107 results on '"YENCİLEK, F."'
Search Results
2. Cystic splenosis mimicking a renal mass: a case report and review of the literature
- Author
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Gürses, B, Kabakç, N, Akşit, H Z, Yencilek, F, Kovanlikaya, A, and Kovanlikaya, İ
- Published
- 2007
3. Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cance
- Author
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Yılmaz, SG, Yencilek, F, Yildirim, A, Yencilek, E, İşbir, Turgay, Yılmaz, SG, Yencilek, F, Yildirim, A, Yencilek, E, İşbir, Turgay, and Yeditepe Üniversitesi
- Subjects
Prostate cancer ,caspase 9 ,rs1052576 ,polymorphism - Abstract
Background: Prostate cancer is one of the most common solid tumors and the second leading cause of the death due to malignancy in men. Caspase 9 (CASP9) is a member of the intrinsic pathway and plays a central role in the apoptosis. Patients and Methods: Genotyping of the CASP9 (rs1052576) polymorphism were performed using real-time polymerase chain reaction for blood samples of prostate cancer patients (n=69) and controls (n=76). Results: There were no significant differences between the groups in the frequency of CASP9 genotypes (chi 2 = 1.363; p=0.506). Patients with CASP9 (rs1052576) CT genotype were 12.8 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.078, 95% CI= 0.009-0.062; p=0.004). Also TT genotype carriers were 11.3 times lower in pathological stage of pT2a (OR=11.33, 95% CI= 2.39-53.748; p=0.000). C allele carriers were 11.36 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.088, 95% CI= 0.019-0.418; p=0.002). Conclusion: CASP9 (rs1052576) C allele was decreasing the risk for pathological stage of patients with prostate cancer and also CT genotype had positive impact on pathological stage of patients with prostate cancer. CASP9 (rs1052576) TT genotype was seemed to be associated with higher risk of pathological stage. Those results implicated that CASP9 variations could be associated with severity of prostate cancer.
- Published
- 2017
4. Apoptosis in the erectile tissues of diabetic and healthy rats
- Author
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ALICI, B., GÜMÜSTAS, M. K., ÖZKARA, H., AKKUS, E., DEMIREL, G., YENCILEK, F., and HATTAT, H.
- Published
- 2000
5. Apolipoprotein E Genotypes in Patients with Prostate Cancer
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Yencilek, F., Yilmaz, S.G., Yildirim, A., Gormus, U., Altinkilic, E.M., Dalan, A.B., İşbir, Turgay, Yencilek, F., Yilmaz, S.G., Yildirim, A., Gormus, U., Altinkilic, E.M., Dalan, A.B., İşbir, Turgay, and Yeditepe Üniversitesi
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Apolipoprotein E genotypes ,Gleason score ,prostate cancer - Abstract
BACKGROUND: Apolipoprotein E (ApoE) is a potential inhibitor of cell proliferation, immune regulation and modulation of cell growth and differentiation; it also has a substantial role in antioxidant activity. ApoE has a potential role in prostate cancer progression.MATERIALS AND METHODS: ApoE genotyping was performed using real-time polymerase chain reaction (RT-PCR) for blood samples from a group of patients with prostate cancer (n=68) and a control group (n=78).RESULTS: The frequency of the E3/E3 genotype was significantly higher in patients compared to controls (p=0.004). E3/E3 genotype carriers were 3.6-fold more likely to be patients than controls (odds ratio=3.67, 95% confidence interval=1.451-9.155; p=0.004). Additionally, the patients with E3/E3 genotype had significantly higher Gleason score (p=0.017), and more patients with this genotype had a Gleason score higher than 7 (p=0.007). Individuals carrying the E4 allele were significantly more common in the control group (p=0.006). The frequency of the E3/E4 genotype was found to be significantly higher in controls compared to patients (p=0.007), and patients were significantly less likely to have this genotype than controls (odds ratio=0.89, 95% confidence interval=0.833-0.967, p=0.007). Individuals carrying the E2/E3 genotype had a significantly lower Gleason score (p=0.049)-all of the patients with this genotype had a Gleason score lower than 7 (p=0.024).CONCLUSION: E3/E3 genotype may be a potential risk factor for prostate cancer and high Gleason scoring. The E4 allele maybe a risk-reducing factor for prostate cancer. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Published
- 2016
6. Chemotherapeutic effect of Everolimus and ABT-737 combination on renal cell carcinoma
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Nayman, A. H., Ilhan, H., Zemheri, E., Yencilek, F., Yildirim, A., Dilek Telci, Nayman, AH, Ilhan, H, Zemheri, E, Yencilek, F, Yildirim, A, Telci, D, and Yeditepe Üniversitesi
- Abstract
… FEBS
- Published
- 2016
7. Investigation of Interleukin-1 beta Polymorphisms in Prostate Cancer
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Yencilek, F, Yildirim, A, Yılmaz, SG, Altinkilic, EM, Dalan, AB, Bastug, Y, İşbir, Turgay, Yencilek, F, Yildirim, A, Yılmaz, SG, Altinkilic, EM, Dalan, AB, Bastug, Y, İşbir, Turgay, and Yeditepe Üniversitesi
- Subjects
prostate cancer ,interleukin-1 beta ,polymorphism - Abstract
Background: Cytokine-mediated immune and inflammatory responses are considered to play an important role in the pathogenesis of prostate cancer. The present study investigated certain interleukin-1 beta (IL1 beta) polymorphisms and their association with prostate cancer. Materials and Methods: Genotyping of the IL1B-31(rs 1143627 G>A) and IL1B-511(rs 16944 A
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- 2015
8. BULBOSPONGIOUSUS MUSCLE ELECTROMYOGRAPHY: A NOVEL DIAGNOSTIC TOOL FOR LIFELONG PREMATURE EJACULATION [Meeting Abstract]
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Serefoglu, EC, Koyuncu, HH, Ugurel, B, Aktekin, B, Yencilek, F, Kadowitz, PJ, Serefoglu, EC, Koyuncu, HH, Ugurel, B, Aktekin, B, Yencilek, F, Kadowitz, PJ, and Yeditepe Üniversitesi
- Abstract
…
- Published
- 2012
9. BILATERAL SINGLE-SESSION RETROGRADE INTRARENAL SURGERY FOR TREATMENT OF BILATERAL RENAL STONES
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Atis, G, Koyuncu, H, Gurbuz, C, Yencilek, F, Arikan, O, Casukurlu, T, Atis, G, Koyuncu, H, Gurbuz, C, Yencilek, F, Arikan, O, Casukurlu, T, and Yeditepe Üniversitesi
- Abstract
…
- Published
- 2012
10. Effect of morphine on lower urinary tract discomfort related to transurethral resection of prostate after general anaesthesia
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Menda, F, Yencilek, F, Koyuncu, H, Temur, S, Bilgen, S, Koner, O, Menda, F, Yencilek, F, Koyuncu, H, Temur, S, Bilgen, S, Koner, O, and Yeditepe Üniversitesi
- Abstract
… World Federat Soc Anaesthesiol (WFSA)
- Published
- 2012
11. Diagnostic utility of DTI in prostate cancer
- Author
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Gürses, B., Tasdelen, N., Yencilek, F., Kilickesmez, N.O., Alp, T., Firat, Z., Gürmen, A.N., Gürses, B., Tasdelen, N., Yencilek, F., Kilickesmez, N.O., Alp, T., Firat, Z., Gürmen, A.N., and Yeditepe Üniversitesi
- Subjects
Diffusion ,Prostate ,Cancer ,Fractional anisotropy ,MRI - Abstract
Purpose: The aim of this study was to compare the diffusion tensor parameters of prostate cancer, prostatitis and normal prostate tissue. Materials and Methods: A total of 25 patients with the suspicion of prostate cancer were included in the study. MRI was performed with 3 T system (Intera Achieva, Philips Medical Systems, The Netherlands). T2 TSE and DTI with ss-EPI were obtained in each subject. TRUS-guided prostate biopsy was performed after the MRI examination. Images were analyzed by two radiologists using a special software system. ROI's were drawn according to biopsy zones which are apex, midgland, base and central zone on each sides of the gland. FA and ADC values in areas of cancer, chronic prostatitis and normal prostate tissue were compared using Student's t-test. Results: Histopathological analysis revealed carcinoma in 68, chronic prostatitis in 67 and was reported as normal in 65 zones. The mean FA of cancerous tissue was significantly higher (p < 0.01) than the FA of chronic prostatitis and normal gland. The mean ADC of cancerous tissue was found to be significantly lower (p < 0.01), compared with non-cancerous tissue. Conclusion: Decreased ADC and increased FA are compatible with the hypercellular nature of prostate tumors. These differences may increase the accuracy of MRI in the detection of carcinoma and to differentiate between cancer and prostatitis. © 2010 Elsevier Ireland Ltd.
