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1. Liver X receptor unlinks intestinal regeneration and tumorigenesis

Author

Das, Srustidhar, Parigi, S. Martina, Luo, Xinxin, Fransson, Jennifer, Kern, Bianca C., Okhovat, Ali, Diaz, Oscar E., Sorini, Chiara, Czarnewski, Paulo, Webb, Anna T., Morales, Rodrigo A., Lebon, Sacha, Monasterio, Gustavo, Castillo, Francisca, Tripathi, Kumar P., He, Ning, Pelczar, Penelope, Schaltenberg, Nicola, De la Fuente, Marjorie, López-Köstner, Francisco, Nylén, Susanne, Larsen, Hjalte List, Kuiper, Raoul, Antonson, Per, Hermoso, Marcela A., Huber, Samuel, Biton, Moshe, Scharaw, Sandra, Gustafsson, Jan-Åke, Katajisto, Pekka, and Villablanca, Eduardo J.

Published
2024
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5. Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF

Author

Kvedaraite, Egle, Lourda, Magda, Mouratidou, Natalia, Düking, Tim, Padhi, Avinash, Moll, Kirsten, Czarnewski, Paulo, Sinha, Indranil, Xagoraris, Ioanna, Kokkinou, Efthymia, Damdimopoulos, Anastasios, Weigel, Whitney, Hartwig, Olga, Santos, Telma E., Soini, Tea, Van Acker, Aline, Rahkonen, Nelly, Flodström Tullberg, Malin, Ringqvist, Emma, Buggert, Marcus, Jorns, Carl, Lindforss, Ulrik, Nordenvall, Caroline, Stamper, Christopher T., Unnersjö-Jess, David, Akber, Mira, Nadisauskaite, Ruta, Jansson, Jessica, Vandamme, Niels, Sorini, Chiara, Grundeken, Marijke Elise, Rolandsdotter, Helena, Rassidakis, George, Villablanca, Eduardo J., Ideström, Maja, Eulitz, Stefan, Arnell, Henrik, Mjösberg, Jenny, Henter, Jan-Inge, and Svensson, Mattias

Published
2024
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6. Subaortic Membrane and Cardiac Catheterization—Beware of Diagnostic Pitfall

Author

Jonathan X. Fang, MBBS, Georgi Fram, MD, Dee Dee Wang, MD, Pedro A. Villablanca, MD, Brian P. O’Neill, MD, Tiberio M. Frisoli, MD, Gennaro Giustino, MD, James C. Lee, MD, William W. O’Neill, MD, and Pedro Engel Gonzalez, MD

Subjects
cardiac catheterization, cardiac hemodynamics, subaortic membrane, subaortic stenosis, transesophageal echocardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2024
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10. Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease

Author

Christoph Kilian, Hanna Ulrich, Viktor A. Zouboulis, Paulina Sprezyna, Jasmin Schreiber, Tomer Landsberger, Maren Büttner, Moshe Biton, Eduardo J. Villablanca, Samuel Huber, and Lorenz Adlung

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Single-cell-based methods such as flow cytometry or single-cell mRNA sequencing (scRNA-seq) allow deep molecular and cellular profiling of immunological processes. Despite their high throughput, however, these measurements represent only a snapshot in time. Here, we explore how longitudinal single-cell-based datasets can be used for deterministic ordinary differential equation (ODE)-based modelling to mechanistically describe immune dynamics. We derived longitudinal changes in cell numbers of colonic cell types during inflammatory bowel disease (IBD) from flow cytometry and scRNA-seq data of murine colitis using ODE-based models. Our mathematical model generalised well across different protocols and experimental techniques, and we hypothesised that the estimated model parameters reflect biological processes. We validated this prediction of cellular turnover rates with KI-67 staining and with gene expression information from the scRNA-seq data not used for model fitting. Finally, we tested the translational relevance of the mathematical model by deconvolution of longitudinal bulk mRNA-sequencing data from a cohort of human IBD patients treated with olamkicept. We found that neutrophil depletion may contribute to IBD patients entering remission. The predictive power of IBD deterministic modelling highlights its potential to advance our understanding of immune dynamics in health and disease.

