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1. Arthroscopic meniscectomy versus non-surgical or sham treatment in patients with MRI confirmed degenerative meniscus lesions: a protocol for an individual participant data meta-analysis

Author

Ewa M Roos, Martin Englund, Victor A van de Graaf, Rudolf W Poolman, Maroeska M Rovers, Stan R W Wijn, Jan J Rongen, Håvard Østerås, May A Risberg, Kristoffer B Hare, and Gerjon Hannink

Subjects
Medicine
Abstract

Introduction Arthroscopic partial meniscectomy (APM) after degenerative meniscus tears is one of the most frequently performed surgeries in orthopaedics. Although several randomised controlled trials (RCTs) have been published that showed no clear benefit compared with sham treatment or non-surgical treatment, the incidence of APM remains high. The common perception by most orthopaedic surgeons is that there are subgroups of patients that do need APM to improve, and they argue that each study sample of the existing trials is not representative for the day-to-day patients in the clinic. Therefore, the objective of this individual participant data meta-analysis (IPDMA) is to assess whether there are subgroups of patients with degenerative meniscus lesions who benefit from APM in comparison with non-surgical or sham treatment.Methods and analysis An existing systematic review will be updated to identify all RCTs worldwide that evaluated APM compared with sham treatment or non-surgical treatment in patients with knee symptoms and degenerative meniscus tears. Time and effort will be spent in contacting principal investigators of the original trials and encourage them to collaborate in this project by sharing their trial data. All individual participant data will be validated for missing data, internal data consistency, randomisation integrity and censoring patterns. After validation, all datasets will be combined and analysed using a one-staged and two-staged approach. The RCTs’ characteristics will be used for the assessment of clinical homogeneity and generalisability of the findings. The most important outcome will be the difference between APM and control groups in knee pain, function and quality of life 2 years after the intervention. Other outcomes of interest will include the difference in adverse events and mental health.Ethics and dissemination All trial data will be anonymised before it is shared with the authors. The data will be encrypted and stored on a secure server located in the Netherlands. No major ethical concerns remain. This IPDMA will provide the evidence base to update and tailor diagnostic and treatment protocols as well as (international) guidelines for patients for whom orthopaedic surgeons consider APM. The results will be submitted for publication in a peer-reviewed journal.PROSPERO registration number CRD42017067240.

Published
2020
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2. Guidance from key organisations on exploring, confirming and interpreting subgroup effects of medical treatments: a scoping review

Author

Johannes B Reitsma, Maroeska M Rovers, Stan R W Wijn, Ly H Le, Michail Belias, Jeroen Hoogland, Joanna IntHout, and Thomas Debray

Subjects
Medicine
Abstract

Objectives With the increasing interest in personalised medicine, the use of subgroup analyses is likely to increase. Subgroup analyses are challenging and often misused, possibly leading to false interpretations of the effect. It remains unclear to what extent key organisations warn for such pitfalls and translate current methodological research to detect these effects into research guidelines. The aim of this scoping review is to determine and evaluate the current guidance used by organisations for exploring, confirming and interpreting subgroup effects.Design Scoping review.Eligibility criteria We identified four types of key stakeholder organisations: industry, health technology assessment organisations (HTA), academic/non-profit research organisations and regulatory bodies. After literature search and expert consultation, we identified international and national organisations of each type. For each organisation that was identified, we searched for official research guidance documents and contacted the organisation for additional guidance.Results Twenty-seven (45%) of the 60 organisations that we included had relevant research guidance documents. We observed large differences between organisation types: 18% (n=2) of the industry organisations, 64% (n=9) of the HTA organisations, 38% (n=8) of academic/non-profit research organisations and 57% (n=8) of regulatory bodies provided guidance documents. The majority of the documents (n=33, 63%) mentioned one or more challenges in subgroup analyses, such as false positive findings or ecological bias with variations across the organisation types. Statistical recommendations were less common (n=19, 37%) and often limited to a formal test of interaction.Conclusions Almost half of the organisations included in this scoping review provided guidance on subgroup effect research in their guidelines. However, there were large differences between organisations in the amount and level of detail of their guidance. Effort is required to translate and integrate research findings on subgroup analysis to practical guidelines for decision making and to reduce the differences between organisations and organisation types.

Published
2019
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3. MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION

Author

F. Van de Werf, D. Ardissino, A. Betriu, D. Cokkinos, E. Falk, K. Fox, D. Julian, M. Lengyel, F.J. Neumann, W. Ruzyllo, C. Thygesen, R. Underwood, A. Vahanian, F. Verheugt, and W. Wijns

Subjects
Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology.