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- 2011
12. ASSESSMENT OF SHORT AND LONG TERM EFFECTS OF ESWL ON THE TREATED AND NON-TREATED CONTRALATERAL KIDNEYS WITH DIFFUSION TENSOR IMAGING AT 3T
- Author
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Yencilek, F, Kilickesmez, M, Koyuncu, H, Sarica, K, Yencilek, F, Kilickesmez, M, Koyuncu, H, Sarica, K, and Yeditepe Üniversitesi
- Abstract
…
- Published
- 2010
13. Reply by the Authors
- Author
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Sarica, K., Yencilek, F., Eryildirim, B., Kuyumcuoglu, U., Sarica, K., Yencilek, F., Eryildirim, B., Kuyumcuoglu, U., and Yeditepe Üniversitesi
- Abstract
[No abstract available]
- Published
- 2009
14. Prevention and management of ureteral injuries occurring during laparoscopic radical prostatectomy: The Heilbronn experience and a review of the literature
- Author
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Teber, D., Gözen, A.S., Cresswell, J., Canda, A.E., Yencilek, F., Rassweiler, J., Teber, D., Gözen, A.S., Cresswell, J., Canda, A.E., Yencilek, F., Rassweiler, J., and Yeditepe Üniversitesi
- Subjects
Reimplantation ,Primary repair ,surgical procedures, operative ,urogenital system ,Ureteral injury ,Laparoscopic radical prostatectomy ,urologic and male genital diseases ,female genital diseases and pregnancy complications - Abstract
Objectives: There is a small risk of ureteral injury during laparoscopic radical prostatectomy (LRP). It is important to recognise and repair such ureteral injuries immediately. Laparoscopic reconstructive surgery has proven to be feasible for the treatment of ureteral injury. We report our experience of ureteral injuries during LRP including the incidence, mechanism of injury, management, prevention and outcome. Materials and methods: During a 9-year period, 2,164 LRP's were performed at our clinic. Three cases were complicated by lower ureteral injuries including two complete and one partial transection. The complete transections occurred during posterior dissection of the bladder neck and seminal vesicles, and the partial transection during an extended lymph node dissection. All were recognised and managed intraoperatively. We performed Lich-Gregoir (LG) extravesical ureteral reimplantation for complete transections, and primary repair for the partial ureteral transection. Results: Overall, the incidence of ureteral injuries was 0.13%. Laparoscopic reconstructive surgery was performed successfully in all cases without complication. This added 71, 46 and 59 min, respectively, to LRP operative time. The postoperative course was uneventful in all patients. Hospital stay was 8 days. After 30, 17 and 14 months of follow-up, intravenous urography (IVU) demonstrated good drainage. Conclusion: Recognition and repair of ureteral injuries during LRP requires a high index of suspicion, and expertise in laparoscopic technique. Laparoscopic reimplantation or primary repair of these injuries during LRP is, in experienced hands, a safe, feasible and minimally invasive procedure with the benefits of laparoscopic surgery maintained for the patient. © Springer-Verlag 2009.
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- 2009
15. Augmented Reality: A New Tool To Improve Surgical Accuracy during Laparoscopic Partial Nephrectomy? Preliminary In Vitro and In Vivo Results
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Teber, D., Guven, S., Simpfendörfer, T., Baumhauer, M., Güven, E.O., Yencilek, F., Rassweiler, J., Teber, D., Guven, S., Simpfendörfer, T., Baumhauer, M., Güven, E.O., Yencilek, F., Rassweiler, J., and Yeditepe Üniversitesi
- Subjects
Augmented Reality ,Computer-Assisted Surgery ,Laparoscopic Partial Nephrectomy ,Soft Tissue Navigation - Abstract
Background: Use of an augmented reality (AR)-based soft tissue navigation system in urologic laparoscopic surgery is an evolving technique. Objective: To evaluate a novel soft tissue navigation system developed to enhance the surgeon's perception and to provide decision-making guidance directly before initiation of kidney resection for laparoscopic partial nephrectomy (LPN). Design, setting, and participants: Custom-designed navigation aids, a mobile C-arm capable of cone-beam imaging, and a standard personal computer were used. The feasibility and reproducibility of inside-out tracking principles were evaluated in a porcine model with an artificially created intraparenchymal tumor in vitro. The same algorithm was then incorporated into clinical practice during LPN. Interventions: Evaluation of a fully automated inside-out tracking system was repeated in exactly the same way for 10 different porcine renal units. Additionally, 10 patients underwent retroperitoneal LPNs under manual AR guidance by one surgeon. Measurements: The navigation errors and image-acquisition times were determined in vitro. The mean operative time, time to locate the tumor, and positive surgical margin were assessed in vivo. Results and limitations: The system was able to navigate and superpose the virtually created images and real-time images with an error margin of only 0.5 mm, and fully automated initial image acquisition took 40 ms. The mean operative time was 165 min (range: 135-195 min), and mean time to locate the tumor was 20 min (range: 13-27 min). None of the cases required conversion to open surgery. Definitive histology revealed tumor-free margins in all 10 cases. Conclusions: This novel AR tracking system proved to be functional with a reasonable margin of error and image-to-image registration time. Mounting the pre- or intraoperative imaging properties on real-time videoendoscopic images in a real-time manner will simplify and increase the precision of laparoscopic procedures. © 2009 European Association of Urology.
- Published
- 2009
16. HYPEROXALURIA INDUCED TUBULAR ISCHEMIA: EVALUATION OF TISSUE HIF-1 ALPHA LEVELS IN RENAL PARENCHYMA IN RABBIT MODEL
- Author
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Yencilek, F, Sarica, K, Erturhan, S, Karakok, M, Kuyumcuoglu, U, Yencilek, F, Sarica, K, Erturhan, S, Karakok, M, Kuyumcuoglu, U, and Yeditepe Üniversitesi
- Abstract
…
- Published
- 2009
17. Complexed prostate specific antigen: better test in the diagnosis of prostate cancer for the clinically relevant 2.5-4 ng/ml total PSA range
- Author
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Mutlu, N., Türkeri, L.N., Yencilek, F., Demir, A., Emerk, K., Mutlu, N., Türkeri, L.N., Yencilek, F., Demir, A., Emerk, K., and Yeditepe Üniversitesi
- Abstract
BACKGROUND: Data on utilizing complexed prostate specific antigen (cPSA) offering increased diagnostic performance over other available clinical parameters in diagnosis of prostate cancer is still controversial. Our objective was to determine diagnostic performance of cPSA compared to total prostate specific antigen (tPSA) and corresponding ratios for possible routine application. METHODS: In a prospective study including overall 315 consecutive men, 177 patients with suspicious digital rectal examination, and/or tPSA value > 2.5 ng/ml underwent prostate biopsy. Serum samples for tPSA, cPSA and free PSA were analyzed using automated chemiluminometric technology. RESULTS: Area under the curve (AUC) for cPSA, although greater, was not statistically different compared to that of tPSA (p = 0.253). AUCs of f/c, f/t and c/t ratios were all found significantly inferior. At clinically relevant 2.37 ng/ml threshold, cPSA performed with 85% sensitivity and significantly higher specificity of 63.1%, compared to same sensitivity and specificity of 57.2% at a 3.00 ng/ml cut off for tPSA. CONCLUSIONS: Utilizing automated assay systems at predetermined cut off value for cPSA we would be able to save 27.1% of the biopsies while missing 13.4% of the cancers. Therefore, results of this study indicate higher discriminatory power of cPSA in diagnosis of prostate cancer for clinically relevant 2.5-4 ng/ml tPSA range.
