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In the context of continuous globalization, how to put the cross-border mobile population under the rule of law for innovative management, it is a much-needed pathway to find in today’s society. This paper proposes to improve the legislation, establish a data platform, management strategies for creating bilateral educational cooperation models. Information fusion using maximum likelihood and least squares methods, collating and analyzing data from multiple sources, innovative governance strategies for cross-border mobile populations. To improve the social integration of cross-border mobile populations at the level of social integration, social recognition, etc. Safeguard social stability at the border. For example, the creation of a bilateral educational cooperation model, it has been proved by experimental results that education helps to improve the local living conditions of cross-border mobile populations. If more education could be made available to the mobile, would allow for broader career options for cross-border mobile populations, increase their social inclusion level by 9 percent, and increase their intention to stay locally by 0.9 percentage points. Provides a good internal environment for its integration, enhancing the stability of cross-border mobile population migration, it is of great significance to the social stability of the border area.

Parental selection is important for heterosis formation during crossbreeding of Populus. However, in poplar hybrids, the effect of parents on vegetative growth heterosis is not well understood. In this study, one female parent (P. simonii XY4) and two male parents (P. nigra OH and P. deltoides × P. nigra BJLY3#) were used to produce two progenies (Hyb1 and Hyb2). Vegetative growth investigation showed that both Hyb1 and Hyb2 performed heterosis in plant growth and ground diameter. The vegetative growth of hybrids was strongly correlated with the male parents but not with the female parents. The gene expression levels in the hybrids were more biased toward the male parents. In Hyb1 and Hyb2, 51.93% and 45.03% of the expressed genes showed the non-additive effect, respectively, and over 65% of the non-additively expressed genes showed the dominant effect. It is noteworthy that genes of paternal expression dominant effect (ELD_♂) account for the majority of dominantly expressed genes, suggesting the paternal contribution to heterosis. KEGG enrichment analysis indicated that a large number of non-additively expressed genes were enriched in the plant hormone signal transduction pathway. WGCNA analysis showed that MEcyan was significantly correlated with the traits of hybrids, and 12 plant hormone signal transduction pathway genes were enriched in this module. Transcription factors (TFs) MYB88, LHY, and TCP4 may be involved in the regulation of these pathway genes. This finding supported that the male parents play an important role in the formation of vegetative growth heterosis of Populus. In addition, the non-additively expressed genes of the signal transduction pathway and the regulation of TFs related to these pathway genes may be one of the reasons for the generation of heterosis. [ABSTRACT FROM AUTHOR]

The red panda (Ailurus fulgens) is a distinctive mammal known for its reliance on a diet primarily consisting of bamboo. The gut microbiota and overall health of animals are strongly influenced by diets and environments. Therefore, conducting research to explore the taxonomical and functional variances within the gut microbiota of red pandas exposed to various dietary and environmental conditions could shed light on the dynamic complexities of their microbial communities. In this study, normal fecal samples were obtained from red pandas residing in captive and semi‐free environments under different dietary regimes and used for metabolomic, 16S rRNA, and metagenomic sequencing analysis, with the pandas classified into four distinct cohorts according to diet and environment. In addition, metagenomic sequencing was conducted on mucus fecal samples to elucidate potential etiological agents of disease. Results revealed an increased risk of gastrointestinal diseases in red pandas consuming bamboo shoots due to the heightened presence of pathogenic bacteria, although an increased presence of microbiota‐derived tryptophan metabolites appeared to facilitate intestinal balance. The red pandas fed bamboo leaves also exhibited a decrease in gut microbial diversity, which may be attributed to the antibacterial flavonoids and lower protein levels in leaves. Notably, red pandas residing in semi‐free environments demonstrated an enriched gut microbial diversity. Moreover, the occurrence of mucus secretion may be due to an increased presence of species associated with diarrhea and a reduced level of microbiota‐derived tryptophan metabolites. In summary, our findings substantiate the influential role of diet and environment in modulating the gut microbiota of red pandas, offering potential implications for improved captive breeding practices. [ABSTRACT FROM AUTHOR]

