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Due to the interaction between the planning and operation of micro energy network, considering the operation optimization can better play the role of micro energy network. But due to the influence of various uncertainties, the deterministic programming solution may be sub‐optimal. In this context, the two‐stage stochastic programming of micro energy network is of great significance. In this paper, from the perspective of electric energy, the closely related P2G, storage system and fuel cell are modeled as a whole, so that the model is simplified to a certain extent. Stochastic scenarios that considers multiple uncertain factors are constructed considering the correlation between electricity demand, wind speed and solar radiation intensity. And a two‐stage stochastic programming model of micro energy network is established. Through the case study, the influence of P2GSS on micro energy network planning under uncertainty environment as well as the difference between stochastic programming and deterministic programming of micro energy network is analyzed. The simulation results show that P2GSS can reduce the economic cost and CO2 emission of micro energy network planning solution. Through the comparison of different planning schemes, it can provides a reference for the planning and construction of the micro‐energy network. [ABSTRACT FROM AUTHOR]

Other rare cutaneous side effects like keratoacanthomas and serum sickness-like reaction have also been reported.4-6 To date severe drug reactions such as EM, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been unreported in the English literature. Erythema multiforme-like drug eruption associated with dupilumab treatment: Report of an unusual case Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by polymorphous eruption and pruritus, while persistent scratching results in lichenification and prurigo nodularis (PN). [Extracted from the article]

In Zaozhuang, economic development affects the discharge amount of industrial wastewater, chemical oxygen demand (COD), and ammonia nitrogen (NH-N). To reveal the trend of water environmental quality related to the economy in Zaozhuang, this paper simulated the relationships between industrial wastewater discharge, COD, NH-N load, and gross domestic product (GDP) per capita for Zaozhuang (2002-2012) using environmental Kuznets curve (EKC) models. The results showed that the added value of industrial GDP, the per capita GDP, and wastewater emission had average annual growth rates of 16.62, 16.19, and 17.89 %, respectively, from 2002 to 2012, while COD and NH-N emission in 2012, compared with 2002, showed average annual decreases of 10.70 and 31.12 %, respectively. The export of EKC models revealed that industrial wastewater discharge had a typical inverted-U-shaped relationship with per capita GDP. However, both COD and NH-N showed the binding curve of the left side of the 'U' curve and left side U-shaped curve. The economy in Zaozhuang had been at the 'fast-growing' stage, with low environmental pollution according to the industrial pollution level. In recent years, Zaozhuang has abated these heavy-pollution industries emphatically, so pollutants have been greatly reduced. Thus, Zaozhuang industrial wastewater treatment has been quite effective, with water quality improved significantly. The EKC models provided scientific evidence for estimating industrial wastewater discharge, COD, and NH-N load as well as their changeable trends for Zaozhuang from an economic perspective. [ABSTRACT FROM AUTHOR]

Aim:Carbonaceous dots (CDs), which have been used for diagnosis, drug delivery and gene delivery, are accumulated in heart at high concentrations. To improve their biocompatibility, polyethylene glycol-modified CDs (PEG-CDs) were prepared. In this study we compared the cardiac toxicity of CDs and PEG-CDs in mouse and zebrafish models.Methods:Mice were intravenously treated with CDs (size: 4.9 nm, 5 mg·kg−1·d−1) or PEG-CDs (size: 8.3 nm, 5 mg·kg−1·d−1) for 21 d. Their blood biochemistry indices, ECG, and histological examination were examined for evaluation of cardiac toxicity. CDs or PEG-CDs was added in incubator of cmlc2 transgenic Zebrafish embryos at 6 hpf, and the shape and size of embryos' hearts were observed at 48 hpf using a fluorescent microscope. Furthermore, whole-mount in situ hybridization was used to examine the expression of early cardiac marker gene (clml2) at 48 hpf.Results:Administration of CDs or PEG-CDs in mice caused mild, but statistically insignificant reduction in serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels detected at 7 d, which were returned to the respective control levels at 21 d. Neither CDs nor PEG-CDs caused significant changes in the morphology of heart cells. Administration of CDs, but not PEG-CDs, in mice caused marked increase of heart rate. Both CDs and PEG-CDs did not affect other ECG parameters. In the zebrafish embryos, addition of CDs (20 μg/mL) caused heart development delay, whereas addition of CDs (80 μg/mL) led to heart malformation. In contrast, PEG-CDs caused considerably small changes in heart development, which was consistent with the results from the in situ hybridization experiments.Conclusion:CDs causes greater cardiac toxicity, especially regarding heart development. Polyethylene glycol modification can attenuate the cardiac toxicity of CDs. [ABSTRACT FROM AUTHOR]