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- 2009
18. Prevention of shockwave induced functional and morphological alterations: An overwiew
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Sarica, K., Yencilek, F., Sarica, K., Yencilek, F., and Yeditepe Üniversitesi
- Subjects
Renal damage ,Antioxidant agents ,Calcium channel blocking agents ,Shock wave lithotripsy - Abstract
Experimental as well as clinical findings reported in the literature suggest that treatment with shock wave lithotripsy (SWL) causes renal parenchymal damage mainly by generating free radicals through ischaemia /reperfusion injury mechanism. Although SWL-induced renal damage is well tolerated in the majority of healthy cases with no permanent functional and/or morphologic side effects, a subset of patients with certain risk factors requires close attention on this aspect among which the ones with pre-existing renal disorders, urinary tract infection, previous lithotripsy history and solitary kidneys could be mentioned. It is clear that in such patients lowering the number of shock waves (per session) could be beneficial and has been applied by the physicians as the first practical step of diminishing SWL induced parenchymal damage. On the other hand, taking the injurious effects of high energy shock wave (HESW) induced free radical formation on renal parenchyma and subsequent histopathologic alterations into account, physicians searched for some protective agents in an attempt to prevent or at least to limit the extent of the functional as well as the morphologic alterations. Among these agents calcium channel blocking agents (verapamil and nifedipine), antioxidant agents (allopurinol, vitamin E and selenium) and potassium citrate have been used to minimize these unestimated adverse effects. Additionally, therapeutic application of these agents on reducing stone recurrence particularly after SWL will gain more importance in the future in order to limit new stone formation in these cases. Lastly, as experimental and clinical studies have demonstrated, combination of anti-oxidants with free radical scavengers may provide superior renal protection against shock wave induced trauma. However, we believe that further investigations are certainly needed to determine the dose-response relationship between the damaging effects of SWL application and the protective role of these agents.
- Published
- 2008
19. Cystic splenosis mimicking a renal mass: A case report and review of the literature
- Author
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Gürses, B., Kabakçi, N., Akşit, H.Z., Yencilek, F., Kovanlikaya, A., Kovanlikaya, I., Gürses, B., Kabakçi, N., Akşit, H.Z., Yencilek, F., Kovanlikaya, A., Kovanlikaya, I., and Yeditepe Üniversitesi
- Subjects
Ferrumoxide ,Autotransplantation ,Splenic trauma ,MR ,Splenosis - Abstract
Splenosis is a well-known entity, caused by autotransplantation of splenic tissue as a result of trauma or splenectomy. Patients are generally asymptomatic, and this entity is diagnosed during routine diagnostic imaging. Cystic changes in splenic implants have been defined before but, as to our knowledge, radiological demonstration of cystic components has not been published in the literature. It is well-known that unusual locations of the splenic implants create diagnostic problems, sometimes leading to unnecessary surgical interventions. In this report splenosis, mimicking a renal tumour, with cystic changes in the biggest splenule, and diagnosis with ferrumoxide-enhanced MRI is presented. © 2007 The Authors.
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- 2007
20. Hemorrhagic cystitis due to viral infection following hematopoietic stem cell transplantation
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Obek, C, Kocagoz, T, Aktas, S, Yencilek, F, Uluc, BO, Koc, Y, Obek, C, Kocagoz, T, Aktas, S, Yencilek, F, Uluc, BO, Koc, Y, and Yeditepe Üniversitesi
- Abstract
…
- Published
- 2007
21. 46 XX male syndrome: A case report
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Yencilek, F., Baykal, C., Yencilek, F., Baykal, C., and Yeditepe Üniversitesi
- Subjects
46 XX male syndrome ,Genetic infertility - Abstract
Introduction: 46 XX male syndrome (de la Chapelle syndrome) is a rarely seen genetic disorder causing male infertility. It is generally a result of unequal crossing over between X and Y chromosomes. Case report: A 26-year-old infertile male was referred to the Urology Department. He had normal external male genital phenotype and secondary sex characters. No gynecomastia was noted. At physical examination soft and atrophic testes were palpated. Laboratory analysis and testis biopsies indicated nonobstructive azospermia. Chromosomal analysis showed 46 XX karyotype. Conclusion: In the literature, there are various phenotypic properties of 46 XX male patients. Thus, translocation of the sex determining region (SRY) the gene probably cannot be the only reason for XX male syndrome. There might be some other abnormalities leading to de la Chapelle syndrome.
- Published
- 2005
22. Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia - reperfusion injury.
- Author
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Erol, B., Sari, U., Amasyali, A. S., Ozkanli, S., Sogut, S., Hanci, V., Efiloglu, O., Danacioglu, Y. O., Engin, P., Yencilek, F., Atis, G., Yildirim, A., Alkoc, O. A., and Caskurlu, T.
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ISCHEMIA ,REPERFUSION ,TESTIS ,MALONDIALDEHYDE ,OXIDANT status - Abstract
We aimed to compare the preventive effects of combined antioxidants ( CA1, 2) with a single antioxidant drug (thymoquinone; TQ) on experimental testis Ischemia/Reperfusion (I/R) injury. Thirty-five adult male Wistar rats were divided into five groups of seven rats each: control, testis I/R, testis I/R + CA1, testis I/R + CA2, and testis I/R + TQ. After 1 h of testicular ischemia, reperfusion was achieved by detorsion for 4 h. Antioxidants were intraperitoneally administered for 30 min prior to reperfusion. All rats were sacrificed 4 h after reperfusion to evaluate the tissue levels of malondialdehyde ( MDA) and total antioxidant status ( TAS) and the immunohistochemical evaluation of tissue inducible and endothelial nitric acid synthase ( iNOS, eNOS) and apoptosis protease-activating factor 1 ( APAF-1). MDA levels were lower and TAS values were higher in the I/R + antioxidant groups than in the I/R group ( p < 0.05). iNOS and eNOS levels in the I/R + antioxidant groups were also lower than those in the I/R group ( p < 0.05). There were no significant differences between the CA groups and the TQ group according to aforementioned parameters. In addition, tissue APAF-1 values were significantly higher in the I/R group than in the other groups. However, there was a significant difference between the TQ and CA groups in APAF-1 levels, which were highest in the TQ group ( p < 0.05). Although TQ alone increased TAS values and reduced tissue iNOS and eNOS levels, combined antioxidant treatment may more effectively reduce apoptosis and increase preventive effects in testis I/R injury. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
23. Treatment of Ureteral Calculi with Semirigid Ureteroscopy: Where Should We Stop?
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Yencilek, F., Sarica, K., Erturhan, S., Yagci, F., and Erbagci, A.