The treatment of diabetic periodontitis poses a significant challenge due to the presence of local inflammation characterized by excessive glucose concentration, bacterial infection, and high oxidative stress. Herein, mesoporous silica nanoparticles (MSN) are embellished with gold nanoparticles (Au NPs) and loaded with manganese carbonyl to prepare a carbon monoxide (CO) enhanced multienzyme cooperative hybrid nanoplatform (MSN‐Au@CO). The Glucose‐like oxidase activity of Au NPs catalyzes the oxidation of glucose to hydrogen peroxide (H2O2) and gluconic acid，and then converts H2O2 to hydroxyl radicals (•OH) by peroxidase‐like activity to destroy bacteria. Moreover, CO production in response to H2O2, together with Au NPs exhibited a synergistic anti‐inflammatory effect in macrophages challenged by lipopolysaccharides. The underlying mechanism can be the induction of nuclear factor erythroid 2‐related factor 2 to reduce reactive oxygen species, and inhibition of nuclear factor kappa‐B signaling to diminish inflammatory response. Importantly, the antibacterial and anti‐inflammation effects of MSN‐Au@CO are validated in diabetic rats with ligature‐induced periodontitis by showing decreased periodontal bone loss with good biocompatibility. To summarize, MSN‐Au@CO is fabricate to utilize glucose‐activated cascade reaction to eliminate bacteria, and synergize with gas therapy to regulate the immune microenvironment, offering a potential direction for the treatment of diabetic periodontitis. [ABSTRACT FROM AUTHOR]

Polyploidization produces abundant phenotypic variation. Little is currently known about adventitious root (AR) development variation due to polyploidization. In this study, we analyzed the morphological, cytological, and physiological variations in AR development between tetraploid and diploid Populus plants during in vitro rooting culture. Compared to the diploids, the AR formation times and rooting rates of the tetraploids' stem explants had non-significant changes. However, the tetraploid ARs exhibited significantly slower elongation growth than the diploid ARs. Cytological observation showed that the tetraploid ARs were characterized by shorter root meristems and reduced meristem cell numbers, suggesting the reasons for the slow AR elongation. Analysis of hormones and related metabolites during AR development demonstrated that the total auxin, cytokinin, and jasmonic acid contents were significantly lower in the tetraploid ARs than in those of the diploids, and that the ratio of total auxins to total CKs at 0 h of AR development was also lower in the tetraploids than in the diploids, whereas the total salicylic acid content of the tetraploids was consistently higher than that of the diploids. qPCR analysis showed that the expression levels of several hormone signaling and cell division-related genes in the tetraploid ARs significantly differed from those in the diploids. In conclusion, the slow elongation of the tetraploid ARs may be caused by the endogenous hormone-mediated meristem shortening. Our findings enhance the understanding of polyploidization-induced variation in AR development of forest trees. [ABSTRACT FROM AUTHOR]

In recent years, atmospheric composite pollution has become increasingly serious, and accelerating VOC governance has become the focus of and difficulty in atmospheric governance. Volatile organic compounds (VOCs) come from a wide range of sources, and industrial sources are the main source of anthropogenic VOC emissions in China. Chemicals, oil refining, and solvents are three typical VOC-emitting industries, and their control is an important part of accelerating and optimizing VOC governance. It can be controlled by source control, process control, and pipe end treatment; among these, pipe end treatment is divided into recovery technology and destruction technology. In pipeline end treatment, with the key materials of adsorption, absorption, catalytic oxidation, and catalytic combustion, the research and development of adsorbents, absorbents and catalysts has become a hot spot in recent years. This paper summarizes the chemical materials used in typical VOC pipe end-treatment technology (including adsorbents used in the adsorption method, absorbents used in the adsorption method, and catalysts used in the catalytic oxidation and catalytic combustion methods), summarizes the advantages and disadvantages of various materials and their application range, and looks forward to the direction of future developments. [ABSTRACT FROM AUTHOR]

With the development of economy and increasing environmental awareness, how to effectively remove organic pollutants in wastewater is a research hotspot. Adsorption is one of the effective methods, and the adsorption material is the key factor to determine the efficiency. In this review, biomass‐derived carbon materials as adsorbents of organic pollutants and the adsorption mechanism are discussed in depth. The effects of carbonization and activation on the morphology and structure of carbon materials; the modification strategies of carbon adsorbents, the adsorption performance of biomass‐derived carbon materials for organic pollutants are described and illustrated; the future work of the biomass‐derived carbon materials is proposed. [ABSTRACT FROM AUTHOR]

