284 results on '"Vitali, Paolo"'
Search Results
2. Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
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Therriault, Joseph, Woo, Marcel S., Salvadó, Gemma, Gobom, Johan, Karikari, Thomas K., Janelidze, Shorena, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Ashton, Nicholas J., Benedet, Andréa Lessa, Montoliu-Gaya, Laia, Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Vitali, Paolo, Friese, Manuel A., Massarweh, Gassan, Soucy, Jean-Paul, Pascoal, Tharick A., Stomrud, Erik, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Gauthier, Serge, Zetterberg, Henrik, Hansson, Oskar, Blennow, Kaj, and Rosa-Neto, Pedro
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- 2024
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3. The neurophysiological brain-fingerprint of Parkinson’s disease
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Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav
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- 2024
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4. Adults with tetralogy of Fallot show specific features of cerebral small vessel disease: the BACH San Donato study
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Melazzini, Luca, Savoldi, Filippo, Chessa, Massimo, Vitali, Paolo, Zanardo, Moreno, Bertoldo, Enrico Giuseppe, Fiolo, Valentina, Griffanti, Ludovica, Carminati, Mario, Frigiola, Alessandro, Giamberti, Alessandro, Secchi, Francesco, Callus, Edward, Codari, Marina, and Sardanelli, Francesco
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- 2022
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5. Videoconference version of the Montreal Cognitive Assessment: normative data for Quebec-French people aged 50 years and older
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Gagnon, Christine, Olmand, Miloudza, Dupuy, Emma Gabrielle, Besnier, Florent, Vincent, Thomas, Grégoire, Catherine-Alexandra, Lévesque, Marianne, Payer, Marie, Bérubé, Béatrice, Breton, Juliana, Lecchino, Catia, Bouabdallaoui, Nadia, Iglesies-Grau, Josep, Gayda, Mathieu, Vitali, Paolo, Nigam, Anil, Juneau, Martin, Hudon, Carol, and Bherer, Louis
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- 2022
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6. Biomarker modeling of Alzheimer’s disease using PET-based Braak staging
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Therriault, Joseph, Pascoal, Tharick A., Lussier, Firoza Z., Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro
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- 2022
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7. MRI versus CT in the detection of brain lesions in patients with infective endocarditis before or after cardiac surgery
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Vitali, Paolo, Savoldi, Filippo, Segati, Flavia, Melazzini, Luca, Zanardo, Moreno, Fedeli, Maria Paola, Benedek, Adrienn, Di Leo, Giovanni, Menicanti, Lorenzo, and Sardanelli, Francesco
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- 2022
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8. Progressive Apraxia of Speech in Quebec French Speakers: A Case Series
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Bouvier, Liziane, Monetta, Laura, Laforce, Robert, Vitali, Paolo, Bocti, Christian, and Martel-Sauvageau, Vincent
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Background: The term progressive apraxia of speech (PAOS) is used to describe speakers presenting with isolated or dominant apraxia of speech in the context of a neurodegenerative syndrome, including primary progressive apraxia of speech (PPAOS) and dominant progressive apraxia of speech (DAOS), respectively. Its motor speech profile has been increasingly explored in the last decade, but description remains vague and very English oriented, although the effect of speakers' language on motor speech phenotypes is increasingly recognized. Although some studies suggest that speakers presenting with isolated PAOS (PPAOS) versus dominant PAOS with concomitant aphasia (DAOS) should be differentiated, distinct characteristics of the two presentations are unclear. Furthermore, a careful description of their clinical presentation in languages other than English is required. Aims: To describe the motor speech characteristics of Quebec French-speaking participants with prominent PAOS and to explore the communication profile of those presenting more specifically with isolated PAOS (PPAOS), and with dominant PAOS and concomitant aphasia (DAOS). Methods & Procedures: A thorough effort to recruit all speakers presenting with PAOS in the larger population areas of the province of Quebec was conducted over a 3-year span. A total of nine participants with PAOS (pwPAOS; PPAOS = 5, DAOS = 4) underwent a comprehensive language and motor speech assessment, and a cognitive screening. Their performance was compared with 30 matched healthy controls. Outcomes & Results: As a group, pwPAOS differed from healthy speakers on all acoustic and perceptual measures. The PPAOS and PAOS subgroups were similar on several measures, but participants from the PPAOS subgroup tended to perform better on articulatory measures and maximum speech rate tasks. Conclusions & Implications: This study provides an in-depth analysis of motor speech characteristics of PAOS in Quebec French speakers and adds further evidence for the differentiation of PPAOS and DAOS. Combining simple perceptual and acoustic analyses represent a promising approach to distinguish the two variants and identify treatment targets.
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- 2021
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9. Computation of contrast-enhanced perfusion using only two CT scan phases: a proof-of-concept study on abdominal organs
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Cressoni, Massimo, Cozzi, Andrea, Schiaffino, Simone, Cadringher, Paolo, Vitali, Paolo, Basso, Gianpaolo, Ippolito, Davide, and Sardanelli, Francesco
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- 2022
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10. Finding the limits of deep learning clinical sensitivity with fractional anisotropy (FA) microstructure maps.
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Gaviraghi, Marta, Ricciardi, Antonio, Palesi, Fulvia, Brownlee, Wallace, Vitali, Paolo, Prados, Ferran, Kanber, Baris, and Gandini Wheeler-Kingshott, Claudia A. M.
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DEEP learning ,ANISOTROPY ,MAPS ,TEMPORAL lobe epilepsy - Abstract
Background: Quantitative maps obtained with diffusion weighted (DW) imaging, such as fractional anisotropy (FA) –calculated by fitting the diffusion tensor (DT) model to the data,—are very useful to study neurological diseases. To fit this map accurately, acquisition times of the order of several minutes are needed because many noncollinear DW volumes must be acquired to reduce directional biases. Deep learning (DL) can be used to reduce acquisition times by reducing the number of DW volumes. We already developed a DL network named “oneminute FA,” which uses 10 DW volumes to obtain FA maps, maintaining the same characteristics and clinical sensitivity of the FA maps calculated with the standard method using more volumes. Recent publications have indicated that it is possible to train DL networks and obtain FA maps even with 4 DW input volumes, far less than the minimum number of directions for the mathematical estimation of the DT. Methods: Here we investigated the impact of reducing the number of DW input volumes to 4 or 7, and evaluated the performance and clinical sensitivity of the corresponding DL networks trained to calculate FA, while comparing results also with those using our one-minute FA. Each network training was performed on the human connectome project open-access dataset that has a high resolution and many DW volumes, used to fit a ground truth FA. To evaluate the generalizability of each network, they were tested on two external clinical datasets, not seen during training, and acquired on different scanners with different protocols, as previously done. Results: Using 4 or 7 DW volumes, it was possible to train DL networks to obtain FA maps with the same range of values as ground truth - map, only when using HCP test data; pathological sensitivity was lost when tested using the external clinical datasets: indeed in both cases, no consistent differences were found between patient groups. On the contrary, our “one-minute FA” did not suffer from the same problem. Conclusion: When developing DL networks for reduced acquisition times, the ability to generalize and to generate quantitative biomarkers that provide clinical sensitivity must be addressed. [ABSTRACT FROM AUTHOR]
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- 2024
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11. COVEPIC (Cognitive and spOrt Virtual EPIC training) investigating the effects of home-based physical exercise and cognitive training on cognitive and physical functions in community-dwelling older adults: study protocol of a randomized single-blinded clinical trial
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Dupuy, Emma Gabrielle, Besnier, Florent, Gagnon, Christine, Vincent, Thomas, Grégoire, Catherine-Alexandra, Blanchette, Caroll-Ann, Saillant, Kathia, Bouabdallaoui, Nadia, Iglesies-Grau, Josep, Payer, Marie, Marin, Marie-France, Belleville, Sylvie, Juneau, Martin, Vitali, Paolo, Gayda, Mathieu, Nigam, Anil, and Bherer, Louis
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- 2021
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12. Predicting functional decline in aging and Alzheimer's disease with PET-based Braak staging.