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CALCULI , *SURGERY , *URETER diseases , *LITHOTRIPSY , *URINARY calculi , *URINARY organ surgery - Abstract
Objectives: To evaluate the efficacy of semirigid ureteroscopy in the management of ureteral stones located in different parts of the ureter. Methods: 1,503 patients were treated with semirigid ureteroscopy. All ureteral stones were either removed only by a basket catheter or disintegrated by pneumatic lithotripsy. Success rates, auxiliary procedures, complication rates and operation time were comparatively evaluated according to stone location. Results: Overall, mean stone size and age were 12.1 ± 3.7 mm and 43.2 ± 9.72 years, respectively. While 1,416 patients (94.2%) were completely stone-free, the procedure was unsuccessful in 87 cases (5.8%). The success rate was relatively low in the proximal ureter (71.7%) when compared with the mid (94.8%) and distal ureter (98.9%) (p = 0.021). Mean operation time was 25.4 ± 11.7 min. Longer duration of operation and higher complication rate were found in proximal ureteral calculi. Stone migration to the kidney and hematuria were the main reasons of failure in the proximal ureter and ureteral stenting was needed for 56.4% of patients with upper ureteral stone. Conclusions: Semirigid ureteroscopy can be the treatment of choice in lower and midureteral stones. However, it is an invasive and less successful treatment modality for proximal ureteral stones with relatively high complication rates. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
24. Intermediate-Risk Group in Patients with Transitional Cell Carcinoma of the Bladder: Prediction of High-Risk Patients in This Heterogeneous Group.
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Yencilek, F., Onal, B., Erozenci, A., Talat, Z., and Ataus, S.
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CELLS , *BLADDER cancer , *CYSTOSCOPY , *CANCER relapse , *URINARY organ cancer , *CANCER - Abstract
Objective: To determine whether recurrence at first follow-up cystoscopy predicts future recurrence in patients with an intermediate risk of superficial bladder cancer. Methods: In total, 304 patients were classified as low (n = 60), intermediate (n = 177) or high risk (n = 67) based on the primary pathological/clinical findings, as previously described in literature. The intermediate-risk group was further divided into 2 subgroups based on recurrence at the first follow-up cystoscopy: A (recurrence negative) and B (recurrence positive). Results: The mean recurrence rates of low-, intermediate- and high-risk patients were 1.76, 6.41 and 9.49, respectively (p < 0.05). Similarly, the difference in the recurrence rates between subgroups A (4.37) and B (9.12) was found to be statistically significant (p = 0.00). Additionally, while the difference between the low-risk group and subgroup A was statistically significant (p = 0.008), there was no significance between subgroup B and the high-risk group (p = 0.892). In the multivariate analysis, the most significant prognostic parameter for recurrence was the outcome of the first follow-up cystoscopy, followed by tumor multiplicity and grade. Conclusions: Patients showing recurrence at first follow-up cystoscopy in the intermediate-risk group should be classified as high-risk patients and treated accordingly. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2009
- Full Text
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25. E155 SWL in lower calyceal calculi: Evaluation of treatment parameters in children and adults in a comparative manner
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Yencilek, F., Goktaç, C., Akca, O., Horuz, R., Gokhan, O., Albayrak, S., and Sarica, K.
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- 2011
- Full Text
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26. E156 SWL management of renal calculi in children: Does age affect the treatment outcome?
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Yencilek, F., Goktaş, C., Akca, O., Horuz, R., Gokhan, O., Albayrak, S., and Sarica, K.
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- 2011
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27. E105 Fragmentation without extraction in ureteral stones: Outcomes of 238 cases
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Yencilek, F., Göktac, C., Horuz, R., Akca, O., Selimoglu, A., Albayrak, S., and Sarica, K.
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- 2011
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28. E86 Increased cardiovascular disease risk may be linked to systematic endothelial dysfunction in calcium oxalate disease
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Yencilek, F., Aydin, H., Tanriverdi, O., Demirel, G. Yanikkaya, Koyuncu, H., and Sarica, K.
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- 2011
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29. E63 Cardiovascular risk is increased in patients with calcium oxalate urolithiasis and correlated with urinary oxalate excretion
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Aydin, H., Yencilek, F., Erihan, B., Okan, B., and Sarica, K.
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- 2011
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30. E22 Human umbilical vein endothelial cells induce oxalate-induced apoptosis of human renal proximal tubule epithelial cells (RPTEC) in co-culture system and is prevented by Pyrrolidine Dithiocarbamate
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Sarica, K., Aydin, H., Telci, D., Yencilek, F., Koyuncu, H., and Yilmaz, B.
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- 2011
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31. E26 Displacement of lower calyceal stones during flexible ureterorenoscopy: Do we need it in every case?
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Sarica, K., Yencilek, F., Koyuncu, H., and Erihan, B.
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- 2011
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32. Detection of kidney stones from X-ray images.
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Altintas?, A., Unsalan, C., Keskin, A.U., and Yencilek, F.
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- 2010
- Full Text
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33. 869Are the moderate risk group with early recurrence high risk group instead?
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Ataus, S., Yencilek, F., Kalkan, M., Erozenci, A., Öner, A., and Solok, V.
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- 2005
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34. 220 ASSESSMENT OF SHORT AND LONG TERM EFFECTS OF ESWL ON THE TREATED AND NON-TREATED CONTRALATERAL KIDNEYS WITH DIFFUSION TENSOR IMAGING AT 3T
- Author
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Yencilek, F., Kiligkesmez, M., Koyuncu, H., and Sarica, K.
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- 2010
- Full Text
- View/download PDF
35. 333 HYPEROXALURIA INDUCED TUBULAR ISCHEMIA: EVALUATION OF TISUE HIF-1 ALPHA LEVELS IN RENAL PARENCHYMA IN RABBIT MODEL
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Yencilek, F., Sarica, K., Erturhan, S., Karakök, M., and Kuyumcuoglu, U.
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- 2009
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36. Diagnostic utility of DTI in prostate cancer.
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Gürses B, Tasdelen N, Yencilek F, Kilickesmez NO, Alp T, Firat Z, Albayrak MS, Ulug AM, and Gürmen AN
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- 2011
37. Nonmuscle-invaziv mesane kanseri tanısı alan hastalarda sigara Içme alıskanlıklarındaki degisim ve sigara bırakmada hekimlerin katkısı
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Fidan Fatma, Faruk Yencilek, Sadi Turkan, Hakkı Uzun, Mehmet Kalkan, Coşkun Şahin, Hakan Koyuncu, Kalkan, M, Uzun, H, Turkan, S, Sahin, C, Fatma, F, Yencilek, F, Koyuncu, H, Yeditepe Üniversitesi, Kalkan, M., Uzun, H., Turkan, S., Sahin, C., Fatma, F., Yencilek, F., and Koyuncu, H.
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medicine.medical_specialty ,Bladder cancer ,business.industry ,Smoking habit ,medicine.medical_treatment ,Cancer ,General Medicine ,Disease ,medicine.disease ,smoking ,smoking cessation ,Statistical significance ,Internal medicine ,Physical therapy ,Medicine ,Smoking cessation ,brifing ,In patient ,Stage (cooking) ,business - Abstract
To assess the impact of a diagnosis of bladder cancer on smoking behavior and to analyze the role of the physician in smoking cessation. Nonmuscle-invasive bladder cancer patients completed a phone survey of their smoking habits. They were asked about smoking behavior before and after the diagnosis of cancer and whether they had been informed by their physician about the relation between smoking and bladder cancer. Two hundred-twelve patients responded to the survey. The mean age was 60.03±6.36 years. Ninety-three of the 135 current smokers (68.9%) were advised to quit smoking, whereas nine of 20 nonsmokers (45%) were not commented about the future risks of smoking. The results showed that 13% of the current smokers and 35% of the current nonsmokers were not warned about the relation of bladder cancer with smoking. Statistical significance was not seen in terms of sex, disease stage, and tumor grade at diagnosis. The relation between smoking and bladder cancer has been well established. However, some patients are not informed to quit smoking by their physicians. © 2015, TIP ARASTIRMALARI DERNEGI. All rights reserved.
