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Your search keyword '"Wehrfritz, Cameron"' showing total 7 results
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2. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

Author

Acuña-Catalán, Diego, Shah, Samah, Wehrfritz, Cameron, Nomura, Mitsunori, Acevedo, Alejandro, Olmos, Cristina, Quiroz, Gabriel, Huerta, Hernán, Bons, Joanna, Ampuero, Estibaliz, Wyneken, Ursula, Sanhueza, Magdalena, Arancibia, Felipe, Contreras, Darwin, Cárdenas, Julio César, Morales, Bernardo, Schilling, Birgit, Newman, John C., and González-Billault, Christian

Published
2024
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7. Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions.

Author

Rose, Jacob, Basisty, Nathan, Zee, Tiffany, Wehrfritz, Cameron, Bose, Neelanjan, Desprez, Pierre-Yves, Kapahi, Pankaj, Stoller, Marshall, and Schilling, Birgit

Subjects
BLADDER stones, LABORATORY mice, ANIMAL disease models, RIBOSOMAL proteins, BLOOD coagulation factors, BLOOD platelet aggregation
Abstract

Cystinuria is one of various disorders that cause biomineralization in the urinary system, including bladder stone formation in humans. It is most prevalent in children and adolescents and more aggressive in males. There is no cure, and only limited disease management techniques help to solubilize the stones. Recurrence, even after treatment, occurs frequently. Other than a buildup of cystine, little is known about factors involved in the formation, expansion, and recurrence of these stones. This study sought to define the growth of bladder stones, guided by micro-computed tomography imaging, and to profile dynamic stone proteome changes in a cystinuria mouse model. After bladder stones developed in vivo, they were harvested and separated into four developmental stages (sand, small, medium and large stone), based on their size. Data-dependent and data-independent acquisitions allowed deep profiling of stone proteomics. The proteomic signatures and pathways illustrated major changes as the stones grew. Stones initiate from a small nidus, grow outward, and show major enrichment in ribosomal proteins and factors related to coagulation and platelet degranulation, suggesting a major dysregulation in specific pathways that can be targeted for new therapeutic options. [ABSTRACT FROM AUTHOR]

Published
2022
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