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The generation efficiency of data products depends on both the computational efficiency and the startup efficiency of algorithms. In meteorological operations, algorithms are typically data-driven, meaning they are initiated immediately upon data arrival to accelerate the generation time of data products. Therefore, data-driven meteorological services urgently require an efficient task scheduling framework to achieve the goal of starting and running algorithms as soon as data arrive, and to improve the generation efficiency of meteorological data products. CMA Big Data and Cloud Platform, referred to as Tianqing and led by National Meteorological Information Center, began nationwide business operations in December 2021. The data processing line (DPL), as the core function of Tianqing, enables the unified management and centralized scheduling of meteorological algorithms. DPL has established various task scheduling capabilities, including timer-triggered scheduling, sequential scheduling, data-arrival scheduling, and manual scheduling. Among these methods, data-arrival scheduling based on data reporting status enables the algorithm to start immediately after data reporting, greatly improving the startup time of meteorological algorithms and the generation time of meteorological data products.Core functions of data-arrival scheduling include data state awareness components, task scheduling execution components, task scheduling post-processing components, and configuration management. Among these components, the data state perception component realizes real-time analysis of the reporting status of various meteorological data in the sky engine, and sends scheduling messages to the task scheduling execution component when the data reporting rate meets scheduling requirements. The task scheduling execution component combines the necessary resource information for the algorithm and computing nodes optimization, generates task scheduling instructions, and implements algorithm startup execution. The post-processing phase of task scheduling includes gathering and updating algorithm execution status, calculation node status, and sending of alarm information for algorithm execution abnormalities. Configuration management supports configuring data-aware scheduling parameters on the front-end page.Real-time analysis of data status and scheduling enables efficient task scheduling that starts and runs the algorithm as soon as data are reported. The scheduling delay is significantly reduced, compared to the original schedule, from 3784 ms to 11 ms. Data-arrival scheduling, as the core capability of CMA Big Data and Cloud Platform, is deployed and operated in real-time in provinces and regions. Currently, the system supports the efficient scheduling of 19 core business algorithms at the national level, with a total of approximately 6.67×105 daily scheduling tasks and an average scheduling delay of 31 ms. Efficient scheduling is achieved with 14 algorithms supported at the provincial level, encompassing a total of approximately 8×104 daily scheduling times and an average scheduling delay of 156 ms. In addition, data aware scheduling achieves seamless integration of upstream and downstream algorithms in meteorological services, providing a solution to eliminate the problem of disconnection between meteorological services and improve collaboration between meteorological services.

Purposes As a coal based solid waste rich in silicon and aluminum oxides, utilization of coal gangue is crucial for the sustainable development of coal industry. Methods Integrated grinding modification of calcined coal gangue and aluminate coupling agent to prepare rubber reinforcement was proposed. The influences of grinding time and the amount of modifier on the surface modification were investigated. Ultrafine particles were obtained through air flow classification, and the influences of modification or not and particle size on the reinforcing and filling properties of rubber were analyzed. Findings The results show that the best comprehensive modification effect is achieved when the duration of ball milling is 30 min and the amount of aluminate coupling agent is 2%. The characteristic functional groups of aluminate coupling agent appear on the surface of coal gangue. Compared with the rubber filled with commercial silica, the rubber filled with the air-flow graded modified filler possesses higher hardness and crosslinking density, its vulcanization performance is better, the tensile strength, elongation at break and permanent deformation at break are reduced, and the fixed extension stress is increased. The particle size distribution of the filler has an obvious effect on the properties of rubber, with the decreases of the particle size of the filler, the vulcanization property is improved, and the tensile property is also improved. The reinforcement performance of modified superfine coal gangue as filler is close to that of silica, which has the potential to replace silica.

Background: The most effective method for improving the prognosis of lung cancer is the application of low-dose computed tomography (LDCT) for pulmonary nodule screening in populations at high risk. Timely diagnosis and treatment of early-stage lung cancer can contribute to higher long-term survival rates. However, it remains difficult to differentiate malignant from benign pulmonary nodules measuring 8–15 mm, and avoid overtreatment on the one hand and delayed diagnosis on the other hand. In this consensus paper, we aimed to clarify the definition of “high-risk indeterminate pulmonary nodules (IPNs)” and discuss appropriate evaluation and management to facilitate timely diagnosis of lung cancer to improve lung cancer outcome. Direction for future research was discussed. Methods: A multi-disciplinary panel of doctors and IT experts from Asia, Canada and the U.S. were invited to participate. Published evidence and consensus guidelines were used to develop this consensus was clarified. Their evaluation and management were discussed. Findings: The experts believed that the prevalence of pulmonary nodules was very high, and it that was difficult to diagnose early-stage lung cancer due to the small size of the nodules, often leading to delayed diagnosis or overtreatment. To address this issue and to improve long-term outcome, the panel considered important to revise the classification of high-risk IPNs, (1) as pulmonary nodules that cannot be clearly diagnosed with non-surgical biopsy procedures, but is highly suspicious for early-stage lung cancer. The panel also recommends the most responsible should arrange imaging evaluations and follow-ups, taking new technologies into account. Artificial intelligence (AI) assessment based on the Medical Internet of Things (MIoT) can be combined with expert opinion to form a human–computer multidisciplinary team (MDT) that can fully implement the three core procedures of the MIoT, namely, comprehensive perception, reliable transmission, and intelligent processing. This will help to upgrade the non-standard diagnosis and treatment, the so-called “handicraft workshop model”, to a modern assembly-line model that meets international standards. The MIoT technology, which has the potential to realize “simplification of complex problems, digitalization of simple problems, programming of digital problems, and systematization of programming problems”, can promote the homogeneous evaluation of pulmonary nodules by enhancing both the sensitivity and the specificity of detecting early-stage lung cancer, in order to avoid delayed diagnosis and overtreatment. Conclusion: To optimize the evaluation of early-stage lung cancer, and to avoid delayed diagnosis and overtreatment, it is necessary to propose and promote the concept of “high-risk IPNs”. The application of current technologies, AI, and a human–computer MDT, will facilitate improvement in nodule evaluation, transforming the current diagnosis and treatment model, which is akin to production in handicraft workshops, into a modern assembly-line model that meets international standards, and will ultimately result in better prognosis.

