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4. Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

Author

Claessen, Guido, De Bosscher, Ruben, Janssens, Kristel, Young, Paul, Dausin, Christophe, Claeys, Mathias, Claus, Piet, Goetschalckx, Kaatje, Bogaert, Jan, Mitchell, Amy M., Flannery, Michael D., Elliott, Adrian D., Yu, Chenglong, Ghekiere, Olivier, Robyns, Tomas, Van De Heyning, Caroline M., Sanders, Prashanthan, Kalman, Jonathan M., Ohanian, Monique, Soka, Magdalena, Rath, Emma, Giannoulatou, Eleni, Johnson, Renee, Lacaze, Paul, Herbots, Lieven, Willems, Rik, Fatkin, Diane, Heidbuchel, Hein, La Gerche, André, Van Soest, Sofie, Bekhuis, Youri, Pauwels, Rik, De Paepe, Jarne, Hespel, Peter, Dymarkowski, Steven, Dresselaers, Tom, Miljoen, Hielko, Favere, Kasper, Paelinck, Bernard, Vermeulen, Dorien, Witvrouwen, Isabel, Hansen, Dominique, Op’t Eijnde, Bert, Thijs, Daisy, Vanvoorden, Peter, Lefebvre, Kristof, D’Ambrosio, Paolo, Rowe, Stephanie, Paratz, Elizabeth, Brosnan, Maria J., and Prior, David L.

Published
2024
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5. Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

Author

Claessen, Guido, De Bosscher, Ruben, Janssens, Kristel, Young, Paul, Dausin, Christophe, Claeys, Mathias, Claus, Piet, Goetschalckx, Kaatje, Bogaert, Jan, Mitchell, Amy M., Flannery, Michael D., Elliott, Adrian D., Yu, Chenglong, Ghekiere, Olivier, Robyns, Tomas, Van De Heyning, Caroline M., Sanders, Prashanthan, Kalman, Jonathan M., Ohanian, Monique, Soka, Magdalena, Rath, Emma, Giannoulatou, Eleni, Johnson, Renee, Lacaze, Paul, Herbots, Lieven, Willems, Rik, Fatkin, Diane, Heidbuchel, Hein, La Gerche, André, Van Soest, Sofie, Bekhuis, Youri, Pauwels, Rik, De Paepe, Jarne, Hespel, Peter, Dymarkowski, Steven, Dresselaers, Tom, Miljoen, Hielko, Favere, Kasper, Paelinck, Bernard, Vermeulen, Dorien, Witvrouwen, Isabel, Hansen, Dominique, Op’t Eijnde, Bert, Thijs, Daisy, Vanvoorden, Peter, Lefebvre, Kristof, D’Ambrosio, Paolo, Rowe, Stephanie, Paratz, Elizabeth, Brosnan, Maria J., and Prior, David L.

Published
2023
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7. Lateral QRS amplitude is independently associated with outcome after cardiac resynchronization therapy: Advancing patient selection?

Author

Trenson, Sander, Kahr, Peter C., Schwaiger, Judith M., Betschart, Pascal, Kuster, Joël, Vandenberk, Bert, Duchenne, Jürgen, Beela, Ahmed S., Stankovic, Ivan, Voros, Gabor, Flammer, Andreas J., Schindler, Matthias, Saguner, Ardan M., Willems, Rik, Ruschitzka, Frank, Steffel, Jan, Breitenstein, Alexander, Voigt, Jens-Uwe, and Winnik, Stephan

Published
2024
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17. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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18. Thromboprophylaxis in COVID‐19: Weight and severity adjusted intensified dosing

Author

Engelen, Matthias M., Vandenbriele, Christophe, Spalart, Valérie, Martens, Caroline P., Vandenberk, Bert, Sinonquel, Pieter, Lorent, Natalie, De Munter, Paul, Willems, Rik, Wauters, Joost, Wilmer, Alexander, Dauwe, Dieter, Gunst, Jan, Guler, Ipek, Janssens, Stefan, Martinod, Kimberly, Pieters, Griet, Peerlinck, Kathelijne, Verhamme, Peter, and Vanassche, Thomas

Published
2022
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23. Nocturnal respiratory rate predicts ICD benefit: A prospective, controlled, multicentre cohort study