Gain or amplification 1q21 (1q21+) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM). Our aim was to explore the presentation and outcomes of patients with MM harboring 1q21 +. We retrospectively analyzed the clinical features and survival outcomes in 474 consecutive patients with MM receiving immunomodulatory drugs or proteasome inhibitor-based regimens as first-line therapies. 1q21 + was detected in 249 (52.5%) patients. Patients with 1q21 + had a higher proportion of subtypes of IgA, IgD, and λ-light chain than non-1q21 +. 1q21 + was associated with more advanced ISS stage and was more frequently accompanied by del(13q), elevated lactate dehydrogenase and lower levels of hemoglobin and platelets. Patients with 1q21 + had shorter PFS (21 months vs. 31 months, P = 0.001) and OS (43 months vs. 72 months, P < 0.001) than those without 1q21 +. Multivariate Cox regression analysis confirmed that 1q21 + was an independent prognostic factor for both PFS (HR 1.277, P = 0.031) and OS (HR 1.547, P = 0.003). Patients with 1q21 + del(13q) double-abnormality had shorter PFS (P < 0.001) and OS (P = 0.001) than those with no FISH abnormalities, and they also had shorter PFS (P = 0.018) and OS (P = 0.026) than those with del(13q) single abnormality. No significant difference in PFS (P = 0.525) or OS (P = 0.245) was found between patients with 1q21 + del(13q) double-abnormality and 1q21 + del(13q) multiple-abnormality. Patients with 1q21 + were more likely to have coexisting negative clinical features and del(13q). 1q21 + was an independent prognostic factor associated with poor outcomes. Concurrence with such unfavorable features may account for poor outcomes given 1q21 +. [ABSTRACT FROM AUTHOR]

Lithium batteries are promising techniques for renewable energy storage attributing to their excellent cycle performance, relatively low cost, and guaranteed safety performance. The performance of the LiFePO4 (LFP) battery directly determines the stability and safety of energy storage power station operation, and the properties of the internal electrode materials are the core and key to determine the quality of the battery. In this work, two kinds of commercial LFP batteries were studied by analyzing the electrical properties and material properties of the electrodes. After performing the rate and cycle performance tests of the battery cell, differential scanning calorimetry, scanning electron microscope, x-ray diffraction, and inductively coupled plasma were used to explore the performance of electrode materials to establish the correlation between the battery performance and the electrochemical reaction law of the internal materials and further to judge the influence of the key material properties on the battery performance. This work opens up an avenue for technical supervision of energy storage power stations. [ABSTRACT FROM AUTHOR]

SUMMARY: Salicylic acid (SA) plays important roles in different aspects of plant development, including root growth, where auxin is also a major player by means of its asymmetric distribution. However, the mechanism underlying the effect of SA on the development of rice roots remains poorly understood. Here, we show that SA inhibits rice root growth by interfering with auxin transport associated with the OsPIN3t‐ and clathrin‐mediated gene regulatory network (GRN). SA inhibits root growth as well as Brefeldin A‐sensitive trafficking through a non‐canonical SA signaling mechanism. Transcriptome analysis of rice seedlings treated with SA revealed that the OsPIN3t auxin transporter is at the center of a GRN involving the coat protein clathrin. The root growth and endocytic trafficking in both the pin3t and clathrin heavy chain mutants were SA insensitivity. SA inhibitory effect on the endocytosis of OsPIN3t was dependent on clathrin; however, the root growth and endocytic trafficking mediated by tyrphostin A23 (TyrA23) were independent of the pin3t mutant under SA treatment. These data reveal that SA affects rice root growth through the convergence of transcriptional and non‐SA signaling mechanisms involving OsPIN3t‐mediated auxin transport and clathrin‐mediated trafficking as key components. Significance Statement: In this study, we found that salicylic acid (SA) inhibited rice root growth by inhibiting the clathrin‐mediated endocytosis of OsPIN3t with a non‐canonical SA signaling mechanism. Meantime, OsPIN3t was at the center of the gene regulatory network containing clathrin, and the clathrin‐mediated root growth was independent of the OsPIN3t under SA treatment. Our study shows that SA regulated rice root growth by convergence of transcriptional and non‐SA signaling mechanism mediated by the OsPIN3 and clathrin. [ABSTRACT FROM AUTHOR]