Published
2024
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11. Pre-service and in-service teachers' cognitions about pronunciation instruction : a cross-sectional study in the Chilean context

Author

Villablanca Agurto, Paula, Dewey, Martin, and Szczepek Reed, Beatrice Barbara

Abstract

The field of Second Language Teacher Cognition (SLTC) has promisingly gained more attention in the past decades. Different studies have enquired into what teachers think, know and believe in order to understand how their mental lives shape their daily practices (Borg, 2015). This interest has also emerged as it can inform English Language Teaching (ELT) educators and researchers about the needs and challenges teachers experience throughout their professional lives. Despite this growing interest, research on teachers' cognitions about pronunciation instruction has mainly focused on experienced practitioners (e.g., Baker, 2011; Henderson et al., 2012) or on teachers after taking short courses about pronunciation pedagogy (e.g., Burri, 2016; Buss, 2017). There is need, therefore, for investigating comprehensively the developmental processes that teachers of English undergo throughout their training and careers (Burri & Baker, 2020, 2021). This doctoral thesis is a response to this need by investigating how the pronunciation-related cognitions and practices of Chilean teachers of English develop during and after their ELT training, and the factors that contribute to them. This was carried in a cross-sectional study in which 293 pre-service and in-service teachers from three Chilean universities were studied and their cognitions compared at different stages of their training and career development. This includes student teachers from first, third and fifth years of ELT training programmes, and novice teachers. The exploration of participants' cognitions was carried out by means of an explanatory sequential mixed methods design, involving two phases. In phase one, online surveys were employed to provide a concrete representation of these Chilean prospective and novice teachers' beliefs about pronunciation instruction. In phase two, 27 surveyed participants took part in semi-structured interviews which aimed at developing the initial research stage. Findings evidence there are noticeable differences in their perceptions regarding the importance of pronunciation teaching, learning goals, models, and the judgements about their own pronunciation and knowledge to teach the content. These contrasts also suggest there is a progressive detachment from traditional perspectives to a flexible pronunciation instruction approach that considers the current role of English as a global language when participants reach later stages of their professional development. However, irrespective of their training and career stage, these cohorts of prospective and novice teachers show similar cognitions about the importance of teaching segmentals and suprasegmentals and their overall confidence for pronunciation teaching. Cohorts at later stages of their development also report similar classroom practices. Additionally, results suggest the different interpretations of the role of pronunciation for communication and as an ELT content very much depend on the level of their professional and career progression. Their prior learning experiences, professional coursework and contextual factors are ratified as shaping their cognitions (Borg, 2015), showing different levels of influence. Within these dimensions, teacher candidates' study-abroad experiences, classroom practice and interaction with the media have helped break some paradigms with respect to traditional approaches for pronunciation instruction and speakers' representation. Teacher education, nonetheless, constitutes the most extensively present element in these pre- and in-service teachers' mental lives and actions. Tensions in participants cognitions are identified as a result of the lack of a coherent narrative in these training programmes, which do not offer pronunciation pedagogy training and focus predominantly on their trainees' linguistic accuracy development. Overall, the study highlights the complex and multifactorial nature of prospective and novice teachers' cognitions, and the needs to continue developing professional coursework that addresses their challenges in light of these results.

Published
2023

13. Análisis comparado de tendencias formativas en periodismo en Chile

Author

Massiel Belén Medina Villablanca and Alixon David Reyes Rodríguez

Subjects
Periodismo, tendencia educacional, competencia profesional, formación de periodistas, entorno digital, Communication. Mass media, P87-96, Journalism. The periodical press, etc., PN4699-5650
Abstract

Objetivo: Este trabajo corresponde a un estudio de análisis comparado, siendo las unidades de análisis conformadas por las mallas curriculares de las carreras de periodismo en Chile. Metodología: El estudio emplea un enfoque cualitativo, con un estudio de caso de sistemas similares como tipo de investigación, a partir de un análisis comparado con diseño transversal. Resultados: Existen coincidencias en las propuestas curriculares, estableciendo tendencias formativas en el periodismo en Chile, y se puede decir que las tendencias de la formación del periodista en Chile, tienen que ver con la adaptación a las transformaciones a las tecnologías, desarrollo de capacidad crítica, reflexiva y analítica, capacidad investigativa e interpretación de datos, elaboración y producción de contenidos, manejo riguroso y ético de la información, aunado a la capacidad de adecuación y adaptación para trabajar en diferentes plataformas mediales, soportes, formatos y géneros periodísticos. Conclusión: Las competencias coincidentes declaradas en los perfiles comprometidos por las carreras de Periodismo en Chile, determinan tendencias formativas del profesional periodista, considerando la diversidad de contextos, demandas y necesidades formativas y ocupacionales.