Author

Dommasch, Michael, Steger, Alexander, Barthel, Petra, Huster, Katharina M, Müller, Alexander, Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Penzel, Thomas, Lubinski, Andrzej, Flevari, Panagiota, Harden, Markus, Friede, Tim, Kääb, Stefan, Merkely, Bela, Sticherling, Christian, Willems, Rik, Huikuri, Heikki V., Bauer, Axel, Malik, Marek, Zabel, Markus, and Schmidt, Georg

Published
2021
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25. Predictors of atrial mechanical sensing and atrioventricular synchrony with a leadless ventricular pacemaker: Results from the MARVEL 2 Study

Author

Garweg, Christophe, Khelae, Surinder Kaur, Steinwender, Clemens, Chan, Joseph Yat Sun, Ritter, Philippe, Johansen, Jens Brock, Sagi, Venkata, Epstein, Laurence M., Piccini, Jonathan P., Pascual, Mario, Mont, Lluis, Willems, Rik, Sheldon, Todd, Splett, Vincent, Stromberg, Kurt, Wood, Nicole, and Chinitz, Larry

Published
2020
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29. Automated electrocardiographic quantification of myocardial scar in patients undergoing primary prevention implantable cardioverter-defibrillator implantation: Association with mortality and subsequent appropriate and inappropriate therapies

Author

Reichlin, Tobias, Asatryan, Babken, Vos, Marc A., Willems, Rik, Huikuri, Heikki V., Junttila, M. Juhani, Schlögl, Simon C., Hnatkova, Katerina, Schaer, Beat A., Malik, Marek, Zabel, Markus, and Sticherling, Christian

Published
2020
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32. The association of mechanical dyssynchrony and resynchronization therapy with survival in heart failure with a wide QRS complex: a two-world study

Author

Stankovic, Ivan, Stefanovic, Milica, Prinz, Christian, Ciarka, Agnieszka, Daraban, Ana Maria, Kotrc, Martin, Aarones, Marit, Szulik, Mariola, Winter, Stefan, Kukulski, Tomasz, Aakhus, Svend, Willems, Rik, Fehske, Wolfgang, Penicka, Martin, Faber, Lothar, Neskovic, Aleksandar N., and Voigt, Jens-Uwe

Published
2020
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34. Competitive athletes with implantable cardioverter–defibrillators—How to program? Data from the Implantable Cardioverter–Defibrillator Sports Registry

Author

Olshansky, Brian, Atteya, Gourg, Cannom, David, Heidbuchel, Hein, Saarel, Elizabeth V., Anfinsen, Ole-Gunnar, Cheng, Alan, Gold, Michael R., Müssigbrodt, Andreas, Patton, Kristen K., Saxon, Leslie A., Wilkoff, Bruce L., Willems, Rik, Dziura, James, Li, Fangyong, Brandt, Cynthia, Simone, Laura, Wilhelm, Matthias, and Lampert, Rachel

Published
2019
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35. Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy

Author

Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, and Zabel, Markus

Published
2018
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36. Serial Cardiac Magnetic Resonance Imaging in Patients with Mitral Valve Prolapse—A Single-Center Retrospective Registry.

Author

Blondeel, Maarten, L'Hoyes, Wouter, Robyns, Tomas, Verbrugghe, Peter, De Meester, Pieter, Dresselaers, Tom, Masci, Pier Giorgio, Willems, Rik, Bogaert, Jan, and Vandenberk, Bert

Subjects
CARDIAC magnetic resonance imaging, MITRAL valve prolapse, VENTRICULAR arrhythmia, VENTRICULAR tachycardia, PAPILLARY muscles
Abstract

