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The article reports on a study conducted to evaluate prevention of peritoneal adhesions by combining charged polypeptides. A standardized peritoneal injury model was used in 48 NMRI mice where the length of adhesion formation was estimated and expressed in percentage of the standardized wound length 7 days and 4 weeks after adhesion induction. The test compounds, polylysine and polyglutamate, were administered intraperitoneally immediately following induction of the peritoneal defect. the study shows that polylysine together with polyglutamate caused a reproducible and significant decrease in the extent of peritoneal adhesions, also when administered in a low concentration.

This article focuses on a study related to the prevention of postoperative peritoneal adhesions by bioactive polymers. Intraperitoneal adhesions frequently occur after abdominal and pelvic surgery and may result in intestinal obstruction and potentially infertility. Various bioactive materials and macromolecules have been reported to decrease the extent of postoperative abdominal adhesions. Intraperitoneal administration of lysozyme, polyglutamate and especially a combination of polylysine and polyglutamate significantly decreased experimental abdominal adhesion formation.