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716 results on '"Winkler, Peter A."'

1. Dose prescription for stereotactic body radiotherapy: general and organ-specific consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery

Author

Brunner, Thomas B., Boda-Heggemann, Judit, Bürgy, Daniel, Corradini, Stefanie, Dieckmann, Ute Karin, Gawish, Ahmed, Gerum, Sabine, Gkika, Eleni, Grohmann, Maximilian, Hörner-Rieber, Juliane, Kirste, Simon, Klement, Rainer J., Moustakis, Christos, Nestle, Ursula, Niyazi, Maximilian, Rühle, Alexander, Lang, Stephanie-Tanadini, Winkler, Peter, Zurl, Brigitte, Wittig-Sauerwein, Andrea, and Blanck, Oliver

Published
2024
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3. Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular tachycardia

Author

Xie, Jingyang, Bicu, Alicia S., Grehn, Melanie, Kuru, Mustafa, Zaman, Adrian, Lu, Xinyu, Janorschke, Christian, van der Pol, Luuk H.G., Fast, Martin F., Fleckenstein, Jens, Both, Marcus, Hohmann, Stephan, Borzov, Egor, Winkler, Peter, Tilz, Roland R., Rades, Dirk, Giordano, Frank A., Buergy, Daniel, Rudic, Boris, Duncker, David, Merten, Roland, Charas, Tomer, Suleiman, Mahmoud, Brunner, Thomas, Scherr, Daniel, Lian, Evgeny, Schweikard, Achim, Blanck, Oliver, Boda-Heggemann, Judit, and Kaestner, Lena

Published
2025
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5. Planning Benchmark Study for Stereotactic Body Radiation Therapy of Pancreas Carcinomas With Simultaneously Integrated Boost and Protection: Results of the DEGRO/DGMP Working Group on Stereotactic Radiation Therapy and Radiosurgery

Author

Moustakis, Christos, Blanck, Oliver, Grohmann, Maximilian, Albers, Dirk, Bartels, Dennis, Bathen, Bastian, Borzì, Giuseppina Rita, Broggi, Sara, Bruschi, Andrea, Casale, Michelina, Delana, Anna, Doolan, Paul, Ebrahimi Tazehmahalleh, Fatemeh, Fabiani, Stefania, Falco, Maria Daniela, Fehr, Roman, Friedlein, Melissa, Gutser, Susanne, Hamada, Abdul Malek, Hancock, Timothy, Köhn, Janett, Kornhuber, Christine, Krieger, Thomas, Lambrecht, Ulrike, Lappi, Sara, Moretti, Eugenia, Mirus, Annalena, Muedder, Thomas, Plaude, Sandija, Polvika, Bernd, Ravaglia, Valentina, Righetto, Roberto, Rinaldin, Giuseppe, Schachner, Henrik, Scaggion, Alessandro, Schilling, Philipp, Szeverinski, Philipp, Villaggi, Elena, Walke, Mathias, Wilke, Lotte, Winkler, Peter, Nicolay, Nils H., Eich, Hans Theodor, Gkika, Eleni, Brunner, Thomas B., and Schmitt, Daniela

Published
2025
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13. Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes.

Author

Freund, Anna, Mayr, Alexander, Winkler, Peter, Weber, Rene, Tervonen, Aapo, Refaeli, Ron, and Lenk, Kerstin

Subjects
CELL morphology, COMPUTATIONAL neuroscience, ASTROCYTES, CALCIUM, HIPPOCAMPUS (Brain)
Abstract

Recent studies indicate that astrocytes show heterogeneity in morphology and physiological function. They integrate synaptic signals and release calcium in reaction to active neurons. These calcium signals are not yet fully understood as they are highly dependent on the cell’s morphology, which can vary across and within brain regions. We found structural heterogeneity among mouse hippocampal CA1 astrocytes based on geometric features, clustering 741 cells into six classes. Of those, we selected 84 cells and reconstructed their morphology based on confocal microscope images and converted them into multi-compartment models with a high detailedness. We applied a computational biophysical model simulating the intracellular ion and IP3 signaling and diusion in those 3D cell geometries. The cells were stimulated with three dierent glutamate stimuli. Calcium mainly oscillated in the stimulated and the neighboring compartment but not in the soma. Significant dierences were found in the peak width, mean prominence, and mean peak amplitude of the calcium signal when comparing the signals in the stimulated and neighboring compartments. Overall, this study highlights the influence of the complex morphology of astrocytes on intracellular ionic signalin [ABSTRACT FROM AUTHOR]