With the trend of global climate change, it is important to study the high temperature heat damage of tea plants and analyze the spatial and temporal distribution characteristics to warn damage early and reduce production losses. An index is established based on daily maximum air temperature and historical heat damage disaster records at 510 meteorological stations over tea regions in Southern Yangtze River and South China from 1961 to 2022, to determine and verify the extent of high temperature heat damage, using methods of disaster inversion and K-means clustering analysis method. The spatial and temporal distribution characteristics of high temperature heat damage are analyzed. The total days with moving average of 14-consecutive-day maximum temperature above 34.5 ℃ are statistically analyzed, and for mild, moderate and severe high temperature heat damage, the value is in the range of 1-17 d, 18-38 d and above 38 d, respectively. The accuracy rate of complete compliance with the validation sample is 73.9%, and the accuracy rate of basic compliance is 91.3%. The total number of heat damage on tea plants in Southern Yangtze River and South China shows fluctuating changes from 1961 to 2022. The total number of heat damage on tea plants in tea regions of Southern Yangtze River and South China is the lowest in 1999 and 1997, respectively, while numbers are the highest in 2021 for both tea regions. Compared to tea regions of Southern Yangtze River, there are more high temperature heat damages in South China, especially mild high temperature heat damages. Moreover, the number of high temperature heat damage on tea plants in South China shows a significant increasing trend in the past 62 years, but the trend of changes in the number of high temperature heat damage on tea plants in most tea regions of Southern Yangtze River is not significant.

Today’s society promotes and improves teaching in various ways. However the teaching of spoken English still lacks the guidance of scientific method. The importance of oral teaching is becoming more and more prominent in English teaching. Therefore, this paper proposes specific oral teaching training strategies to explore effective methods of oral evaluation after applying the DTW construction strategy. The cultivation strategy of spoken English has been improved from the perspective of teachers. The speech evaluation system is designed and implemented to normalize the speech signal and then add windows to it in frames. SMFCC, volume intensity, and fundamental trajectory were chosen as the feature parameters of the system comparison. Parameters were extracted from the amplitude spectrum, and after feature extraction, parameter distance calculation was carried out on the feature parameters so as to get the results of English-speaking level scoring. According to the study, the teaching model that incorporates the English-speaking development strategy significantly improves the students’ speaking ability compared to the control class. Moreover, the evaluation system’s performance in terms of exact agreement rate and neighbor agreement rate is consistently above 90%, which indicates that the system can objectively evaluate the students’ oral proficiency.

In order to improve the defect recognition efficiency of transmission lines, the industry is currently using aerial images for automatic visual defect detection to ensure the safe operation of transmission lines. This paper proposes a method for defect recognition from coarse to fine, based on convolutional neural networks and connected domain algorithms, to improve recognition accuracy. The recognition speed is improved by using the knowledge distillation method of target detection networks based on decoupled features, adversarial features, and attention features. It has been found that the optimized recognition model improves the precision rate by 7%, the recall rate by 8%, and the average accuracy rate by 10%. The FPS of the model optimized by knowledge distillation is 62.5, and the average value of the FPS of other versions of this model is 47.35. It is believed that the two optimization ideas introduced in this paper can enhance the previous transmission line defect recognition algorithm in terms of accuracy and recognition speed.

With the increasing demand for high-quality skilled talents, building a teaching management system suitable for the characteristics of modern apprenticeship is the key to ensuring the smooth implementation of practical teaching. After the contemporary apprenticeship quality management system, this article takes vocational college students under the current apprenticeship management system in S city as the research object, uses principal component analysis and multiple choice linear regression methods to evaluate student initiative and explore the relevant influencing factors, Assess the impact and degree of influence of various factors on the agency of vocational college students. The results show that motivation investment (0.2421) and emotional investment (0.2335) are closely related to the evaluation results of student agency. The agency of the selected students is at a lower than average level, with an evaluation score of 2.9096. The impact value of the modern apprenticeship management system on student agency is 3.561, above average. Among them, The impact of factor process (3.838) is the greatest

Computer teaching in colleges and universities under the background of informationization is developing rapidly, but the teaching mode still has more serious problems, and computer teaching reform needs to be emphasized. This paper first proposes solutions to the problems of computer teaching in colleges and universities. Secondly, it uses hierarchical analysis to construct a computer teaching evaluation system model, then carries out educational information data mining through the DMOTE method, and uses C4.5 to optimize the model of DMOTE. Setting up a controlled experiment to analyze the students’ performance after receiving teaching reform, most of the students in the experimental group scored in the two segments of 80-89 and 90 or more, accounting for 60%, and the number of students scoring less than 60 points was less, only 6%. After the reform of the computer model, the students’ performance improvement is more obvious, and the reform effect is good.

The global system of nature reserves is facing adjustment and restructuring towards the goal of harmonizing ecological conservation with regional development. We use multiple ecoregion data at both global and national scales as ecological indicators to explore the gap areas of China's nature reserves, which can help to build a global network of nature reserve systems and lay a spatial foundation for global biodiversity conservation. This paper comprehensively resorts to the ideas and modeling approaches involved in gap analysis, conservation prioritization analysis and eco-region planning. After identifying in both global and national scales the potential areas with gaps in national nature reserves in China, it proposes conservation priority areas and optimization strategies. The study finds that in a global extent, the areas with the gaps in China cover a large area and are distributed widely, mostly on the both sides of the Tengchong-Heihe Line. The conservation priority areas are concentrated in mid-subtropical humid areas, plateau subtropical sub-humid areas and semi-arid areas, and plateau temperate humid/sub-humid areas. These areas are usually not sufficiently protected due to their diversified landforms, complex ecosystems and lack of protection measures. The results have verified and identified the areas with gaps in the building of Chinese national nature reserve system. They may make a unique and important contribution to global ecological conservation efforts in terms of protected area system optimization and conservation network building. Synopsis: This paper analyses the conservation gaps in China's national nature reserves and proposes conservation priority areas for optimising the layout of the nature reserve network.

Liver cancer is a prevalent malignant tumor with high mortality worldwide, making it urgent to explore new targets for liver cancer therapy. N-terminal EF-hand calcium binding protein 3 (NECAB3) is a new recognized regulator of cancer, while its role in liver cancer remained elusive. Thus, the study clarified the action of NECAB3 on liver cancer development and explored the detailed mechanism. We found that NECAB3 was enhanced in liver cancer. Knockdown of NECAB3 restrained liver cancer cell migration and invasion. Besides, knockdown of NECAB3 suppressed the activation of the hypoxia-inducible factor 1-alpha (HIF-1α)/Ras like without CAAX 1 (RIT1) pathway. Furthermore, NECAB3 regulated liver cancer migration and invasion through modulating RIT1 expression. Moreover, downregulation of NECAB3 suppressed liver cancer tumor growth in vivo. In conclusion, NECAB3 was upregulated in liver cancer. Knockdown of NECAB3 suppressed aggressive phenotype of liver cancer via modulating the HIF-1α/RIT1 axis, providing a possible target for liver cancer therapy.