Background: Mitral valve prolapse (MVP) and mitral annular disjunction (MAD) are common valvular abnormalities that have been associated with ventricular arrhythmias (VA). Cardiac magnetic resonance imaging (CMR) has a key role in risk stratification of VA, including assessment of late gadolinium enhancement (LGE). Methods: Single-center retrospective analysis of patients with MVP or MAD who had >1 CMR and >1 24 h Holter registration available. Data are presented in detail, including evolution of VA and presence of LGE over time. Results: A total of twelve patients had repeated CMR and Holter registrations available, of which in four (33%) patients, it was conducted before and after minimal invasive mitral valve repair (MVR). After a median of 4.7 years, four out of eight (50%) patients without surgical intervention had new areas of LGE. New LGE was observed in the papillary muscles and the mid to basal inferolateral wall. In four patients, presenting with syncope or high-risk non-sustained ventricular tachycardia (VT), programmed ventricular stimulation was performed and in two (50%), sustained monomorphic VT was easily inducible. In two patients who underwent MVR, new LGE was observed in the basal inferolateral wall of which one presented with an increased burden of VA. Conclusions: In patients with MVP and MAD, repeat CMR may show new LGE in a small subset of patients, even shortly after MVR. A subgroup of patients who presented with an increase in VA burden showed new LGE upon repeat CMR. VA in patients with MVP and MAD are part of a heterogeneous spectrum that requires further investigation to establish risk stratification strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Use of Real‐Time Cine MRI to Assess the Respirophasic Variation of the Inferior Vena Cava—Proof‐of‐Concept and Validation Against Transthoracic Echocardiography.

Author

Bogaert, Jan, Bekhuis, Youri, Rosseel, Thomas, Laveaux, Stijn, Dausin, Christophe, Voigt, Jens‐Uwe, Claessen, Guido, Dresselaers, Tom, La Gerche, André, Willems, Rik, Heidbüchel, Hein, De Bosscher, Ruben, Janssens, Kristel, Herbots, Lieven, Hespel, Peter, Mitchell, Amy, Brosnan, Maria, Prior, David, Claus, Piet, and Goetschalckx, Kaatje

Subjects
VENA cava inferior, MAGNETIC resonance imaging, ECHOCARDIOGRAPHY, PROOF of concept, INTRACLASS correlation
Abstract

Background: In clinical practice, the right heart filling status is assessed using the respirophasic variation of the inferior vena cava (IVC) assessed by transthoracic echocardiography (TTE) showing moderate correlations with the catheter‐based reference standard. Purpose: To develop and validate a similar approach using MRI. Study Type: Prospective. Population: 37 male elite cyclists (mean age 26 ± 4 years). Field Strength/Sequence: Real‐time balanced steady‐state free‐precession cine sequence at 1.5 Tesla. Assessment: Respirophasic variation included assessment of expiratory size of the upper hepatic part of the IVC and degree of inspiratory collapse expressed as collapsibility index (CI). The IVC was studied either in long‐axis direction (TTE) or using two transverse slices, separated by 30 mm (MRI) during operator‐guided deep breathing. For MRI, in addition to the TTE‐like diameter, IVC area and major and minor axis diameters were also assessed, together with the corresponding CIs. Statistical Tests: Repeated measures ANOVA test with Bonferroni correction. Intraclass correlation coefficient (ICC) and Bland–Altman analysis for intrareader and inter‐reader agreement. A P value <0.05 was considered statistically significant. Results: No significant differences in expiratory IVC diameter were found between TTE and MRI, i.e., 25 ± 4 mm vs. 25 ± 3 mm (P = 0.242), but MRI showed a higher CI, i.e., 76% ± 14% vs. 66% ± 14% (P < 0.05). As the IVC presented a noncircular shape, i.e., major and minor expiratory diameter of 28 ± 4 mm and 21 ± 4 mm, respectively, the CI varied according to the orientation, i.e., 63% ± 27% vs. 75% ± 16%, respectively. Alternatively, expiratory IVC area was 4.3 ± 1.1 cm2 and showed a significantly higher CI, i.e., 86% ± 14% than diameter‐based CI (P < 0.05). All participants showed a CI >50% with MRI versus 35/37 (94%) with TTE. ICC values ranged 0.546–0.841 for MRI and 0.545–0.704 for TTE. Conclusion: Assessment of the respirophasic IVC variation is feasible with MRI. Adding this biomarker may be of particular use in evaluating heart failure patients. Level of Evidence: 1 Technical Efficacy Stage: 2 [ABSTRACT FROM AUTHOR]

Published
2024
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39. Landmark Evolutions in Time and Indication for Cardiac Resynchronization Therapy: Results from a Multicenter Retrospective Registry.

