before and after the activation, the materials remained in microspheric morphology, shown by SEM measurement, while the specific surface area of the activated material increased significantly and reached 1562 m ^2 g ^−1 measured by BET. The graphitization degree of the material showed synchronized increase with calcination temperature, which was detected by Raman spectroscopy. The materials activated were rich in nitrogen, revealed by XPS for elemental analysis. When activated at the temperature of 850 °C, the material demonstrated lower internal resistance (0.6 Ω cm ^−2 ), higher alternating current density (24.27 × 10 ^–4 A·cm ^−2 ) and the highest power density (1531 ± 51 mW·m ^−2 ) which was 1.4 times that of the original carbon felt. It was illustrated by the electrochemical tests that the material prepared from the precursor chitosan microspheres as cathode catalyst has the high activity of oxygen reduction reaction in MFCs.

It is significant to render visible-light photocatalytic activity to undoped ZnO nanostructures via intrinsic defect engineering. In this work, undoped ZnO nanocrystals were derived via co-precipitation synthesis. The resulting ZnO nanocrystals were characterized by means of X-ray diffraction, scanning electron microscopy, photoluminescence spectroscopy, and ultraviolet-visible absorption spectroscopy, respectively. The visible-light photocatalytic activity of the products were characterized by monitoring the decomposition of methyl orange in water under visible-light illumination of a 300 W halogen lamp. It is found that undoped ZnO nanocrystals exhibit visible-light photocatalytic activity with their first-order rate constant up to 4.6 × 10−3 min−1. Density functional calculations show that oxygen vacancies create deep energy levels at EV + 0.76 eV in the bandgap of ZnO. In conjunction with the density functional calculations, the photocatalytic degradation of methyl orange under visible-light irradiation provides direct evidence that oxygen vacancies in ZnO nanocrystals yield the visible-light photocatalytic activity. Our results demonstrate that visible-light photocatalytic activity can be endowed to undoped ZnO nanocrystals by manipulating the intrinsic defects in ZnO. Intrinsic defect-modulated ZnO photocatalysts thus represent a powerful configuration for further development toward visible-light responsive photocatalysis.

ZnWO4 nanoplates with highly exposed {0 1 ¯ 1} facets were synthesized via a hydrothermal technique. The phase, morphology, and optical characteristics of ZnWO4 nanoplates were characterized with scanning electron microscopy, transmission electron microscopy, X–ray diffraction, diffuse ultraviolet–visible light (UV–Vis) reflectance spectroscopy, photoluminescence (PL) spectrophotometry, and PL lifetime spectroscopy. Optical characterizations, along with the density functional calculations, confirm that the strong blue PL band of ZnWO4 nanoplates originates from the intrinsic defects in ZnWO4 nanoplates. Furthermore, photocatalytic tests show that ZnWO4 nanoplates exhibit strong photo-oxidative capability of complete mineralization of the organic pollutant (methyl orange) in water, whereas ZnWO4 nanoparticles can only cleave the organic molecules into fragments. The superior photo-oxidative capability of ZnWO4 nanoplates can be attributed to the specific chemical bonding and stereochemistry on the exposed facets. This work demonstrates that crystal facet engineering is an efficient strategy to endow ZnWO4 with strong photo-oxidative capability.

Eu3+ doped ZnWO4 phosphors were synthesized via the co-precipitation technique followed by subsequent thermal annealing in the range of 400–1000 °C. The phase, morphology, elemental composition, chemical states, optical absorption, and photoluminescence (PL) of the phosphors were characterized by X-ray diffraction, scanning electron microscopy, dispersive X-ray spectroscopy, X-ray photoelectron spectrometry, diffuse UV–vis reflectance spectroscopy, PL spectrophotometry, and PL lifetime spectroscopy, respectively. It is found that the PL from Eu3+ doped ZnWO4 is tunable through the control of the annealing temperature. Density functional calculations and optical absorption confirm that thermal annealing created intrinsic defects in ZnWO4 lattices play a pivotal role in the color tunable emissions of the Eu3+ doped ZnWO4 phosphors. These data have demonstrated that intrinsic defect engineering in ZnWO4 lattice is an alternative and effective strategy for tuning the emission color of Eu3+ doped ZnWO4. This work shows how to harness the intrinsic defects in ZnWO4 for the preparation of color tunable light-emitting phosphors.

Eu2+ and Eu3+ doubly doped ZnWO4 nanoplates with highly exposed {100} facets were synthesized via a facile hydrothermal route in the presence of surfactant cetyltrimethyl ammonium bromide. These ZnWO4 nanoplates were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectrometry, diffuse UV-vis reflectance spectroscopy, photoluminescence spectrophotometry, and photoluminescence lifetime spectroscopy to determine their morphological, structural, chemical, and optical characteristics. It is found that Eu-doped ZnWO4 nanoplates exhibit superior photo-oxidative capability to completely mineralize the methyl orange into CO2 and H2O, whereas undoped ZnWO4 nanoparticles can only cleave the organic molecules into fragments. The superior photocatalytic performance of Eu-doped ZnWO4 nanoplates can be attributed to the cooperative effects of crystal facet engineering and defect engineering. This is a valuable report on crystal facet engineering in combination with defect engineering for the development of highly efficient photocatalysts.