Published
2024
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15. Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study

Author

Schwartz, Christoph, Romagna, Alexander, Stefanits, Harald, Zimmermann, Georg, Ladisich, Barbara, Geiger, Philipp, Rechberger, Julian, Winkler, Sophie, Weiss, Lukas, Fastner, Gerd, Trinka, Eugen, Weis, Serge, Spiegl-Kreinecker, Sabine, Steinbacher, Jürgen, McCoy, Mark, Johannes, Trenkler, Gruber, Andreas, Rezai Jahromi, Behnam, Niemelä, Mika, Winkler, Peter A., and Thon, Niklas

Published
2020
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17. Trends and outcomes for non-elective neurosurgical procedures in Central Europe during the COVID-19 pandemic

Author

Grassner, Lukas, Petr, Ondra, Warner, Freda M., Dedeciusova, Michaela, Mathis, Andrea Maria, Pinggera, Daniel, Gsellmann, Sina, Meiners, Laura C., Freigang, Sascha, Mokry, Michael, Resch, Alexandra, Kretschmer, Thomas, Rossmann, Tobias, Navarro, Francisco Ruiz, Gruber, Andreas, Spendel, Mathias, Winkler, Peter A., Marhold, Franz, Sherif, Camillo, Wais, Jonathan P., Rössler, Karl, Pfisterer, Wolfgang, Mühlbauer, Manfred, Trivik-Barrientos, Felipe A., Rath, Sebastian, Voldrich, Richard, Krska, Lukas, Lipina, Radim, Kerekanic, Martin, Fiedler, Jiri, Kasik, Petr, Priban, Vladimir, Tichy, Michal, Krupa, Petr, Cesak, Tomas, Kroupa, Robert, Callo, Andrej, Haninec, Pavel, Pohlodek, Daniel, Krahulik, David, Sejkorova, Alena, Sames, Martin, Dvorak, Josef, Suchomel, Petr, Tomas, Robert, Klener, Jan, Juran, Vilem, Smrcka, Martin, Linzer, Petr, Kaiser, Miroslav, Hrabovsky, Dusan, Jancalek, Radim, Kälin, Vincens, Bozinov, Oliver, Niggli, Cedric, Serra, Carlo, Guatta, Ramona, Kuhlen, Dominique E., Wanderer, Stefan, Marbacher, Serge, Lavé, Alexandre, Schaller, Karl, Esculier, Clarinde, Raabe, Andreas, Kramer, John L. K., Thomé, Claudius, and Netuka, David

Published
2021
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23. Lumbar Spinous Process–Splitting Technique for Ligamentum Flavum Cyst Removal.

Author

Tomasi, Santino Ottavio, Umana, Giuseppe Emmanuele, Scalia, Gianluca, Raudino, Giuseppe, Stevanovic, Vlado, Krainz, Herbert, Kral, Michael, Nicoletti, Giovanni Federico, and Winkler, Peter A.

Abstract

Background Laminotomy for lumbar stenosis is a well-defined procedure and represents a routine in every neurosurgical department. It is a common experience that the uni- or bilateral paraspinal muscle detachment, together with injury of the supra- and interspinous ligaments, can lead to postoperative pain. In the literature, the application of a minimally invasive technique, the lumbar spinous process–splitting (LSPS) technique, has been reported. Methods In this study, we present a case series of 12 patients who underwent LSPS from September 2019 to April 2020. Two patients had a cyst of the ligamentum flavum, eight a single-level lumbar canal stenosis (LCS), and two a two-level LCS. Moreover, we propose a novel morphological classification of postoperative muscle atrophy and present volumetric analysis of the decompression achieved. Results There were no complications related to this technique. In all patients, the vertebral canal area was more than doubled by the procedure. The muscle sparing showed grade A, according to our classification. Conclusion To our knowledge, this is the first description of this surgical technique and the first LSPSL case series in Europe. Furthermore, cases of ligamentum flavum cyst removal using this safe and effective technique have not yet been reported. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Large Deviation Principle for Random Permutations.