Published
2024
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14. Transcatheter Aortic Valve Replacement is Ready for Most Low-risk Patients: A Systematic Review of the Literature

Author

Ahmad Jabri, Anas Alameh, Gennaro Giustino, Pedro Engel Gonzalez, Brian O’Neill, Rodrigo Bagur, Pedro Cox, Tiberio Frisoli, James Lee, Dee Dee Wang, William W O’Neill, and Pedro Villablanca

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Transcatheter aortic valve replacement (TAVR) has undergone rapid expansion, emerging as a viable therapeutic option for low-risk patients in lieu of surgical aortic valve replacement. This paper aims to provide a review of the scientific evidence concerning TAVR in low-risk patients, encompassing both observational and clinical trial data. Furthermore, a substantial proportion of low-risk patients possesses a bicuspid aortic valve, necessitating careful examination of the pertinent anatomic and clinical considerations to TAVR that is highlighted in this review. Additionally, the review expands upon some of the unique challenges associated with alternate access in low-risk patients evaluated for TAVR. Last, this review outlines the pivotal role of a multidisciplinary heart team approach in the execution of all TAVR procedures and the authors’ vision of ‘minimalist TAVR’ as a new era in low-risk TAVR.

Published
2024
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15. Percutaneous Mechanical Aspiration for Infective Endocarditis: Proceedings From an Inaugural Multidisciplinary Summit and Comprehensive Review

Author

Marinacci, Lucas X., Sethi, Sanjum S., Paras, Molly L., El Sabbagh, Abdallah, Secemsky, Eric A., Sohail, M. Rizwan, Starck, Christoph, Bearnot, Benjamin, Yucel, Evin, Schaerf, Raymond H.M., Akhtar, Yasir, Younes, Ahmad, Patton, Marquand, Villablanca, Pedro, Reddy, Seenu, Enter, Daniel, Moriarty, John M., Keeling, William Brent, El Hajj Younes, Stephanie, Kiell, Charles, and Rosenfield, Kenneth

Published
2024
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16. Hemodynamic Effects and Clinical Outcomes of Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO) in Cardiogenic Shock

Author

Villablanca, Pedro Arturo, Fadel, Raef Ali, Giustino, Gennaro, Jabri, Ahmad, Basir, Mir Babar, Cowger, Jennifer, Alaswad, Khaldoon, O'Neill, Brian, Gonzalez, Pedro Engel, Gyzm, Gillian Grafton, Frisoli, Tiberio, Lee, James, Aurora, Lindsey, Gorgis, Sarah, Nemeh, Hassan, Apostolou, Dimitrios, Alqarqaz, Mohammad, Koenig, Gerald C., Aronow, Herbert D., Fuller, Brittany, Aggarwal, Vikas, and O'Neill, William

Published
2025
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17. Transcatheter edge‐to‐edge repair in papillary muscle injury complicating acute myocardial infarction

Author

Dan Haberman, Rodrigo Estévez‐Loureiro, Andrew Czarnecki, Paolo Denti, Pedro Villablanca, Konstantinos Spargias, Doron Sudarsky, Leor Perl, Paul Fefer, Lisa Manevich, Giulia Masiero, Luis Nombela‐Franco, Lion Poles, Berenice Caneiro‐Queija, Nicolas Bowers, Davide Schiavi, Giuseppe Tarantini, Francesco Melillo, Michael Chrissoheris, Danny Dvir, Francesco Maisano, Maurizio Taramasso, and Mony Shuvy

Subjects
Mitral regurgitation, Myocardial infarction, Papillary muscle rupture, Transcatheter edge‐to‐edge repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims Acute mitral regurgitation (MR) in the setting of myocardial infarction (MI) may be the result of papillary muscle rupture (PMR). This condition is associated with high morbidity and mortality. We aim to evaluate the feasibility of transcatheter edge‐to‐edge mitral valve repair (TEER) in this acute setting. Methods and results We analysed data from the International Registry of MitraClip in Acute Mitral Regurgitation following acute Myocardial Infarction (IREMMI) of 30 centres in Europe, North America, and the middle east. We included patients with post‐MI PMR treated with TEER as a salvage procedure, and we evaluated immediate and 30‐day outcomes. Twenty‐three patients were included in this analysis (9 patients suffered complete papillary muscle rupture, 9 partial and 5 chordal rupture). The patients' mean age was 68 ± 14 years. Patients were at high surgical risk with median EuroSCORE II 27% (IQR 16, 28) and 20 out of 23 (87% were in cardiogenic shock). All patients were treated with vasopressors, and 17 out of 23 patients required mechanical support. TEER procedure was performed on the median 6 days after the index MI date IQR (3, 11). Procedural success was achieved in 87% of patients. The grade of MR was significantly decreased after the procedure. MR reduction to 0 or 1 + was achieved in 13 patients (57%), to 2 + in 7 patients (30%), P