Asymmetric metasurfaces supporting quasi-bound states in the continuum (BICs) with high Q-factors and strong light–matter interaction properties are attractive platforms for label-free biosensing applications. Recently, various meta-atom geometries have been exploited to support sharp high-Q quasi-BIC resonance. However, which meta-atom design may be a better practical choice remains unclear. Here, we compared several established meta-atom designs to address this issue by conducting an extensive theoretical discussion on sensing capability and fabrication difficulty. We theoretically revealed that the tetramer meta-atom geometry produces a higher surface sensitivity and exhibits a larger size-to-wavelength ratio than other meta-atom schemes. Furthermore, we found that metasurfaces with a higher depth considerably enhance surface sensitivity. The performance of two asymmetric tetramer metasurfaces (ATMs) with different heights was demonstrated experimentally. Both shallow and thick ATM structures exhibit sharp high Q-factor resonances with polarization-insensitive features. Notably, the surface sensitivity is 1.62 times for thick ATM compared to that for shallow ones. The combination of properties opens new opportunities for developing biosensing or chemical-sensing applications with high performance.

The model of distributed PV is constructed firstly, then the characteristics of distributed PV are studied and the electromechanical transient current equations are given. Using the actual PV grid-connected controller, a simulation system based on PSASP simulation platform is built. Through this system, the transient power characteristics of distributed PV during low voltage ride-through period are studied. Through theoretical analysis and experimental verification, the fault characteristics of distributed photovoltaic power supply are comprehensively expounded.

On a global scale, drought, salinity, extreme temperature, and other abiotic stressors severely limit the quality and yield of crops. Therefore, it is crucial to clarify the adaptation strategies of plants to harsh environments. Chloroplasts are important environmental sensors in plant cells. For plants to thrive in different habitats, chloroplast homeostasis must be strictly regulated, which is necessary to maintain efficient plant photosynthesis and other metabolic reactions under stressful environments. To maintain normal chloroplast physiology, two important biological processes are needed: the import and degradation of chloroplast proteins. The orderly import of chloroplast proteins and the timely degradation of damaged chloroplast components play a key role in adapting plants to their environment. In this review, we briefly describe the mechanism of chloroplast TOC-TIC protein transport. The importance and recent progress of chloroplast protein turnover, retrograde signaling, and chloroplast protein degradation under stress are summarized. Furthermore, the potential of targeted regulation of chloroplast homeostasis is emphasized to improve plant adaptation to environmental stresses.

During the normal operation of pressurized water reactors, tritium has contributed more than 95 % of the total radioactivity of all the radionuclides discharged into the environment and has been recognized as the key radionuclide in the design and operation of reactors. In the paper, the tritium production of the AP1000 reactor by the Westinghouse approach has been introduced and the diffusion fractions of tritium from fuel rods in the approach have been reviewed according to advances in research on the diffusion of tritium from zirconium alloys. The historical tritium discharge data from the predecessors with very similar core designs of the AP1000 reactor have been collected and sorted. According to the statistical results, the average tritium discharge approximates the tritium generated from neutron activation of boric acid and lithium hydroxide and it shows that the release fraction of tritium through fuel cladding with zirconium alloy may be neglected for the best-estimated condition. The release of tritium from secondary neutron sources has been validated by a comparison of historical tritium discharge from the predecessors with and without secondary sources. In addition, it indicates that local maximum tritium emissions from the U.S. Pressurized Water Reactors are remarkably affected by batch liquid release, especially before or during the overhauls. It will help recognize the tritium generation in the primary loops and optimize the management of radioactive emissions for the utilities of the AP1000 reactor in the future.

Background/Aim. Prediabetes (PD) refers to the condition in which the blood sugar level is higher than normal but has not reached the diagnostic criteria for diabetes mellitus (DM) yet. Impaired glucose tolerance (IGT) is a major prediabetic symptom since most patients with type 2 DM have progressed from the previous PD phase. The aim of the study was to observe the changes in serum metabolomics in patients with IGT treated with Hibiscus esculentus L. (H. esculentus) combined with the change of lifestyle. Methods. Sixty patients with IGT were divided into two groups. In one group, the subjects made a life-style change (LC group, simple diet control), and the other group of subjects made a lifestyle change combined with H. esculentus (LCH group) treatment with daily consumption of 20 g of dried H. esculentus fruit tea. The aim was to compare the blood glucose, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, and serum metabolomics after a 60-day clinical observation period. Results. There was no statistical significance in the glucose level between the two groups by the end of the observation period. The HOMA-IR index in the LCH group was lower than in the LC group (1.7 ± 1.1 vs. 2.4 ± 1.2, p = 0.030). Serum metabolomics revealed that the levels of d-galactose, d-glucose, turanose, and uric acid in the LCH group were significantly lower than those in the LC group (16.7 ± 3.9 mmol/L vs. 21.2 ±2.9 mmol/L, 101.5 ± 40.2 mmol/L vs. 132.9 ± 36.7 mmol/L, 1.8 ± 1.6 mmol/L vs. 3.76 ± 2.46 mmol/L, 44.56 ± 15.7 μmol/L vs. 67.8 ± 23.5 μmol /L, respectively). The levels of lactic acid and conjugated linoleic acid in the LCH group were significantly higher than those in the LC group (3.3 ± 0.5 mmol/L vs. 2.3 ± 0.8 mmol/L, 6.9 ± 6.1 mmol/L vs. 2.1 ± 1.2 mmol/L, respectively). Conclusion. H. esculentus, combined with a change of lifestyle, can reduce insulin resistance and the levels of multiple monosaccharides and blood uric acid in IGT patients. Regulation of the metabolism of lactic acid and conjugated linoleic acid may be the potential mechanism of how H. esculentus reduces insulin resistance.

Self-powered photodetectors with broadband and polarization-sensitive photoresponse are desirable for many important applications such as wearable electronic devices and wireless communication systems. Recently, two-dimensional (2D) materials have been demonstrated as promising candidates for self-powered photodetectors owing to their advantages in light–matter interaction, transport, electronic properties, and so on. However, their performance in speed, broadband response, and multifunction is still limited. Here, we report a PdSe2 photodetector with asymmetric van der Waals (vdWs) contacts formed by using a homojunction configuration. This device achieves a high responsivity approaching 53 mA/W, a rise/decay time of about 0.72 ms/0.24 ms, and a detectivity of more than 5.17 × 1011 Jones in the visible-near infrared regime (532–1470 nm). In addition, a linear polarization-sensitive response can be observed with an anisotropy ratio of 1.11 at 532 nm and 1.62 at 1064 nm. Furthermore, a strong anisotropic response endows this photodetector with outstanding polarization imaging capabilities, realizing a contrast-enhanced degree of linear polarization imaging. Our proposed device architecture demonstrated the great potential of PdSe2-based asymmetric vdWs contacts for high-performance photodetectors operating without any external bias.

