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This study examined potential exercise-induced changes in sclerostin and in bone turnover markers in young women following two modes of high intensity interval exercise that involve impact (running) or no-impact (cycling). Healthy, recreationally active, females (n=20; 22.5±2.7 years) performed two exercise trials in random order: high intensity interval running (HIIR) on a treadmill and high intensity interval cycling (HIIC) on a cycle ergometer. Trials consisted of eight 1 min running or cycling intervals at ≥90% of maximal heart rate, separated by 1 min passive recovery intervals. Blood samples were collected at rest (pre-exercise) and 5 min, 1h, 24h, and 48h following each exercise trial. Serum was analyzed for sclerostin, cross linked telopeptide of type I collagen (CTXI), and procollagen type I amino-terminal propeptide (PINP). A significant time effect was found for sclerostin, which increased from pre-exercise to 5 min after exercise in both trials (100.2 to 131.6 pg/ml in HIIR; 102.3 to 135.8 pg/ml in HIIC, p<0.001) and returned to baseline levels by 1h, with no difference between exercise modes and no exercise mode-by-time interaction. CTXI did not significantly change following either trial. PINP showed an overall time effect following HIIR, but none of the post hoc pairwise comparisons were statistically significant. In young women, a single bout of high intensity exercise induces an increase in serum sclerostin, irrespective of exercise mode (impact versus no-impact), but this response is not accompanied by a response in either bone formation or resorption markers. [ABSTRACT FROM AUTHOR]

Horizontal winds in the mesosphere have been measured over Ascension Island (8° S, 14° W) in the tropical mid-Atlantic region throughout the years 2002-2011. The observations were made by a very high frequency (VHF) meteor radar. The observations reveal the presence of atmospheric tides of large amplitude. The observations are analysed to characterise the seasonal and interannual variability of the diurnal and semidiurnal tides. Monthly-mean diurnal tidal amplitudes are found to reach values as large as 48ms-1 in the meridional component and 41ms-1 in the zonal. A semiannual seasonal variation is found in diurnal tidal amplitudes with amplitude maxima at the equinoxes and amplitude minima at the solstices. Diurnal tidal meridional vertical wavelengths are generally in the range 24-30 km. The diurnal zonal vertical wavelengths are similar to the meridional, except for the winter months when the zonal vertical wavelengths are much longer, occasionally exceeding 100 km. Semidiurnal amplitudes are observed to be significantly smaller than diurnal amplitudes. Semidiurnal vertical wavelengths range from 20 to more than 100 km. Our observations of tidal amplitudes and phases are compared with the predictions of the extended Canadian Middle Atmosphere Model (eCMAM) and the Whole Atmosphere Community Climate Model (WACCM). Both eCMAM and WACCM reproduce the trend for greater diurnal amplitudes in the meridional component than the zonal. However, eCMAM tends to overestimate meridional amplitudes, while WACCM underestimates both zonal and meridional amplitudes. Vertical wavelength predictions are generally good for both models; however, eCMAM predicts shorter diurnal zonal vertical wavelengths than are observed in winter, while WACCM predicts longer zonal vertical wavelengths than observed for the semidiurnal tide for most months. Semidiurnal amplitude predictions are generally good for both models. It is found that larger-than-average diurnal and semidiurnal tidal amplitudes occur when the stratospheric quasi-biennial oscillation (QBO) at 10 hPa is eastwards, and smaller-than-average amplitudes occur when it is westwards. Correlations between the amplitude perturbations and the El Niño Southern Oscillation are also found. The precise mechanism for these correlations remains unclear. [ABSTRACT FROM AUTHOR]