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Macedo, Arthur C, Therriault, Joseph, Tissot, Cécile, Fernandez-Arias, Jaime, Ferreira, Pamela C L, Vitali, Paolo, Servaes, Stijn, Rahmouni, Nesrine, Vermeiren, Marie, Bezgin, Gleb, Lussier, Firoza Z, Stevenson, Jenna, Wang, Yi-Ting, Socualaya, Kely Quispialaya, Kunach, Peter, Nazneen, Tahnia, Hosseini, Seyyed Ali, Pallen, Vanessa, Stevenson, Alyssa, and Ferrari-Souza, João Pedro
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- 2024
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13. CT Arthrography of the Elbow: What Radiologists Should Know.
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Folco, Gianluca, Messina, Carmelo, Gitto, Salvatore, Fusco, Stefano, Serpi, Francesca, Zagarella, Andrea, Gallazzi, Mauro Battista, Arrigoni, Paolo, Aliprandi, Alberto, Porta, Marco, Vitali, Paolo, Sconfienza, Luca Maria, and Albano, Domenico
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ELBOW ,ARTICULAR ligaments ,JOINT capsule ,RADIOLOGISTS ,COMPUTED tomography ,RADIATION exposure - Abstract
Computed tomography (CT) arthrography is a quickly available imaging modality to investigate elbow disorders. Its excellent spatial resolution enables the detection of subtle pathologic changes of intra-articular structures, which makes this technique extremely valuable in a joint with very tiny chondral layers and complex anatomy of articular capsule and ligaments. Radiation exposure has been widely decreased with the novel CT scanners, thereby increasing the indications of this examination. The main applications of CT arthrography of the elbow are the evaluation of capsule, ligaments, and osteochondral lesions in both the settings of acute trauma, degenerative changes, and chronic injury due to repeated microtrauma and overuse. In this review, we discuss the normal anatomic findings, technical tips for injection and image acquisition, and pathologic findings that can be encountered in CT arthrography of the elbow, shedding light on its role in the diagnosis and management of different orthopedic conditions. We aspire to offer a roadmap for the integration of elbow CT arthrography into routine clinical practice, fostering improved patient outcomes and a deeper understanding of elbow pathologies. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Topographical distribution of amyloid-β, tau and atrophy in behavioral / dysexecutive AD patients
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Therriault, Joseph, Pascoal, Tharick A., Savard, Melissa, Benedet, Andrea L., Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Thomas, Emilie, Terada, Tatsuhiro, Rej, Soham, Massarweh, Gassan, Nasreddine, Ziad, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Gauthier, Serge, and Rosa-Neto, Pedro
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- 2020
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15. The role of clinical and neuroimaging features in the diagnosis of CADASIL
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Bersano, Anna, Bedini, Gloria, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, Corato, Manuel, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, and on behalf of Lombardia GENS-group
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- 2018
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16. Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease
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Therriault, Joseph, Pascoal, Tharick A., Savard, Melissa, Benedet, Andrea L., Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Thomas, Emilie, Terada, Tatsuhiro, Rej, Soham, Massarweh, Gassan, Nasreddine, Ziad, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Gauthier, Serge, and Rosa-Neto, Pedro
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- 2021
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17. Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease.
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Therriault, Joseph, Servaes, Stijn, Tissot, Cécile, Rahmouni, Nesrine, Ashton, Nicholas J., Benedet, Andréa Lessa, Karikari, Thomas K., Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Wang, Yi‐Ting, Fernandez‐Arias, Jaime, Stevenson, Alyssa, Socualaya, Kely Quispialaya, Haeger, Arlette, Nazneen, Tahnia, Aumont, Étienne, Hosseini, Ali, Rej, Soham, and Vitali, Paolo
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INTRODUCTION: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed. METHODS: We assessed the diagnostic performance of p‐tau181, p‐tau217, and p‐tau231 in plasma and CSF in 174 individuals evaluated by dementia specialists and assessed with amyloid‐PET and tau‐PET. Receiver operating characteristic (ROC) analyses assessed the performance of plasma and CSF biomarkers to identify amyloid‐PET and tau‐PET positivity. RESULTS: Plasma p‐tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p‐tau. Plasma p‐tau181 (AUC = 76%) and p‐tau231 (AUC = 82%) assessments performed inferior to CSF p‐tau181 (AUC = 87%) and p‐tau231 (AUC = 95%) for amyloid‐PET positivity. However, plasma p‐tau217 (AUC = 91%) had diagnostic performance indistinguishable from CSF (AUC = 94%) for amyloid‐PET positivity. DISCUSSION: Plasma and CSF p‐tau217 had equivalent diagnostic performance for biomarker‐defined AD. Our results suggest that plasma p‐tau217 may help reduce the need for invasive lumbar punctures without compromising accuracy in the identification of AD. Highlights: p‐tau217 in plasma performed equivalent to p‐tau217 in CSF for the diagnosis of AD, suggesting the increased accessibility of plasma p‐tau217 is not offset by lower accuracy.p‐tau biomarkers in plasma had lower mean fold‐changes between amyloid‐PET negative and positive groups than p‐tau biomarkers in CSF.CSF p‐tau biomarkers had greater effect sizes than plasma p‐tau biomarkers when differentiating between amyloid‐PET positive and negative groups.Plasma p‐tau181 and plasma p‐tau231 performed worse than p‐tau181 and p‐tau231 in CSF for AD diagnosis. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode.
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Aumont, Etienne, Bussy, Aurélie, Bedard, Marc-André, Bezgin, Gleb, Therriault, Joseph, Savard, Melissa, Arias, Jaime Fernandez, Sziklas, Viviane, Vitali, Paolo, Poltronetti, Nina Margherita, Pallen, Vanessa, Thomas, Emilie, Gauthier, Serge, Kobayashi, Eliane, Rahmouni, Nesrine, Stevenson, Jenna, Tissot, Cecile, Chakravarty, Mallar M., and Rosa-Neto, Pedro
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- 2023
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19. Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA
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Mandelli, Maria Luisa, Vitali, Paolo, Santos, Miguel, Henry, Maya, Gola, Kelly, Rosenberg, Lynne, Dronkers, Nina, Miller, Bruce, Seeley, William W., and Gorno-Tempini, Maria Luisa
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- 2016
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20. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework.
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Macedo, Arthur C., Tissot, Cécile, Therriault, Joseph, Servaes, Stijn, Yi-Ting Wang, Fernandez-Arias, Jaime, Rahmouni, Nesrine, Lussier, Firoza Z., Vermeiren, Marie, Bezgin, Gleb, Vitali, Paolo, Kok Pin Ng, Zimmer, Eduardo R., Guiot, Marie-Christine, Pascoal, Tharick A., Gauthier, Serge, and Rosa-Neto, Pedro
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- 2023
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21. Case report: Chorea and cognitive decline in a young woman: instrumental and genetic assessment of a case originally diagnosed as multiple sclerosis.
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Dato, Clemente, Micaglio, Emanuele, Moresco, Giada, Rondinone, Ornella, Vitali, Paolo, Pappone, Carlo, Fontana, Laura, Miozzo, Monica, and Bet, Luciano
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MULTIPLE sclerosis ,COGNITION disorders ,YOUNG women ,CHOREA ,GENETIC variation - Abstract
We describe the case of a young woman affected by debilitating chorea and rapidly progressive cognitive decline. While her original diagnosis was multiple sclerosis, we performed a full instrumental and genetic assessement, though which we identified multiple genetic variants, including a novel variant of the APP gene. We propose some possible mechanisms by which such variants may contribute to neuroinflammation and ultimately lead to this devastating clinical course. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET.
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Therriault, Joseph, Lussier, Firoza Z., Tissot, Cécile, Chamoun, Mira, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Bezgin, Gleb, Servaes, Stijn, Kunach, Peter, Wang, Yi‐Ting, Fernandez‐Arias, Jaime, Vermeiren, Marie, Pascoal, Tharick A., Massarweh, Gassan, Vitali, Paolo, Soucy, Jean‐Paul, Saha‐Chaudhuri, Paramita, Gauthie, Serge, and Rosa‐Neto, Pedro
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AMYLOID plaque ,POSITRON emission tomography ,MILD cognitive impairment ,OLDER people ,CLINICAL trials - Abstract
Introduction: [18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694. Methods: We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2‐year follow‐up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker‐defined groups Results: Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow‐up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortex Discussion: Larger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti‐amyloid therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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23. Hippocampal subfield volumes and memory performances: associations with stimulus modality and free recall or recognition.
