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The Act Belong Commit ® mental health promotion campaign aims to improve population mental well-being. Based on a social-franchising model, partnerships are sought with organizations offering 'mentally healthy activities' that foster social connectedness and mental well-being. There are four categories of partner organizations sought: Site (government agencies and health services), Associate (organizations with state-wide or national services), Community (local, grass-roots community groups) and Schools. This research explored organizational perceptions of the Act Belong Commit ® Partnership Program. A purposive sample of 14 organizational representatives across all four partner categories participated in semi-structured interviews online or face-to-face between July and September 2021. Reflexive thematic analysis was used to identify three main themes: (a) A passion for promoting mental health; (b) Implementation, innovation, adaption and creation (e.g. the ability to adapt, create and deliver activities aligned with the campaign message; and (c) Future sustainability (e.g. recommendations for the sustainability of the programme). The use of reflexive thematic analysis enabled deeper insights into the complexity of the partnerships. Findings describe how the Act Belong Commit ® Partnership Program supports mutually desirable objectives and extends the campaign reach. Embedded in a shared belief system that incorporates a passion for good mental health, the model supports the flexibility to adapt, create and deliver fit-for-purpose activities that promote mental well-being in the places where people live, work and play. [ABSTRACT FROM AUTHOR]

The linear stability of plane Couette flow subject to one rigid boundary and one flexible boundary is considered at both finite and asymptotically large Reynolds number. The wall flexibility is modelled using a very simple Hooke-type law involving a spring constant K and is incorporated into a boundary condition on the appropriate Orr–Sommerfeld eigenvalue problem. This problem is analyzed at large Reynolds number by the method of matched asymptotic expansions and eigenrelations are derived that demonstrate the existence of neutral modes at finite spring stiffness, propagating with speeds close to that of the rigid wall and possessing wavelengths comparable to the channel width. A large critical value of K is identified at which a new short wavelength asymptotic structure comes into play that describes the entirety of the linear neutral curve. The asymptotic theories compare well with finite Reynolds number Orr–Sommerfeld calculations and demonstrate that only the tiniest amount of wall flexibility is required to destabilize the flow, with the linear neutral curve for the instability emerging as a bifurcation from infinity. [ABSTRACT FROM AUTHOR]

This article contributes to normative debates about residential segregation and its relationship to inequality. It defends a position often disregarded in literature: that there is merit to advancing residential integration through some scenarios where advantaged individuals move to disadvantaged areas. It develops this case in dialogue with three other views. In relation to advocates of addressing the inequalities of residential segregation through redistribution, it defends integration as a means of tackling social and political factors that sustain injustice. It challenges those who defend relocating disadvantaged individuals to advantaged areas by highlighting the burdens and demand for cultural assimilation this imposes on the disadvantaged. It considers the worry that advantaged individuals relocating to disadvantaged areas harbours the problematic features of gentrification. It responds that these concerns, while important in some cases, do not arise in all scenarios of this kind. [ABSTRACT FROM AUTHOR]

Wind tunnel tests are reported that investigate three aspects of aerodynamic flows through battle damaged airfoils. The first aspect investigated was the effect of camber. This showed that reducing camber weakened the strength of the jet flow through the damage and delayed the onset of strong jet flows to higher incidences. The second investigation used five hole probe measurements to survey the flow field on a battle damaged flat plate airfoil. The measurements indicated that the use of the jet-to-freestream velocity ratio is a poor criteria for determining whether damage flows have undergone transition to strong jets. Finally, the influence of a star shaped hole to simulate more realistic battle damage was investigated. It was shown that in terms of damage flow characteristics and changes in lift, drag, and pitching moment coefficients, the use of a circular hole is a reasonable simulation of battle damage. DOI: 10.2514/1.24144

A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is characterized by profound apoptosis‐induced depletion of CD4 and CD8 T cells and severely impaired T cell function. OX40, a member of the TNF receptor superfamily, is a positive co‐stimulatory molecule expressed on activated T cells. When engaged by OX40 ligand, OX40 stimulates T cell proliferation and shifts the cellular immune phenotype toward TH1 with increased production of cytokines that are essential for control of invading pathogens. The purpose of the present study was to determine if administration of agonistic Ab to OX40 could reverse sepsis‐induced immunosuppression, restore T cell function, and improve survival in a clinically relevant animal model of sepsis. The present study demonstrates that OX40 agonistic Ab reversed sepsis‐induced impairment of T cell function, increased T cell IFN‐γ production, increased the number of immune effector cells, and improved survival in the mouse cecal ligation and puncture model of sepsis. Importantly, OX40 agonistic Ab was not only effective in murine sepsis but also improved T effector cell function in PBMCs from patients with sepsis. The present results provide support for the use of immune adjuvants that target T cell depletion and T cell dysfunction in the therapy of sepsis‐induced immunosuppression. In addition to the checkpoint inhibitors anti‐PD‐1 and anti‐PD‐L1, OX40 agonistic Ab may be a new therapeutic approach to the treatment of this highly lethal disorder. [ABSTRACT FROM AUTHOR]