Author

Bijnens, Jeroen, Trenson, Sander, Voros, Gabor, Martens, Pieter, Ingelaere, Sebastian, Betschart, Pascal, Voigt, Jens-Uwe, Dupont, Matthias, Breitenstein, Alexander, Steffel, Jan, Willems, Rik, Ruschitzka, Frank, Mullens, Wilfried, Winnik, Stephan, and Vandenberk, Bert

Subjects
CARDIAC pacing, HEART assist devices, BUNDLE-branch block, ATRIAL fibrillation, HEART failure patients, HEART transplantation
Abstract

Background: Cardiac resynchronization therapy (CRT) has evolved into an established therapy for patients with chronic heart failure and a wide QRS complex. Data on long-term outcomes over time are scarce and the criteria for implantation remain a subject of investigation. Methods: An international, multicenter, retrospective registry includes 2275 patients who received CRT between 30 November 2000 and 31 December 2019, with a mean follow-up of 3.6 ± 2.7 years. Four time periods were defined, based on landmark trials and guidelines. The combined endpoint was a composite of all-cause mortality, heart transplantation, or left ventricular assist device implantation. Results: The composite endpoint occurred in 656 patients (29.2%). The mean annual implantation rate tripled from 31.5 ± 17.4/year in the first period to 107.4 ± 62.4/year in the last period. In the adjusted Cox regression analysis, the hazard ratio for the composite endpoint was not statistically different between time periods. When compared to sinus rhythm with left bundle branch block (LBBB), a non-LBBB conduction pattern (sinus rhythm: HR 1.51, 95% CI 1.12–2.03; atrial fibrillation: HR 2.08, 95% CI 1.30–3.33) and a QRS duration below 130 ms (HR 1.64, 95% CI 1.29–2.09) were associated with a higher hazard ratio. Conclusions: Despite innovations, an adjusted regression analysis revealed stable overall survival over time, which can at least partially be explained by a shift in patient characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Long‐term outcome after upgrade to cardiac resynchronization therapy: A propensity score‐matched analysis.

Author

Trenson, Sander, Voros, Gabor, Martens, Pieter, Ingelaere, Sebastian, Betschart, Pascal, Voigt, Jens‐Uwe, Dupont, Matthias, Breitenstein, Alexander, Steffel, Jan, Willems, Rik, Ruschitzka, Frank, Mullens, Wilfried, Winnik, Stephan, and Vandenberk, Bert

Subjects
HEART assist devices, CARDIAC pacing, IMPLANTABLE cardioverter-defibrillators, PROPENSITY score matching, HEART failure patients, CARDIAC pacemakers, KIDNEY physiology
Abstract

Aim: Cardiac resynchronization therapy (CRT) is a cornerstone in the management of chronic heart failure in patients with a broad or paced QRS. However, data on long‐term outcome after upgrade to CRT are scarce. Methods and results: This international, multicentre retrospective registry included 2275 patients who underwent a de novo or upgrade CRT implantation with a mean follow‐up of 3.6 ± 2.7 years. The primary composite endpoint included all‐cause mortality, heart transplantation, or ventricular assist device implantation. The secondary endpoint was first heart failure admission. Multivariable Cox regression and propensity score matching (PSM) analyses were performed. Patients who underwent CRT upgrade (n = 605, 26.6%) were less likely female (19.7% vs. 28.8%, p < 0.001), more often had ischeemic cardiomyopathy (49.8% vs. 40.2%, p < 0.001), and had worse renal function (median estimated glomerular filtration rate 50.3 ml/min/1.73 m2 [35.8–69.5] vs. 59.9 ml/min/1.73 m2 [43.0–76.5], p < 0.001). The incidence rate of the composite endpoint was 10.8%/year after CRT upgrade versus 7.1%/year for de novo implantations (p < 0.001). PSM for the primary endpoint resulted in 488 pairs. After propensity score matching, upgrade to CRT was associated with a higher chance to reach the composite endpoint (multivariable hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.08–1.70), for both upgrade from pacemaker (multivariable HR 1.33, 95% CI 1.03–1.70) and implantable cardioverter‐defibrillator (ICD) (multivariable HR 1.40, 95% CI 1.01–1.95). PSM for the secondary endpoint resulted in 277 pairs. After PSM, upgrade to CRT was associated with a higher chance for heart failure admission (HR 1.74, 95% CI 1.26–2.41). Conclusion: In this retrospective analysis, the outcome of patients who underwent upgrades to CRT differed significantly from patients who underwent de novo CRT implantation, particularly for upgrades from ICD. Importantly, this difference in outcome does not imply a causal relation between therapy and outcome but rather a difference between two different patient populations. [ABSTRACT FROM AUTHOR]

Published
2024
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46. QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators.