Horizontal winds in the mesosphere have been measured over Ascension Island (8° S, 14° W) in the tropical mid-Atlantic region throughout the years 2002-2011. The observations were made by a VHF meteor radar. The results reveal the presence of atmospheric tides of large amplitude. The results are analysed to characterise the seasonal and interannual variability of the diurnal and semidiurnal tides. Monthly-mean diurnal tidal amplitudes are found to reach values as large as 48 m s-1 in the meridional component and 41 m s-1 in the zonal. A semiannual seasonal variation is found in diurnal-tidal amplitudes with amplitude maxima at the equinoxes and amplitude minima at the solstices. Diurnal tidal meridional vertical wavelengths are generally in the range 24-30 km. The diurnal zonal vertical wavelengths are similar to the meridional, except for the winter months when the zonal vertical wavelengths are much longer, occasionally exceeding 100 km. Semidiurnal amplitudes are observed to be significantly smaller than diurnal amplitudes. Semidiurnal vertical wavelengths range from 20 to more than 100 km. Our observations of tidal amplitudes and phases are compared with the predictions of the extended Canadian Middle Atmosphere Model (eCMAM) and the Whole Atmosphere Community Climate Model (WACCM). Both eCMAM and WACCM reproduce the trend for greater diurnal amplitudes in the meridional component than the zonal. However, in winter eCMAM tends to over-estimate meridional amplitudes, while WACCM under-estimates zonal and meridional amplitudes. Semidiurnal amplitude predictions are generally good for both models. Vertical wavelength predictions are also generally good for both models, however eCMAM predicts shorter zonal vertical wavelengths than observed for the diurnal tide in winter, while WACCM predicts longer zonal semidiurnal vertical wavelengths than observed for most months. It is found that larger-than-average diurnal and semidiurnal tidal amplitudes occur when the stratospheric QBO at 10 hPa is eastwards, and smaller-than-average amplitudes occur when it is westwards. However, the precise mechanism for this modulation of tidal amplitudes by the stratospheric QBO remains unclear. [ABSTRACT FROM AUTHOR]

The article focuses on a study which aims at analyzing the validation and calibration of the E-Region Wind Interferometer (ERWIN II). It informs that the ERWIN II combines imaging capabilities of a charge-couple device (CCD) detector and is associated with Michelson interferometry and describes the methodology of the study in which a data analysis algorithm is used to apply the imaging capabilities of the CCD detector.

Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 days of life results in higher bone mineral density (BMD), greater trabecular connectivity and higher peak load of lumbar vertebrae (LV) at adulthood. The effect of lengthening the duration of exposure to ISO on bone development has not been studied. This study determined if providing ISO for the first 21 days of life, which more closely mimics the duration that infants are fed soy protein formula, results in higher BMD, improved bone structure and greater strength in femurs and LV than a 5-day protocol. Female CD-1 mice were randomized to subcutaneous injections of ISO (7 mg/kg body weight/day) or corn oil from postnatal day 1 to 21. BMD, structure and strength were measured at the femur and LV at 4 months of age, representing young adulthood. At the LV, exposure to ISO resulted in higher (P < 0.05) BMD, trabecular connectivity and peak load compared with control (CON). Exposure to ISO also resulted in higher (P < 0.05) whole femur BMD, higher (P < 0.05) bone volume/total volume and lower (P < 0.05) trabecular separation at the femur neck, as well as greater (P < 0.05) peak load at femur midpoint and femur neck compared with the CON group. Exposure to ISO throughout suckling has favorable effects on LV outcomes, and, unlike previous studies using 5-day exposure to ISO, femur outcomes are also improved. Duration of exposure should be considered when using the CD-1 mouse to model the effect of early life exposure of infants to ISO. [ABSTRACT FROM PUBLISHER]