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Aumont, Etienne, Bussy, Aurelie, Bezgin, Gleb, Therriault, Joseph, Savard, Melissa, Arias, Jaime Fernandez, Poltronetti, Nina Margherita, Pallen, Vanessa, Thomas, Emilie, Vitali, Paolo, Chakravarty, Mallar, Bedard, Marc‐Andre, and Rosa‐Neto, Pedro
- Abstract
Background: Age‐related memory decline is well associated with hippocampal atrophy, although the specific role of hippocampal subfields in memory function has not been thoroughly investigated yet. In this study, we investigated the associations between hippocampal subfield volumes and free recall and recognition performances in verbal and visual memory tasks in older adults without dementia. Method: We selected 97 right‐handed participants without dementia aged 60 to 85, 42 males, from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort. From T2‐weighted MRIs with 0.7*0.7*1mm voxel size, the hippocampi were segmented five subfields: 1) DG (DG); 2) CA2 with CA3 (CA2/CA3); 3) CA1; 4) strata radiatum, lacunosum and moleculare (SRLM); and 5) subiculum by using the MAGeT‐Brain algorithm. Memory was assessed with Rey Auditory Learning test for verbal free recall (RAVLT7) and recognition (RAVLT‐R), and with Aggie Figure Learning test for visual free recall (AFLT7) and recognition (AFLT‐R). Linear models were used to test the association between hippocampal subfield volumes and memory performances with age, sex and total intracranial volume as covariates (p<0.05, corrected for false discovery rate). Result: The volumes of bilateral CA1 and SRLM were significantly associated with RAVLT7 and RAVLT‐R. The right DG volume was significantly associated with AFLT7 and RAVLT7. AFLT7 was also associated with the volume of right CA2/CA3 while AFLT‐R was not associated with any hippocampal subfield (see Figures 1 & 2). Conclusion: Our results are consistent with the view that hippocampal subfields contribute differently to memory traces: CA1 for recollection that requires contextual information; the DG for pattern separation (creating new distinct representations of each stimulus); and CA3 for pattern completion (the recollection of a stimulus from a partial memory). Contextual information is more important when recollecting known words, while distinct and efficient encoding may be especially useful for search strategies inherent to free recall. Pattern completion could be particularly useful to efficiently recollect visual abstract figures based on visual features during free recall. Overall, this shows that hippocampal subfield segmentation offers a better understanding of their distinctive roles in cognition. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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24. Plasma p‐tau 181 outperforms FDG‐PET and plasma‐NfL in the diagnosis of biological AD.
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Socualaya, Kely Quispialaya, Therriault, Joseph, Aliaga, Antonio, Servaes, Stijn, Tissot, Cécile, Rahmouni, Nesrine, Macedo, Arthur C., Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Vitali, Paolo, Soucy, Jean‐Paul, Gauthier, Serge, and Rosa‐Neto, Pedro
- Abstract
Background: To compare the performance of plasma p‐tau181, plasma‐NfL and FDG‐PET in the diagnosis of biological AD. Method: We included 787 participants (cognitively unimpaired (CU, n = 251), mild cognitive impairment (MCI, n = 412), and Alzheimer's dementia (AD, n = 124) from the ADNI database. Participants underwent measures of plasma p‐tau181, plasma‐NfL, CSF P‐tau181, [18F]FDG‐PET, amyloid‐PET and cognitive screening tests. ROC analyses were used to determine diagnostic accuracy of plasma P‐tau181, NfL and [18F]FDG‐PET using clinical diagnosis and core AD biomarkers (amyloid‐PET and CSF P‐tau181) as reference standards. We assessed whether plasma P‐tau181 and [18F]FDG‐PET diagnostic accuracies were significantly different with a bootstrap‐based test (pROC package in R). Second, correlations of [18F]FDG‐PET, plasma‐NfL, plasma P‐tau181 with P‐tau181 CSF, Aβ‐PET, and cognitive performance were evaluated. Correlation coefficients were compared via Cocor package, a statistical framework for comparing associations between intercorrelated measurements. Result: Across the total sample we observed that plasma P‐tau181, plasma‐NfL, and [18F]FDG‐PET were able to identify individuals with CSF evidence of AD as well as participants who are amyloid‐PET+. In the MCI group, plasma P‐tau181 outperformed [18F]FDG‐PET and plasma‐NfL in identifying AD pathophysiology measured via CSF P‐tau181 (p = 0.0007), and amyloid‐PET (p = 0.001). We also observed that both plasma P‐tau181, plasma‐NfL and [18F]FDG‐PET were associated with AD pathophysiology measured by core AD biomarkers (CSF and amyloid‐PET). However, [18F]FDG‐PET was more closely associated with cognitive outcomes than plasma P‐tau181 and plasma NfL (MoCA: p < 0.0001; MMSE: p< 0.0001; CDR‐SB: p < 0.0001) Conclusion: This study investigated the diagnostic properties of plasma P‐tau181 and two neurodegenerative biomarkers (plasma‐NfL and [18F]FDG‐PET) as well as their to identify biological AD. While plasma P‐tau181, plasma‐NfL concentrations and [18F]FDG‐PET were associated with AD pathophysiology measured by core AD biomarkers (CSF and amyloid‐PET), plasma P‐tau181 outperformed [18F]FDG‐PET and plasma‐NfL in identifying individuals with AD pathophysiology. However, we also observed that [18F]FDG‐PET was more strongly associated with neuropsychological assessments than plasma P‐tau181 and plasma‐NfL. Taken together, our study suggests that plasma P‐tau181 may aid in the evaluation of individuals by identifying those with underlying AD pathophysiology. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
25. Plasma biomarkers as stand‐alone tests in the diagnosis of Alzheimer's disease.
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Therriault, Joseph, Benedet, Andrea Lessa, González Escalante, Armand, Jonaitis, Erin M., Ashton, Nicholas J., Karikari, Thomas K, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Lussier, Firoza Z, Stevenson, Jenna, Milà‐Alomà, Marta, Pascoal, Tharick A., Vitali, Paolo, Gauthier, Serge, Zetterberg, Henrik, Johnson, Sterling C., Blennow, Kaj, Suarez‐Calvet, Marc, and Rosa‐Neto, Pedro
- Abstract
Background: Several recent studies have provided evidence for high diagnostic performance of plasma biomarkers for AD, with Area Under the Curve values sometimes exceeding 90%. However, positive and negative predictive values are rarely reported yet are critical for interpreting individual‐level screening test results. Method: We determined positive and negative predictive values of plasma biomarkers (p‐tau181, p‐tau217, p‐tau231, GFAP and NfL) for biological AD (A+T+, determined either with PET or CSF) in the TRIAD, WRAP, ALFA+, BIODEGMAR, ADNI and McGill memory clinic cohorts (total n = 2219). We also determined positive and negative predictive values for specific clinical scenarios: MCI and mild AD – two populations that may benefit from disease‐modifying therapies in AD. Prevalence estimates of biological AD in these groups were taken from the Mayo Clinic Study of Aging. Result: P‐tau217 had the highest positive and negative predictive values of all biomarkers in all cohorts, with above 80% positive and negative predictive values. In individuals with MCI, an etiologically heterogeneous syndrome, plasma p‐tau217 had sufficiently high performance to rule out biological AD in differential diagnosis. In mild AD dementia, plasma p‐tau217 could rule in biological AD, but follow‐up with PET/CSF will likely be needed to confirm the absence of AD. Conclusion: Plasma biomarkers have the potential to be used as stand‐alone diagnostic tools in specific clinical scenarios. In MCI, a negative plasma p‐tau217 could rule out AD as a cause of cognitive impairment, but a positive result should be followed up with PET/CSF. In mild AD dementia, a positive plasma p‐tau217 result can rule in biological AD, but a negative result should be followed up with PET/CSF. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
26. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer's disease.