Published
2024
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18. Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF

Author

Egle Kvedaraite, Magda Lourda, Natalia Mouratidou, Tim Düking, Avinash Padhi, Kirsten Moll, Paulo Czarnewski, Indranil Sinha, Ioanna Xagoraris, Efthymia Kokkinou, Anastasios Damdimopoulos, Whitney Weigel, Olga Hartwig, Telma E. Santos, Tea Soini, Aline Van Acker, Nelly Rahkonen, Malin Flodström Tullberg, Emma Ringqvist, Marcus Buggert, Carl Jorns, Ulrik Lindforss, Caroline Nordenvall, Christopher T. Stamper, David Unnersjö-Jess, Mira Akber, Ruta Nadisauskaite, Jessica Jansson, Niels Vandamme, Chiara Sorini, Marijke Elise Grundeken, Helena Rolandsdotter, George Rassidakis, Eduardo J. Villablanca, Maja Ideström, Stefan Eulitz, Henrik Arnell, Jenny Mjösberg, Jan-Inge Henter, and Mattias Svensson

Subjects
Science
Abstract

Abstract Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142− /low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142− /low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.

Published
2024
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22. The Transcatheter Aortic Valve Replacement-Conduction Study: The Value of the His-Ventricular Interval in Risk Stratification for Post-TAVR Atrioventricular-Block

Author

Raad, Mohamad, Greenberg, Joshua, Altawil, Mahmoud, Lee, James, Wang, Dee Dee, Oudeif, Ahmed, Birchak, John, Abdelrahim, Elsheikh, Makki, Tarek, Mohammed, Mustafa, Chehab, Omar, Ignatius, Abel, Singh, Gurjit, Maskoun, Waddah, O'Neill, Brian, Lahiri, Marc, Eng, Marvin, Villablanca, Pedro, Wyman, Janet F., Khan, Arfaat, Epstein, Andrew E., O'Neill, William, Schuger, Claudio, and Frisoli, Tiberio M.

Published
2024
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23. Transjugular Transcatheter Tricuspid Valve Replacement: Early Compassionate Use Outcomes

Author

Stolz, Lukas, Cheung, Anson, Boone, Robert, Fam, Neil, Ong, Geraldine, Villablanca, Pedro, Jabri, Ahmad, De Backer, Ole, Mølller, Jacob Eifer, Tchétché, Didier, Oliva, Omar, Chak-yu So, Kent, Lam, Yat-yin, Latib, Azeem, Scotti, Andrea, Coisne, Augustin, Sudre, Arnaud, Dreyfus, Julien, Nejjari, Mohammed, Favre, Paul-Emile, Cruz-Gonzalez, Ignacio, Estévez-Loureiro, Rodrigo, Barreiro-Perez, Manuel, Makkar, Raj, Patel, Dhairya, Leurent, Guillaume, Donal, Erwan, Modine, Thomas, and Hausleiter, Jörg

Published
2024
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27. The National Institutes of Health Stroke Scale is comparable to the ICH score in predicting outcomes in spontaneous acute intracerebral hemorrhage

Author

Suzie A. Kazaryan, Kristina Shkirkova, Jeffrey L. Saver, David S. Liebeskind, Sidney Starkman, Sebina Bulic, Roy Poblete, May Kim-Tenser, Shujing Guo, Robin Conwit, Pablo Villablanca, Scott Hamilton, and Nerses Sanossian

