Search

Your search keyword '"Xiao, Jingjing"' showing total 410 results
Start Over Author "Xiao, Jingjing" Language english
410 results on '"Xiao, Jingjing"'

3. A deep-learning-based framework for identifying and localizing multiple abnormalities and assessing cardiomegaly in chest X-ray

Author

Fan, Weijie, Yang, Yi, Qi, Jing, Zhang, Qichuan, Liao, Cuiwei, Wen, Li, Wang, Shuang, Wang, Guangxian, Xia, Yu, Wu, Qihua, Fan, Xiaotao, Chen, Xingcai, He, Mi, Xiao, JingJing, Yang, Liu, Liu, Yun, Chen, Jia, Wang, Bing, Zhang, Lei, Yang, Liuqing, Gan, Hui, Zhang, Shushu, Liu, Guofang, Ge, Xiaodong, Cai, Yuanqing, Zhao, Gang, Zhang, Xi, Xie, Mingxun, Xu, Huilin, Zhang, Yi, Chen, Jiao, Li, Jun, Han, Shuang, Mu, Ke, Xiao, Shilin, Xiong, Tingwei, Nian, Yongjian, and Zhang, Dong

Published
2024
Full Text
View/download PDF

22. Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs

Author

Liao Jun, Yang Xianwu, Yang Jiejie, Xiao Jingjing, Liu Xuyang, Zhuo Yingquan, Yang Jiafei, and Gu Huajian

Subjects
fractalkine, cx3cr1, hepatopulmonary syndrome, tube formation, macrophages, Biology (General), QH301-705.5
Abstract

This study aimed to investigate effects of pulmonary fractalkine (FKN/CX3CL1) on angiogenesis and tube formation. Tube forming capability of pulmonary vascular endothelial cells (PVECs) was evaluated. CCK-8 assay was used to evaluate proliferation of PVECs. RT-PCR assay was used to determine angiogenesis specific biomarkers. Western blot was applied to identify CX3CR1, Akt, phosphorylated Akt (p-Akt), Erk1/2, phosphorylated Erk1/2 (p-Erk1/2), vascular endothelial growth factor A (VEGFA), and inducible nitric oxide synthase (iNOS) expression. VEGF-A and platelet-derived growth factor (PDGF) levels were examined using ELISA. FKN was safe and triggered tube formation in PVECs. FKN significantly enhanced VEGF-A, PDGF, and iNOS gene transcription compared to the Control group (p < 0.05). CX3CR1 interfering (LV5-CX3CR1 shRNA) remarkably reduced CX3CR1 expression compared to those in LV5 blank group (p < 0.05). Ratios of p-Akt/Akt and p-Erk/Erk were significantly decreased in CX3CR1 shRNA-treated PVECs administered Akt inhibitor (or Erk inhibitor) and 10 ng/mL FKN compared to CX3CR1 shRNA-treated PVECs administered 10 ng/mL FKN (p < 0.05). FKN increased VEGF-A and iNOS expression through activating Akt/Erk pathway. FKN promoted VEGF-A/iNOS expression and triggered p-Akt/Akt and p-Erk/Erk pathway through modulating CX3CR1. FKN-treated macrophages enhanced activation of Akt/Erk pathway. FKN-treated macrophages enhanced PDGF and VEGF-1 expression in PVECs. FKN modulated pulmonary angiogenesis and tube formation through modulating CX3CR1 and growth factors and activating p-Akt/Akt and p-Erk/Erk signaling pathway.

Published
2023
Full Text
View/download PDF

49. MyoFold: Joint myocardial tissue composition and wall motion quantification via a highly folded sequence.

Author

Guo, Rui, Fan, Yingwei, Liu, Bowei, Qian, Xiaofeng, Dai, Jiahuan, Si, Dongyue, Wang, Yuanyuan, Wang, Ancong, Dong, Guozhao, Jin, Yongsheng, Xiao, Jingjing, Ding, Haiyan, and Tang, Xiaoying

Subjects
HEART beat, MAGNETIC resonance imaging, TISSUES
Abstract

Purpose: This study aims to develop and evaluate a novel cardiovascular MR sequence, MyoFold, designed for the simultaneous quantifications of myocardial tissue composition and wall motion. Methods: MyoFold is designed as a 2D single breathing‐holding sequence, integrating joint T1/T2 mapping and cine imaging. The sequence uses a 2‐fold accelerated balanced SSFP (bSSFP) for data readout and incorporates electrocardiogram synchronization to align with the cardiac cycle. MyoFold initially acquires six single‐shot inversion‐recovery images, completed during the diastole of six successive heartbeats. T2 preparation (T2‐prep) is applied to introduce T2 weightings for the last three images. Subsequently, over the following six heartbeats, segmented bSSFP is performed for the movie of the entire cardiac cycle, synchronized with an electrocardiogram. A neural network trained using numerical simulations of MyoFold is used for T1 and T2 calculations. MyoFold was validated through phantom and in vivo experiments, with comparisons made against MOLLI, SASHA, T2‐prep bSSFP, and the conventional cine. Results: In phantom studies, MyoFold exhibited a 10% overestimation in T1 measurements, whereas T2 measurements demonstrated high accuracy. In vivo experiments revealed that MyoFold T1 had comparable accuracy to SASHA and precision similar to MOLLI. MyoFold demonstrated good agreement with T2‐prep bSSFP in myocardial T2 measurements. No significant differences were observed in the quantification of left‐ventricle wall thickness and function between MyoFold and the conventional cine. Conclusion: MyoFold presents as a rapid, simple, and multitasking approach for quantitative cardiovascular MR examinations, offering simultaneous assessment of tissue composition and wall motion. The sequence's multitasking capabilities make it a promising tool for comprehensive cardiac evaluations in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results