Published
2015
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4. Arthroscopic partial meniscectomy for the degenerative meniscus tear: a comparison of patients included in RCTs and prospective cohort studies

Author

Stan R W Wijn, Gerjon Hannink, Jonas B Thorlund, Raine Sihvonen, Martin Englund, Maroeska M Rovers, and meniscus IPDMA collaboration group

Subjects
Arthroscopy, Degenerative meniscus tear, IPDMA, Knee, Meniscectomy, Osteoarthritis, Orthopedic surgery, RD701-811
Abstract

Background and purpose: Concerns exist regarding the generalizability of results from randomized controlled trials (RCTs) evaluating arthroscopic partial meniscectomy (APM) to treat degenerative meniscus tears. It has been suggested that study populations are not representative of subjects selected for surgery in daily clinical practice. Therefore, we aimed to compare patients included in trials and prospective cohort studies that received APM for a degenerative meniscus tear. Patients and methods: Individual participant data from 4 RCTs and 2 cohort studies undergoing APM were collected. 1,970 patients were analyzed: 605 patients included in RCTs and 1,365 included in the cohorts. We compared patient and disease characteristics, knee pain, overall knee function, and health-related quality of life at baseline between the RCT and cohort groups using standardized differences, ratios comparing the variance of continuous covariates, and graphical methods such as quantile–quantile plots, side-by-side boxplots, and non-parametric density plots. Results: Differences between RCT and the cohort were observed primarily in age (younger patients in the cohort; standardized difference: 0.32) and disease severity, with the RCT group having more severe symptoms (standardized difference: 0.38). While knee pain, overall knee function, and quality of life generally showed minimal differences between the 2 groups, it is noteworthy that the largest observed difference was in knee pain, where the cohort group scored 7 points worse (95% confidence interval 5–9, standardized difference: 0.29). Conclusion: Patients in RCTs were largely representative of those in cohort studies regarding baseline scores, though variations in age and disease severity were observed. Younger patients with less severe osteoarthritis were more common in the cohort; however, trial participants still appear to be broadly representative of the target population.

Published
2023
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5. Confounding adjustment methods in longitudinal observational data with a time-varying treatment: a mapping review

Author

Maroeska M Rovers, Stan R W Wijn, and Gerjon Hannink

Subjects
Medicine
Abstract

Objectives To adjust for confounding in observational data, researchers use propensity score matching (PSM), but more advanced methods might be required when dealing with longitudinal data and time-varying treatments as PSM might not include possible changes that occurred over time. This study aims to explore which confounding adjustment methods have been used in longitudinal observational data to estimate a treatment effect and identify potential inappropriate use of PSM.Design Mapping review.Data sources We searched PubMed, from inception up to January 2021, for studies in which a treatment was evaluated using longitudinal observational data.Eligibility criteria Methodological, non-medical and cost-effectiveness papers were excluded, as were non-English studies and studies that did not study a treatment effect.Data extraction and synthesis Studies were categorised based on time of treatment: at baseline (interventions performed at start of follow-up) or time-varying (interventions received asynchronously during follow-up) and sorted based on publication year, time of treatment and confounding adjustment method. Cumulative time series plots were used to investigate the use of different methods over time. No risk-of-bias assessment was performed as it was not applicable.Results In total, 764 studies were included that met the eligibility criteria. PSM (165/201, 82%) and inverse probability weighting (IPW; 154/502, 31%) were most common for studies with a treatment at baseline (n=201) and time-varying treatment (n=502), respectively. Of the 502 studies with a time-varying treatment, 123 (25%) used PSM with baseline covariates, which might be inappropriate. In the past 5 years, the proportion of studies with a time-varying treatment that used PSM over IPW increased.Conclusions PSM is the most frequently used method to correct for confounding in longitudinal observational data. In studies with a time-varying treatment, PSM was potentially inappropriately used in 25% of studies. Confounding adjustment methods designed to deal with a time-varying treatment and time-varying confounding are available, but were only used in 45% of the studies with a time-varying treatment.