Background: Pseudohypoparathyroidism (PHP) is a series of diseases related to pathological changes and neurocognitive and endocrine abnormalities, mainly due to the GNAS mutation on chromosome 20q13.2, which weakens receptor‐mediated hormone signal transduction. Considering its complex genetic and epigenetic characteristics, GNAS may produce complex clinical phenotypes in families or sporadic cases. This study presented a case of familial PHP caused by a deletion mutation in the 20q13.2 region. Methods and Results: The proband and her second daughter had PHP, and the proband's mother had pseudo‐PHP. Whole‐genome sequencing revealed that the proband had an 849.81 kb deletion spanning GNAS near the maternal 20q13.2 chromosome. Multiplex ligation‐dependent probe amplification methylation analysis indicated that the proband as well as her mother and second daughter had seemingly abnormal GNAS methylation. This is different from the phenotype (feeding difficulty, slow growth, and special facial features) of previously reported cases with the deletion of fragments near the 20q13.2 chromosome. Conclusions: This report demonstrated the variability of 20q13.2 deletion phenotypes and the clinical importance of using multiple molecular genetic detection methods. [ABSTRACT FROM AUTHOR]

Senescence of activated hepatic stellate cells (aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression. Senescent cells often accompanied by a multi‐faceted senescence‐associated secretory phenotype (SASP). Induction of aHSCs senescence by inhibiting SASP may be a potential therapeutic model against hepatic fibrosis. To evaluate the role of atractylenolide III (ATR III) in the development of chemotherapeutic drug‐induced SASPs in hepatic stellate cells. Etoposide‐induced senescent HSC‐LX2 model was established and treated with ATR III at different concentrations (20, 30 and 40 μM). We found that ATR III dose‐dependently enhanced senescence in etoposide‐induced LX2 cells. ATR III dose‐dependently decreased the release and expression of SASP factors (interleukin [IL]‐1α, IL‐1β, IL6 and IL‐8) in senescent cells. ATR III regulated cyclic GMP‐AMP synthase (cGAS)/nuclear factor κ (NF‐κB) signalling to affect SASP expression in senescent cells. The addition of 2'3′ cGAMP counteracted the effect of ATR III. The release of SASP factors in the conditioned medium from senescent cells could affect cell migration, proliferation and contraction through paracrine manner. Our results indicated ATR III could still enter senescence and prevent the production of SASP and its paracrine effects in senescent cells, an effect that may be related to the possible inhibition of cGAS/NF‐κB signalling by ATR III. Our study proves that ATR III may be an effective potential drug against liver fibrosis by promoting aHSC senescence, which can provide a new choice for the future clinical treatment of liver fibrosis. [ABSTRACT FROM AUTHOR]

Objective: To assess the immunogenicity and safety of the enterovirus 71 vaccine (Vero cell) (EV71 vaccine) and trivalent split-virion influenza vaccine (IIV3). Methods: Healthy infants aged 6–7 months were recruited from Zhejiang Province, Henan Province, and Guizhou Province and randomly assigned to the simultaneous vaccination group, EV71 group, and IIV3 group at a ratio of 1:1:1. Then, 3 mL blood samples were collected before vaccination and 28 days after the second dose of vaccine. Cytopathic effect inhibition assay was used to detect EV71 neutralization antibody, and cytopathic effect inhibition assay was used to detect influenza virus antibody. Results: A total of 378 infants were enrolled and received the first dose of vaccine and were included in the safety analysis, and 350 infants were involved in the immunogenicity analysis. The adverse events rates were 31.75%, 28.57%, and 34.13% in the simultaneous vaccination group, EV71 group, and IIV3 group (p > 0.05), respectively. No vaccine-related serious adverse events were reported. After two doses of EV71 vaccine, the seroconversion rates of EV71 neutralizing antibody were 98.26% and 97.37% in the simultaneous vaccination group and the EV71 group, respectively. After two doses of IIV3, the simultaneous vaccination group and the IIV3 group, respectively, had seroconversion rates of 80.00% and 86.78% for H1N1 antibody, 99.13% and 98.35% for H3N2 antibody, and 76.52% and 80.99% for B antibody. There was no statistically significant difference in the seroconversion rates of influenza virus antibodies between groups (p > 0.05). Conclusions: The coadministration of EV71 vaccine and IIV3 has good safety and immunogenicity in infants aged 6–7 months. [ABSTRACT FROM AUTHOR]