Author

Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Vanderberk, Bert, Sprenkeler, David, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A., Friede, Tim, Bauer, Axel, Huikuri, Heikki V., Willems, Rik, Schmidt, Georg, Sticherling, Christian, Zabel, Markus, and Malik, Marek

Subjects
IMPLANTABLE cardioverter-defibrillators, HEART failure, CARDIAC pacing
Published
2024
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47. TEMPORARY REMOVAL: Lateral QRS amplitude is independently associated with outcome after cardiac resynchronization therapy: advancing patient selection?

Author

Trenson, Sander, Kahr, Peter C., Schwaiger, Judith M., Betschart, Pascal, Kuster, Joël, Vandenberk, Bert, Duchenne, Jürgen, Beela, Ahmed S., Stankovic, Ivan, Voros, Gabor, Flammer, Andreas J., Schindler, Matthias, Saguner, Ardan M., Willems, Rik, Ruschitzka, Frank, Steffel, Jan, Breitenstein, Alexander, Voigt, Jens-Uwe, and Winnik, Stephan

Published
2024
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50. Evolution of ventricular and valve function in patients with right ventricular pacing – A randomized controlled trial comparing leadless and conventional pacing.

Author

Garweg, Christophe, Duchenne, Jürgen, Vandenberk, Bert, Mao, Yankai, Ector, Joris, Haemers, Peter, Poels, Patricia, Voigt, Jens‐Uwe, and Willems, Rik

Subjects
HEART valve physiology, LEFT heart ventricle, ELECTRODES, ECHOCARDIOGRAPHY, CLINICAL trials, VENTRICULAR ejection fraction, TRICUSPID valve diseases, ARTIFICIAL implants, GLOBAL longitudinal strain, CARDIAC pacing, TREATMENT effectiveness, RANDOMIZED controlled trials, SEVERITY of illness index, DESCRIPTIVE statistics, RESEARCH funding, CARDIAC pacemakers, PEPTIDE hormones, PATIENT safety
Abstract

Background: Leadless pacemakers (PMs) were recently introduced to overcome lead‐related complications. They showed high safety and efficacy profiles. Prospective studies assessing long‐term safety on cardiac structures are still missing. Objective: The purpose of this study was to compare the mechanical impact of Micra with conventional PM on heart function. Methods: We conducted a non‐inferiority trial in patients with an indication for single chamber ventricular pacing. Patients were 1:1 randomized to undergo implantation of either Micra or conventional monochamber ventricular pacemaker (PM). Patients underwent echocardiography at baseline, 6 and 12 months after implantation. Analysis included left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) and valve function. N‐terminal‐pro hormone B‐type natriuretic peptide (NT‐pro‐BNP) levels were measured at baseline and 12 months. Results: Fifty‐one patients (27 in Micra group and 24 in conventional group) were included. Baseline characteristics were similar for both groups. At 12 months, (1) the left ventricular function as assessed by LVEF and GLS worsened similarly in both groups (∆LVEF −10 ± 7.3% and ∆GLS +5.7 ± 6.4 in Micra group vs. −13.4 ± 9.9% and +5.2 ± 3.2 in conventional group) (p = 0.218 and 0.778, respectively), (2) the severity of tricuspid valve regurgitation was significantly lower with Micra than conventional pacing (p = 0.009) and (3) median NT‐pro‐BNP was lower in Micra group (970 pg/dL in Micra group versus 1394 pg/dL in conventional group, p = 0.041). Conclusion: Micra is non inferior to conventional PMs concerning the evolution of left ventricular function at 12‐month follow‐up. Our data suggest that Micra has a comparable mechanical impact on the ventricular systolic function but resulted in less valvular dysfunction. [ABSTRACT FROM AUTHOR]

Published
2023
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