Published
2022
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6. 2014 ESC/EACTS Guidelines on myocardial revascularization. The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Author

S. Windecker, P. Kolh, F. Alfonso, J. P. Collet, J. Cremer, V. Falk, G. Filippatos, C. Hamm, S. J. Head, P. Juni, A. P. Kappetein, A. Kastrati, J. Knuuti, U. Landmesser, G. Laufer, F. J. Neumann, D. J. Richter, P. Schauerte, M. Sousa Uva, G. G. Stefanini, D. P. Taggart, L. Torracca, M. Valgimigli, W. Wijns, A. Witkowski, ESC Committee for Practice Guidelines, J. L. Zamorano, S. Achenbach, H. Baumgartner, J. J. Bax, H. Bueno, V. Dean, C. Deaton, C. Erol, R. Fagard, R. Ferrari, D. Hasdai, A. W. Hoes, P. Kirchhof, P. Lancellotti, A. Linhart, P. Nihoyannopoulos, M. F. Piepoli, P. Ponikowski, P. A. Sirnes, J. L. Tamargo, M. Tendera, A. Torbicki, EACTS Clinical Guidelines Committee, Document reviewers, J. Pepper, A. Anyanwu, L. Badimon, J. Bauersachs, A. Baumbach, F. Beygui, N. Bonaros, M. De Carlo, D. Dobrev, J. Dunning, E. Eeckhout, S. Gielen, H. Luckraz, H. Mahrholdt, G. Montalescot, D. Paparella, A. J. Rastan, M. Sanmartin, P. Sergeant, S. Silber, J. Tamargo, J. ten Berg, H. Thiele, R. J. van Geuns, H. O. Wagner, S. Wassmann, O. Wendler, F. Weidinger, F. Ibrahimov, V. Legrand, I. Terzi, A. Postadzhiyan, B. Skoric, G. M. Georgiou, M. Zelizko, A. Junker, J. Eha, H. Romppanen, J. L. Bonnet, A. Aladashvili, R. Hambrecht, D. Becker, T. Gudnason, A. Segev, O. Sakhov, A. Mirrakhimov, B. Pereira, H. Felice, T. Trovik, D. Dudek, H. Pereira, M. A. Nedeljkovic, M. Hudec, A. Cequier, D. Erlinge, M. Roffi, S. Kedev, F. Addad, A. Yildirir, J. Davies, BUGIARDINI, RAFFAELE, Dobrev, Dobromir (Beitragende*r), University of Zurich, Windecker, Stephan, S. Windecker, P. Kolh, F. Alfonso, J.-P. Collet, J. Cremer, V. Falk, G. Filippato, C. Hamm, S. J. Head, P. Juni, A. P. Kappetein, A. Kastrati, J. Knuuti, U. Landmesser, G. Laufer, F.-J. Neumann, D. J. Richter, P. Schauerte, M. Sousa Uva, G. G. Stefanini, D. P. Taggart, L. Torracca, M. Valgimigli, W. Wijn, A. Witkowski, ESC Committee for Practice Guideline, J. L. Zamorano, S. Achenbach, H. Baumgartner, J. J. Bax, H. Bueno, V. Dean, C. Deaton, C. Erol, R. Fagard, R. Ferrari, D. Hasdai, A. W. Hoe, P. Kirchhof, P. Lancellotti, A. Linhart, P. Nihoyannopoulo, M. F. Piepoli, P. Ponikowski, P. A. Sirne, J. L. Tamargo, M. Tendera, A. Torbicki, EACTS Clinical Guidelines Committee, Document reviewer, J. Pepper, A. Anyanwu, L. Badimon, J. Bauersach, A. Baumbach, F. Beygui, N. Bonaro, M. De Carlo, D. Dobrev, J. Dunning, E. Eeckhout, S. Gielen, H. Luckraz, H. Mahrholdt, G. Montalescot, D. Paparella, A. J. Rastan, M. Sanmartin, P. Sergeant, S. Silber, J. Tamargo, J. ten Berg, H. Thiele, R.-J. van Geun, H.-O. Wagner, S. Wassmann, O. Wendler, F. Weidinger, F. Ibrahimov, V. Legrand, I. Terzi, A. Postadzhiyan, B. Skoric, G. M. Georgiou, M. Zelizko, A. Junker, J. Eha, H. Romppanen, J.-L. Bonnet, A. Aladashvili, R. Hambrecht, D. Becker, T. Gudnason, A. Segev, R. Bugiardini, O. Sakhov, A. Mirrakhimov, B. Pereira, H. Felice, T. Trovik, D. Dudek, H. Pereira, M. A. Nedeljkovic, M. Hudec, A. Cequier, D. Erlinge, M. Roffi, S. Kedev, F. Addad, A. Yildirir, and J. Davies