Author

Borga, Jacopo, Das, Sayan, Mukherjee, Sumit, and Winkler, Peter

Subjects
LARGE deviations (Mathematics), PERMUTATIONS, PHASE transitions, PROBABILITY measures, MALVACEAE
Abstract

We derive a large deviation principle for random permutations induced by probability measures of the unit square, called permutons. These permutations are called |$\mu $| - random permutations. We also introduce and study a new general class of models of random permutations, called Gibbs permutation models , which combines and generalizes |$\mu $| -random permutations and the celebrated Mallows model for permutations. Most of our results hold in the general setting of Gibbs permutation models. We apply the tools that we develop to the case of |$\mu $| -random permutations conditioned to have an atypical proportion of patterns. Several results are made more concrete in the specific case of inversions. For instance, we prove the existence of at least one phase transition for a generalized version of the Mallows model where the base measure is non-uniform. This is in contrast with the results of Starr (2009, 2018) on the (standard) Mallows model, where the absence of phase transition, that is, phase uniqueness, was proven. Our results naturally lead us to investigate a new notion of permutons, called conditionally constant permutons, which generalizes both pattern-avoiding and pattern-packing permutons. We describe some properties of conditionally constant permutons with respect to inversions. The study of conditionally constant permutons for general patterns seems to be a new challenging problem. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Author

Klughammer, Johanna, Kiesel, Barbara, Roetzer, Thomas, Fortelny, Nikolaus, Nemc, Amelie, Nenning, Karl-Heinz, Furtner, Julia, Sheffield, Nathan C., Datlinger, Paul, Peter, Nadine, Nowosielski, Martha, Augustin, Marco, Mischkulnig, Mario, Ströbel, Thomas, Alpar, Donat, Ergüner, Bekir, Senekowitsch, Martin, Moser, Patrizia, Freyschlag, Christian F., Kerschbaumer, Johannes, Thomé, Claudius, Grams, Astrid E., Stockhammer, Günther, Kitzwoegerer, Melitta, Oberndorfer, Stefan, Marhold, Franz, Weis, Serge, Trenkler, Johannes, Buchroithner, Johanna, Pichler, Josef, Haybaeck, Johannes, Krassnig, Stefanie, Mahdy Ali, Kariem, von Campe, Gord, Payer, Franz, Sherif, Camillo, Preiser, Julius, Hauser, Thomas, Winkler, Peter A., Kleindienst, Waltraud, Würtz, Franz, Brandner-Kokalj, Tanisa, Stultschnig, Martin, Schweiger, Stefan, Dieckmann, Karin, Preusser, Matthias, Langs, Georg, Baumann, Bernhard, Knosp, Engelbert, Widhalm, Georg, Marosi, Christine, Hainfellner, Johannes A., Woehrer, Adelheid, and Bock, Christoph

Published
2018
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31. Neurologic phenotypes associated with COL4A1/2 mutations: Expanding the spectrum of disease

Author

Zagaglia, Sara, Selch, Christina, Nisevic, Jelena Radic, Mei, Davide, Michalak, Zuzanna, Hernandez-Hernandez, Laura, Krithika, S., Vezyroglou, Katharina, Varadkar, Sophia M., Pepler, Alexander, Biskup, Saskia, Leão, Miguel, Gärtner, Jutta, Merkenschlager, Andreas, Jaksch, Michaela, Møller, Rikke S., Gardella, Elena, Kristiansen, Britta Schlott, Hansen, Lars Kjærsgaard, Vari, Maria Stella, Helbig, Katherine L., Desai, Sonal, Smith-Hicks, Constance L., Hino-Fukuyo, Naomi, Talvik, Tiina, Laugesaar, Rael, Ilves, Pilvi, Õunap, Katrin, Körber, Ingrid, Hartlieb, Till, Kudernatsch, Manfred, Winkler, Peter, Schimmel, Mareike, Hasse, Anette, Knuf, Markus, Heinemeyer, Jan, Makowski, Christine, Ghedia, Sondhya, Subramanian, Gopinath M., Striano, Pasquale, Thomas, Rhys H., Micallef, Caroline, Thom, Maria, Werring, David J., Kluger, Gerhard Josef, Cross, J. Helen, Guerrini, Renzo, Balestrini, Simona, and Sisodiya, Sanjay M.

Published
2018
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38. 3D-Druckschablonen zur intraoperativen Herstellung von patientenspezifischen Kranioplastie Implantaten - Technik und klinische Ergebnisse

Author

Pöppe, Johannes, Schwartz, Christoph, Spendel, Mathias, Winkler, Peter A., Wittig, Jörn, and Griessenauer, Christoph J.