Objectives: Recently, the Mayo Clinic introduced a new staging system (the Mayo Additive Staging System [MASS]) for patients with newly diagnosed multiple myeloma (NDMM) based on the number of high‐risk (HR) abnormalities, including HR IgH translocations, 1q gain/amplification, chromosome 17 abnormalities, International Staging System (ISS)‐III, and elevated lactate dehydrogenase. Patients with 0, 1, or ≥2 HR abnormalities were defined as stage I, II, or III, respectively. We aimed to validate the real‐world prognostic value of the MASS. Methods: We retrospectively analyzed the cytogenetic and laboratory results of 544 patients with NDMM at a single center. Results: Ninety (16.5%) patients had no HR factors (MASS I), 193 (35.5%) had 1 HR factor (MASS II), and 261 (48%) had ≥2 HR factors (MASS III). The median progression‐free survival (PFS) and overall survival (OS) times were 48, 28, and 20 months and 137, 73, and 39 months in the three groups, respectively (p <.001). In the subgroup analysis, patients had different OS outcomes based on the MASS when grouped by age, renal function, or therapeutic regimens. The MASS identified patients with the worst outcomes among those rated revised ISS II. Conclusion: The MASS system is a reliable risk stratification tool for patients with NDMM in real‐world clinical practice. [ABSTRACT FROM AUTHOR]

The Second Revision of the International Staging System (R2‐ISS) was recently introduced to improve risk stratification over that provided by the extensively applied standard revised International Staging System (R‐ISS). In addition to the variables included in the R‐ISS, the R2‐ISS incorporates chromosome 1q gain/amplification and divides the patients into 4 groups with different survival outcomes, better stratifying patients within the R‐ISS intermediate‐risk. The new model was developed based on a great quantity of data from patients participating in uniform clinical trials and has not been validated in real‐world clinical practice. Therefore, we retrospectively analyzed the prognostic value of the R2‐ISS in 474 consecutive patients with multiple myeloma receiving immunomodulatory drugs or proteasome inhibitor‐based regimens as their first‐line treatment. According to the R2‐ISS, 41 (8.6%), 76 (16%), 275 (58%), and 82 (17.3%) patients were identified as R2‐ISS I, R2‐ISS II, R2‐ISS III, and R2‐ISS IV, respectively. The median progression‐free survival (PFS) was 48 (95% CI: 38–58), 35 (95% CI: 23–47), 24 (95% CI: 21–27), and 12 (95% CI: 7–17) months, and the estimated median overall survival (OS) was 110 (95% CI: 42–178), 88 (95% CI: 75–101), 50 (95% CI: 43–57), and 26 (95% CI: 19–33) months (p < 0.001) in the 4 groups, respectively. The R2‐ISS could also classify groups with distinct survival among patients with renal impairment or classified as R‐ISS II. Adjusted by age, sex, treatment approaches and transplantation status, the R2‐ISS was an independent prognostic factor associated with OS with a hazard ratio of 7.055 (95% CI: 3.626–13.726) (p < 0.001) for R2‐ISS IV versus R2‐ISS I and 2.707 (95% CI: 1.436–5.103) (p = 0.002) for R2‐ISS III versus R2‐ISS I. In conclusion, our results suggest that the R2‐ISS is a simple and robust risk stratification tool for patients with multiple myeloma treated with novel drugs and could be used in everyday clinical practice. [ABSTRACT FROM AUTHOR]

The present systematic review and meta-analysis of randomized clinical trials (RCTs) aimed to investigate the effects of pulmonary rehabilitation in individuals with chronic obstructive pulmonary disease (COPD). The RCTs of pulmonary rehabilitation programs published between 1999 and 2021 were retrieved from electronic databases (PubMed, Cochrane Library, and Embase). Two reviewers independently assessed the topical relevance and trial quality and extracted data for meta-analysis using the Stata software version 14.0. A total of 39 trials involving 2,397 participants with COPD were evaluated. We found that patients who received pulmonary rehabilitation program had significant improvement in the 6-min walk test (6MWT), St. George Respiratory Questionnaire score, and the modified British Medical Research Council score as compared to those who received usual care. Yoga and Tai Chi showed significant improvement in the forced expiratory volume (FEV1)% in 1 s predicted value. However, no significant difference was detected in the modified Borg score, forced vital capacity (FVC), and FEV1/FVC predicted value between the pulmonary rehabilitation and usual care groups. Yoga and Tai Chi showed a significant improvement in the FEV1% predicted value. Also, pulmonary rehabilitation program improved the exercise capacity, the quality of life, and dyspnoea in patients with COPD. A total of 39 trials involving 2,397 participants with COPD were evaluated. We found that patients who received pulmonary rehabilitation program had significant improvement in the 6MWT, St. George Respiratory Questionnaire score, and the modified British Medical Research Council score as compared to those who received usual care. Yoga and Tai Chi showed significant improvement in the FEV1% predicted value. No significant difference was detected in the modified Borg score, FVC, and FEV1/FVC predicted value between the pulmonary rehabilitation and usual care groups. [ABSTRACT FROM AUTHOR]