Subjects
intracerebral hemorrhage, clinimetrics, prognosis, clinical trial, NIHSS, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundValidating the National Institutes of Health NIH Stroke Scale (NIHSS) as a tool to assess deficit severity and prognosis in patients with acute intracerebral hemorrhage would harmonize the assessment of intracerebral hemorrhage (ICH) and acute ischemic stroke (AIS) patients, enable clinical use of a readily implementable and non-imaging dependent prognostic tool, and improve monitoring of ICH care quality in administrative datasets.MethodsAmong randomized trial ICH patients, the relation between NIHSS scores early after Emergency Department arrival and 3-month outcomes of dependency or death (modified Rankin Scale, mRS 3–6) and case fatality was examined. NIHSS predictive performance was compared to a current standard prognostic scale, the intracerebral hemorrhage score (ICH score).ResultsAmong the 384 patients, the mean age was 65 (±13), with 66% being male. The median NIHSS score was 16 (interquartile range (IQR) 9–25), the mean initial hematoma volume was 29 mL (±38), and the ICH score median was 1 (IQR 0–2). At 3 months, the mRS had a median of 4 (IQR 2–6), with dependency or death occurring in 70% and case fatality in 26%. The NIHSS and ICH scores were strongly correlated (r = 0.73), and each was strongly correlated with the 90-day mRS (NIHSS, r = 0.61; ICH score, r = 0.62). The NIHSS performed comparably to the ICH score in predicting both dependency or death (c = 0.80 vs. 0.80, p = 0.83) and case fatality (c = 0.78 vs. 0.80, p = 0.29). At threshold values, the NIHSS predicted dependency or death with 74.1% accuracy (NIHSS 17.5) and case fatality with 75.0% accuracy (NIHSS 18.5).ConclusionThe NIHSS forecasts 3-month functional and case fatality outcomes with accuracy comparable to the ICH Score. Widely documented in routine clinical care and administrative data, the NIHSS can serve as a valuable measure for clinical prognostication, therapy development, and case-mix risk adjustment in ICH patients.Clinical trial registrationClinicaltrials.gov, NCT00059332.

Published
2024
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28. Detecting and monitoring rodents using camera traps and machine learning versus live trapping for occupancy modeling

Author

Jaran Hopkins, Gabriel Marcelo Santos-Elizondo, and Francis Villablanca

Subjects
detection, occupancy, machine learning, effort, camera trapping, live trapping, Evolution, QH359-425, Ecology, QH540-549.5
Abstract

Determining best methods to detect individuals and monitor populations that balance effort and efficiency can assist conservation and land management. This may be especially true for small, non-charismatic species, such as rodents (Rodentia), which comprise 39% of all mammal species. Given the importance of rodents to ecosystems, and the number of listed species, we tested two commonly used detection and monitoring methods, live traps and camera traps, to determine their efficiency in rodents. An artificial-intelligence machine-learning model was developed to process the camera trap images and identify the species within them which reduced camera trapping effort. We used occupancy models to compare probability of detection and occupancy estimates for six rodent species across the two methods. Camera traps yielded greater detection probability and occupancy estimates for all six species. Live trapping yielded biasedly low estimates of occupancy, required greater effort, and had a lower probability of detection. Camera traps, aimed at the ground to capture the dorsal view of an individual, combined with machine learning provided a practical, noninvasive, and low effort solution to detecting and monitoring rodents. Thus, camera trapping with machine learning is a more sustainable and practical solution for the conservation and land management of rodents.

Published
2024
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29. Blue-shift photoconversion of near-infrared fluorescent proteins for labeling and tracking in living cells and organisms

Author

Francesca Pennacchietti, Jonatan Alvelid, Rodrigo A. Morales, Martina Damenti, Dirk Ollech, Olena S. Oliinyk, Daria M. Shcherbakova, Eduardo J. Villablanca, Vladislav V. Verkhusha, and Ilaria Testa

Subjects
Science
Abstract

Abstract Photolabeling of intracellular molecules is an invaluable approach to studying various dynamic processes in living cells with high spatiotemporal precision. Among fluorescent proteins, photoconvertible mechanisms and their products are in the visible spectrum (400–650 nm), limiting their in vivo and multiplexed applications. Here we report the phenomenon of near-infrared to far-red photoconversion in the miRFP family of near infrared fluorescent proteins engineered from bacterial phytochromes. This photoconversion is induced by near-infrared light through a non-linear process, further allowing optical sectioning. Photoconverted miRFP species emit fluorescence at 650 nm enabling photolabeling entirely performed in the near-infrared range. We use miRFPs as photoconvertible fluorescent probes to track organelles in live cells and in vivo, both with conventional and super-resolution microscopy. The spectral properties of miRFPs complement those of GFP-like photoconvertible proteins, allowing strategies for photoconversion and spectral multiplexed applications.