Taxus cuspidata S. et Z. is a precious species of frigid zone plant belonging to the Taxaceae family, which possesses anticancer, anti-inflammatory, hypoglycemic, and antibacterial pharmacological properties. While taxane extracted from Taxus chinensis has been reported to elicit antioxidant activities, whether Taxus cuspidata S. et Z. has skin-protective actions against injuries remained unknown. This study aims to explore the pharmacological effects of three Taxus extracts on skin melanin deposition, oxidation, inflammation, and allergy so as to provide new ideas for the prevention and treatment of various diseases related to skin damage.

Abstract Background and purpose The complications of radical surgery for cervical cancer can increase patient suffering and affect their quality of life. This retrospective study assessed the safety of radical hysterectomy (RH) with pelvic lymph node dissection (PLND) by observing the complications of patients with cervical cancer who underwent this procedure in a single centre over 10 years. Our findings may provide experience and evidence for preventing and reducing complications. Methods A total of 2226 cervical cancer patients who met the inclusion criteria were enrolled. All patients underwent RH + PLND. Intraoperative injury to adjacent tissues and short-term and long-term complications were recorded to analyze factors associated with the occurrence of complications. Results Postoperative complications occurred in 34.41% (766/2226) of patients, including 7.68% of patients with injury to adjacent tissues, 31.45% with short-term complications, and 2.96% with long-term complications. Age, tumor size, invasion depth, parametrial invasion, lymph vascular space invasion (LVSI), lymph node metastasis, International Federation of Gynaecology and Obstetrics (FIGO) stage, and surgical procedure were closely associated with the postoperative complications of RH + PLND (P IB2, and who underwent open surgery were more prone to complications.

Cold exposure increases the risk of adverse events related to cardiovascular causes, especially in the elderly. In this review, we focus on recent findings concerning the impact of aging on the regulatory mechanisms of cold-induced cardiovascular responses. In response to cold exposure, the initial physiological thermoregulation in healthy young persons, such as cutaneous vasoconstriction to reduce heat loss, is attenuated in older individuals, resulting in a reduced ability of the older persons to maintain body temperature in cold environment. Impaired sympathetic skin response, reduced noradrenergic neurotransmitter synthesis, insufficient noradrenergic transmitters, and altered downstream signaling pathways inside the vascular smooth muscle may be among the underlying mechanisms for the maladaptive vasoconstrictive response to cold stress in the elderly. The increase in blood pressure during cold exposure in young persons may be further augmented in aging adults, due to greater central arterial stiffness or diminished baroreflex sensitivity with aging. Cold stress raises myocardial oxygen demand caused by increased afterload in both young and old adults. The elderly cannot adjust to meet the increased oxygen demand due to reduced left ventricular compliance and coronary blood flow with advancing age, rendering the elderly more susceptible to hypothermia-induced cardiovascular complications from cold-related diseases. These age-associated thermoregulatory impairments may further worsen patients' health risk with existing cardiovascular diseases such as hypertension, coronary artery disease, and heart failure. We searched PubMed for papers related to cold stress and its relationship with aging, and selected the most relevant publications for discussion.

In this work, the microstructure and properties of Nb-16Si-24Zr alloy directionally solidified by electromagnetic cold crucible under different process parameters were investigated. As the pulling rate increases, the size of both primary Nbss and eutectic Nbss decreases, resulting in a straighter primary dendrite γ-Nb5Si3 and a fishbone like Nbss/γ-Nb5Si3 coupling structure of secondary eutectic. As the power supply increases, the size of the nascent Nbss and γ-Nb5Si3 increases, and the coupling growth trend of Nbss and Nb5Si3 weakens. As the pulling rate and power supply increase, the toughness shows a trend of first increasing and then decreasing, while the room temperature compressive strength gradually increases.

To explore the technological innovation efficiency of industrial enterprises above designated size and its influencing factors under the China’s economic census industry classification, using the stochastic frontier approach to estimates the innovation efficiency of the 34 industry from 2008 to 2018. Taking the sales revenue of new products as the dependent variable, R&D capital stock and R&D personnel equivalent are taken as the independent variable, control variables are reasonably selected. The characteristics and influencing factors of innovation efficiency between industries are analyzed. The results show that the innovation efficiency of all industries in China is steadily improving, and the difference between industries is gradually narrowing. Industries with high innovation efficiency are related to future competition and national economy and people’s livelihood, while industries with low innovation efficiency are concentrated in mining and supply industry. The low input and low output industries are in the majority. The influence of innovation capital input on output is greater than that of personnel input. The proportion of state-owned property rights and capital constraints have a negative effect on innovation output, while the sales income has a positive effect on innovation output. Therefore, China should further improve the innovation efficiency of industrial industries, adopt classified policies, and increase the number of industries with low input and high output. The conclusion of the paper is of reference value to the development of China’s 14th five-year industry and the medium and long term planning.

Maritime activities play a crucial role in the social and economic development of human societies. Many countries around the world have become powerful as a result of the flourishing maritime activities. However, maritime activities entail high risks, making ship navigation safety a paramount concern for maritime authorities, practitioners, and scholars worldwide. In recent years, the continuous growth in the number and tonnage of vessels, coupled with the increasing density of waterway traffic, has posed a serious threat to maritime safety, leading to a rise in maritime accidents. This paper conducts a comprehensive analysis by examining distress alarm data from the Guangzhou Coastal Radio Station over a decade from 2010 to 2019, and integrating it with Port State Control (PSC) inspection data from the Guangzhou Port Supervision and Inspection Station. The aim is to explore scientific and effective approaches for analyzing the safety status of ship navigation, preemptively preventing maritime accidents, and thereby providing valuable insights for maritime management agencies and navigation security departments to enhance their maritime management capabilities and navigation safety service levels.

You should leave 8 mm of space above the abstract and 10 mm after the abstract. The heading Abstract should be typed in bold 9-point Arial. The body of the abstract should be typed in normal 9-point Times in a single paragraph, immediately following the heading. The text should be set to 1 line spacing. The abstract should be centred across the page, indented 17 mm from the left and right page margins and justified. It should not normally exceed 200 words.

The Nb-16Si-20Ti-4Cr-1.5Al-4Hf-4Zr-1Ta-xB (x=0, 2, 4)-yMg (y=0, 0.2, 0.4) alloys were prepared by non-consumable arc melting. The effects of B and Mg addition on the microstructure and room temperature fracture toughness have been investigated. The results reveal that when the content of B element reached 4 at.%, the intermediate metastable phase Nb3Si was precipitated in Nb-Si based alloys. The cooperation of B and Mg synergistically enhances the room temperature fracture toughness of Nb-Si based alloy. B and Mg element causes the eutectic point of Nb-Si based alloy to shift to the right. The 2B-0.4Mg alloy shows the best fracture toughness, and its KQ value is 14.41 MPa·m 1/2, which increased by 34% compared to the matrix alloy. Crack deflection and secondary cracking increase the room-temperature fracture toughness of Nb-Si-based alloys.