- Author
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Fernández Arias, Jaime, Therriault, Joseph, Thomas, Emilie, Lussier, Firoza Z., Bezgin, Gleb, Tissot, Cécile, Servaes, Stijn, Mathotaarachchi, Sulantha S., Schoemaker, Dorothée, Stevenson, Jenna, Rahmouni, Nesrine, Min Su Kang, Pallen, Vanessa, Poltronetti, Nina Margherita, Yi-Ting Wang, Kunach, Peter, Chamoun, Mira, S., Kely M. Quispialaya, Vitali, Paolo, and Massarweh, Gassan
- Published
- 2023
- Full Text
- View/download PDF
27. PHYSICAL FITNESS MODERATES THE AGE-RELATED ASSOCIATION BETWEEN EXECUTIVE FUNCTIONING AND MOBILITY
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Dupuy, Emma Gabrielle, Besnier, Florent, Gagnon, Christine, Breton, Juliana, Vincent, Thomas, Catherine-Alexandra Grégoire, Payer, Marie, Bérubé, Béatrice, Miloudza Olmand, Levesque, Marianne, Lecchino, Catia, Bouabdallaoui, Nadia, Iglésies-Grau, Josep, Marie-France Marin, Belleville, Sylvie, Juneau, Martin, Vitali, Paolo, Gayda, Mathieu, Nigam, Anil, and Bherer, Louis
- Published
- 2022
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- View/download PDF
28. Cardiorespiratory Fitness Moderates the Age-Related Association Between Executive Functioning and Mobility: Evidence From Remote Assessments.
- Author
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Dupuy, Emma Gabrielle, Besnier, Florent, Gagnon, Christine, Breton, Juliana, Vincent, Thomas, Grégoire, Catherine-Alexandra, Lecchino, Catia, Payer, Marie, Bérubé, Béatrice, Olmand, Miloudza, Levesque, Marianne, Bouabdallaoui, Nadia, Iglesies-Grau, Josep, Juneau, Martin, Vitali, Paolo, Gayda, Mathieu, Nigam, Anil, and Bherer, Louis
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CARDIOPULMONARY system physiology ,PHYSICAL fitness ,EXECUTIVE function - Abstract
Background and Objectives In older adults, executive functions are important for daily-life function and mobility. Evidence suggests that the relationship between cognition and mobility is dynamic and could vary according to individual factors, but whether cardiorespiratory fitness reduces the age-related increase of interdependence between mobility and cognition remains unexplored. Research Design and Methods One hundred eighty-nine participants (aged 50–87) were divided into 3 groups according to their age: middle-aged (MA; <65), young older adults (YOA; 65–74), and old older adults (OOA; ≥75). Participants performed Timed Up and Go and executive functioning assessments (Oral Trail Making Test and Phonologic verbal fluency) remotely by videoconference. Participants completed the Matthews questionnaire to estimate their cardiorespiratory fitness (VO2 max in ml/min/kg). A 3-way moderation was used to address whether cardiorespiratory fitness interacts with age to moderate the relationship between cognition and mobility. Results Results showed that the cardiorespiratory fitness × age interaction moderated the association between executive functioning and mobility (β = −0.05; p =.048; R
2 = 17.6; p <.001). At lower levels of physical fitness (<19.16 ml/min/kg), executive functioning significantly influenced YOA's mobility (β = −0.48, p =.004) and to a greater extent OOA's mobility (β = −0.96, p =.002). Discussion and Implications Our results support the idea of a dynamic relationship between mobility and executive functioning during aging and suggest that physical fitness could play a significant role in reducing their interdependency. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
29. Geriatric dementia care at Ontario Shores: A new model of care
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Viau, Katelynn, Yaddaden, Amel, Lussier, Maxime, Bier, Nathalie, Earle, Julie, Duff-Woskosky, Andra, Bartfay, Wally, Desai, Chaitali, Zavitz, Karen, Horsburgh, Sheri, Gamble, Brenda, Lee, Linda, Hillier, Loretta M., Patel, Tejal, Molnar, Frank, Clarke, Jo-Anne, Borrie, Michael, Cammer, Allison, Morgan, Debra, Whiting, Susan, de Vos, Maya, Henri-Bhargava, Alexandre, Votova, Kristine, Delmar, Paul, Kerchner, Geoffrey A, Wang, Guoqiao, Bateman, Randall, Klein, Gregory, Andjelkovic, Mirjana, Abi-Saab, Danielle, Bullain, Szofia, Montoya, Alonso, Fontoura, Paulo, Doody, Rachelle, Tai, Elaine, Harvey, David, Hofmann, Carsten, Ristic, Smiljana, Rehal, Sunita, Voyle, Nicola, Baudler, Monika, Verreault, Phylicia, Rousseau, François, Keller, Evelyn, Simard, Alexandra, Azouaou, Nassima, Jarboui, Manel, Talleria, Lorraine, Duguay, Johanne, Mérette, Chantale, Labbé, Annie, de Arco, Rossana Peredo Nunez, Yous, Marie-Lee, Ploeg, Jenny, Kaasalainen, Sharon, Martin, Lori Schindel, Palumbo, Mary Val, Rambur, Betty, McKenna, Lori, Voyer, Philippe, Allaire, Émilie, Li, Bing, Thaut, Michael, Yogaparan, Thirumagal, Shanmuganathan, Thirunathan, Vickneswaran, Anicha, Sriharan, Sruthy, DeMarco, Mari L., Hsiung, Ging-Yuek Robin, Best, John R., Chertkow, Howard, Gauthier, Serge, Karlawish, Jason, Feldman, Howard, Spaner, Caroline, Christie, Brian, Musteata, Stela, Gawryluk, Jodie, Hofer, Scott, Henri-Bhargava, Alex, Kenny, Rebecca, Elliot, Valerie, Kosteniuk, Julie, Chow, Amanda Froehlich, Bayly, Melanie, O’Connell, Megan E., Kortzman, August, O’Connell, Megan, Kirk, Andrew, Conn, David, Sokoloff, Lisa, Feldman, Sid, Chau, James, Moser, Andrea, Lingum, Navena, Gingrich, Shaen, Shaikh, Salma, Rabheru, Kiran, Cassidy, Keri-Leigh, Checkland, Claire, Parsons, Daria, Massie, Ariane S., Mitchell, Julie Spence, Aksenchuk, Sophia, Lindsay, Barbara, Howard, Maria, Shaw, Courtney, Armitage, Gerrard, Capstick, Andrea, McNeil, Heather, Holyoke, Paul, Vines, Chanile, Giosa, Justine, Khan, Bilal, Shultz, Mary, BEAUCHET, Olivier, Sekhon, Harmehr, Allali, Gilles, Montembeault, Maxime, Brodeur, Catherine, Macoir, Joël, Maxwell, Colleen, Maclagan, Laura, Campitelli, Michael, Yao, Shenzhen, Dharma, Christoffer, Sherin, Tracey, Hogan, David, Bronskill, Susan, Ivo, Jessica, Faisal, Sadaf, McDougall, Aidan, Bauer, Jillian, Pritchard, Sarah, Chang, Feng, Mehta, Deval, Syed, Ali, Carter, Caitlin, Sharma, Shaambhavi, Nagge, Jeff, Naglie, Gary, Stasiulis, Elaine, Yamin, Stephanie, Vrkljan, Brenda, Tuokko, Holly, Sanford, Sarah, Porter, Michelle, Polgar, Jan, Myers, Anita, Moorhouse, Paige, Mazer, Barbara, Marshall, Shawn, Gélinas, Isabelle, Crizzle, Alexander, Byszewski, Anna, Belchior, Patricia, Bédard, Michel, Rapoport, Mark, Minish, Duane, Yetman, Linda, Stephenson, Margaret, McCloskey, Rose, Agbaku, Mansa, Jarrett, Pamela, Cavanagh, Jennifer, Loncar, Adele, Demers, Vickie, Gobessi, Linda, Lodha, Vinay, Scerbe, Andrea, Astell, Arlene, DesRoches, Andrea, Panyavin, Ivan, Feltz, Nick, Wittich, Walter, Aubin, Gabrielle, Hogan, Mariah, Swaminathan, Swathi, Altschuler, Aviva, Murphy, Kelly, Guthrie, Dawn, Williams, Nicole, Campos, Jennifer, Mick, Paul, Orange, Joseph