Circular RNAs (circRNAs) have been found to play important roles in drug resistance of human neoplasms. The aim of this study was to explore the effect of circ_0005273 on cisplatin (DDP) resistance of cervical cancer (CC) cells and identify its underlying mechanism. The quantitative real-time polymerase chain reaction (qRT-PCR) was performed to analyse circ_0005273 and miR-133b expressions, and cell counting kit-8 (CCK-8), Hoechst 33258 staining and caspase-3 activity analysis were performed to evaluate cell proliferation and apoptosis. Luciferase reporter, RNA binding protein immunoprecipitation (RIP) and RNA pull down assays were applied to explore the interaction between circ_0005273 and miR-133b. Our research showed that circ_0005273 and miR-133b expressions were upregulated and downregulated in DDP-resistant CC cancer tissues and cell lines, respectively. Both of circ_0005273 and miR-133b levels were correlated with FIGO stage, DDP status and overall survival rates. Knockdown of circ_0005273 enhanced the sensitivity of DDP-resistant CC cells to DDP by inhibiting cell proliferation and promoting cell apoptosis. Furthermore, circ_0005273 acts as a competing endogenous RNA to modulate miR-133b expression. Downregulation of miR-133b partly reversed the DDP sensitivity of circ_0005273 knockdown in DDP-resistant CC cells. In summary, our study elucidated the role of circ_0005273/miR-133b axis in DDP resistance of CC cells, which might be a potential therapeutic target for DDP-resistant CC patients. What is already known on this subject? The detailed regulatory mechanisms underlying DDP chemoresistance are still unclear. Recently, literatures reported that circ_0005273 exerts a regulatory role in the tumorigenesis and progression of human cancers including thyroid carcinoma, pancreatic carcinoma, colorectal carcinoma and breast carcinoma. What do the results of this study add? Circ_0005273 contributes to the DDP resistance of CC cells via sponging miR-133b. What are the implications of these findings for clinical practice and/or further research? The results help to reverse DDP chemoresistance, and the circ_0005273/miR-133b axis might be a potential therapeutic target for DDP-resistant CC patients. [ABSTRACT FROM AUTHOR]

In order to discuss the purification software technology of ultrahigh voltage transformer oil, the index variation trend of antioxidation stability test after each oil adsorption was investigated, and the relationship between the adsorption times and antioxidation stability parameters was obtained. It was proved that the antioxidation stability of the oil was getting better and better with the increase of adsorption times. The composition of hydrocarbon of new oil and recycled oil is analyzed by infrared spectroscopy. The composition of hydrocarbon of new oil and recycled oil is very similar to that of new oil, and their molecular composition structure has not changed much. The experimental results show that: according to dLT929-2005, the absorbance of samples at 1610∼720 cm−1 was measured, and the values of C A , C N and C P were obtained. A 1 mmNaCl liquid pool is used. Sample ① is the new oil; ② is the last simulated oil regeneration; ③ is the D111 overhaul recycled oil; ④ is again the living oil. It is proved that the composition of the oil is more reasonable and can be reused for adsorption and regeneration. In addition, the aromatic carbon value C A of oil after adsorption treatment decreases due to natural consumption, and new oil can be added appropriately to increase the carbon value C A . [ABSTRACT FROM AUTHOR]

Aim: The underlying mechanisms connecting obesity and periodontal diseases remain unclear. This study investigates the potential causal association of obesity with periodontal diseases using Mendelian randomization (MR). Materials and Methods: Single‐nucleotide polymorphisms of obesity traits including body mass index (BMI), waist circumference (WC), and WC adjusted for BMI (WCadjBMI) from large‐scale genome‐wide association studies were screened for instrumental variables. The single trait periodontitis and the combined trait comprising periodontitis and loose teeth were adopted as surrogates for periodontal diseases. Inverse‐variance weighted (IVW), series of sensitivity analyses and multivariable MR were employed to determine the association of obesity with periodontal diseases. Results: IVW results showed that per 1‐SD increment in BMI (odds ratio, OR = 1.115; 95% confidence interval [CI] = 1.064–1.169; p <.001) and WC (OR = 1.117; 95% CI = 1.052–1.185; p <.001), but not WCadjBMI, were significantly associated with an increased risk of periodontitis/loose teeth. Moreover, the MR estimates were consistent across other MR sensitivity analyses and multivariable MR. However, a causal association of obesity with the single trait periodontitis was not identified. Conclusions: The presented evidence supports previous epidemiological findings by showing a potential causal association of genetic liability to obesity with periodontal diseases. The biological mechanisms underlying this association warrant further investigation. [ABSTRACT FROM AUTHOR]

