1. Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial
- Author
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Ronald Chow, Liting Zhu, Yvette M. van der Linden, Keyue Ding, William F. Demas, Peter Hoskin, Ralph M. Meyer, Scott Babington, Michael Brundage, Jackson S.Y. Wu, Rebecca Wong, Manouk van Acht, Rinus Wanders, Carolyn F. Wilson, Edward Chow, William F. Hartsell, Abdenour Nabid, Vithusha Ganesh, Daniel E. Roos, Radiation Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and Radiotherapie
- Subjects
Male ,medicine.medical_treatment ,law.invention ,0302 clinical medicine ,Quality of life ,Randomized controlled trial ,law ,QUALITY-OF-LIFE ,Medicine ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Pain Measurement ,Pain response ,Palliative Care ,Age Factors ,Hematology ,Middle Aged ,Oncology ,030220 oncology & carcinogenesis ,Female ,CLINICAL-TRIALS ,medicine.medical_specialty ,SEX-DIFFERENCES ,UNITED-STATES ,Bone Neoplasms ,PALLIATIVE RADIOTHERAPY ,03 medical and health sciences ,Sex Factors ,Age ,RADIATION-THERAPY ,MANAGEMENT ,Humans ,Radiology, Nuclear Medicine and imaging ,Patient Reported Outcome Measures ,Brief Pain Inventory ,Aged ,BARRIERS ,Radiotherapy ,business.industry ,Bone metastases ,Cancer ,Gender ,medicine.disease ,CANCER PAIN ,Clinical trial ,Radiation therapy ,Mood ,Physical therapy ,Re-irradiation ,business ,Cancer pain ,CONSENSUS - Abstract
Background and purpose: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.Materials and methods: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (00) before and 2 months after re-irradiation.Results: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in 00 scores at 2 months.Conclusion: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age. Trial Registration: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912. (C) 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 126 (2018) 541-546
- Published
- 2018