B., Pichora-Fuller, M. Kathleen, Savundranayagam, Marie Y., Phillips, Natalie A., Giroud, Nathalie, Pichora-Fuller, Kathy, Al-Yawer, Faisal, Rehan, Sana, Phillips, Natalie, Beauchet, Olivier, Niculescu, Iulia, Iaboni, Andrea, Quirt, Hannah, Penko, Marion, Tsokas, Mario, Marshall, Cecelia, Flint, Alastair, McGilton, Katherine, O’Connell, Megan E, Stewart, Norma J, Seitz, Dallas, Daku, Jean, Hack, Tracy, Hoium, Faye, Kennett-Russill, Deb, Sauter, Kristen, Holley, Joanna, Wimhurst, Christine, Katchaluba, Janet, Mitchell, Debbie, Severina, Elmira, Dallaire-Théroux, Caroline, Saikali, Stéphan, Duchesne, Simon, Sivananthan, Saskia, Mirza, Saira, Saeed, Usman, Knight, Jo, Ramirez, Joel, Stuss, Donald, Yu, Di, Swardfager, Walter, Keith, Julia, Nestor, Sean, Black, Sandra, Masellis, Mario, Joyal, Marilyne, Kotz, Sonja A., Lenglos, Christophe, Renauld, Emmanuelle, Wilson, Maximiliano A., Fecteau, Shirley, Appel, Lora, Kisonas, Erika, Appel, Eva, Bartlett, Deanna, Klein, Jennifer, Rosenberg, Jarred, Smith, Christopher, Ali, Suad, Narang, Tanya, Wiseman, Micaela, Ein, Natalie, Orchanian-Cheff, Ani, Rylett, Jane, Hogan, David B., Rockwood, Kenneth, Dixon, Roger, Sun, Winnie, Hawkins, Stacey A., Awde, Carolee, Kay, Kelly, Huntsbarger, Deana, Ferrier, Erin, Sourial, Nadia, Arsenault-Lapierre, Genevieve, McAiney, Carrie, Vedel, Isabelle, Ingram, K. Jennifer, Frank, Andrew, Sabra, Iman, Wallace, Bruce, Breau, Michael, Sweet, Lisa, Goubran, Rafiq, Knoefel, Frank, Goubran, Rafik, Stroulia, Eleni, Ault, Laura, Kecskemet, Judith, Guseva, Elena, Lungu, Ovidiu, Goldman, Sondra, Wilchesky, Machelle, Johri, Fozia, Turner, Angelese, Lavoie, Monica, Tang-Wai, David, Leonard, Carol, Graham, Naida L., Rochon, Elizabeth, Middleton, Laura, Herrmann, Nathan, Oh, Paul, Regan, Kayla, Bechard, Lauren, Lanctôt, Krista, Freeman, Shannon, Pettersen, Jacqueline, Tomasone, Jennifer, Dupuis, Sherry, Giangregorio, Lora, Ferris, Rebecca, Stultz, Tim, Mallard, Kirsten, Campbell, Elaine, Chatterjee, Atri, Mackenzie, Ian, Reinshagen, Veronica Hirsh, Ducharme, Blake, Mousavi, Ali, Gill, Sascha, Mouches, Pauline, Wang, Meng, Rajasheskar, Deepthi, MacMaster, Frank, Forkert, Nils, Smith, Eric, Ismail, Zahinoor, Varatharajah, Breni, Camicioli, Richard, Gee, Myrlene, Zwiers, Angela, Sekhon, Ramnik, Charlton, Anna, Arsenault-Lapierre, Geneviève, Ingram, Jennifer, Hawkins, Stacey, Mousavi, SeyedAli, Mackenzie, Ian R. A., Hirsh-Reinshagen, Veronica, Hsiung, Ging-Yuek. R., Gillingham, Susan M.E., Anderson, Nicole D., Alain, Claude, Georgievski, Georgi, Alfaro, Leonardo, McClenaghan, Meridith, Soares, Daniela, Matheson, Maureen, Stanoulis, Krisanne, Boyle, Daniel, Chau, Linh, Pelc, Jordan, Snash, Nadia, Byrne, Joanne, Elalouf, Karine, Alfaro, Andrea Urqueta, Johnson, Aaron, Marinier, Julie-Andrée, Kehayia, Eva, Gagné, Jean-Pierre, Murphy, Caitlin, Ellen, Ruth, Flowers, Brandi, Boulton, Karen Lee, Subotic, Arsenije, McCreary, Cheryl R., Nguyen, Amanda, Saad, Feryal, Alvarez, Ana, Beaudin, Andrew E, Pike, Bruce, Smith, Eric E, Hu, Sophie, Patten, Scott, Fick, Gordon, Sapkota, Shraddha, Mirza, Saira Saeed, Scott, Christopher J., Stuss, Donald T., Black, Sandra E., Le Blanc, Gabriella, Ducharme, Simon, Meilleur-Durand, Synthia, Lévesque, Marianne, St-Onge, Frédéric, Cunnane, Stephen, Villeneuve, Sylvia, Callahan, Brandy, Laforce, Robert, Cetin-Sahin, Deniz, Cummings, Greta G., Schuster, Tibor, Karanofsky, Mark, De Jesus, Belmir J., Cassani, Raymundo, Cecchi, Marco, Fadem, K. C., McGeown, William J., Falk, Tiago H., Chu, Charlene, Zdaniuk, Natalia, Wang, Rosalie, Ouellet, Marie-Christine, Cassivi-Joncas, Alison, Godard-Sebillotte, Claire, Rochette, Louis, Pelletier, Eric, Strumpf, Erin, Margo-Dermer, Eva, Silver, Hilah, Vafaei, Rod, Fok, Alice C, Hsiung, Ging-Yuek R., Ursenbach, Jake, Bethell, Jennifer, Neuman, Mark D, Bateman, Brian T, Hill, Andrea, Wunsch, Hannah, Ritchie, Kim, Cramm, Heidi, Aiken, Alice, Donnelly, Catherine, Goldie, Katie, Delara, Mahin, Ozzoude, Miracle, Varriano, Brenda, McLaughlin, Paula, Troyer, Angela, Bartha, Robert, Symons, Sean, Kwan, Donna, Tan, Brian, Swartz, Richard H., Saposnik, Gustavo, Tartaglia, Maria C., Ahuja, Manan, Siddhpuria, Shailee, Gormley, Jessica, Reppas, Christina, Wong, Eric, Lee, Justin, Patterson, Christopher, Walker, Jennifer, Warry, Wayne, Blind, Melissa, Allaby, Cheryl, Pitawanakwat, Karen, Zhao, Yantao, Lemieux, Andrine, Jacklin, Kristen, Crowshoe, Lindsay, Boehme, Gail, McKenna, Betty, Boyling, Elaine, Webkamigad, Sharlene, Bigeagle, Louise, Akan, Nicole, Wallace, Lindsay, Theou, Olga, Bennett, David, Darvesh, Sultan, Kirkland, Susan, Fisk, John, Andrew, Melissa, Cullen, Stephanie, Carroll, Susan, Mahon, Joel, Sarquis-Adamson, Yanina, Montero-Odasso, Manuel, Sharma, Nabina, Beaton, Derek, Roberts, Angela, Munoz, Doug, Swartz, Richard, Breen, David, Lang, Anthony, Fischer, COrrine, Fischer, Corrine, Kumar, Sanjeeve, Freedman, Morris, Finger, Elizabeth, Zinman, Lorne, Grimes, David A., Sunderland, Kelly M., Binns, Malcolm A., Strother, Stephen C., Mandzia, Jennifer, Orange, JB, Tartaglia, Carmela, El Shatshat, Amna, Rao, Praveen P.N., Teves, Julia, Bodkin, R Jack, Ho, Joanne M-W, Mehdizadeh, Sina, Dolatabadi, Elham, Ng, Kimberley-Dale, Arora, Twinkle, Jizmejian, Melody, Mansfield, Avril, Taati, Babak, Levy, Jake, Savard, Melissa, Pascoal, Tharick, Soucy, Jean-Paul, Rosa-Neto, Pedro, Martins, Felicia, Waller, Shannon, Flora, Parminder, Morland, Chris, Donovan, Steve, Fels, Deborah, Desai, Shital, Boger, Jennifer, Shashtri, Karan, Persaud, Deanna, Marashi, Sheida, Nedlund, Ann-Charlotte, Mäki-Petäjä-Leinonen, Anna, Nygård, Louise, Issakainen, Mervi, ryd, Charlotta, Pan, Yuhan, Joddrell, Phil, Dove, Erica, Owens, Hollis, Park, Elly, Liu, Lili, Kaufman, David, Simonian, Natalie, Chen, Ying, Sunderland, Kelly, Fraser, Julia, Swartz, Rick, Strother, Stephen, Legrand, Diego, Roberge, Pasquale, Vanasse, Alain, Bocti, Christian, Pirrie, Lorraine, Gray, Carolyn