ABSTRACT Greater exposure to Pb(Ⅱ) increases the likelihood of harmful effects in the environment. In this study, the aquatic unicellular alga Chlorella protothecoides ( C. protothecoides) and Chlorella vulgaris ( C. vulgaris) were chosen to assess the acute and chronic toxicity of Pb(Ⅱ) exposure. Results of the observations show dose-response relationships could be clearly observed between Pb(Ⅱ) concentration and percentage inhibition (PI). Exposure to Pb(Ⅱ) increased malondialdehyde (MDA) content by up to 4.22 times compared with the control, suggesting that there was some oxidative damage. ANOVA analysis shows that Pb(Ⅱ) decreased chlorophyll (chl) content, indicating marked concentration-dependent relationships, and the lowest levels of chl a, chl b, and total-chl were 14.53, 18.80, and 17.95% of the controls, respectively. A real-time PCR assay suggests the changes in transcript abundances of three photosynthetic-related genes. After 120 h exposure Pb(Ⅱ) reduced the transcript abundance of rbcL, psaB, and psbC, and the relative abundances of the three genes of C. protothecoides and C. vulgaris in response to Pb(Ⅱ) were 54.66-98.59, 51.68-95.59, 37.89-95.48, 36.04-94.94, 41.19-91.20, and 58.75-96.80% of those of the controls, respectively. As for 28 d treatments, the three genes displayed similar inhibitory trend. This research provides a basic understanding of Pb(Ⅱ) toxicity to aquatic organisms. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 1346-1354, 2014. [ABSTRACT FROM AUTHOR]

Over several decades, studies of the relationship between task conflict and team innovation have yielded mixed findings. In the present study, drawing on the resource-based view (RBV), we consider that task conflict can activate a dynamic pool of knowledge resources and argue that the impact of task conflict on team innovation is dependent upon the knowledge integration capacity of a team, which is defined as a team’s ability to effectively combine, capitalize, and utilize the resource pool. A study of 59 teams revealed that, in general, task conflict and team innovation exhibit an inverted U-shape relationship, which was moderated by knowledge integration capability. The implications of our findings with respect to conflict research and conflict management are discussed. [ABSTRACT FROM AUTHOR]

This study explores the extent to which employee turnover, a proxy variable to employee loyalty, helps mediate the relationship between Taiwanese firms' corporate social responsibility (CSR) performance and financial outcome. The results show that a firm's CSR performance is negatively correlated with employee turnover and turnover variability, and moreover, employee turnover is negatively correlated with a firm's financial performance. The result is especially noteworthy for studies regarding Taiwanese companies since quite a few of them are original equipment manufacturers (hereafter also referred to as OEMs), of intermediate goods. For the sample firms, although the contribution of social responsibility appears to have insignificantly direct benefit on financial performance, we document that the extent to which CSR conducts influence on long-term financial outcomes may be moderated and mediated by employee enthusiasm. [ABSTRACT FROM AUTHOR]

The rational design of carbonaceous hybrid nanostructures is very important for obtaining high photoactivity. TiO2 particles strewn with an optimal quantity of carbon nanodots have a much higher photoactivity than that of TiO2 covered with a carbon layer, showing the importance of carbon morphology in the photocatalysis of carbonaceous hybrid nanostructures. [ABSTRACT FROM AUTHOR]

Because of its novel physical properties, two-dimensional materials have attracted great attention. From first-principle calculations and vibration frequencies analysis, we predict a new family of two-dimensional materials based on the idea of octet stability: honeycomb lattices of pnictogens (N, P, As, Sb, Bi). The buckled structures of materials come from the sp3 hybridization. These materials have indirect band gap ranging from 0.43 eV to 3.7 eV. From the analysis of projected density of states, we argue that the s and p orbitals together are sufficient to describe the electronic structure under tight-binding model, and the tight-binding parameters are obtained by fitting the band structures to first-principle results. Surprisingly large on-site spin-orbit coupling is found for all the pnictogen lattices except nitrogen. Investigation on the electronic structures of both zigzag and armchair nanoribbons reveals the possible existence of spin-polarized ferromagnetic edge states in some cases, which are rare in one-dimensional systems. These edge states and magnetism may exist under the condition of high vacuum and low temperature. This new family of materials would have promising applications in electronics, optics, sensors, and solar cells. [ABSTRACT FROM AUTHOR]

In the purpose of expanding the family of two-dimensional materials, we predict the existence of two-dimensional octa-structure of nitrogen group elements that are composed of squares and octagons in first-principle method based on density functional theory (DFT). From our calculations, electronic structures of all monolayers show that they are semiconductors with indirect (N, P, Bi) and direct (As, Sb) band gaps (0.57–2.61 eV). Nano-ribbons of three different unpassivated edges and their band structures are also investigated. Because of the reconstruction on the edges and dangling bonds, there exist ferromagnetic edge states in P, As, Sb nano-ribbons with different edges, and a Dirac point near π is found in the band structure of one specific N nano-ribbon. These structures may be useful in future applications, such as semiconductor devices, spintronics, hydrogen storage and quantum computation. [ABSTRACT FROM AUTHOR]