Subjects
Carotid Artery Diseases, Graft Rejection, Reoperation, Diabetic Cardiomyopathies, Decision Making, Heart Valve Diseases, Myocardial Infarction, Medizin, Contrast Media, Coronary Disease, 610 Medicine & health, Guideline, Myocardial ischaemia, Risk Assessment, 2705 Cardiology and Cardiovascular Medicine, Percutaneous coronary intervention, Peripheral Arterial Disease, Fibrinolytic Agents, Patient Education as Topic, 360 Social problems & social services, Humans, Hypoglycemic Agents, Blood Transfusion, Drug Interactions, Thrombolytic Therapy, Coronary Artery Bypass, Renal Insufficiency, Chronic, Heart Failure, Patient Care Team, ta3126, Informed Consent, ACUTE CORONARY SYNDROMES, Bare-metal stent, Anticoagulants, Arrhythmias, Cardiac, ta3121, 10020 Clinic for Cardiac Surgery, Cardiac Imaging Techniques, Myocardial revascularization, Chronic Disease, Purinergic P2Y Receptor Antagonists, CORONARY ARTERY DISEASE, Stents, Heart-Assist Devices, Drug-eluting stent, Cardiology and Cardiovascular Medicine
Abstract

No abstract available - Guidelines

Published
2014
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7. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology

Author

Montalescot, Gilles, Sechtem, Udo, Achenbach, Stephan, Andreotti, Felicita, Arden, Chris, Budaj, Andrzej, Bugiardini, Raffaele, Crea, Filippo, Cuisset, Thomas, Di Mario, Carlo, Ferreira, J Rafael, Gersh, Bernard J, Gitt, Anselm K, Hulot, Jean-Sebastien, Marx, Nikolaus, Opie, Lionel H, Pfisterer, Matthias, Prescott, Eva, Ruschitzka, Frank, Sabaté, Manel, Senior, Roxy, Taggart, David Paul, van der Wall, Ernst E, Vrints, Christiaan J M, Zamorano, Jose Luis, Baumgartner, Helmut, Bax, Jeroen J, Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Cetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F, Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Valgimigli, Marco, Claeys, Marc J, Donner-Banzhoff, Norbert, Frank, Herbert, Funck-Brentano, Christian, Gaemperli, Oliver, Gonzalez-Juanatey, José R, Hamilos, Michalis, Husted, Steen, James, Stefan K, Kervinen, Kari, Kristensen, Steen Dalby, Maggioni, Aldo Pietro, Pries, Axel R, Romeo, Francesco, Rydén, Lars, Simoons, Maarten L, Steg, Ph Gabriel, Timmis, Adam, Yildirir, Aylin, G. Montalescot, U. Sechtem, S. Achenbach, F. Andreotti, C. Arden, A. Budaj, R. Bugiardini, F. Crea, T. Cuisset, C. Di Mario, J. R. Ferreira, B. J. Gersh, A. K. Gitt, J.-S. Hulot, N. Marx, L. H. Opie, M. Pfisterer, E. Prescott, F. Ruschitzka, M. Sabate, R. Senior, D. P. Taggart, E. E. van der Wall, C. J. M. Vrint, J. L. Zamorano, H. Baumgartner, J. J. Bax, H. Bueno, V. Dean, C. Deaton, C. Erol, R. Fagard, R. Ferrari, D. Hasdai, A. W. Hoe, P. Kirchhof, J. Knuuti, P. Kolh, P. Lancellotti, A. Linhart, P. Nihoyannopoulo, M. F. Piepoli, P. Ponikowski, P. A. Sirne, J. L. Tamargo, M. Tendera, A. Torbicki, W. Wijn, S. Windecker, M. Valgimigli, M. J. Claey, N. Donner-Banzhoff, H. Frank, C. Funck-Brentano, O. Gaemperli, J. R. Gonzalez-Juanatey, M. Hamilo, S. Husted, S. K. Jame, K. Kervinen, S. D. Kristensen, A. P. Maggioni, A. R. Prie, F. Romeo, L. Ryden, M. L. Simoon, P. G. Steg, A. Timmi, A. Yildirir, University of Zurich, and Montalescot, G