Steele, Nippak, Pria, Coughlan, Dave, Teselink, Johannes, Hermann, Nathan, Rasquinha, Fawn, Lanctot, Krista, Webber, Jodi, Woo, Kevin, Chamoun, Elicia, Coulombe, Valérie, Sellami, Leila, Paquette-Raynard, Emmanuelle, Gardner, Sandra, van Zon, Lorraine, Moy, Sally, Sidrak, Mariam, Sternhill, Janis, Feldman, Sidney, Karuza, Jurgis, Berall, Anna, Thomas, Neil, Mattek, Nora, Riley, Thomas, Reynolds, Christina, Marcoe, Jennifer, Sharma, Nicole, Kaye, Jeffrey, Jagtap, Shreya, Rotenberg, Shlomit, Vandermorris, Susan, Anderson, ND, Dawson, DR, Chater, Catherine, Soor, Jaspreet, Ji, Xiang, Koo, Morgan, Compagnone, Jordana, Kertes, Peter, Juby, Angela, Mager, Diana, Davis, Christopher, Jay, David, Blackburn, Toni, Brocks, Dion, Lee, Hyunwoo, Wiggermann, Vanessa, Rauscher, Alexander, Lam, Kevin, Tam, Roger, Popuri, Karteek, Beg, Mirza Faisal, Jacova, Claudia, Sossi, Vesna, Bindra, Jessica, Bouvier, Liziane, Monetta, Laura, Vitali, Paolo, Martel-Sauvageau, Vincent, Godin, Judith, McNeil, Shelly, McElhaney, Janet, Laughton, Thomas, Ho, Joanne, Tung, Jennifer, Dubé, Joseph B., Lin, Tianzhen, Best, Sarah, Truemner, Julia, Sargeant, Patricia L., Borrie, Michael J., Fogarty, Jennifer, Bassi, Nimi, Di Prospero, Cynthia, Whitehead, Victor, Pilon, Randi, Wong, Timothy, Elhayek, Nada, Dasgupta, Monidipa, Davis, Daniel, ORegan, Niamh, Kröger, Edeltraut, Furrer, Daniela, Wilcheski, Machelle, Morin, Michèle, Carmichael, Pierre-Hugues, Champoux, Nathalie, Monette, Johanne, Giguère, Anik, Aubin, Michèle, Durand, Pierre, Whiteside, Jena, Mele, Bria, Merrikh, Daria, Goodarzi, Zahra, Seary, Judith Anne, Bulley, Heather, Diciacca, Allison, Esseltine, Julia, Gaiger, Erin, Jankovic, Ivana, Mackenzie, Stephanie, McBride, Meghan, Knopp-Sihota, Jennifer A., Hoben, Mathias, Poss, Jeffrey W., Rachor, Geoffrey S., Estabrooks, Carole A., and Iroanyah, Ngozi
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Abstracts: Posters - Published
- 2020
30. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry
- Author
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Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond-Ginsbach, Caspar, and Candelise, Livia
- Published
- 2016
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31. Discordance and Concordance Between Cerebrospinal and [18F]FDG-PET Biomarkers in Assessing Atypical and Early-Onset AD Dementia Cases.
- Author
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Quispialaya, Kely Mónica, Therriault, Joseph, Aliaga, Antonio, Zimmermann, Maria, Fernandez-Arias, Jaime, Lussier, Firoza, Massarweh, Gassan, Pascoal, Tharick, Soucy, Jean-Paul, Gauthier, Serge, Jean-Claude, Bertrand, Gilfix, Brian, Vitali, Paolo, and Rosa-Neto, Pedro
- Published
- 2022
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32. Carotid dissection mimicking a new attack of cluster headache
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Candeloro, Elisa, Canavero, Isabella, Maurelli, Maurizia, Cavallini, Anna, Ghiotto, Natascia, Vitali, Paolo, and Micieli, Giuseppe
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- 2013
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33. Herpes simplex encephalitis in glioma patients: a challenging diagnosis
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Berzero, Giulia, Di Stefano, Anna Luisa, Dehais, Caroline, Sanson, Marc, Gaviani, Paola, Silvani, Antonio, Salmaggi, Andrea, Vitali, Paolo, Diamanti, Luca, Baldanti, Fausto, Farina, Lisa Maria, Ceroni, Mauro, and Marchioni, Enrico
- Published
- 2015
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34. Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer's disease.
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Therriault, Joseph, Pascoal, Tharick A., Savard, Mélissa, Mathotaarachchi, Sulantha, Benedet, Andréa L., Chamoun, Mira, Tissot, Cécile, Lussier, Firoza Z., Rahmouni, Nesrine, Stevenson, Jenna, Qureshi, Muhammad Naveed Iqbal, Kang, Min Su, Thomas, Émilie, Vitali, Paolo, Soucy, Jean-Paul, Massarweh, Gassan, Saha-Chaudhuri, Paramita, Gauthier, Serge, and Rosa-Neto, Pedro
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ALZHEIMER'S disease ,TAU proteins ,NETWORK hubs ,LARGE-scale brain networks ,NEURAL circuitry - Abstract
Alzheimer's disease (AD) phenotypes might result from differences in selective vulnerability. Evidence from preclinical models suggests that tau pathology has cell-to-cell propagation properties. Therefore, here, we tested the cell-to-cell propagation framework in the amnestic, visuospatial, language, and behavioral/dysexecutive phenotypes of AD. We report that each AD phenotype is associated with a distinct network-specific pattern of tau aggregation, where tau aggregation is concentrated in brain network hubs. In all AD phenotypes, regional tau load could be predicted by connectivity patterns of the human brain. Furthermore, regions with greater connectivity displayed similar rates of longitudinal tau accumulation in an independent cohort. Connectivity-based tau deposition was not restricted to a specific vulnerable network but was rather a general property of brain organization, linking selective vulnerability and transneuronal spreading models of neurodegeneration. Together, this study indicates that intrinsic brain connectivity provides a framework for tau aggregation across diverse phenotypic manifestations of AD. Determining behavior by following tau: Although some of the symptoms of Alzheimer's disease (AD) are conserved among patients, multiple phenotypes exist, including amnestic, visuospatial, language, and behavioral/dysexecutive. Understanding the mechanisms mediating the different behavioral phenotypes will help the development of specific treatments. Here, Therriault and colleagues studied the pattern of tau pathology spreading in multiple cohorts of patients with different phenotypes and showed that each phenotype was associated with a specific connectivity-based pattern of tau aggregation. The results suggest that intrinsic brain connectivity drives tau aggregation pattern, thus determining the behavioral phenotype of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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35. A generalized deep learning network for fractional anisotropy reconstruction: Application to epilepsy and multiple sclerosis.