One prominent feature of the contemporary world is international trade: a regularized pattern of cross-border exchanges of goods and services facilitated and regulated by a set of rules and norms. Country A and Country B agree to participate in a structured trade system creating gains that would not exist without the arrangement - an amount of (opportunities to produce) wealth beyond what would exist if both countries were autarkic or, anyhow, not engaged in trade. This includes concern for the distribution of the gains of trade, but does not include concern for poverty reduction, development, and wider moral issues - these, James argues, are "not the generally understood and accepted aim[s] of trade". 54 See Kurjanska and Risse, "Fairness in trade II"; Risse, I On Global Justice i ; Risse and Wollner, "Three images of trade". [Extracted from the article]

Reports on a collaborative theoretical and experimental study of the structure and electronic excitation spectrum of the boron atom with rare gases. Features in the fluorescence excitation spectrum; Determining the lowest vibrational state of the boron atom cluster; Simulation of the fluorescence excitation spectrum.

A total of 514 individuals from the Sydney area volunteered their fingerprint scans for analysis. The prints were classified using the eight main patterns of the National Crime Information Centre system. Additional information from the volunteers, including sex and ancestry, was documented. Using this information, the frequencies of each pattern for each biogeographical ancestry (BGA) group and sex were calculated. Trends showed that males and females have a difference in the frequency of plain arches; none of the other patterns showed clear differentiation. BGA trends showed that European and Middle Eastern groups had more similar frequencies for the less common patterns (plain arch, tented arch, radial loop, central pocket loop whorl and double loop whorl). Whereas for the common patterns of ulnar loop and plain whorl, European and South Asian groups were more similar in frequency. [ABSTRACT FROM AUTHOR]

Background: Multidrug resistant (MDR) bacterial pathogens are a serious problem of increasing importance facing the medical community. MDR bacteria typically infect the most immunologically vulnerable: patients in intensive care units, patients with extensive comorbidities, oncology patients, hemodialysis patients, and other immune suppressed individuals are likely to fall victim to these pathogens. One promising novel approach to treatment of MDR bacteria is immuno-adjuvant therapy to boost patient immunity. Success with this strategy would have the major benefit of providing protection against a number of MDR pathogens. Objectives: This study had two main objectives. First, immunophenotyping of peripheral blood mononuclear cells from patients with sepsis associated with MDR bacteria was performed to examine for findings indicative of immunosuppression. Second, the ability of three immuno-adjuvants with distinct mechanisms of action to reverse CD4 and CD8 T cell dysfunction, a pathophysiological hallmark of sepsis, was evaluated. Results: Septic patients with MDR bacteria had increased expression of the inhibitory receptor PD-1 and its ligand PD-L1 and decreased monocyte HLA-DR expression compared to non-septic patients. All three immuno-adjuvants, IL-7, anti-PD-L1, and OX-40L, increased T cell production of IFN-γ in a subset of septic patients with MDR bacteria: IL-7 was most efficacious. There was a strong trend toward increased mortality in patients whose T cells failed to increase IFN-γ production in response to the three treatments. Conclusion: Immuno-adjuvant therapy reversed T cell dysfunction, a key pathophysiological mechanism in septic patients with MDR bacteria. [ABSTRACT FROM AUTHOR]

Plane Poiseuille flow has long served as the simplest testing ground for Tollmien--Schlichting wave instability. In this paper, we provide a comprehensive comparison of equilibrium Tollmien--Schlichting wave solutions arising from new high-resolution Navier--Stokes calculations and the corresponding predictions of various large- Reynolds-number asymptotic theories developed in the last century, such as doubledeck theory, viscous nonlinear critical layer theory and strongly nonlinear critical layer theory. In the relatively small to moderate amplitude regime, the theories excellently predict the behaviour of the numerical solutions at Reynolds numbers of order 106 and above, whilst for larger amplitudes our computations suggest the need for further asymptotic theories to be developed. [ABSTRACT FROM AUTHOR]

A self-sustaining interaction between a roll/streak structure and a three-dimensional Tollmien-Schlichting wave is considered at high-Reynolds-number within the asymptotic suction boundary layer. Strongly nonlinear governing equations, taking the form of a vortex-wave interaction (VWI) are derived and solved numerically. Finite amplitude travelling wave states, bifurcating from the lower branch of the linear neutral curve, are obtained. These states exhibit spanwise focusing, developing steep wall-shear gradients at specific spanwise locations as the wave amplitude rises. A spanwise-local analytic analysis reveals explicitly how the solution gradually loses regularity as the nonlinearity of the VWI system is increased. [ABSTRACT FROM AUTHOR]

This paper explores the political structures suitable for the realization of John Rawls’The Law of Peoples(1999). In particular, it explores whether Rawls’ principles and fundamental foundations recommend establishing global institutions and, if so, whether, and in what sense, these institutions should be democratic. It is often suggested, either implicitly or explicitly, thatThe Law of Peopleswould operate through the bilateral and multilateral interactions of, ideally conceived, nation-states. This paper argues, on the contrary, that it would advise a series of democratic global institutions. The case is developed with respect to the idea of a global institution with the remit of regulating international trade and applied, in the contemporary context, to the World Trade Organization (WTO). [ABSTRACT FROM PUBLISHER]