Subjects
Male, medicine.medical_specialty, Acute coronary syndrome, Cardiotonic Agents, Angina pectoris, anti-ischaemic drugs, medicine.medical_treatment, 610 Medicine & health, Coronary Artery Disease, Fractional flow reserve, Myocardial ischaemia, Coronary revascularization, GUIDELINES, Risk Assessment, 2705 Cardiology and Cardiovascular Medicine, Angina, Coronary artery disease, Electrocardiography, Coronary artery bypass surgery, Percutaneous Coronary Intervention, Internal medicine, Myocardial Revascularization, Humans, Medicine, Angina, Stable, cardiovascular diseases, Myocardial infarction, Coronary Artery Bypass, Aged, Evidence-Based Medicine, Primary Health Care, business.industry, Coronary flow reserve, Percutaneous coronary intervention, Prognosis, medicine.disease, Cardiac Imaging Techniques, Risk factors, CHRONIC STABLE ANGINA, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, 10209 Clinic for Cardiology, Cardiology, Stable coronary artery disease, Female, Cardiology and Cardiovascular Medicine, business, Risk Reduction Behavior
Abstract

99mTc : technetium-99m 201TI : thallium 201 ABCB1 : ATP-binding cassette sub-family B member 1 ABI : ankle-brachial index ACC : American College of Cardiology ACCF : American College of Cardiology Foundation ACCOMPLISH : Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension ACE : angiotensin converting enzyme ACIP : Asymptomatic Cardiac Ischaemia Pilot ACS : acute coronary syndrome ADA : American Diabetes Association ADP : adenosine diphosphate AHA : American Heart Association ARB : angiotensin II receptor antagonist ART : Arterial Revascularization Trial ASCOT : Anglo-Scandinavian Cardiac Outcomes Trial ASSERT : Asymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial AV : atrioventricular BARI 2D : Bypass Angioplasty Revascularization Investigation 2 Diabetes BEAUTIFUL : Morbidity-Mortality Evaluation of the If Inhibitor Ivabradine in Patients With Coronary Artery Disease and Left Ventricular Dysfunction BIMA : bilateral internal mammary artery BMI : body mass index BMS : bare metal stent BNP : B-type natriuretic peptide BP : blood pressure b.p.m. : beats per minute CABG : coronary artery bypass graft CAD : coronary artery disease CAPRIE : Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events CASS : Coronary Artery Surgery Study CCB : calcium channel blocker CCS : Canadian Cardiovascular Society CFR : coronary flow reserve CHARISMA : Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilization, Management and Avoidance CI : confidence interval CKD : chronic kidney disease CKD-EPI : Chronic Kidney Disease Epidemiology Collaboration CMR : cardiac magnetic resonance CORONARY : The CABG Off or On Pump Revascularization Study COURAGE : Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation COX-1 : cyclooxygenase-1 COX-2 : cyclooxygenase-2 CPG : Committee for Practice Guidelines CT : computed tomography CTA : computed tomography angiography CV : cardiovascular CVD : cardiovascular disease CXR : chest X-ray CYP2C19*2 : cytochrome P450 2C19 CYP3A : cytochrome P3A CYP3A4 : cytochrome P450 3A4 CYP450 : cytochrome P450 DANAMI : Danish trial in Acute Myocardial Infarction DAPT : dual antiplatelet therapy DBP : diastolic blood pressure DECOPI : Desobstruction Coronaire en Post-Infarctus DES : drug-eluting stents DHP : dihydropyridine DSE : dobutamine stress echocardiography EACTS : European Association for Cardiothoracic Surgery EECP : enhanced external counterpulsation EMA : European Medicines Agency EASD : European Association for the Study of Diabetes ECG : electrocardiogram Echo : echocardiogram ED : erectile dysfunction EF : ejection fraction ESC : European Society of Cardiology EXCEL : Evaluation of XIENCE PRIME or XIENCE V vs. Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization FAME : Fractional Flow Reserve vs. Angiography for Multivessel Evaluation FDA : Food & Drug Administration (USA) FFR : fractional flow reserve FREEDOM : Design of the Future Revascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease GFR : glomerular filtration rate HbA1c : glycated haemoglobin HDL : high density lipoprotein HDL-C : high density lipoprotein cholesterol HR : hazard ratio HRT : hormone replacement therapy hs-CRP : high-sensitivity C-reactive protein HU : Hounsfield units ICA : invasive coronary angiography IMA : internal mammary artery IONA : Impact Of Nicorandil in Angina ISCHEMIA : International Study of Comparative Health Effectiveness with Medical and Invasive Approaches IVUS : intravascular ultrasound JSAP : Japanese Stable Angina Pectoris KATP : ATP-sensitive potassium channels LAD : left anterior descending LBBB : left bundle branch block LIMA : Left internal mammary artery LDL : low density lipoprotein LDL-C : low density lipoprotein cholesterol LM : left main LMS : left main stem LV : left ventricular LVEF : left ventricular ejection fraction LVH : left ventricular hypertrophy MACE : major adverse cardiac events MASS : Medical, Angioplasty, or Surgery Study MDRD : Modification of Diet in Renal Disease MERLIN : Metabolic Efficiency with Ranolazine for Less Ischaemia in Non-ST-Elevation Acute Coronary Syndromes MERLIN-TIMI 36 : Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes: Thrombolysis In Myocardial Infarction MET : metabolic equivalents MI : myocardial infarction MICRO-HOPE : Microalbuminuria, cardiovascular and renal sub-study of the Heart Outcomes Prevention Evaluation study MPI : myocardial perfusion imaging MRI : magnetic resonance imaging NO : nitric oxide NSAIDs : non-steroidal anti-inflammatory drugs NSTE-ACS : non-ST-elevation acute coronary syndrome NYHA : New York Heart Association OAT : Occluded Artery Trial OCT : optical coherence tomography OMT : optimal medical therapy PAR-1 : protease activated receptor type 1 PCI : percutaneous coronary intervention PDE5 : phosphodiesterase type 5 PES : paclitaxel-eluting stents PET : positron emission tomography PRECOMBAT : Premier of Randomized Comparison of Bypass Surgery vs. Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease PTP : pre-test probability PUFA : polyunsaturated fatty acid PVD : peripheral vascular disease QoL : quality of life RBBB : right bundle branch block REACH : Reduction of Atherothrombosis for Continued Health RITA-2 : Second Randomized Intervention Treatment of Angina ROOBY : Veterans Affairs Randomized On/Off Bypass SAPT : single antiplatelet therapy SBP : systolic blood pressure SCAD : stable coronary artery disease SCORE : Systematic Coronary Risk Evaluation SCS : spinal cord stimulation SES : sirolimus-eluting stents SIMA : single internal mammary artery SPECT : single photon emission computed tomography STICH : Surgical Treatment for Ischaemic Heart Failure SWISSI II : Swiss Interventional Study on Silent Ischaemia Type II SYNTAX : SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery TC : total cholesterol TENS : transcutaneous electrical neural stimulation TERISA : Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina TIME : Trial of Invasive vs. Medical therapy TIMI : Thrombolysis In Myocardial Infarction TMR : transmyocardial laser revascularization TOAT : The Open Artery Trial WOEST : What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing Guidelines summarize and evaluate all evidence available, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well …