Operation of a Meteor Radar (MWR) at Eureka, Ellesmere Island (80° N, 86° W) began in February 2006: this is the location of the Polar Environmental and Atmospheric Research Laboratory (PEARL), operated by the "Canadian Network for the Detection of Atmospheric Change" (CANDAC). The first 36 months of tidal wind data (82-97 km) are here combined with contemporaneous tides from the Meteor Radar (MWR) at Adventdalen, Svalbard (78° N, 16° E), to provide the first significant evidence for interannual variability (IAV) of the High Arctic's diurnal and semidiurnal migrating (MT) and non-migrating tides (NMT). The three-year monthly means for both diurnal (DT) and semi-diurnal (SDT) winds demonstrate significantly different amplitudes and phases at Eureka and Svalbard. Typically the summer-maximizing DT is much larger (∼24ms-1 at 97 km) at Eureka, while the Svalbard tide (5-24ms-1 at 97 km)) is almost linear (north-south) rather than circular. Interannual variations are smallest in the summer and autumn months. The High Arctic SDT has maxima centred on August/September, followed in size by the winter features; and is much larger at Svalbard (24ms-1 at 97 km, versus 14-18ms-1 in central Canada). Depending on the location, the IAV are largest in spring/winter (Eureka) and summer/autumn (Svalbard). Fitting of wave-numbers for the migrating and nonmigrating tides (MT, NMT) determines dominant tides for each month and height. Existence of NMT is consis- tent with nonlinear interactions between migrating tides and (quasi) stationary planetary wave (SPW) S =1 (SPW1). For the diurnal oscillation, NMT s = 0 for the east-west (EW) wind component dominates (largest tide) in the late autumn and winter (November-February); and s =+2 is frequently seen in the north-south (NS) wind component for the same months. The semi-diurnal oscillation's NMT s =+1 dominates from March to June/July. There are patches of s =+3 and +1, in the late fall-winter. These wave numbers are also consistent with SPW1-MT interactions. Comparisons for 2007 of the observed DT and SDT at 78- 80° N, with those within the Canadian Middle Atmosphere Model Data Assimilation System CMAM-DAS, are a major feature of this paper. The diurnal tides for the two locations have important similarities as observed and modeled, with seasonal maxima in the mesosphere from April to October, and similar phases with long/evanescent wavelengths. However, differences are also significant: observed Eureka amplitudes are generally larger than the model; and at Svalbard the modeled tide is classically circular, rather than anomalous. For the semi-diurnal tide, the amplitudes and phases differ markedly between Eureka and Svalbard for both MWR-radar data and CMAM-DAS data. The seasonal variations from observed and modeled archives also differ at each location. Tidal NMT-amplitudes and wave-numbers for the model differ substantially from observations. [ABSTRACT FROM AUTHOR]

Operation of a Meteor Wind Radar (MWR) at Eureka, Ellesmere Island (80° N, 86° W) began in February 2006; this is the location of the Polar Environmental and Atmospheric Research Laboratory (PEARL), operated by the "Canadian Network for the Detection of Atmospheric Change" (CANDAC). The first 36 months of wind data (82- 97 km) are here combined with contemporaneous winds from the Meteor Wind Radar at Adventdalen, Svalbard (78° N, 16° E), to provide the first evidence for substantial interannual variability (IAV) of longitudinally spaced observations of mean/background winds and waves at such High Arctic latitudes. The influences of "Sudden Stratospheric Warmings" (SSW) are also apparent. Monthly meridional (north-south, NS) 3-year means for each location/radar demonstrate that winds (82-97 km) differ significantly between Canada and Norway, with winterequinox values generally northward over Eureka and southward over Svalbard. Using January 2008 as case study, these oppositely directed meridional winds are related to mean positions of the Arctic mesospheric vortex. The vortex is from the Canadian Middle Atmosphere Model, with its Data Assimilation System (CMAM-DAS). The characteristics of "Sudden stratospheric Warmings" SSW in each of the three winters are noted, as well as their uniquely distinctive shortterm mesospheric wind disturbances. Comparisons of the mean winds over 36 months at 78 and 80_ N, with those within CMAM-DAS, are featured. E.g. for 2007, while both monthly mean EW and NS winds from CMAM/radar are quite similar over Eureka (82-88 km), the modeled autumn-winter NS winds over Svalbard (73-88 km) differ significantly from observations. The latter are southward, and the modeled winds over Svalbard are predominately northward. The mean positions of the winter polar vortex are related to these differences. [ABSTRACT FROM AUTHOR]

Nitric acid (HNO3) is one of the key products that are operationally retrieved by the European Space Agency (ESA) from the emission spectra measured by the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) onboard ENVISAT. The product version 4.61/4.62 for the observation period between July 2002 and March 2004 is validated by comparisons with a number of independent observations from ground-based stations, aircraft/balloon campaigns, and satellites. Individual HNO3 profiles of the ESA MIPAS level-2 product show good agreement with those of MIPAS-B and MIPAS-STR (the balloon and aircraft version of MIPAS, respectively), and the balloon-borne infrared spectrometers MkIV and SPIRALE, mostly matching the reference data within the combined instrument error bars. In [ABSTRACT FROM AUTHOR]