Subjects
ddc: 610, Medicine and health, technology, industry, and agriculture
Abstract

Objective: In patients with large craniectomy defects and no autologous implant available manually molded Polymethylmethacrylate (PMMA) implants are feasible for cranioplasty. Even though those implants are readily available and cost-effective satisfying cosmetic results cannot always be achieved. In [for full text, please go to the a.m. URL]

Published
2022

40. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Author

Blumcke, Ingmar, Spreafico, Roberto, Haaker, Gerrit, Coras, Roland, Kobow, Katja, Bien, Christian G., Pfäfflin, Margarete, Elger, Christian, Widman, Guido, Schramm, Johannes, Becker, Albert, Braun, Kees P., Leijten, Frans, Baayen, Johannes C., Aronica, Eleonora, Chassoux, Francine, Hamer, Hajo, Stefan, Hermann, Rössler, Karl, Thom, Maria, Walker, Matthew C., Sisodiya, Sanjay M., Duncan, John S., McEvoy, Andrew W., Pieper, Tom, Holthausen, Hans, Kudernatsch, Manfred, Meencke, Joachim H., Kahane, Philippe, Schulze-Bonhage, Andreas, Zentner, Josef, Heiland, Dieter H., Urbach, Horst, Steinhoff, Bernhard J., Bast, Thomas, Tassi, Laura, Lo Russo, Giorgio, Özkara, Cigdem, Oz, Buge, Krsek, Pavel, Vogelgesang, Silke, Runge, Uwe, Lerche, Holger, Weber, Yvonne, Honavar, Mrinalini, Pimentel, José, Arzimanoglou, Alexis, Ulate-Campos, Adriana, Noachtar, Soheyl, Hartl, Elisabeth, Schijns, Olaf, Guerrini, Renzo, Barba, Carmen, Jacques, Thomas S., Cross, Helen J., Feucht, Martha, Mühlebner, Angelika, Grunwald, Thomas, Trinka, Eugen, Winkler, Peter A., Gil-Nagel, Antonio, Delgado, Rafael Toledano, Mayer, Thomas, Lutz, Martin, Zountsas, Basilios, Garganis, Kyriakos, Rosenow, Felix, Hermsen, Anke, von Oertzen, Tim J., Diepgen, Thomas L., and Avanzini, Giuliano

Published
2017
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41. The early meteorological network of the Societas Meteorologica Palatina (1781–1792): foundation, organization, and reception.

Author

Winkler, Peter

Subjects
METEOROLOGICAL charts, HISTORICAL maps, NAPOLEONIC Wars, 1800-1815, PLANETARY atmospheres, EARLY death, CLIMATE extremes, DENDROCHRONOLOGY
Abstract

The Societas Meteorologica Palatina arranged the first international meteorological network in a modern sense, being in operation between 1781 and 1792 during the last period of enlightenment. A total of 39 stations contributed observations. The original aim was to investigate influences of the moon and planets on the atmosphere. Instruments were provided free of charge; a physically very advanced instruction guaranteed reliable observational results, and the data collected at 3 different hours per day were printed at high cost in the Ephemerides Societatis Meteorologicae Palatinae (denoted Ephemerides hereafter) of Mannheim. This wealth of data has become a famous treasure trove for scientists and has been used later very often for climatic studies, for climatic comparisons of different locations in textbooks, for overcoming wrong but generally accepted or even outdated (e.g. scholastic) views; for finding new explanations for meteorological phenomena, and for studying extremes of meteorological parameters. Even in modern times, the data were evaluated and used to reconstruct historical weather maps. Although, meanwhile, some problems of the historical instruments have been recognized, most of the conclusions are still basically correct. The data were also used for verifying geomagnetic models or proxy data from tree-ring analysis. This network stimulated many scholars for special meteorological studies, and it was attractive for new stations to join the network. The early death of the meteorological secretary Johann Jakob Hemmer and the Napoleonic Wars brought about the end of the project. Nevertheless, many of the stations continued the observations using the available instruments. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Randomized Clinical Trials and Observational Tribulations: Providing Clinical Evidence for Personalized Surgical Pain Management Care Models.

Author

Abraham, Ivo, Lewandrowski, Kai-Uwe, Elfar, John C., Li, Zong-Ming, Fiorelli, Rossano Kepler Alvim, Pereira, Mauricio G., Lorio, Morgan P., Burkhardt, Benedikt W., Oertel, Joachim M., Winkler, Peter A., Yang, Huilin, León, Jorge Felipe Ramírez, Telfeian, Albert E., Dowling, Álvaro, Vargas, Roth A. A., Ramina, Ricardo, Asefi, Marjan, de Carvalho, Paulo Sérgio Teixeira, Defino, Helton, and Moyano, Jaime

Subjects
CLINICAL trials, PAIN management, MEDICAL protocols, ANATOMICAL variation, OPERATIVE surgery
Abstract