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- 2015
38. Intrarenal Surgery vs Percutaneous Nephrolithotomy in the Management of Lower Pole Stones Greater than 2 cm
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A.T. Ozdemir, Esin Yencilek, Faruk Yencilek, Yavuz Bastug, Hakan Koyuncu, Mehmet Kalkan, Koyuncu, H., Yencilek, F., Kalkan, M., Bastug, Y., Yencilek, E., Ozdemir, A.T., and Yeditepe Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Percutaneous ,Time Factors ,Urology ,medicine.medical_treatment ,Stone free ,Operative Time ,Procedures, operative ,Kidney ,lcsh:RC870-923 ,Calculi ,Kidney Calculi ,Young Adult ,Postoperative Complications ,Statistical significance ,Lithotripsy ,Surgical ,medicine ,Ureteroscopy ,Effective treatment ,Humans ,Percutaneous nephrolithotomy ,Intraoperative Complications ,Nephrostomy, Percutaneous ,Retrospective Studies ,Nephrostomy ,Surgical Procedures ,business.industry ,Lower pole ,Retrograde obturation ,Length of Stay ,Middle Aged ,lcsh:Diseases of the genitourinary system. Urology ,Operative ,Surgery ,Treatment Outcome ,Nephrostomy, percutaneous ,Additional procedure ,Retrograde Obturation ,Female ,Original Article ,business ,Tomography, X-Ray Computed - Abstract
Purpose: To compare the efficacy of RIRS and PNL in lower pole stones ?2 cm. Materials and and Methods: A total of 109 patients who underwent PNL or RIRS for solitary lower pole stone between April 2009 and December 2012, were retrospectively analyzed. Lower pole stone was diagnosed with CT scan. Stone size was assessed as the longest axis of the stone. All patients were informed about the advantages, disadvantages and probable complications of both PNL and RIRS before the selection of the procedure. Patients decided the surgery type by themselves without being under any influences and written informed consent was obtained from all patients prior to the surgery. Patients were divided into two groups according to the patients' preference of surgery type. Group 1 consisted of 77 patients who underwent PNL and Group 2 consisted of 32 patients treated with RIRS. Stone free statuses, postoperative complications, operative time and hospitalization time were compared in both groups. Results: There was no statistical significance between the two groups in mean age, stone size, stone laterality, mean follow-up periods and mean operative times. In PNL group, stone-free rate was 96.1% at first session and 100% after the additional procedure. In Group 2, stone-free rate was 90.6% at the first procedure and 100% after the additional procedure. The final stone-free rates and operative times were similar in both groups. Conclusions: RIRS should be an effective treatment alternative to PNL in lower pole stones larger than 2 cm, especially in selected patients.
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- 2015
39. Systemic endothelial function measured by flow-mediated dilation is impaired in patients with urolithiasis
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Faruk Yencilek, Hasan Aydin, Ezgi Yeşil, Hakan Sari, Esin Yencilek, Yencilek, E., Sarı, H., Yencilek, F., Yeşil, E., Aydın, H., and Yeditepe Üniversitesi
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Brachial Artery ,Urology ,Urinary system ,030232 urology & nephrology ,Blood Pressure ,Urine ,030204 cardiovascular system & hematology ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Urolithiasis ,Risk Factors ,Internal medicine ,medicine.artery ,medicine ,Humans ,Citrates ,Endothelial dysfunction ,Brachial artery ,Triglycerides ,Oxalates ,Creatinine ,Triglyceride ,business.industry ,Cholesterol, HDL ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Cardiovascular risk ,Flow-mediated dilation ,Blood pressure ,Endocrinology ,chemistry ,Cardiovascular Diseases ,Case-Control Studies ,Blood Circulation ,Uric acid ,Female ,Urinary Calculi ,Endothelium, Vascular ,business - Abstract
Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH). Endothelial function was assessed as flow-mediated dilation (FMD) at the brachial artery. Age, sex, and body mass index were similar in patients and controls. Of urine stone risk factors, oxalate and citrate were higher in patients than controls. Fasting blood glucose, total LDL cholesterol, and triglyceride were higher, and HDL cholesterol was lower in patients than controls. Although within normal limits systolic blood pressure was higher in patient group, patients with urolithiasis had a lower %FMD than controls. Percent FMD was negatively correlated with urinary oxalate/creatinine ratio (p = 0.019, r = -0.315), calcium/creatinine ratio (p = 0.0001, r = -0.505) age (p
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- 2017
40. Effects of caspase 9 gene polymorphism in patients with prostate cancer
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Faruk Yencilek, Esin Yencilek, Asif Yildirim, Turgay Isbir, Seda Gulec Yilmaz, Yilmaz, S.G., Yencilek, F., Yildirim, A., Yencilek, E., İşbir, Turgay, and Yeditepe Üniversitesi
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0301 basic medicine ,Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Polymorphism ,Genotype ,Malignancy ,Real-Time Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Gene Frequency ,Risk Factors ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Genotyping ,Pathological ,Alleles ,Aged ,Neoplasm Staging ,Pharmacology ,business.industry ,Prostatic Neoplasms ,Middle Aged ,medicine.disease ,Rs1052576 ,Caspase 9 ,030104 developmental biology ,Apoptosis ,030220 oncology & carcinogenesis ,Gene polymorphism ,business ,Research Article - Abstract
Background: Prostate cancer is one of the most common solid tumors and the second leading cause of the death due to malignancy in men. Caspase 9 (CASP9) is a member of the intrinsic pathway and plays a central role in the apoptosis. Patients and Methods: Genotyping of the CASP9 (rs1052576) polymorphism were performed using real-time polymerase chain reaction for blood samples of prostate cancer patients (n=69) and controls (n=76). Results: There were no significant differences between the groups in the frequency of CASP9 genotypes (χ2=1.363; p=0.506). Patients with CASP9 (rs1052576) CT genotype were 12.8 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.078, 95% CI= 0.009-0.062; p=0.004). Also TT genotype carriers were 11.3 times lower in pathological stage of pT2a (OR=11.33, 95% CI=2.39-53.748; p=0.000). C allele carriers were 11.36 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.088, 95% CI=0.019-0.418; p=0.002). Conclusion: CASP9 (rs1052576) C allele was decreasing the risk for pathological stage of patients with prostate cancer and also CT genotype had positive impact on pathological stage of patients with prostate cancer. CASP9 (rs1052576) TT genotype was seemed to be associated with higher risk of pathological stage. Those results implicated that CASP9 variations could be associated with severity of prostate cancer.