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Gaviraghi, Marta, Ricciardi, Antonio, Palesi, Fulvia, Brownlee, Wallace, Vitali, Paolo, Prados, Ferran, Kanber, Baris, and Wheeler-Kingshott, Claudia A. M. Gandini
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DEEP learning ,MULTIPLE sclerosis ,TEMPORAL lobe epilepsy ,ANISOTROPY ,DIFFUSION gradients ,EPILEPSY - Abstract
Fractional anisotropy (FA) is a quantitative map sensitive to microstructural properties of tissues in vivo and it is extensively used to study the healthy and pathological brain. This map is classically calculated by model fitting (standard method) and requires many diffusion weighted (DW) images for data quality and unbiased readings, hence needing the acquisition time of several minutes. Here, we adapted the U-net architecture to be generalized and to obtain good quality FA from DW volumes acquired in 1minute. Our network requires 10 input DW volumes (hence fast acquisition), is robust to the direction of application of the diffusion gradients (hence generalized), and preserves/improves map quality (hence good quality maps). We trained the network on the human connectome project (HCP) data using the standard model-fitting method on the entire set of DW directions to extract FA (ground truth). We addressed the generalization problem, i.e., we trained the network to be applicable, without retraining, to clinical datasets acquired on different scanners with different DW imaging protocols. The network was applied to two different clinical datasets to assess FA quality and sensitivity to pathology in temporal lobe epilepsy and multiple sclerosis, respectively. For HCP data, when compared to the ground truth FA, the FA obtained from 10 DW volumes using the network was significantly better (p < 10
-4 ) than the FA obtained using the standard pipeline. For the clinical datasets, the network FA retained the same microstructural characteristics as the FA calculated with all DW volumes using the standard method. At the subject level, the comparison between white matter (WM) ground truth FA values and network FA showed the same distribution; at the group level, statistical differences of WM values detected in the clinical datasets with the ground truth FA were reproduced when using values from the network FA, i.e., the network retained sensitivity to pathology. In conclusion, the proposed network provides a clinically availablemethod to obtain FA froma generic set of 10 DW volumes acquirable in 1minute, augmenting data quality compared to direct model fitting, reducing the possibility of bias from sub-sampled data, and retaining FA pathological sensitivity, which is very attractive for clinical applications. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
36. Subject-specific features of excitation/inhibition profiles in neurodegenerative diseases.
- Author
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Monteverdi, Anita, Palesi, Fulvia, Costa, Alfredo, Vitali, Paolo, Pichiecchio, Anna, Ramusino, Matteo Cotta, Bernini, Sara, Jirsa, Viktor, Wheeler-Kingshott, Claudia A. M. Gandini, and D'Angelo, Egidio
- Subjects
BRAIN anatomy ,BRAIN ,ALZHEIMER'S disease ,MAGNETIC resonance imaging ,REGRESSION analysis ,FUNCTIONAL connectivity ,DISCRIMINANT analysis ,NEUROPSYCHOLOGICAL tests ,AMYOTROPHIC lateral sclerosis ,CLUSTER analysis (Statistics) ,PSYCHOMOTOR disorders ,FRONTOTEMPORAL dementia - Abstract
Brain pathologies are characterized by microscopic changes in neurons and synapses that reverberate into large scale networks altering brain dynamics and functional states. An important yet unresolved issue concerns the impact of patients' excitation/inhibition profiles on neurodegenerative diseases including Alzheimer's Disease, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. In this work, we used The Virtual Brain (TVB) simulation platform to simulate brain dynamics in healthy and neurodegenerative conditions and to extract information about the excitatory/inhibitory balance in single subjects. The brain structural and functional connectomes were extracted from 3T-MRI (Magnetic Resonance Imaging) scans and TVB nodes were represented by a Wong-Wang neural mass model endowing an explicit representation of the excitatory/inhibitory balance. Simulations were performed including both cerebral and cerebellar nodes and their structural connections to explore cerebellar impact on brain dynamics generation. The potential for clinical translation of TVB derived biophysical parameters was assessed by exploring their association with patients' cognitive performance and testing their discriminative power between clinical conditions. Our results showed that TVB biophysical parameters differed between clinical phenotypes, predicting higher global coupling and inhibition in Alzheimer's Disease and stronger N-methyl-D-aspartate (NMDA) receptor-dependent excitation in Amyotrophic Lateral Sclerosis. These physio-pathological parameters allowed us to perform an advanced analysis of patients' conditions. In backward regressions, TVB-derived parameters significantly contributed to explain the variation of neuropsychological scores and, in discriminant analysis, the combination of TVB parameters and neuropsychological scores significantly improved the discriminative power between clinical conditions. Moreover, cluster analysis provided a unique description of the excitatory/inhibitory balance in individual patients. Importantly, the integration of cerebro-cerebellar loops in simulations improved TVB predictive power, i.e., the correlation between experimental and simulated functional connectivity in all pathological conditions supporting the cerebellar role in brain function disrupted by neurodegeneration. Overall, TVB simulations reveal differences in the excitatory/inhibitory balance of individual patients that, combined with cognitive assessment, can promote the personalized diagnosis and therapy of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
37. White matter involvement in sporadic Creutzfeldt-Jakob disease
- Author
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Caverzasi, Eduardo, Mandelli, Maria Luisa, DeArmond, Stephen J., Hess, Christopher P., Vitali, Paolo, Papinutto, Nico, Oehler, Abby, Miller, Bruce L., Lobach, Irina V., Bastianello, Stefano, Geschwind, Michael D., and Henry, Roland G.
- Published
- 2014
- Full Text
- View/download PDF
38. Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia
- Author
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Vitali, Paolo, Dronkers, Nina, Pincherle, Alexander, Giovagnoli, Anna Rita, Marras, Carlo, D’Incerti, Ludovico, Ghielmetti, Francesco, Spreafico, Roberto, and Villani, Flavio
- Published
- 2011
- Full Text
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39. Training-induced brain remapping in chronic aphasia: a pilot study
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Vitali, Paolo, Abutalebi, Jubin, Tettamanti, Marco, Danna, Massimo, Ansaldo, Ana-Ines, Perani, Daniela, Joanette, Yves, and Cappa, Stefano F.
- Subjects
Speech therapy -- Case studies ,Articulation disorders -- Care and treatment -- Case studies ,Psychology and mental health ,Care and treatment ,Case studies - Abstract
Background. The neural correlates of training-induced improvements of cognitive functions after brain damage remain still scarcely understood. In the specific case of aphasia, although several investigations have addressed the issue [...]
- Published
- 2007
40. Frontal and cerebellar atrophy supports FTLD-ALS clinical continuum and neuropsychology
- Author
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Pizzarotti, Beatrice, Palesi, Fulvia, Vitali, Paolo, Castellazzi, Gloria, Anzalone, Nicoletta, Alvisi, Elena, Martinelli, Daniele, Bernini, Sara, Cotta Ramusino, Matteo, Ceroni, Mauro, Micieli, Giuseppe, Sinforiani, Elena, DAngelo, Egidio, Costa, Alfredo, and Gandini Wheeler-Kingshott, Claudia Angewla Michela
- Subjects
mental disorders - Abstract
Objective: Frontotemporal Lobe Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases more often considered as a continuum from clinical, epidemiologic and genetic perspectives. We used localized brain atrophy to evaluate common and specific features of FTLD, FTLD-ALS and ALS patients to clarify this clinical continuum. Methods: We used voxel-based morphometry (VBM) on structural MRI images to localize volume alterations of brain regions in group comparisons: patients (20 FTLD, 7 FTLD-ALS, 18 ALS) versus controls (39 CTR) and patient groups between themselves. We used whole-brain cortical thickness (CT) to assess correlations with brain volume to propose mechanistic explanations of the heterogeneous clinical presentations. We assessed whether brain atrophy can explain cognitive impairment, measured with neuropsychological tests (Frontal Assessment Battery, verbal fluency and semantic fluency). Results: Common (mainly frontal) and specific areas of atrophy between FTLD, FTLD-ALS and ALS patients were detected, on the one hand confirming the suggestion of a clinical continuum, while on the other hand defining morphological specificities for each clinical group (e.g. a different cerebral and cerebellar involvement between FTLD and ALS). CT values suggested extensive network disruption in the pathological process, with indications of a correlation between white matter volume and CT in ALS. The correlation between neuropsychological scores pointed at an important role of the cerebellum, together with frontotemporal regions, in explaining cognitive impairment at the level of executive and linguistic functions. Conclusions: We identified common elements that explain the FTLD-ALS clinical continuum, while also identifying specificities of each group, partially explained by different cerebral and cerebellar involvement.