Objective To report the characteristics of cardiac involvement in a group of patients with mitochondrial encephalomyopathy with lactic academia and stroke⁃like episodes (MELAS). Methods A total of 113 patients with MELAS who were admitted to Peking University First Hospital from January 2010 to December 2019 were included. The type and severity of heart disease were judged by electrocardiogram (ECG) and echocardiography. Cardiac dysfunction and systolic function were assessed by New York Heart Association (NYHA) classification and left ventricular ejection fraction (LVEF). Results All 113 patients were from 112 families, and the main genotype was m. 3243 A＞G (81.42%, 92/113). ECG was performed in 113 cases, among which 14 (12.38%) had abnormal cardiac conduction, including 10 (8.85%) with pre⁃excitation syndrome, 3 (2.65%) with complete or incomplete right bundle branch block, and one (0.88%) with Ⅰ° atrioventricular block. Echocardiography was performed in 70 cases, among which 18 (25.71%) had myocardial lesions, including 13 (18.57%) with myocardial damage and 5 (7.14%) with pulmonary hypertension (PH). Only one case had NYHA Ⅱ with decreased left ventricular systolic function. In 32 patients with cardiac disease, only one patient presented cardiac symptoms in the 7th year of the course of disease. Conclusions MELAS patients may have various manifestations of cardiac involvement, including cardiomyopathy, heart failure, arrhythmia, and so on. Attention should be paid to cardiac⁃related examinations.

The thermal storage temperature and water-rock interaction process of the Lushan convective geothermal system (Qinling stratigraphic zonation fracture zone in China) are clarified by using surface cold water and geothermal fluid as the research objects. In this study, a conceptual model of the temperature profile of the geothermal system in the study area was developed using surface temperature inversion, the cation temperature scale, the SiO2 temperature scale method, the mineral equilibrium phase method, the silicon-enthalpy model, the FixAl method, and the Cl-enthalpy model. The inversion temperature at the surface is in the range of 33-39°C, and the temperature difference indicates the direction of the Checun-Lushan fracture. The study area is recharged from atmospheric precipitation, and the temperature of the recharge area is approximately 5.8–7.7°C (the temperature of the alkali field is approximately 10°C), and the recharge elevation is approximately 1200 m. The thermal storage pattern in the study area is near-surface hydrothermal thermal storage transferred to shallow thermal storage and then to deep thermal storage. The near-surface hydrothermal thermal storage temperature is at a constant temperature of 60°C, and the shallow thermal storage temperature is calculated by K-Mg and Li-Mg geothermometers to be between 99 and 112°C. The thermal storage temperature is simulated using the FixAl method, with deviation values ranging from 2.9% to 15.0%. The silicon-enthalpy model calculates the deep thermal storage temperature to be between 181 and 230°C. The mixing ratio of geothermal water in the study area is extremely high, with a cold water mixing ratio of 85.4–94.8%. The home ground fluid temperature was estimated to be approximately 282°C using the Cl-enthalpy model. The main thermally controlled conductivity channel in the study area is the Checun-Lushan fracture zone. The water vapor formed by convection at depth moves upward to approximately 5 km to form a deep thermal reservoir, and this convection and upward movement cause it to mix with cold water from the fracture zone to form a shallow thermal reservoir, which moves to the near-surface, forming a hydrothermal-type reservoir, which is later discharged in the form of a spring. The conceptual model of geothermal system temperature established in this study provides a basis for further development and utilization of Lushan hot springs and provides guidance for future thermal storage temperature calculations of convection-type geothermal systems in uplifted mountains.

In the reliability analysis of slope stability, the deterministic analysis method is usually used to calculate the safety factor to evaluate the stability of slope. However, the inherent spatial variability of rock mass properties cannot be considered and described adequately in traditional deterministic method, resulting in the inaccurate calculation of slope failure probability. Based on Hoek-Brown criterion and random finite difference method (RFDM), the reliability analysis of slope stability and random response of pile are discussed in this paper considering spatial variability of rock mass. The uniaxial compressive strength σci and material constant for the intact rock mi are regarded as random field variables and geological strength index GSI is assumed to be a random variable. The results show that the spatial variability of rock mass parameters has a significant effect on slope failure probability and pile response. Ignoring the spatial variability of rock mass parameters will overestimate slope failure probability and the mean value of the maximum bending moment of anti-slide pile, and underestimate the mean value of displacement at pile head. The results can provide design guidance for slope reinforcement as well as layout optimization of anti-sliding piles.

The cylindrical filament wound composite overwrapped pressure vessels (COPV) with metal liner has been widely used in spaceflight due to their high strength and low weight. After the autofrettage process, the plastic deformation of the metal liner is constrained by composite winding layers, which introduce depressions to the metal liner that causes local buckling. To predict the local buckling of the inner liner with depressions of the pressure vessel after the autofrettage process, a local buckling analysis method for the metal liner of COPV was developed in this article. The finite element method is used to calculate the overall stress distribution in the pressure vessel before and after the autofrettage process, and the influence of local depressions on the buckling is evaluated. The axial buckling of the pressure vessel under external pressure is analyzed. The control equation of the metal liner with depressions is developed, considering the changes in the pressure and the bending moment of the liner depressions and its vicinity during the loading and unloading process. Taking the cylindrical COPV (38 L) with aluminum alloy liner as an example, the effects of liner thickness, liner radius, the thickness-to-diameter ratio, autofrettage pressure, and the length of straight section on the autofrettage process are discussed. The results show that the thickness of the inner liner has the most significant influence on the buckling of the liner, followed by the length of the straight section and the radius of the inner liner, while the autofrettage pressure has the least influence.

There are many challenges in the process of underground engineering construction, such as high stress, extremely soft rock, strong mining and other complex conditions. The surrounding rock is difficult to control and its deformation is serious due to the stress concentration and energy accumulation, leading to frequent roof fall, collapse, rock burst and other accidents. Anchor bolt is the main support mode of underground engineering chamber. In order to absorb energy released by surrounding rock deformation and control the deformation of surrounding rock, it is necessary to develop energy-absorbing bolt with high constant resistance, high elongation and high prestress. This paper summarizes and analyzes the development process, performance test and field application of energy-absorbing bolt. Energy-absorbing bolt absorb energy by structural slip and material deformation. According to the working principle, the energy-absorbing bolt can be divided into three types: rod structure type, mechanical structure type and body material type. Compared with structural energy-absorbing bolt, the structure of material energy-absorbing bolt is relatively simple, which can give full play to the mechanical properties of material. The author's team developed a new constant resistance energy-absorbing bolt, and carried out static tensile and dynamic impact tests. The results show that the bolt has high strength, high elongation and high energy absorption characteristics, which can meet the requirements of surrounding rock control under complex conditions. In the future, the test, design, construction and acceptance standards of the constant resistance energy-absorbing bolt should be formulated to realize its application in underground engineering in different fields such as mine, traffic, municipal engineering and water conservancy.