Proving clinical superiority of personalized care models in interventional and surgical pain management is challenging. The apparent difficulties may arise from the inability to standardize complex surgical procedures that often involve multiple steps. Ensuring the surgery is performed the same way every time is nearly impossible. Confounding factors, such as the variability of the patient population and selection bias regarding comorbidities and anatomical variations are also difficult to control for. Small sample sizes in study groups comparing iterations of a surgical protocol may amplify bias. It is essentially impossible to conceal the surgical treatment from the surgeon and the operating team. Restrictive inclusion and exclusion criteria may distort the study population to no longer reflect patients seen in daily practice. Hindsight bias is introduced by the inability to effectively blind patient group allocation, which affects clinical result interpretation, particularly if the outcome is already known to the investigators when the outcome analysis is performed (often a long time after the intervention). Randomization is equally problematic, as many patients want to avoid being randomly assigned to a study group, particularly if they perceive their surgeon to be unsure of which treatment will likely render the best clinical outcome for them. Ethical concerns may also exist if the study involves additional and unnecessary risks. Lastly, surgical trials are costly, especially if the tested interventions are complex and require long-term follow-up to assess their benefit. Traditional clinical testing of personalized surgical pain management treatments may be more challenging because individualized solutions tailored to each patient's pain generator can vary extensively. However, high-grade evidence is needed to prompt a protocol change and break with traditional image-based criteria for treatment. In this article, the authors review issues in surgical trials and offer practical solutions. [ABSTRACT FROM AUTHOR]

Published
2023
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44. The Changing Environment in Postgraduate Education in Orthopedic Surgery and Neurosurgery and Its Impact on Technology-Driven Targeted Interventional and Surgical Pain Management: Perspectives from Europe, Latin America, Asia, and The United States.

Author

Lewandrowski, Kai-Uwe, Elfar, John C., Li, Zong-Ming, Burkhardt, Benedikt W., Lorio, Morgan P., Winkler, Peter A., Oertel, Joachim M., Telfeian, Albert E., Dowling, Álvaro, Vargas, Roth A. A., Ramina, Ricardo, Abraham, Ivo, Assefi, Marjan, Yang, Huilin, Zhang, Xifeng, Ramírez León, Jorge Felipe, Fiorelli, Rossano Kepler Alvim, Pereira, Mauricio G., de Carvalho, Paulo Sérgio Teixeira, and Defino, Helton

Subjects
ORTHOPEDIC surgery, PAIN management, RETRACTORS (Surgery), NEUROSURGERY, SURGICAL robots, ORTHOPEDISTS, HEALTH policy, DEEP brain stimulation
Abstract

Personalized care models are dominating modern medicine. These models are rooted in teaching future physicians the skill set to keep up with innovation. In orthopedic surgery and neurosurgery, education is increasingly influenced by augmented reality, simulation, navigation, robotics, and in some cases, artificial intelligence. The postpandemic learning environment has also changed, emphasizing online learning and skill- and competency-based teaching models incorporating clinical and bench-top research. Attempts to improve work–life balance and minimize physician burnout have led to work-hour restrictions in postgraduate training programs. These restrictions have made it particularly challenging for orthopedic and neurosurgery residents to acquire the knowledge and skill set to meet the requirements for certification. The fast-paced flow of information and the rapid implementation of innovation require higher efficiencies in the modern postgraduate training environment. However, what is taught typically lags several years behind. Examples include minimally invasive tissue-sparing techniques through tubular small-bladed retractor systems, robotic and navigation, endoscopic, patient-specific implants made possible by advances in imaging technology and 3D printing, and regenerative strategies. Currently, the traditional roles of mentee and mentor are being redefined. The future orthopedic surgeons and neurosurgeons involved in personalized surgical pain management will need to be versed in several disciplines ranging from bioengineering, basic research, computer, social and health sciences, clinical study, trial design, public health policy development, and economic accountability. Solutions to the fast-paced innovation cycle in orthopedic surgery and neurosurgery include adaptive learning skills to seize opportunities for innovation with execution and implementation by facilitating translational research and clinical program development across traditional boundaries between clinical and nonclinical specialties. Preparing the future generation of surgeons to have the aptitude to keep up with the rapid technological advances is challenging for postgraduate residency programs and accreditation agencies. However, implementing clinical protocol change when the entrepreneur–investigator surgeon substantiates it with high-grade clinical evidence is at the heart of personalized surgical pain management. [ABSTRACT FROM AUTHOR]

Published
2023
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