Published
2023
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30. Short-term dietary changes can result in mucosal and systemic immune depression

Author

Siracusa, Francesco, Schaltenberg, Nicola, Kumar, Yogesh, Lesker, Till R., Steglich, Babett, Liwinski, Timur, Cortesi, Filippo, Frommann, Laura, Diercks, Björn-Phillip, Bönisch, Friedericke, Fischer, Alexander W., Scognamiglio, Pasquale, Pauly, Mira J., Casar, Christian, Cohen, Yotam, Pelczar, Penelope, Agalioti, Theodora, Delfs, Flemming, Worthmann, Anna, Wahib, Ramez, Jagemann, Bettina, Mittrücker, Hans-Willi, Kretz, Oliver, Guse, Andreas H., Izbicki, Jakob R., Lassen, Kara G., Strowig, Till, Schweizer, Michaela, Villablanca, Eduardo J., Elinav, Eran, Huber, Samuel, Heeren, Joerg, and Gagliani, Nicola

Published
2023
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32. Feasibility and Outcomes of a Cardiovascular Medicine Inclusive Extracorporeal Membrane Oxygenation (ECMO) Service

Author

Fadel, Raef A., Almajed, Mohamed Ramzi, Parsons, Austin, Kalsi, Jasmeet, Shadid, Muthanna, Maki, Mohamed, Alqarqaz, Mohammad, Aronow, Herb, Cowger, Jennifer, Fuller, Brittany, Frisoli, Tiberio, Grafton, Gillian, Kim, Henry, Jones, Crystal, Koenig, Gerald, Khandelwal, Akshay, Nemeh, Hassan, O’Neill, Brian, Tanaka, Daizo, Williams, Celeste, Villablanca, Pedro, O’Neill, William, Alaswad, Khaldoon, and Basir, Mir Babar

Published
2024
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35. A Multi-Scale Species Distribution Model for Migrating and Overwintering Western Monarch Butterflies: Climate Is the Best Predictor

Author

Ashley R. Fisher, William T. Bean, and Francis X. Villablanca

Subjects
multi-scale SDM, Danaus plexippus, western monarch, overwintering, climatic predictors, overfit, Biology (General), QH301-705.5
Abstract

Western Monarch butterflies (Danaus plexippus) migrate from inland breeding ranges to coastal overwintering grounds in California. Given that migratory individuals may make multi-scale habitat selection decisions, we considered a multi-scale species distribution model (SDM) using range-wide climatic and local landscape-level predictors of migratory and overwintering habitat and community-science presence data. The range-wide model output was included as a predictor in the local-scale model, generating multi-scale habitat suitability. The top range-wide predictor was the minimum temperature in December, contributing 83.7% to the model, and was positively associated with presence. At the local scale, the strongest predictors of presence were the range-wide output and percent coverage of low and medium levels of development, contributing > 95%, with 61–63% from the range-wide output, with local-scale suitability coinciding with the California coastal zones. Development’s positive association with overwintering monarch presence was counterintuitive. It is likely that our local-scale model is overfit to these development zones, but it is unclear whether this overfitting resulted from modeler choices, monarchs overwintering close to human development, biased detection near human development, or a combination of these factors. Therefore, alternative approaches to collecting local-scale attribute data are suggested while recognizing the primacy of climate in restricting overwinter sites.

Published
2024
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37. Impact of the COVID-19 Pandemic on Global TAVR Activity: The COVID-TAVI Study