This article aims to improve the stretching quality of the flat noodles products by optimizing the key processes such as refining, formula and steaming on the breaking distance of whole grain flat noodles.The results show that the breaking distance of whole grain flat noodles prepared by backfilling rice bran is significantly better than that of whole rice refining. Meanwhile, scanning electron microscopy analysis shows that the grains of backfilled whole grain rice slurry are small, fine and uniform. The particle size results show that 83.91% of the particles are below 10 μm, and 14.93% of the particles are between 10 μm to 100 μm, while only 1.16% of them are larger than 100 μm, which is close to polished rice slurry. To further improve the stretching quality, the rice bran to be backfilled is selected. At the same time, the effect of adding soy protein isolate, guar gum, konjac mannan, cassava starch, gluten and other ingredients on the breaking distance of flat noodles is compared. The stretching quality of whole grain flat noodles prepared from homologous defatted rice bran and added soybean protein isolate is the closest to that of ordinary rice noodles. The material-toliquid ratio of the optimized steaming process is 1∶1.4 (g∶mL) and the products are steamed for 9 min.

CIPKs are a subclass of serine/threonine (Ser/Thr) protein kinases. CBLs are ubiquitous Ca2+ sensors that interact with CIPK with the aid of secondary Ca2+ messengers for regulation of growth and development and response to stresses faced by plants. The divergent roles of the CIPK-CBL interaction in plants include responding to environmental stresses (salt, cold, drought, pH, ABA signaling, and ion toxicity), ion homeostasis (K+, NH4+, NO3−, and microelement homeostasis), biotic stress, and plant development. Each member of this gene family produces distinct proteins that help plants adapt to diverse stresses or stimuli by interacting with calcium ion signals. CIPK consists of two structural domains—an N-terminal domain and a C-terminal domain—connected by a junction domain. The N-terminal domain, the site of phosphorylation, is also called the activation domain and kinase domain. The C-terminal, also known as the regulatory domain of CIPK, further comprises NAF/FISL and PPI. CBL comprises four EF domains and conserved PFPF motifs and is the site of binding with the NAF/FISL domain of CIPK to form a CBL-CIPK complex. In addition, we also performed a bibliometric analysis of the CIPK gene family of data extracted from the WoSCC. A total of 95 documents were retrieved, which had been published by 47 sources. The production over time was zigzagged. The top key terms were gene, CIPK, abiotic stress, and gene expression. Beijing Forestry University was the top affiliation, while The Plant Cell was the top source. The genomics and metabolomics of this gene family require more study.

Abstract Objective This study aimed to evaluate the clinical outcomes for patients with stage IB2/IIA2 cervical squamous cell carcinoma treated with neoadjuvant chemotherapy combined with radical surgery. Methods A total of 68 patients with cervical squamous cell carcinoma were randomly divided into the experimental group (n = 35) and the control group (n = 33). The patients in the experimental group received paclitaxel plus cisplatin neoadjuvant chemotherapy for two cycles, then underwent radical hysterectomy and bilateral adnexectomy at 2 weeks post-chemotherapy. The control group only underwent radical hysterectomy and bilateral adnexectomy after the diagnosis of cervical squamous cell carcinoma. The toxic and side effects of chemotherapy in the experimental group were observed. Also, the operation method, operation time, blood loss, grade of wound healing, complications, and postoperative pathology were noted in the two groups. Primary foci and pelvic lymph node recurrence and distant metastasis were observed, and 3-year and 5-year survival rates were calculated. Results Only one patient in the experiment had grade III bone marrow suppression; no other grade III and IV chemotherapy toxic reactions were observed. The operation was successfully completed in all patients. The operation time, intraoperative blood loss, placement of the ureteral catheter, bladder injury, ureteric injury, postoperative urinary tub, pelvic drainage tube indwelling time, anal exhaust time, postoperative complications, and metastatic ratio of lymph nodes were not significantly different between the two groups (P > 0.05). The number of dissected lymph nodes, deep myometrial invasion, and vascular tumor emboli showed a significant difference in the experimental group compared with the control group (P < 0.05). The 3-year disease-free survival (82.9% vs 81.9%), 5-year disease-free survival (71.4% vs 60.6%), 3-year overall survival (91.4% vs 87.8%), and 5-year overall survival (82.9% vs 75.6%) were not statistically significantly different between the experimental group and the control group (P > 0.05). Conclusions Neoadjuvant chemotherapy in IB2/IIA2 stage cervical squamous cell carcinoma showed low toxic side effects. Radical surgery after chemotherapy is safe and feasible. It plays a coordinating role in reducing the tumor infiltration depth of the deep muscle layer and the incidence of vascular tumor emboli, reducing the use of postoperative adjuvant therapy, and improving the quality of life of patients, but does not improve the 3-year/5-year survival rate.

The hot tensile tests were conducted in this study to investigate the effects of Nb, B, Mo, and V on hot ductility of 25CrMo alloy steel in a temperature range of 650–850°C with strain rates of 0.005 and 0.5 s−1. Besides, the influences of ferrite transformation and precipitates on hot ductility were also investigated by the use of SEM and TEM. Thermo-Calc and J Mat Pro were used for calculating equilibrium precipitates and CCT curves, respectively. The results indicated that the hot ductility is deteriorated with the addition of 0.04% Nb due to Nb(C,N) particles and ferrite transformation. The addition of B inhibits ferrite transformation and improves hot ductility. The hot ductility is improved with increasing strain rate from 0.005 to 0.5 s−1 due to the nucleation and growth behavior of ferrite. The fast strain rate promotes nucleation of ferrite; however, the ferrite has no sufficient time to grow up. The addition of Mo inhibits ferrite transformation and improves hot ductility. The addition of 0.12% V has no obvious effect on ferrite transformation. The hot ductility has deteriorated a little with the addition of 0.12% V due to the solution V that increases stress during hot deformation.