Objectives: Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV) infection. We established a high-throughput, simple, low-cost, and accurate HPV-typing assay (polymerase chain reaction-melting temperature [PCR-Tm] analysis) to detect HPV in CA. Materials and Methods: We detected 280 cervical scraping samples, including positive samples of HPV-6 (26), HPV-11 (12), HPV-16 (22), HPV-42 (18), HPV-43 (25), HPV-multiple (19), HPV- other type (58), and HPV-negative samples (100). All samples were compared by PCR-Tm analysis and a flow fluorescence hybridization assay. Sequencing was used to confirm the results of the PCR-Tm analysis. Results: PCR-Tm analysis was specific for each genotype (HPV-6, HPV-11, HPV-16, HPV-42, and HPV-43). The sensitivity of the PCR-Tm analysis assay for each genotype was 103, 103, 103, 103, and 102 copies/reaction, respectively. Most of the 158 samples, including 58 HPV-other type positive and 100 HPV-negative samples tested by the flow fluorescence hybridization assay, were tested negative by PCR-Tm analysis. For the 122 remaining samples, 26 HPV-6, 12 HPV-11, 22 HPV-16, 18 HPV-42, 25 HPV-43, and 19 multiple HPV infections were detected through PCR-Tm analysis. In total, 25 HPV-6, 12 HPV-11, 21 HPV-16, 18 HPV-42, 25 HPV-43, and only 10 multiple HPV infections were detected by the flow fluorescence hybridization assay. The kappa coefficient for the analysis of PCR-Tm analysis and flow fluorescence hybridization assay was 0.940 (P < 0.0001), and the 95% confidence interval of the kappa coefficient was 90.3–97.7%. Conclusion: PCR-Tm analysis enabled the detection of HPV-6, HPV-11, HPV-16, HPV-42, and HPV-43, including single and multiple infections. [ABSTRACT FROM AUTHOR]

Problem definition: This paper investigates the impact of COVID-19 on e-commerce sales and the underlying operational driver. Academic/practical relevance: As COVID-19 continues to disrupt offline retail, anecdotal evidence suggests a rapid growth of e-commerce. However, the pandemic may also significantly decrease offline logistics capacity, which in turn decreases e-commerce sales. Then, how does e-commerce respond to COVID-19, and what are the corresponding opportunities and challenges? Methodology: We leverage e-commerce sales data from Alibaba and construct a city-day panel across three years, representing sales for all buyers and sellers on the platform across 339 cities in mainland China. We develop three identification strategies to estimate the overall impact of COVID-19 (based on a year-on-year comparison), the impact of COVID-19 intensity (based on the different number of cases across cities), and the impact of corresponding containment measures (leveraging policy changes of checkpoint, partial shutdown, and complete shutdown measures across cities). Results: We provide two key findings. First, across different identification strategies, we observe a common drop and recovery pattern, which illustrates the digital resilience of e-commerce during the pandemic. For example, we estimate an overall decrease of 22% in e-commerce sales during the period of the Wuhan shutdown (January 23–April 7, 2020). However, it recovers in most cities within five weeks. Second, we identify a key operational driver—logistics capacity—that significantly explains the decline and recovery of e-commerce sales during and after the outbreak. Managerial implications: We provide important evidence on how e-commerce responds to and recovers from COVID-19, contrary to the common perception. The evidence in the recovery phase can also inform platforms and policymakers to design digital strategies and invest in logistics infrastructure. [ABSTRACT FROM AUTHOR]