Phosphoric acid-modified biochar (PMBC) was prepared using biochar (BC) as the carbon source and phosphoric acid as the activating agent. The PMBC exhibited an ordered vessel structure after deashing treatment, but the sidewalls became much rougher, the polarity (O/C atomic ratio of BC = 0.2320 and O/C atomic ratio of PMBC = 0.1604) decreased, and the isoelectric points (PI of BC = 5.22 and PI of PMBC = 5.51) and specific surface area (SSA of BC = 55.322 m 2 /g and SSA of PMBC = 62.285 m 2 /g) increased. The adsorption characterization of the removal of sulfadiazine (SDZ) from PMBC was studied. The adsorption of SDZ by PMBC was in accordance with the Langmuir isotherm model and the pseudo-second-order kinetics model, and the adsorption thermodynamics were shown as Gibbs free energy < 0, an enthalpy change of 19.157 kJ/mol, and an entropy change of 0.0718 kJ/(K·mol). The adsorption of SDZ by PMBC was a complicated monolayer adsorption that was spontaneous, irreversible, and endothermic, and physical adsorption and chemical adsorption occurred simultaneously. The adsorption process was controlled by microporous capture, electrostatic interactions, hydrogen-bond interactions, and π-π interactions. PMBC@TiO 2 photocatalysts with different mass ratios between TiO 2 and PMBC were prepared via the in situ sol-gel method. PMBC@TiO 2 exhibited both an ordered vessel structure (PMBC) and irregular particles (TiO 2 ), and it was linked via Ti-O-C bonds. The optimal mass ratio between TiO 2 and PMBC was 3:1. The removal of SDZ via PMBC@TiO 2 was dependent on the coupling of adsorption and photocatalysis. The PMBC-enhanced photocatalytic performance of PMBC@TiO 2 resulted in a higher absorption of UV and visible light, greater generation of reactive oxygen species, high levels of adsorption of SDZ on PMBC, and the conjugated structure and oxygen-containing functional groups that promoted the separation efficiency of the hole-electron pairs.

Aim: Our preliminary results show that huperzine A, an acetylcholinesterase inhibitor used to treat Alzheimer's disease (AD) patients in China, exhibits different pharmacokinetic features in elderly and young healthy subjects. However, its pharmacokinetic data in elderly subjects remains unavailable to date. Thus, we developed a population pharmacokinetic (PPK) model of huperzine A in elderly Chinese people, and identified the covariate affecting its pharmacokinetics for optimal individual administration., Methods: A total of 341 serum huperzine A concentration records was obtained from 2 completed clinical trials (14 elderly healthy subjects in a phase I pharmacokinetic study; 35 elderly AD patients in a phase II study). Population pharmacokinetic analysis was performed using the non-linear mixed-effect modeling software Phoenix NLME1.1.1. The effects of age, gender, body weight, height, creatinine, endogenous creatinine clearance rate as well as drugs administered concomitantly were analyzed. Bootstrap and visual predictive checks were used simultaneously to validate the final population pharmacokinetics models., Results: The plasma concentration-time profile of huperzine A was best described by a one-compartment model with first-order absorption and elimination. Age was identified as the covariate having significant influence on huperzine A clearance. The final PPK model of huperzine A was: CL (L/h)=2.4649(*)(age/86)((-3.3856)), Ka=0.6750 h(-1), V (L)=104.216. The final PPK model was demonstrated to be suitable and effective by the bootstrap and visual predictive checks., Conclusion: A PPK model of huperzine A in elderly Chinese subjects is established, which can be used to predict PPK parameters of huperzine A in the treatment of elderly AD patients.

Background: Highly cross-linked polyethylene (HXLPE) has been reported as an effective material for decreasing polyethylene wear and osteolysis in total knee arthroplasty (TKA). Because no single study to date has been large enough to definitively determine the benefit of HXLPE in TKA, we conducted a meta-analysis to pool the results from randomized controlled trials (RCTs) and non-RCTs to make such a determination., Methods: Potential candidate articles were identified by searching the Cochrane Library, Medline (1966-2015.10), PubMed (1966-2015.10), Embase (1980-2015.10), ScienceDirect (1985-2015.10), and other databases. "Gray studies" were identified from the included articles' reference lists. Pooled data were analyzed using RevMan 5.1., Results: Three RCTs and three non-RCTs were included in the meta-analysis. There were no significant differences between the groups in the total number of reoperations (P = 0.11), reoperations for prosthesis loosening (P = 0.08), radiolucent line (P = 0.20), osteolysis (P = 0.38), prosthesis loosening (P = 0.10), and mechanical failures related to the tibial polyethylene (P = 1.00). Similarly, no significant differences between the two groups were found in postoperative total knee score (P = 0.18) or functional score (P = 0.23)., Conclusions: The meta-analysis showed that compared with conventional polyethylene, HXLPE did not improve the clinical and radiographic outcomes in mid-term follow-up after TKA. Additional high-quality multicenter prospective RCTs with good design, large study populations and long-term follow-up will be necessary to further clarify the effect of HXLPE in TKA.

The rational design of carbonaceous hybrid nanostructures is very important for obtaining high photoactivity. TiO2 particles strewn with an optimal quantity of carbon nanodots have a much higher photoactivity than that of TiO2 covered with a carbon layer, showing the importance of carbon morphology in the photocatalysis of carbonaceous hybrid nanostructures.