Author

Armario, Xavier, Carron, Jennifer, Simpkin, Andrew J., Elhadi, Mohamed, Kennedy, Ciara, Abdel-Wahab, Mohamed, Bleiziffer, Sabine, Lefèvre, Thierry, Wolf, Alexander, Pilgrim, Thomas, Villablanca, Pedro A., Blackman, Daniel J., Van Mieghem, Nicolas M., Hengstenberg, Christian, Swaans, Martin J., Prendergast, Bernard D., Patterson, Tiffany, Barbanti, Marco, Webb, John G., Behan, Miles, Resar, Jon, Chen, Mao, Hildick-Smith, David, Spence, Mark S., Zweiker, David, Bagur, Rodrigo, Teles, Rui, Ribichini, Flavio L., Jagielak, Dariusz, Park, Duk-Woo, Kornowski, Ran, Wykrzykowska, Joanna J., Bunc, Matjaz, Estévez-Loureiro, Rodrigo, Poon, Karl, Götberg, Matthias, Jeger, Raban V., Ince, Hüseyin, Packer, Erik J.S., Angelillis, Marco, Nombela-Franco, Luis, Guo, Yingqiang, Savontaus, Mikko, Al-Moghairi, Abdulrahman M., Parasca, Catalina Andreea, Kliger, Chad, Roy, David, Molnár, Levente, Silva, Mariana, White, Jonathon, Yamamoto, Masanori, Carrilho-Ferreira, Pedro, Toggweiler, Stefan, Voudris, Vassileios, Ohno, Yohei, Rodrigues, Inês, Parma, Radosław, Ojeda, Soledad, Toutouzas, Kostas, Regueiro, Ander, Grygier, Marek, AlMerri, Khaled, Cruz-González, Ignacio, Fridrich, Viliam, de la Torre Hernández, José M., Noble, Stephane, Kala, Petr, Asmarats, Lluis, Kurt, Ibrahim Halil, Bosmans, Johan, Erglis, Martins, Casserly, Ivan, Iskandarani, Dounia, Bhindi, Ravinay, Kefer, Joelle, Yin, Wei-Hsian, Rosseel, Liesbeth, Kim, Hyo-Soo, O'Connor, Stephen, Hellig, Farrel, Sztejfman, Matias, Mendiz, Oscar, Pineda, Andres M., Seth, Ashok, Pllaha, Elton, de Brito, Fabio S., Jr., Bajoras, Vilhelmas, Balghith, Mohammed A., Lee, Michael, Eid-Lidt, Guering, Vandeloo, Bert, Vaz, Vinicius Daher, Alasnag, Mirvat, Ussia, Gian Paolo, Tay, Edgar, Mayol, Jorge, Gunasekaran, Sengottuvelu, Sardella, Gennaro, Buddhari, Wacin, Kao, Hsien-Li, Dager, Antonio, Tzikas, Apostolos, Gudmundsdottir, Ingibjörg J., Edris, Ahmad, Gutiérrez Jaikel, Luis Abel, Arias, Eduardo A., Al-Hijji, Mohammed, Ertürk, Mehmet, Conde-Vela, César, Boljević, Darko, Ferrero Guadagnoli, Adolfo, Hermlin, Toomas, ElGuindy, Ahmed M., Lima-Filho, Moysés de Oliveira, de Moura Santos, Luciano, Perez, Luis, Maluenda, Gabriel, Akyüz, Ali Rıza, Alhaddad, Imad A., Amin, Haitham, So, Chak-Yu, Al Nooryani, Arif A., Vaca, Carlos, Albistur, Juan, Nguyen, Quang Ngoc, Arzamendi, Dabit, Grube, Eberhard, Modine, Thomas, Tchétché, Didier, Hayashida, Kentaro, Latib, Azeem, Makkar, Raj R., Piazza, Nicolo, Søndergaard, Lars, McEvoy, John William, and Mylotte, Darren

Published
2024
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41. Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results

Author

Goldsmith, Kelly C., Park, Julie R., Kayser, Kimberly, Malvar, Jemily, Chi, Yueh-Yun, Groshen, Susan G., Villablanca, Judith G., Krytska, Kateryna, Lai, Lillian M., Acharya, Patricia T., Goodarzian, Fariba, Pawel, Bruce, Shimada, Hiroyuki, Ghazarian, Susan, States, Lisa, Marshall, Lynley, Chesler, Louis, Granger, Meaghan, Desai, Ami V., Mody, Rajen, Morgenstern, Daniel A., Shusterman, Suzanne, Macy, Margaret E., Pinto, Navin, Schleiermacher, Gudrun, Vo, Kieuhoa, Thurm, Holger C., Chen, Joseph, Liyanage, Marlon, Peltz, Gerson, Matthay, Katherine K., Berko, Esther R., Maris, John M., Marachelian, Araz, and Mossé, Yael P.