- Published
- 2019
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41. 99mTc-HMPAO and 99mTc-ECD perform differently in typically hypoperfused areas in Alzheimer's disease
- Author
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Koulibaly, Pierre Malick, Nobili, Flavio, Migneco, Octave, Vitali, Paolo, Robert, Philippe H., Girtler, Nicola, Darcourt, Jacques, and Rodriguez, Guido
- Published
- 2003
- Full Text
- View/download PDF
42. Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia.
- Author
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Savard, Melissa, Pascoal, Tharick A., Servaes, Stijn, Dhollander, Thijs, Iturria-Medina, Yasser, Min Su Kang, Vitali, Paolo, Therriault, Joseph, Mathotaarachchi, Sulantha, Benedet, Andrea Lessa, Gauthier, Serge, and Rosa-Neto, Pedro
- Published
- 2022
- Full Text
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43. Verbal recognition declines in later Braak Stages compared to verbal delayed recall.
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Arias, Jaime Fernandez, Therriault, Joseph, Lussier, Firoza Z, Pascoal, Tharick A, Tissot, Cécile, Wang, Yi‐Ting, Bezgin, Gleb, Servaes, Stijn, Kang, Min Su, Chamoun, Mira, Stevenson, Jenna, Rahmouni, Nesrine, Poltronetti, Nina Margherita, Kunach, Peter, Ottoy, Julie, Stevenson, Alyssa, Mathotaarachchi, Sulantha, Massarweh, Gassan, Vitali, Paolo, and Gauthier, Serge
- Abstract
Background: Episodic memory decline is a hallmark of cognitive impairment due to Alzheimer's Disease (AD). Literature has consistently indicated that delayed recall is compromised early in the disease. Recognition memory seems disrupted at late stages, although findings are mixed. Recent PET studies have demonstrated that the presence of tau in the medial temporal lobe (MTL) relates to early deterioration of delayed recall, but no PET studies have assessed how recognition memory relates to tau. We sought to investigate this relationship across the Braak staging continuum. Method: Tau PET ([18F]‐MK6240) was acquired for 140 cognitively unimpaired elderly (CU), 54 MCI patients and 33 AD patients. Participants were segregated into Braak stages, based on in vivo PET neuroimaging of tau. Episodic memory was assessed using RAVLT delayed recall and recognition tests. MRI were segmented into probabilistic grey (GM) and white (WM) maps, non‐linearly registered to the ADNI template using Dartel and smoothed with an 8mm FWHM gaussian kernel. Independent samples t‐tests or their nonparametric counterparts were conducted to evaluate differences in memory scores by Braak stage. Voxel‐wise linear regression models were applied, using VoxelStats, with either delayed recall or recognition scores as dependent variables and tau PET as a predictor. Global amyloid, age, sex, education and APOE genotype were entered as covariates. Results: Pairwise comparisons revealed that recognition memory is spared in early Braak stages. Voxel‐wise analyses in the whole sample unveiled that delayed recall and recognition memory relate to tau in virtually the same cortical areas. However, the strength of the relationships widely varied by memory type. Tau‐PET in anterior MTL and posterior hippocampus shows stronger associations with delayed recall, while tau binding in lateral temporal, temporooccipital and posterior areas exhibits stronger associations with recognition memory. Conclusion: Our findings support the differentiation between delayed recall and recognition across the AD spectrum. Relationships between delayed recall and tau in the MTL are in concordance with previous research. Moreover, the contrast in the strength of the associations between memory and tau aggregation further supports the notion that delayed recall is already impaired in early Braak stages while recognition is damaged in later Braak stages. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
44. Generating animal and tool names: An fMRI study of effective connectivity
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Vitali, Paolo, Abutalebi, Jubin, Tettamanti, Marco, Rowe, James, Scifo, Paola, Fazio, Ferruccio, Cappa, Stefano F., and Perani, Daniela
- Published
- 2005
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45. Resting SPECT-neuropsychology correlation in very mild Alzheimer's disease
- Author
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Nobili, Flavio, Brugnolo, Andrea, Calvini, Piero, Copello, Francesco, De Leo, Caterina, Girtler, Nicola, Morbelli, Silvia, Piccardo, Arnoldo, Vitali, Paolo, and Rodriguez, Guido
- Published
- 2005
- Full Text
- View/download PDF
46. Neuroimaging in Dementia
- Author
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Vitali, Paolo, Migliaccio, Raffaella, Agosta, Federica, Rosen, Howard J., and Geschwind, Michael D.
- Published
- 2008
47. Functional MRI in Malformations of Cortical Development: Activation of Dysplastic Tissue and Functional Reorganization
- Author
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Vitali, Paolo, Minati, Ludovico, DʼIncerti, Ludovico, Maccagnano, Elio, Mavilio, Nicola, Capello, Dario, Dylgjeri, Suela, Rodriguez, Guido, Franceschetti, Silvana, Spreafico, Roberto, and Villani, Flavio
- Published
- 2008
48. ALZHEIMER'S DEMENTIA EARLY DIAGNOSIS, CHARACTERIZATION, PROGNOSIS AND TREATMENT DECISION VIA A SOFTWARE‐AS‐MEDICAL DEVICE WITH AN ARTIFICIAL INTELLIGENT AGENT.
- Author
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Battista, Petronilla, Nemni, Raffaello, Vitali, Paolo, Alì, Marco, Zanardo, Moreno, Salvatore, Christian, Sirabian, Graziella, Capelli, Dario, Bet, Luciano, Callus, Edward, Bertoldo, Enrico Giuseppe, Fiolo, Valentina, Minafra, Brigida, Fundarò, Cira, Scotti, Giuseppe, Sardanelli, Francesco, Papa, Sergio, and Castiglioni, Isabella
- Abstract
Background: TRACE4AD (DeepTrace Technologies s.r.l, Italy) is a machine learning‐based software‐as‐medical device able to predict the conversion to Alzheimer's disease (AD) dementia of subjects at risk within 24‐months exploiting automatic processing of T1‐weighted MPRAGE brain MRI study and neuropsychological tests. TRACE4AD provides a report with the predicted individual risk of conversion to AD dementia, specific cognitive deficits, and suggestions supporting neurologists in diagnosis and characterization, prognosis, and decision‐making. We tested TRACE4AD in the clinical setting in its ability, at baseline, to: a) predict amnestic Mild Cognitive Impairment (MCI) conversion to AD dementia within 24‐months; b) characterize cognitive deficits; c) support neurologists' decision‐making. Method: We retrospectively included 92 subjects (mean age 73.12±7.6, 46% female): 32 patients from two Italian centers where TRACE4AD was implemented after user training; and 60 subjects from the ADNI dataset. All patients had a brain MPRAGE study at baseline, 77/92 patients (83.7%) also performed a neuropsychological assessment at baseline, 75/92 patients (81.5%) had a stable clinical diagnosis at 24‐month. TRACE4AD extracted the gray matter map from MPRAGE and used it (combined with cognitive measures when available) to make inferences. Reference standards were: a) the neurologist's clinical diagnosis at 24‐months, b) the neuropsychological assessment at the baseline, c) the agreement with the neuro exam and intervention decision time and type defined by neurologists at the baseline. Result: TRACE4AD accurately predicted conversion to AD dementia in 93.3% of patients based on the MRI, and in 96.6% based on MRI and cognitive measures. Cognitive deficits were found in agreement with the neuropsychological assessment for all patients except one who presented with major depression. We found disagreement between the neurologist's decision at baseline and the tool in only two patients, defined with normal cognition by the neurologist and predicted at high risk of AD dementia conversion by the tool. TRACE4AD supported neurologists' decision by 12 months in 15/17 patients for the prompt decision at baseline. Conclusion: TRACE4AD is promising, safe, and effective in supporting neurologists in the clinical practice of MCI across different centers. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
49. The neural correlates of therapy with semantic feature analysis in chronic anomia: An event-related fMRI study
- Author
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Marcotte, Karine, Vitali, Paolo, Delgado, Ana Paula, and Ansaldo, Ana Inés
- Published
- 2006
- Full Text
- View/download PDF
50. Sensorimotor organization in double cortex syndrome
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Jirsch, Jeffrey D., Bernasconi, Neda, Villani, Flavio, Vitali, Paolo, Avanzini, Giuliano, and Bernasconi, Andrea
- Published
- 2006
- Full Text
- View/download PDF
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