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- 2017
41. Bilateral Single-Session Retrograde Intrarenal Surgery for the Treatment of Bilateral Renal Stones
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Ozgur Arikan, Faruk Yencilek, Hakan Koyuncu, Cenk Gurbuz, Turhan Caskurlu, Gokhan Atis, Atis, G., Koyuncu, H., Gurbuz, C., Yencilek, F., Arikan, O., Caskurlu, T., and Yeditepe Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Renal calculi ,Urology ,medicine.medical_treatment ,Operative Time ,Stone size ,Kidney ,lcsh:RC870-923 ,Kidney Calculi ,medicine ,Humans ,In patient ,Intraoperative Complications ,General surgery ,Nephrostomy, Percutaneous ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Renal Calculi ,Length of Stay ,Middle Aged ,Lithotripsy, Laser ,lcsh:Diseases of the genitourinary system. Urology ,Laser lithotripsy ,Surgery ,Endoscopy ,Lithotomy position ,Abdominal Radiography ,Treatment Outcome ,Renal ultrasonography ,General Surgery ,Kidney calculi ,Female ,business ,Single session - Abstract
Purpose The aim of the study was to evaluate the efficacy and safety of bilateral single-session retrograde intrarenal surgery in the treatment of bilateral renal stones. Materials and Methods From December 2008 to February 2012, 42 patients who had undergone bilateral single-session retrograde intrarenal surgery (RIRS) and laser lithotripsy were included in the study. The procedures were performed in the lithotomy position on an endoscopy table under general anesthesia, beginning on the side in which the stone size was smaller. Plain abdominal radiography, intravenous urograms (IVU), renal ultrasonography (USG) and / or non-contrast tomography (CT) scans were conducted for all patients. The success rate was defined as patients who were stone-free or only had residual fragment less than 4 mm. Results A total of 42 patients (28 male, 14 female) with a mean age 39.2 ± 14.2 were included in the present study. The mean stone size was 24.09 ± 6.37 mm with a mean operative time of 51.08 ± 15.22 minutes. The stone-free rates (SFR) were 92.8% and 97.6% after the first and second procedures, respectively. The average hospital stay was 1.37 ± 0.72 days. In two patients (4.7%), minor complications (Clavien I or II) were observed, whereas no major complications (Clavien III-V) or blood transfusions were noted in the studied group. Conclusions Bilateral single-session RIRS and laser lithotripsy can be performed safely and effectively with a high success rate and low complication rate in patients with bilateral renal stones.
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- 2013
42. Effect of morphine on lower urinary tract discomfort after transurethral resection of prostate under general anesthesia: A randomised clinical study
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Hakan Koyuncu, Sibel Temur, Sevgi Bilgen, Nurcan Sancar, Faruk Yencilek, Ferdi Menda, Özge Köner, Menda, F., Temur, S., Bilgen, S., Yencilek, F., Koyuncu, H., Sancar, N., Koner, O., and Yeditepe Üniversitesi
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Male ,medicine.medical_specialty ,Sedation ,medicine.medical_treatment ,Analgesic ,Lower urinary tract discomfort ,Anesthesia, General ,Double-Blind Method ,Lower Urinary Tract Symptoms ,medicine ,Humans ,Prospective Studies ,Urinary Tract ,Prospective cohort study ,Saline ,Aged ,Transurethral resection of the prostate ,Pain, Postoperative ,Morphine ,business.industry ,Transurethral Resection of Prostate ,Surgery ,Anesthesiology and Pain Medicine ,Urinary tract surgery ,Anesthesia ,Postoperative Nausea and Vomiting ,medicine.symptom ,business ,Postoperative nausea and vomiting ,medicine.drug - Abstract
Background: Lower urinary tract (LUT) discomfort is a common complaint after transurethral resection of the prostate (TURP), and it may lead to agitation and restlessnes. We have evaluated the efficacy of morphine for preventing TURP-related LUT discomfort symptoms. Methods: This was a prospective randomised study including 60 patients (American Society of Anesthesiologists class I and II) who were scheduled to undergo TURP. The patients were divided into two equally sized groups (group M: morphine, group C: control). A standartized anesthesia method was used. Group M patients received morphine 0.04 mg/kg intravenous (iv) in 100 ml of normal saline followed by an infusion of morphine for 24 h (0.01 mg/kg/h); group C patients received 100 ml normal saline 20 min before the expected extubation time, followed by a normal saline infusion which looked identical to that of the morphine infusion. The incidences and severity of LUT discomfort, postoperative pain, sedation level, postoperative nausea and vomiting (PONV) and respiratory depression were recorded at 0, 1, 2, 6, 12 and 24 h postoperatively. Results: The incidence of LUT discomfort was lower in group M patients at all time points during the study (p < 0.05) except for 2 h postoperatively, and the severity of LUT discomfort was also lower this group at 0, 12 and 24 h postoperatively (p = 0.001, p = 0.04 and p = 0.02, respectively). Pain (numeric rating scale) scores were lower in group M patients at 0 (p = 0.003) and 6 h (p < 0.001). The need for rescue analgesic was lower in group M patients (19 patients in group C, 10 patients in group M; p = 0.04). The incidence of PONV was higher in group M patients (p = 0.03). The incidence of pruritus, respiratory depression and over-sedation were similar among the groups. Conclusion: Based on these results, we conclude that morphine effectively reduces LUT discomfort after TURP at a cost of postoperative nausea and vomiting. © 2013 Japanese Society of Anesthesiologists.
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- 2013
43. Emergent stenting after uncomplicated ureteroscopy: Evaluation of 23 patients
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Faruk Yencilek, Hakan Koyuncu, Orhan Tanriverdi, Esin Yencilek, Kemal Sarica, Tanriverdi, O., Yencilek, F., Koyuncu, H., Yencilek, E., Sarica, K., and Yeditepe Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Ureteral Calculi ,Colic ,Urology ,Urinary system ,Radiography ,urologic and male genital diseases ,Postoperative Complications ,Ureter ,Edema ,Ureteroscopy ,Humans ,Ureteral Diseases ,Medicine ,Emergency Treatment ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Ureteral wall ,female genital diseases and pregnancy complications ,Surgery ,medicine.anatomical_structure ,surgical procedures, operative ,Operative time ,Female ,Stents ,medicine.symptom ,Complication ,business - Abstract
Objectives To evaluate the causes of emergent stent placement during the postoperative early period after uncomplicated ureteroscopy in 23 patients. Methods Of 276 uncomplicated ureteroscopy procedures performed for the management of ureteral calculi, double-J stent placement was necessary on an emergent basis in 23 patients because of intolerable colic pain and extreme patient discomfort. All stents were inserted within 24 hours after the procedure. Results Of the 23 patients requiring emergent stent placement, 14 were men and 9 were women. The stones had been located in the lower ureter in 11, mid-ureter in 6, and upper ureter in 6 patients. All patients had undergone an uncomplicated procedure with no complication evident either during or immediately after ureteroscopic stone management. The intraoperative findings for the 23 patients revealed extensive edema formation, unrecognized small stones embedded in the edematous ureteral wall, unpassed small fragments gathered at the orifice, obstructing blood clots, and kinking of the ureter. A retrospective evaluation of the operative CD recordings and radiographic findings clearly showed that a longer operative time, repeated access, management of a large stone, impacted calculi with ureteral wall edema, a mildly narrowed ureteral segment, ignored caliceal small calculi, and a recent history of urinary tract infection contributed to the need for postoperative intervention. Conclusions Ureteral catheterization, at least in the form of overnight stent placement, might prevent the formation of transient ureteral obstruction, with resultant postoperative patient discomfort and colic pain evident in selected cases. © 2011 Elsevier Inc.
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- 2011
44. Clinical course of pediatric urolithiasis: Follow-up data in a long-term basis
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Sakip Erturhan, Bilal Eryildirim, Faruk Yencilek, Hakan Koyuncu, Kemal Sarica, Koyuncu, H., Yencilek, F., Erturhan, S., Eryildirım, B., Sarica, K., and Yeditepe Üniversitesi
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Male ,Nephrology ,medicine.medical_specialty ,Pediatrics ,Time Factors ,Adolescent ,Urology ,Remission, Spontaneous ,Pediatric urolithiasis ,Spontaneous remission ,Urolithiasis ,Risk Factors ,Recurrence ,Internal medicine ,Secondary Prevention ,medicine ,Spontaneous passage ,Humans ,Prospective Studies ,Pediatric stones ,Child ,Prospective cohort study ,Natural course ,business.industry ,Metabolic risk ,Infant, Newborn ,Clinical course ,Infant ,Prognosis ,Surgery ,Child, Preschool ,Urologic Surgical Procedures ,Female ,Abnormality ,business ,Follow-Up Studies - Abstract
Objective: To evaluate the natural course of the stone disease in pediatric patients from different perspectives among which the spontaneous passage and stone recurrence rates evaluated during the follow-up. Materials and methods: A total of 142 children referring with primary urinary stone disease were evaluated and followed. All children in the study were divided into two groups with respect to the age (Group 1: 0-5 years and Group 2: 6-15 years). Children were followed with respect to spontaneous passage rates, recurrence-regrowth rates, physical as well as the renal growth rates. Results: Stone recurrence has been noted in 44% of patients in group 1, this value was 31% in group 2. Children with at least one identifiable metabolic abnormality tended to have higher recurrence rates than the others despite conservative measures. The average stone recurrence rate in children without any metabolic abnormality was 14% and nearly 50% in children with an identifiable metabolic abnormality. Conclusions: We may emphasize that due to the high recurrence and re-growth rates, all children with urinary stone disease should be followed closely with regular visits. The evaluation of metabolic risk factors in children with renal stone disease is the basis of medical treatment aimed at preventing recurrent stone events and the growth of pre-existing calculi. © 2010 Springer Science+Business Media, B.V.