Published
2013
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8. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)

Author

Brignole, Michele, Auricchio, Angelo, Baron-Esquivias, Gonzalo, Bordachar, Pierre, Boriani, Giuseppe, Breithardt, Ole-A, Cleland, John, Deharo, Jean-Claude, Delgado, Victoria, Elliott, Perry M, Gorenek, Bulent, Israel, Carsten W, Leclercq, Christophe, Linde, Cecilia, Mont, Lluís, Padeletti, Luigi, Sutton, Richard, Vardas, Panos E, Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J, Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Cetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F, Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Blomstrom-Lundqvist, Carina, Badano, Luigi P, Aliyev, Farid, Bänsch, Dietmar, Bsata, Walid, Buser, Peter, Charron, Philippe, Daubert, Jean-Claude, Dobreanu, Dan, Faerestrand, Svein, Le Heuzey, Jean-Yves, Mavrakis, Hercules, McDonagh, Theresa, Merino, Jose Luis, Nawar, Mostapha M, Nielsen, Jens Cosedis, Pieske, Burkert, Poposka, Lidija, Ruschitzka, Frank, Van Gelder, Isabelle C, Wilson, Carol M, University of Zurich, Brignole, Michele, Department of Cardiology, Ospedali del Tigullio, CHU Bordeaux [Bordeaux], Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cardiology, Karolinska University Hospital, Karolinska Institutet [Stockholm], Cardiology Department, University of Barcelona, European Society of Cardiology (ESC) - European Heart Rhythm Association (EHRA), M. Brignole, A. Auricchio, G. Baron-Esquivia, P. Bordachar, G. Boriani, O.-A. Breithardt, J. Cleland, J.-C. Deharo, V. Delgado, P. M. Elliott, B. Gorenek, C. W. Israel, C. Leclercq, C. Linde, L. Mont, L. Padeletti, R. Sutton, P. E. Varda, J. L. Zamorano, S. Achenbach, H. Baumgartner, J. J. Bax, H. Bueno, V. Dean, C. Deaton, C. Erol, R. Fagard, R. Ferrari, D. Hasdai, A. W. Hoe, P. Kirchhof, J. Knuuti, P. Kolh, P. Lancellotti, A. Linhart, P. Nihoyannopoulo, M. F. Piepoli, P. Ponikowski, P. A. Sirne, J. L. Tamargo, M. Tendera, A. Torbicki, W. Wijn, S. Windecker, C. Blomstrom-Lundqvist, L. P. Badano, F. Aliyev, D. Bansch, W. Bsata, P. Buser, P. Charron, J.-C. Daubert, D. Dobreanu, S. Faerestrand, J.-Y. Le Heuzey, H. Mavraki, T. McDonagh, J. L. Merino, M. M. Nawar, J. C. Nielsen, B. Pieske, L. Poposka, F. Ruschitzka, I. C. Van Gelder, C. M. Wilson, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
medicine.medical_treatment, Heart Valve Diseases, Myocardial Infarction, 030204 cardiovascular system & hematology, Ventricular tachycardia, 0302 clinical medicine, 2737 Physiology (medical), Bicuspid Aortic Valve Disease, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Pregnancy, Secondary Prevention, 030212 general & internal medicine, Child, ComputingMilieux_MISCELLANEOUS, Heart Valve Prosthesis Implantation, Cardiac resynchronization therapy, Cardiac Pacing, Artificial, Atrial fibrillation, Implantable cardioverter-defibrillator, Magnetic Resonance Imaging, 3. Good health, Defibrillators, Implantable, Europe, Pacemaker, Aortic Valve, Cardiology, Catheter Ablation, cardiovascular system, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Cardiology and Cardiovascular Medicine, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Heart Defects, Congenital, Reoperation, medicine.medical_specialty, Prosthesis-Related Infections, Defibrillation, Pregnancy Complications, Cardiovascular, Heart failure, 610 Medicine & health, Syncope, 11171 Cardiocentro Ticino, 2705 Cardiology and Cardiovascular Medicine, Sick sinus syndrome, 03 medical and health sciences, Rare Diseases, Internal medicine, Physiology (medical), medicine, Bradycardia, Humans, cardiovascular diseases, Emergency Treatment, Postoperative Care, business.industry, Contraindications, Remote Consultation, Arrhythmias, Cardiac, Stroke Volume, Cardiomyopathy, Hypertrophic, ta3121, medicine.disease, Cardiac pacing, Ventricular fibrillation, Heart Transplantation, business
Abstract