Nicotine withdrawal symptoms, mainly anxiety, cause high level of relapse rate after quitting smoking. Vitamin D supplementation has shown its potential for the prevention and treatment of anxiety disorders; however, neurobiological studies about the effect of vitamin D on nicotine withdrawal-induced anxiety are limited. To investigate the effect and molecular mechanism of vitamin D3 supplement by dietary on anxiety-like behavior during nicotine withdrawal, male C57/BL6 mice were divided into four groups: vehicle, nicotine only, vitamin D3 only, and nicotine plus vitamin D3. Mice were administrated with nicotine in drinking water (200 µg/mL), and vitamin D3 in feed for 6 weeks. During nicotine withdrawal, vitamin D3-treated mice showed significantly less anxiety-like behavior by an open-field test and marble buried test that performed an increase in the duration of the central zone and a decrease buried marble, respectively. Moreover, vitamin D3 supplementation attenuated the hippocampal NR2A expression on both protein and mRNA levels in nicotine and vitamin D3-treated mice. Our data showed that dietary supplementation with vitamin D3 ameliorated nicotine withdrawal-induced anxiety, which may be related to downregulation of NR2A expression in hippocampus. Vitamin D3 may provide a new dietary intervention with the easy access for smoking cessation.

C17H12F2O1, monoclinic, P1‾$P\overline{1}$ (no. 2), a = 7.3832(8) Å, b = 8.6467(9) Å, c = 11.3278(11) Å, α = 87.633(8)°, β = 88.022(8)°, γ = 65.364(10)°, V = 654.88(13) Å3, Z = 2, Rgt(F) = 0.0369, wRref(F2) = 0.0987, T = 293(2) K.

In tunnel design and construction, the stability evaluation of tunnel roof wedge usually adopts traditional deterministic analysis methods, which cannot appropriately reflect the spatial variability of rock mass. Based on limit equilibrium method, an efficient approach for evaluating the safety factor integral expression of tunnel roof wedge is presented in this study. This approach considers the influence of spatial variability of rock mass joint friction angle and is validated by universal distinct element code (UDEC). Based on random field method and Monte Carlo simulation (MCS), a generated random field is substituted into the established safety factor integral expression to calculate the safety factor of the tunnel wedge, in which the spatial variability of rock mass joint friction angle is well considered. The failure probability of roof wedge is calculated with consideration of geological and geometry parameters uncertainties. The results indicate that the spatial variability of rock mass joint friction angle has a significant influence on the failure probability of tunnel roof wedge. Ignoring the spatial variability of rock mass mechanical parameters will cause an overestimated failure probability of tunnel roof wedge.

WSN (Wireless Sensor Network) is an important way to transmit intelligent electricity business data, but it is more and more difficult to meet different performance requirements of different businesses. In the view of WSN power control problem, an adaptive power control algorithm based on intelligent electricity business classification was proposed in this paper. Firstly, the theory of node power control was analyzed. Secondly, the business classification and interference power adjustment factors were increased, to combine intelligent electricity business with network topology of WSN and realize the modeling of business classification based adaptive power control algorithm. Finally, this algorithm was compared with optimal power algorithm and LINT algorithm by simulation experiment in the performance of packet loss rate, delay and throughput. Simulation results showed that the algorithm proposed in this paper is better than others.

Alepterolic acid is a natural diterpenoid isolated from Aleuritopteris argentea (S. G. Gmél.) Fée, a fern with potential medicinal activity, used in China as a folk medicine to regulate menstruation and prevent cancer. Nevertheless, there are few reports about the structural modification of this natural product. With the wide application of 1,2,3-triazole derivatives in medicines, pesticides, functional materials, the synthesis of 1,2,3-triazoles derivatives has attracted the attention of synthetic chemists. In this article, 23 new derivatives of alepterolic acid combined with 1,2,3-triazole were designed and synthesized by esterification and click chemistry reaction in a fast, conventional and efficient way. All the products were obtained in good yields (72 to 97 %). The structure of these compounds was confirmed by 1H-, 13C-NMR and mass spectral data. The use of the easily available reactants and the common reaction conditions furnish an efficient method for the synthesis of alepterolic acid derivatives. The preparation of these compounds would enable further biological evaluation in the future

Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality. The regulation mechanism of miRNA is involved in the production and development of various diseases, but the regulation mechanism of miRNA in AP is still not fully elucidated. The expression of miR-339-3p was detected using quantitative real-time PCR. The levels of TNF-α, IL-1β, and IL-6 were detected using enzyme-linked immunosorbent assay. Cell apoptosis was measured using flow cytometry. The protein expressions of TNF receptor-associated factor 3 (TRAF3), Bcl-2, C-caspase 3, Bax, p-p38, and p38 were measured using western blot. Luciferase reporter assay and RNA immunoprecipitation assay were applied to ensure that miR-399-3p targeted TRAF3. Caerulein promoted the expression of TNF-α, IL-1β, and IL-6, enhanced the expression of C-caspase 3 and Bax while inhibited Bcl-2 protein expression. Meanwhile, caerulein also reduced the expression of miR-339-3p and induced the expression of TRAF3 in rat pancreatic acinar cells. miR-399-3p transfection inhibited the levels of TNF-α, IL-1β, and IL-6 and C-caspase 3 and Bax protein expression as well as suppressed cell apoptosis, while increased Bcl-2 protein expression in caerulein-induced AP. TRAF3 has been verified as a target of miR-339-3p. Interestingly, the reduction of miR-399-3p inhibited the p38 pathway, which was impaired by the upregulation of TRAF3. In addition, the suppression effects of miR-339-3p on cell inflammation and apoptosis in caerulein-induced AP were reversed by enhancing TRAF3 expression. In this study, in vitro model of AP was characterized by strong inflammation and cell apoptosis. We have first demonstrated the regulatory network of miR-339-3p and TRAF3. Overexpression of miR-339-3p inhibited cell inflammation and cell apoptosis in caerulein-induced AP through modulating TRAF3 expression via the p38 pathway, providing a new therapeutic target in the treatment of AP.

ObjectiveTo study the regulatory role of GLI1/GLI2, a nuclear transcription factor of the Sonic hedgehog (Shh) signaling pathway, in epithelial–mesenchymal transition (EMT) related to hepatic fibrosis in patients with biliary atresia (BA).MethodsThe messenger RNA (mRNA) and protein expression levels of GLI1/GLI2, Snail/Slug, and other Shh- and EMT-related cytokines were tested in the liver tissues of BA patients and animals. Then, GLI1/GLI2 was silenced and overexpressed in mouse intrahepatic bile duct epithelial cells (mIBECs) and BA animals to investigate changes in the mRNA and protein expression of EMT key factors and liver fibrosis indicators. After silencing and overexpression of GLI1/GLI2, immunofluorescence was used to detect the expression of cytokeratin-19 (CK19) and α-smooth muscle actin (α-SMA) in mIBECs, and hematoxylin and eosin (HE) staining and Masson staining were used to observe the degree of liver fibrosis in the BA animals.ResultsCompared with the control, the mRNA and protein expression levels of GLI2, Snail, vimentin, and α-SMA were significantly increased and those of E-cadherin were significantly decreased in liver tissue from BA patients and animals. Overexpression of GLI2 increased the mRNA and protein expression levels of Snail, vimentin, and α-SMA and that of E-cadherin was significantly decreased in mIBECs and BA animals. After GLI2 silencing, the opposite pattern was observed. Immunofluorescence detection showed enhanced expression of the bile duct epithelial cell marker CK19 in mIBECs after GLI2 silencing and enhanced expression of the mesenchymal cell marker α-SMA after GLI2 overexpression. HE and Masson staining suggested that the GLI2-overexpressing group had a significantly higher degree of fibrosis.ConclusionThe Shh signaling pathway plays an important role in fibrogenesis in BA. GLI2 can significantly regulate EMT in mIBECs and livers of BA mice.