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- 2011
45. Increased 10-year cardiovascular disease and mortality risk scores in asymptomatic patients with calcium oxalate urolithiasis
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Binnur Okan, Faruk Yencilek, Hasan Aydin, Kemal Sarica, Ismet Bilger Erihan, Aydin, H., Yencilek, F., Erihan, I.B., Okan, B., Sarica, K., and Yeditepe Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,Cardiovascular mortality risk ,Calcium oxalate ,Asymptomatic ,Gastroenterology ,Citric Acid ,Excretion ,chemistry.chemical_compound ,Young Adult ,Urolithiasis ,Risk Factors ,Internal medicine ,Medicine ,Humans ,Longitudinal Studies ,Aged ,Retrospective Studies ,Aged, 80 and over ,Oxalates ,Framingham Risk Score ,Calcium Oxalate ,business.industry ,Case-control study ,Retrospective cohort study ,Middle Aged ,Cardiovascular disease risk ,Urinary calcium ,Endocrinology ,Blood pressure ,Cross-Sectional Studies ,chemistry ,Cardiovascular Diseases ,Case-Control Studies ,Linear Models ,Calcium ,Female ,medicine.symptom ,business - Abstract
Both the prevalence of cardiovascular risk factors and event rate are increased in patients with urolithiasis. Screening is recommended to all patients who have high cardiovascular risk. The aim of this study was to document 10-year risk of cardiovascular disease and mortality in asymptomatic patients with urolithiasis. Consecutive 200 patients with calcium oxalate urolithiasis were compared with 200 age- and sex-matched healthy controls. Ten-year cardiovascular disease risk was calculated with the Framingham Risk Score and mortality risk with SCORE risk score. Calcium, oxalate, and citrate excretion were studied as urinary stone risk factors. The results indicate that patients with urolithiasis had higher total cholesterol (p < 0.0001), lower HDL-cholesterol (p < 0.0001), and higher systolic blood pressure (p < 0.0001) and hsCRP (p < 0.0001) compared with controls. Patients with urolithiasis had a higher Framingham Risk Scores [OR 8.36 (95% CI 3.81-18.65), p = 0.0001] and SCORE risk score [OR 3.02 (95% CI 1.30-7.02), p = 0.0006] compared with controls. The Framingham and SCORE risk score were significantly correlated with urinary calcium (p = 0.0001, r = 0.460, and p = 0.005, r = 0.223, respectively) and oxalate excretion (p = 0.0001, r = 0.516, p = 0.001, r = 0.290, respectively). In multiple linear regression analysis, urinary calcium and oxalate excretion, age, sex, total cholesterol, HDL-cholesterol, hsCRP and smoking were the independent predictors of 10-year cardiovascular disease risk and urinary calcium and oxalate excretion, age, sex, total cholesterol, fasting blood glucose for 10-year cardiovascular mortality. In conclusion, patients with calcium oxalate urolithiasis carry high risk of cardiovascular disease and mortality. All patients should be screened at the initial diagnosis of urolithiasis for the risk factors. © 2011 Springer-Verlag.
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- 2011
46. Treatment of ureteral calculi with semirigid ureteroscopy: Where should we stop?
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Sakip Erturhan, Ahmet Erbagci, Faruk Yagci, Kemal Sarica, Faruk Yencilek, Yencilek, F., Sarica, K., Erturhan, S., Yagci, F., Erbagci, A., and Yeditepe Üniversitesi
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Adult ,Male ,Ureteral stone ,medicine.medical_specialty ,Ureteral Calculi ,medicine.diagnostic_test ,business.industry ,Urology ,Equipment Design ,Treatment ,Ureter ,medicine.anatomical_structure ,Pneumatic lithotripsy ,Ureteroscopes ,Ureteroscopy ,Humans ,Medicine ,Female ,business - Abstract
Objectives: To evaluate the efficacy of semirigid ureteroscopy in the management of ureteral stones located in different parts of the ureter. Methods: 1,503 patients were treated with semirigid ureteroscopy. All ureteral stones were either removed only by a basket catheter or disintegrated by pneumatic lithotripsy. Success rates, auxiliary procedures, complication rates and operation time were comparatively evaluated according to stone location. Results: Overall, mean stone size and age were 12.1 ± 3.7 mm and 43.2 ± 9.72 years, respectively. While 1,416 patients (94.2%) were completely stone-free, the procedure was unsuccessful in 87 cases (5.8%). The success rate was relatively low in the proximal ureter (71.7%) when compared with the mid (94.8%) and distal ureter (98.9%) (p = 0.021). Mean operation time was 25.4 ± 11.7 min. Longer duration of operation and higher complication rate were found in proximal ureteral calculi. Stone migration to the kidney and hematuria were the main reasons of failure in the proximal ureter and ureteral stenting was needed for 56.4% of patients with upper ureteral stone. Conclusions: Semirigid ureteroscopy can be the treatment of choice in lower and midureteral stones. However, it is an invasive and less successful treatment modality for proximal ureteral stones with relatively high complication rates.
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- 2010
47. Factors affecting sexual function in premenopausal age women with type 2 diabetes: A comprehensive study
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Kemal Sarica, Faruk Yencilek, Hasan Aydin, Rukset Attar, Raziye Narin, Ateş Karateke, Bülent Erol, Yencilek, F., Attar, Rukset, Erol, B., Narin, R., Aydn, H., Karateke, A., Sarca, K., Yeditepe Üniversitesi, and Zonguldak Bülent Ecevit Üniversitesi
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Adult ,medicine.medical_specialty ,Time Factors ,Sexual Behavior ,Female sexual dysfunction ,Type 2 diabetes ,Body Mass Index ,Pregnancy ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,risk factors ,Young adult ,Socioeconomic status ,Marital Status ,business.industry ,Obstetrics ,Smoking ,Age Factors ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Menstruation ,Parity ,Endocrinology ,Sexual dysfunction ,Cross-Sectional Studies ,Reproductive Medicine ,Diabetes Mellitus, Type 2 ,Premenopause ,Social Class ,female sexual dysfunction ,Case-Control Studies ,Female ,medicine.symptom ,menstruation ,business ,Sexual function ,Body mass index - Abstract
WOS: 000282160600049, PubMed: 20074725, Objective: To compare the factors affecting sexual function in premenopausal women with type 2 diabetes using the female sexual function index (FSFI). Design: Cross-sectional study. Setting: Premenopausal women with type 2 diabetes and healthy volunteers in an academic research environment. Patient(s): Sixty-two type 2 diabetic women were compared with 50 controls. The FSFI scores of the patients were compared according to age, duration of diabetes, marriage, socioeconomic status, parity, menstruation regularity, body mass index (BMI), and smoking. Intervention(s): None. Main Outcome Measure(s): Female sexual function index scores. Result(s): The mean FSFI score in diabetics was lower than in controls. Menstrual irregularity and duration of diabetes affected female sexual function unlike age, BMI, socioeconomic status, duration of marriage, or parity. Regularly menstruating women had higher FSFI scores (27.1 +/- 6.7) than irregularly menstruating women (20.7 +/- 7.4). Type 2 diabetics were divided into three groups according to duration of diabetes. The women having diabetes longer than 10 years had the worse sexual function. Also, smoking affected inversely female sexual well being. Conclusion(s): Menstrual disturbance, smoking, and longer duration of diabetes (more than 10 years) impair FSFI scores in premenopausal women with type 2 diabetes. (Fertil Steril (R) 2010;94:1840-3. (C)2010 by American Society for Reproductive Medicine.)