Objective: Pre-eclampsia (PE) is a pregnancy-associated disease characterized by placental dysfunction and increased oxidative stress. Apocyanin is a potent antioxidant and anti-inflammatory which has shown beneficial effects on PE pathogenesis. Aspirin is recognized as the recommendable drug in PE prevention and therapy. Therefore, we aimed to investigate the effects of combining apocyanin and aspirin to treat PE on rat models induced by N-nitro-L-arginine methyl ester (L-NAME) from gestational day (GD) 6 to 16 and elucidate the potential mechanisms.Methods: First, female pregnant rats were divided into five different groups: pregnant control, PE, PE + apocyanin, PE + aspirin, and PE + apocyanin + aspirin. Animals received apocyanin (16 mg/kg/day) orally or aspirin by gavage (1.5 mg/kg BM/day) from GD 4 to 16. Blood pressure and urine protein content were monitored every 4 days.Results: In the PE rat model, elevated systolic blood pressure and proteinuria were ameliorated by the combination of apocyanin and aspirin. Meanwhile, compared with single-dose apocyanin or aspirin, the combined treatment significantly corrected abnormal pregnancy outcomes, decreased sFlt-1 and PlGF, and alleviated oxidative stress both in blood and placental tissues. Moreover, the combined treatment upregulated PI3K, Akt, Nrf2, and HO-1 protein levels in the placental tissues from PE rats.Conclusion: Overall, our results suggested that combined treatment of apocyanin and aspirin ameliorates the PE symptoms compared with single-dose apocyanin or aspirin in a PE rat model. Also, we demonstrated that activating the PI3K/Nrf2/HO-1 pathway can be a valuable therapeutic target to improve the pregnancy outcomes of PE. [ABSTRACT FROM AUTHOR]

BACKGROUND: Patients with advanced pancreatic cancer (APC) and liver metastases have much poorer prognoses than patients with other metastatic patterns. OBJECTIVE: This study aimed to develop and validate a radiomics model to discriminate patients with pancreatic cancer and liver metastases from those with other metastatic patterns. METHODS: We evaluated 77 patients who had APC and performed texture analysis on the region of interest. 58 patients and 19 patients were allocated randomly into the training and validation cohorts with almost the same proportion of liver metastases. An independentsamples t -test was used for feature selection in the training cohort. Random forest classifier was used to construct models based on these features and a radiomics signature (RS) was derived. A nomogram was constructed based on RS and CA19-9, and was validated with calibration plot and decision curve. The prognostic value of RS was evaluated by Kaplan-Meier methods. RESULTS: The constructed nomogram demonstrated good discrimination in the training (AUC = 0.93) and validation (AUC = 0.81) cohorts. In both cohorts, patients with RS > 0.61 had much poorer overall survival than patients with RS < 0.61. CONCLUSIONS: This study presents a radiomics nomogram incorporating RS and CA19-9 to discriminate patients who have APC with liver metastases from patients with other metastatic patterns. [ABSTRACT FROM AUTHOR]

Objective: To investigate the diagnosis, treatment, and maternal and fetal outcomes of placental abruption.Materials and Methods: We recruited 585 cases of placental abruption from the Women and Children's Hospital Affiliated to Xiamen University between January 2012 and December 2017. Cases were categorized into four groups (class 0-III) according to the clinical guidelines published by the Obstetrics and Gynecology Branch of the Chinese Medical Association. We then compared clinical data and auxiliary examinations across the four groups.Results: The differences were statistically significant (p < .01) among the four groups of placental abruption with regard to the incidence of an abnormal ultrasound finding. Positive ultrasound signs were evident in 6.4% of the patients categorized as class 0 and 100.0% of patients categorized as class III. Monitoring showed that fetal heart rate (FHR) was abnormal in class II patients with placental abruption; patients in class III showed no fetal heart sounds. Cesarean section was carried out for 26.6%, 75.1%, 65.2%, and 47.1% of patients in classes 0, I, II, and III, respectively. The rate of cesarean section for classes I and II was the highest, while the lowest rate occurred for class 0. Postpartum hemorrhage occurred in 2.5%, 9.3%, 15.2%, and 29.4% of patients across the four groups, DIC occurred in 0.0%, 1.3%, 2.3%, and 23.5% of cases, and perinatal death occurred in 1.0%, 1.3%, 7.6%, and 100.0% of cases, respectively. The highest incidence of postpartum hemorrhage was in class III (29.4%) and the lowest was in class 0 (2.5%). The highest incidence of DIC was in class III (23.5%) and the lowest was in class 0 (0.0%). The highest incidence of neonatal asphyxia was in class II (34.1%) and the lowest was in class 0 (10.1%). Regarding perinatal death, the highest incidence was in class III (100.0%) and the lowest was in class 0 (1.0%). These data showed significance differences when compared across the four groups of patients (p < .01).Conclusions: We recommend that the diagnosis of placental abruption should consider risk factors, clinical features, FHR monitoring, and dynamic ultrasound monitoring. Early diagnosis and treatment can improve maternal and infant prognosis. [ABSTRACT FROM AUTHOR]