Abbreviations 1st AV : First-degree atrioventricular block AF : atrial fibrillation AT : atrial tachyarrhythmia ATP : Anti-tachycardia pacing AV : atrioventricular BBB : bundle branch block CHF : congestive heart failure CI : confidence interval CPG : Committee for Practice Guidelines CRT : cardiac resynchronization therapy CRT-D : cardiac resynchronization therapy and defibrillator CRT-P : cardiac resynchronization therapy and pacemaker ECG : electrocardiogram EDMD : Emery-Dreifuss muscular dystrophy EF : ejection fraction EPS : electrophysiological study ESC : European Society of Cardiology HCM : hypertrophic cardiomyopathy HF : heart failure HR : hazard ratio HV : His-ventricular ICD : implantable cardioverter defibrillator ILR : implantable loop recorder IVCD : intraventricular conduction delay LBBB : left bundle branch block LQTS : long QT syndrome LV : left ventricular LVEF : left ventricular ejection fraction LVSD : left ventricular systolic dysfunction MR : mitral regurgitation MRI : magnetic resonance imaging NYHA : New York Heart Association PM : pacemaker OR : odds ratio QALY : quality-adjusted life year RBBB : right bundle branch block RCT : randomized controlled trial RV : right ventricular SB : sinus bradycardia SNRT : sinus node recovery time SR : sinus rhythm SSS : sick sinus syndrome TAVI : transcatheter aortic valve implantation VF : ventricular fibrillation VT : ventricular tachycardia VV : interventricular (delay) ### Acronyms of the trials referenced in the recommendations or reported in the tables ADEPT : ADvanced Elements of Pacing Randomized Controlled Trial ADOPT : Atrial Dynamic Overdrive Pacing Trial AOPS : Atrial Overdrive Pacing Study APAF : Ablate and Pace in Atrial Fibrillation ASSERT : ASymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial ATTEST : ATrial Therapy Efficacy and Safety Trial AVAIL CLS/CRT : AV Node Ablation with CLS and CRT Pacing Therapies for Treatment of AF trial B4 : Bradycardia detection in Bundle Branch Block BELIEVE : Bi vs. Left Ventricular Pacing: an International Pilot Evaluation on Heart Failure Patients with Ventricular Arrhythmias BIOPACE : Biventricular pacing for atrioventricular block to prevent cardiac desynchronization BLOCK-HF : Biventricular versus right ventricular pacing in patients with AV block B-LEFT : Biventricular versus LEFT Univentricular Pacing with ICD Back-up in Heart Failure Patients CARE-HF : CArdiac REsynchronization in Heart Failure CLEAR : CLinical Evaluation on Advanced Resynchronization COMBAT : COnventional vs. Biventricular Pacing in Heart Failure and Bradyarrhythmia COMPANION : COmparison of Medical Therapy, Pacing and Defibrillation in Heart Failure DANPACE : DANish Multicenter Randomized Trial on Single Lead Atrial PACing vs. Dual Chamber Pacing in Sick Sinus Syndrome DECREASE-HF : The Device Evaluation of CONTAK RENEWAL 2 and EASYTRAK 2: Assessment of Safety and Effectiveness in Heart Failure FREEDOM : Optimization Study Using the QuickOpt Method GREATER-EARTH : Evaluation of Resynchronization Therapy for Heart Failure in Patients with a QRS Duration GREATER Than 120 ms LESSER-EARTH : Evaluation of Resynchronization Therapy for Heart Failure in Patients with a QRS Duration Lower Than 120 ms HOBIPACE : HOmburg BIventricular PACing Evaluation IN-CHF : Italian Network on Congestive Heart Failure ISSUE : International Study on Syncope of Unexplained Etiology MADIT : Multicenter Automatic Defibrillator Trial MIRACLE : Multicenter InSync RAndomized CLinical Evaluation MOST : MOde Selection Trial in Sinus-Node Dysfunction MUSTIC : MUltisite STimulation In Cardiomyopathies OPSITE : Optimal Pacing SITE PACE : Pacing to Avoid Cardiac Enlargement PAVE : Left Ventricular-Based Cardiac Stimulation Post AV Nodal Ablation Evaluation PATH-CHF : PAcing THerapies in Congestive Heart Failure II Study Group PIPAF : Pacing In Prevention of Atrial Fibrillation Study PIRAT : Prevention of Immediate Reinitiation of Atrial Tachyarrhythmias POT : Prevention Or Termination Study PREVENT-HF : PREventing VENTricular Dysfunction in Pacemaker Patients Without Advanced Heart Failure PROSPECT : PRedictors Of Response to Cardiac Resynchronization Therapy RAFT : Resynchronization–Defibrillation for Ambulatory Heart Failure Trial RethinQ : Cardiac REsynchronization THerapy IN Patients with Heart Failure and Narrow QRS REVERSE : REsynchronization reVErses Remodelling in Systolic left vEntricular dysfunction SAFARI : Study of Atrial Fibrillation Reduction SCD HeFT : Sudden Cardiac Death in Heart Failure Trial SMART-AV : The SMARTDelay Determined AV Optimization: a Comparison with Other AV Delay Methods Used in Cardiac Resynchronization Therapy SYDIT : The SYncope DIagnosis and Treatment SYNPACE : Vasovagal SYNcope and PACing TARGET : TARgeted Left Ventricular Lead Placement to Guide Cardiac Resynchronization Therapy THEOPACE : Effects of Oral THEOphylline and of Permanent PACEmaker on the Symptoms and Complications of Sick Sinus Syndrome VASIS-PM : VAsovagal Syncope International Study on PaceMaker therapy V-HeFT : Vasodilator in HEart Failure Trial VPSII : Second Vasovagal Pacemaker Study (VPS II) Additional references are mentioned with ‘w’ in the main text and can be found on the online addenda along with 5 figures (1, 6, 7, 9, 11, 12) and 10 tables (3, 4, 5, 9, 11, 12, 19, 21, 22, 23). They are available on the ESC website only at http://www.escardio.org/guidelines-surveys/esc-guidelines/Pages/cardiac-pacing-and-cardiac-resynchronisation-therapy.aspx Guidelines summarize and evaluate all available evidence, at the time of the writing process, on a …

Published
2013
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