Published
2023
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45. Trends in surgical and transcatheter interventions for tricuspid regurgitation: A national inpatient sample analysis from 2011 to 2020

Author

Villablanca, Pedro, Jabri, Ahmad, Alhuneafat, Laith, Maligireddy, Anand, Rasheed, Waqas, Kapcin, Kyle, Manalo, Katie, Latib, Azeem, Giustino, Gennaro, Fadel, Raef, Al Abdouh, Ahmad, Mhanna, Mohammed, Amoroso, Nicholas, Wang, Dee Dee, O'Neill, Brian, Bagur, Rodrigo, Madanat, Luai, Renard, Brian, Aggarwal, Vikas, Alqarqaz, Mohammad, So, Kent, Genereux, Philippe, Hanson, Ivan D., Abbas, Amr E., and O'Neill, William W.

Published
2024
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46. Outcomes following TAVR in patients with cardiogenic shock: A systematic review and meta-analysis

Author

Jabri, Ahmad, Ayyad, Mohammed, Albandak, Maram, Al-Abdouh, Ahmad, Madanat, Luai, Khalefa, Basma Badrawy, Alhuneafat, Laith, Ayyad, Asem, Lemor, Alejandro, Mhanna, Mohammed, Al Jebaje, Zaid, Fadel, Raef, Gonzalez, Pedro Engel, O'Neill, Brian, Bagur, Rodrigo, Hanson, Ivan D., Abbas, Amr E., Frisoli, Tiberio, Lee, James, Wang, Dee Dee, Aggarwal, Vikas, Alaswad, Khaldoon, O'Neill, William W., Aronow, Herbert D., AlQarqaz, Mohammad, and Villablanca, Pedro

Published
2024
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47. Clinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment: The VIVID Registry

Author

Simonato, Matheus, Whisenant, Brian K., Unbehaun, Axel, Kempfert, Jörg, Ribeiro, Henrique B., Kornowski, Ran, Erlebach, Magdalena, Bleiziffer, Sabine, Windecker, Stephan, Pilgrim, Thomas, Tomii, Daijiro, Guerrero, Mayra, Ahmad, Yousif, Forrest, John K., Montorfano, Matteo, Ancona, Marco, Adam, Matti, Wienemann, Hendrik, Finkelstein, Ariel, Villablanca, Pedro, Codner, Pablo, Hildick-Smith, David, Ferrari, Enrico, Petronio, Anna Sonia, Shamekhi, Jasmin, Presbitero, Patrizia, Bruschi, Giuseppe, Rudolph, Tanja, Cerillo, Alfredo, Attias, David, Nejjari, Mohammed, Abizaid, Alexandre, Felippi de Sá Marchi, Maurício, Horlick, Eric, Wijeysundera, Harindra, Andreas, Martin, Thukkani, Arun, Agrifoglio, Marco, Iadanza, Alessandro, Baer, L. Matthew, Nanna, Michael G., and Dvir, Danny

Published
2023
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50. How cy pres promotes transdisciplinary convergence science: an academic health center for women’s cardiovascular and brain health

Author

Amparo Villablanca, Brittany N. Dugger, Saivageethi Nuthikattu, Joohi Chauhan, Samson Cheung, Chen-Nee Chuah, Siedah L. Garrison, Dragan Milenkovic, Jennifer E. Norman, Luca Cerny Oliveira, Bridgette P. Smith, and Susan D. Brown

Subjects
Cy pres funding mechanism, UC Davis Women’s Cardiovascular and Brain Health research center, transdisciplinary team, convergence research, implementation science, basic science and animal modeling, neuropathology, behavioral science, Medicine
Abstract

Cardiovascular disease (CVD) is largely preventable, and the leading cause of death for men and women. Though women have increased life expectancy compared to men, there are marked sex disparities in prevalence and risk of CVD-associated mortality and dementia. Yet, the basis for these and female-male differences is not completely understood. It is increasingly recognized that heart and brain health represent a lifetime of exposures to shared risk factors (including obesity, hyperlipidemia, diabetes, and hypertension) that compromise cerebrovascular health. We describe the process and resources for establishing a new research Center for Women’s Cardiovascular and Brain Health at the University of California, Davis as a model for: (1) use of the cy pres principle for funding science to improve health; (2) transdisciplinary collaboration to leapfrog progress in a convergence science approach that acknowledges and addresses social determinants of health; and (3) training the next generation of diverse researchers. This may serve as a blueprint for future Centers in academic health institutions, as the cy pres mechanism for funding research is a unique mechanism to leverage residual legal settlement funds to catalyze the pace of scientific discovery, maximize innovation, and promote health equity in addressing society’s most vexing health problems.

Published
2024
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