Cherenkov radiation in natural transparent materials is generally forward-propagating, owing to the positive group index of radiation modes. While negative-index metamaterials enable reversed Cherenkov radiation, the forward photon emission from a swift charged particle is prohibited. In this work, we theoretically investigate emission behaviours of a swift charged particle in the nanometallic layered structure. Our results show that Cherenkov photons are significantly enhanced by longitudinal plasmon modes resulting from the spatial nonlocality in metamaterials. More importantly, longitudinal Cherenkov photons can be directed either forward or backward, stringently depending on the particle velocity. The enhanced flexibility to route Cherenkov photons holds promise for many practical applications of Cherenkov radiation, such as novel free-electron radiation sources and new types of Cherenkov detectors.

The selenium-enriched lotus leaf sclerotium mycelium fermented in 20 L bio-tank was used as raw material to optimize the extraction process of selenium polysaccharide in mycelium and analyze the structure of water-soluble selenium polysaccharide through anti-cancer effect. The optimal extraction conditions of selenium polysaccharide were obtained by experiment and Box-Behnken design method: extraction time was 50 min, extraction temperature was 83 °C, ratio of material to liquid was 1:130 (g:mL), extraction times were 2 times. It is 44.62%, which is 0.02% higher than the predicted value. At this time, the selenium content in the polysaccharide reaches 31.9 μg/g. The purified selenium polysaccharide is analyzed for anticancer effect, which has proliferation inhibition effect on various human cancer cells and inhibits tumor in vivo. Growing. Keywords: Lotus leaf pleated umbrella, Mycelium, Selenium polysaccharide, Response surface analysis, Anticancer effect

In order to handle the non-linear system and the complex disturbance in marine engines, a finite-time convergence active disturbance rejection control (ADRC) technique is developed for the control of engine speed. First, a model for the relationship between engine speed and fuel injection is established on the basis of the mean value engine model. Then, to deal with the load disturbances and model parameter perturbation of the diesel engine, this paper designs an ADRC approach to achieve finite-time stability. Finally, simulation experiments show that the proposed method has better control effect and stronger disturbance rejection ability in comparison with the standard linear ADRC.

Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and is characterized by immune inflammation. The pathogenesis of SLE is complex and involves genetic and environmental components. Methods In this study, single nucleotide polymorphisms (SNPs) closely related to SLE were searched through integration analysis of public gene expression profiles from Gene Expression Omnibus and European Bioinformatics Institute data, and immunochip data in a genome-wide association study. Results SLE-associated SNPs were identified in 17 genes common among datasets. The mRNA expression levels of three genes among them were verified to differ between SLE patients and healthy controls subjects based on real-time polymerase chain reaction and sequencing of peripheral blood mononuclear cells (PBMCs). The GG genotype frequency of rs116253043 in LY6G6D was significantly lower in SLE patients and the GC genotype frequency of rs328 on LPL was significantly higher in SLE patients than in controls. VARS2 levels were significantly higher in SLE PBMCs than controls, but there was no significant difference in allele or genotype frequencies of the two SNPs (rs115470445 [C/T] and rs114394807 [A/G]) between groups. Conclusion Our results suggest that the GG genotype of rs116253043 plays a protective role against SLE, whereas the C allele of rs328 is a risk factor for SLE and rs116253043 with the GC genotype is an SLE-susceptibility SNP.

School bullying is a severe issue that accounts for a considerable proportion of juvenile delinquency. The increasing amount of research from different countries and ages related to school bullying shows various findings that confuse the public. As a result, this paper aims to review the leading causes and impacts of general school bullying that covers elementary children to high school students and school response to students’ bullying behavior. Regarding the bully, their behavior is associated with gender, grades, relationships, family, and other factors. Not only individual and environmental risk factors triggering the bullying are interpreted, but also the mental health problems and academic achievement influence of victims who suffered from bullying are revealed in the result.

Vacuum freeze-drying technology is the best way to preserve the quality of food at present, which can maintain the nutrition and flavor of food to the maximum extent. It has the characteristics of being green, convenient, and nutritious. This paper analyses the principle of vacuum freeze-drying technology and introduces its application in the processing of fruits and vegetables, meat food, aquatic products, and drinks, discusses the four operation processes of pre-treatment, pre-freezing, freeze-drying, and post-treatment, and finally summarizes the existing problems, deficiencies and development prospects.

Ice slurry precooling technology is a preservation technology that has unique advantages in the preservation of fruits and vegetables. It can make fruits and vegetables quickly drop to a suitable storage temperature. This paper summarizes the preparation methods of ice slurry, including the wall scraping method, undercooling method, vacuum method, fluidized bed method, and direct contact method. The wall scraping method, which has been widely used in industry and commerce, is the main method to design the dynamic ice slurry system between the buffer of fruit and vegetable air conditioning storehouse. Finally, this paper summarizes the characteristics and application of ice slurry precooling and makes a summary and prospect.

This paper first analyzes the commonness and current problems in the systematic construction of the university history museum, and then, combining with the experience and practice in the systematic optimization construction of the university history museum in our college, focuses on the conception of the content setting and spatial hierarchy optimization of the history museum, as well as the specific construction organization and working mechanism. It provides an example and reference for the systematic optimization and construction of history museums in other universities.

Rockburst is one of the dynamic disasters that seriously threatened the safety of mine production.The stress concentration in the isolated working face and its roadway is high, and the characteristics of the violent roof movement make it more easy to occur rock burst.In view of the characteristics of isolated working face in Tangshan Coal Mine, firstly, the comprehensive index method was used to determine the dangerous grade of working face Y484, and the working face was divided into seven weak impact strength, two medium impact strength and three strong impact strength areas.Later, borehole stress gauge and cross-point method were adopted to determine the peak position and influence range of support pressure in the area.According to different dangerous grades of rock burst, the technology of borehole pressure relief and blasting pressure relief were used to pre-control rock burst.The application study shows that the comprehensive prevention and control technology is safe and effective for the prevention and control of working face Y484.