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- 2010
48. The effect of indomethacin on hyperoxaluria-induced renal tubular epithelial injury
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Yencilek, Faruk, Erturhan, Sakıp, Cangüven, Önder, Erol, Bülent, Koyuncu, Hakan, Göktaş, Cemal, Sarıca, Kemal, Yencilek, Faruk, Erturhan, Sakıp, Cangüven, Önder, Erol, Bülent, Koyuncu, Hakan, Göktaş, Cemal, Sarıca, Kemal, Yeditepe Üniversitesi, Yencilek, F., Erturhan, S., Cangüven, Ö., Erol, B., Koyuncu, H., Göktaş, C., Sarica, K., and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Hyperoxaluria ,Üroloji ve Nefroloji ,Indomethacin ,Renal tubular injury - Abstract
Amaç: Bu çalışmanın amacı anti-inflamatuvar bir ajan olan indometazinin, hiperoksalürinin neden olduğu tübüler hücre hasarı sonucu gelişen apopitozis ve kristal birikimi üzerine etkisini hayvan modeli üzerinde belirlemektir. Gereç ve yöntem: Elli Yeni Zelanda tavşanı 3 gruba ayrılmıştır. İlk 2 grup hiperoksalürik diyetle beslenmiş, Grup 3 ise herhangi bir ilave işlem ya da tedavi uygulanmayan kontrol grubunu oluşturmuştur. Grup 1’deki hayvanlara yalnızca hiperoksalürik diyet verilirken, Grup 2’deki hayvanlara hiperoksalürik diyete ek olarak indometazin de uygulanmıştır. Hayvanlar erken (7. gün) ve geç (28. gün) dönemde kurban edilmiş ve renal doku örnekleri, kristal birikimi ve apopitozis açılarından patolojik inceleme için gönderilmiştir. Bulgular: Kristal birikiminin mevcudiyeti ve derecesi, indometazinle tedavi edilmiş olan gruptan elde edilen örneklerde hem erken, hem de geç dönemde anlamlı olarak daha azdı (p, Objective: The aim of this study was to determine the effect of indomethacin, an anti-inflammatory agent, on apoptosis and crystal deposition developing as a consequence of tubular cell injury induced by hyperoxaluria in an animal model. Materials and methods: Fifty New Zealand rabbits were divided into 3 groups. The first 2 groups were fed with hyperoxaluric diet and Group 3 was the control group with no supplementary procedure or treatment. While the animals in Group 1 were given only hyperoxaluric diet, Group 2 animals was applied indomethacin in addition to the hyperoxaluric diet. Animals were sacrificed at the early (7th day) and late (28th day) periods and renal tissue specimens were sent for the pathological analysis of crystal deposition and apoptosis. Results: The presence and degree of crystal deposition were significantly less in the specimens obtained from indomethacin-treated group during both the early and late periods (p
- Published
- 2009
49. Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia?
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Faruk Yencilek, Gazi Yildirim, Rukset Attar, Cem Ficicioglu, N. Tecellioglu, Oya Akcin, Yildirim, G., Ficicioglu, C., Akcin, O., Attar, Rukset, Tecellioglu, N., Yencilek, F., and Yeditepe Üniversitesi
- Subjects
Infertility ,Adult ,Male ,medicine.medical_treatment ,Kartagener's syndrome ,ICSI ,Intracytoplasmic sperm injection ,Male infertility ,Pentoxifylline ,Andrology ,Primary ciliary dyskinesia ,Pregnancy ,Medicine ,Humans ,Sperm Injections, Intracytoplasmic ,Infertility, Male ,reproductive and urinary physiology ,business.industry ,urogenital system ,Cilium ,Obstetrics and Gynecology ,General Medicine ,Immotile cilia syndrome ,medicine.disease ,Sperm ,medicine.anatomical_structure ,Treatment Outcome ,Sperm Motility ,Female ,business ,Respiratory tract ,medicine.drug ,Ciliary Motility Disorders - Abstract
Primary ciliary dyskinesia (PCD), previously known as immotile cilia syndrome, can cause respiratory and reproductive problems. Because of the impaired motion of microtubules the patients suffer upper respiratory tract problems. Infertility is an other issue of these patients. Several attempt have been proposed to bring back sperm motion and to improve intracytoplasmic sperm injection (ICSI) results. With our case we have described the management of a male infertility that causes from immotile cilia. The role of ICSI with incubated and activated ejaculatory sperm by pentoxifylline in the patient of PCD or as commonly named immotile cilia syndrome. © 2008 Springer-Verlag.
- Published
- 2009
50. Role of Papaverine Hydrochloride Administration in Patients With Intractable Renal Colic: Randomized Prospective Trial
- Author
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Cemal Göktaş, Ugur Yilmaz, Cemil Yilmaz, Faruk Yencilek, Can Aktaş, Kemal Sarica, Yencilek, F., Aktas, C., Goktas, C., Yilmaz, C., Yilmaz, U., Sarica, K., and Yeditepe Üniversitesi
- Subjects
Nephrology ,Adult ,Male ,medicine.medical_specialty ,Randomization ,Ureteral Calculi ,Adolescent ,Colic ,Visual analogue scale ,Phosphodiesterase Inhibitors ,Urology ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Papaverine ,medicine ,Humans ,Renal colic ,Prospective Studies ,Pain Measurement ,business.industry ,Therapeutic effect ,Middle Aged ,Pain, Intractable ,Pethidine ,Treatment Outcome ,Anesthesia ,Female ,medicine.symptom ,business ,medicine.drug ,Follow-Up Studies - Abstract
Objectives: To evaluate the therapeutic effect of papaverine hydrochloride in the treatment of patients with renal colic pain unresponsive to conventional treatment. Methods: From March 2007 to January 2008, a total of 561 patients with severe renal colic pain due to a ureteral stone were treated with conventional agents (hyoscine-N-butylbromide and diclofenac sodium) in the emergency and urology departments. Of these 561 patients, 110, with no response to the treatment and persistent severe pain, were randomized into 3 groups for additional treatment. The patients in group 1 (n = 37) received intravenous hyoscine-N-butylbromide, those in group 2 (n = 37) received papaverine hydrochloride, and those in group 3 (n = 36) received pethidine. Before and after treatment, all patients completed a visual analog scale (VAS) questionnaire, with a scale of 0 (no pain) to 10 (maximal complaint), to measure their subjective pain. The mean VAS score of each group was compared with that of the other groups. Results: The pretreatment mean VAS scores of all 3 groups were not significantly different statistically from each other (4.02 ± 1.20, 4.36 ± 1.97, and 4.27 ± 1.50; P > .05). However, after treatment, the mean VAS scores of the patients treated with papaverine (0.93 ± 0.29) and pethidine (0.81 ± 0.38) were significantly different from those of the hycosine group (3.67 ± 2.21; P < .001). However, the mean VAS scores of groups 2 and 3 were comparable (P = .67). Unlike opioids, no papaverine-related severe side effects were observed. Conclusions: Our results indicate that papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. © 2008 Elsevier Inc. All rights reserved.
- Published
- 2008
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