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2. Functionalized Protein Binders in Developmental Biology.

Author

Schnider, Sophie T., Vigano, M. Alessandra, Affolter, Markus, and Aguilar, Gustavo

Abstract

Developmental biology has greatly profited from genetic and reverse genetic approaches to indirectly studying protein function. More recently, nanobodies and other protein binders derived from different synthetic scaffolds have been used to directly dissect protein function. Protein binders have been fused to functional domains, such as to lead to protein degradation, relocalization, visualization, or posttranslational modification of the target protein upon binding. The use of such functionalized protein binders has allowed the study of the proteome during development in an unprecedented manner. In the coming years, the advent of the computational design of protein binders, together with further advances in scaffold engineering and synthetic biology, will fuel the development of novel protein binder–based technologies. Studying the proteome with increased precision will contribute to a better understanding of the immense molecular complexities hidden in each step along the way to generate form and function during development. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Longer transplant-free and liver-related event-free survival in obeticholic acid-treated patients with primary biliary cholangitis compared to external controls from two large real-world cohorts

Author

Terracciani, F., De Vincentis, A., D'Amato, D., Invernizzi, P., Morgando, A., Vanni, E., Viganò, M., Alvaro, D., Venere, R., Lleo, A., Colapietro, F., Degasperi, E., Viganò, R., Giannini, E.G., Labanca, S., Feletti, V., Mussetto, A., Cozzolongo, R., Losito, F., Pompili, M., Ponziani, F.R., Niro, G.A., Cotugno, R., Pozzoni, P., Chessa, L., Cuccorese, G., Pace Palitti, V., Russello, M., Cannavò, M., Frazzetto, E., Bertino, G., Marzioni, M., Terreni, N., Zolfino, T., Saitta, C., Pellicelli, A., Coco, B., Brunetto, M., Cazzagon, N., Floreani, A., Muratori, L., Rosina, F., Stefano, M. Di, Scifo, G., Baiocchi, L., Grassi, G., Sacco, R., Izzi, A., Crocè, S.L., Fiorini, C., Marra, F., Galli, A., Simone, L., Morelli, O., Abenavoli, L., Pizzolante, F., De Matthaeis, N., Scaravaglio, M., Gimignani, G., Boano, V., Manfredi, G.F., Marignani, M., Fanella, S., Giacchetto, M., Castellaneta, A., Poggi, G., Buzzanca, V., Scivetti, P., Tortora, A., Casella, S., Bellia, V., Omazzi, B.F., Alagna, G., Ricci, C., Poisa, P., Rigamonti, C., Calvaruso, V., Corpechot, C., Carrat, F., Hirschfield, G., Gulamhusein, A., Levy, C., Tananka, A., Montano-Loza, A. J, Londono, M., Eaton, J. E, Dalekos, G. N, Gatselis, N., Abbas, N., Trivedi, P., Thorburn, D., Bonder, A., van der Meer, A., Zigmond, E., Kremer, A. E, Bruns, T., Chazouilleres, O., Hansen, B. E, Carbone, M., and Vespasiani-Gentilucci, U.

Published
2024
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4. The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Author

Lai, Q., De Matthaeis, N., Finotti, M., Galati, G., Marrone, G., Melandro, F., Morisco, F., Nicolini, D., Pravisani, R., Giannini, E. G., Aglitti, A., Aliberti, C., Baccarani, U., Bhoori, S., Borzio, M., Brancaccio, G., Burra, P., Cabibbo, G., Casadei Gardini, A., Carrai, P., Cillo, U., Conti, F., Cucchetti, A., D'Ambrosio, R., Dell'Unto, C., Di Costanzo, G. G., Di Sandro, S., Foschi, F. G., Fucilli, F., Gambato, M., Gasbarrini, A., Giuliante, F., Ghinolfi, D., Grieco, A., Gruttaduria, S., Guarino, M., Kostandini, A., Iavarone, M., Lenci, I., Levi Sandri, G. B., Losito, F., Lupo, L. G., Manzia, T. M., Mazzocato, S., Mescoli, C., Miele, L., Muley, M., Persico, M., Plaz Torres, M. C., Pompili, M., Ponziani, F. R., Rapaccini, G. L., Rendina, M., Renzulli, M., Rossi, M., Rreka, E., Russo, F. P., Sacco, R., Sangiovanni, A., Sessa, A., Simonetti, N., Sposito, C., Tortora, R., Trevisani, F., Vigano, L., Vigano, M., Villa, E., Vincenzi, V., Violi, P., and Vitale, A.

Subjects
clopidogrel, aspirin, Clinical Biochemistry, incidence, occurrence, survival, General Medicine, Biochemistry, Settore MED/18
Abstract

To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment.A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT.A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006).Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

Published
2023

5. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author

Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Mangano, S., Tonato, M., Zucca, E., Valsecchi, M.G., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., Dell'Oro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.

Published
2014
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6. Overview of Prognostic Systems for Hepatocellular Carcinoma and ITA.LI.CA External Validation of MESH and CNLC Classifications

Author

Vitale, A, Farinati, F, Finotti, M, Di Renzo, C, Brancaccio, G, Piscaglia, F, Cabibbo, G, Caturelli, E, Missale, G, Marra, F, Sacco, R, Giannini, Eg, Trevisani, F, Cillo, U, Bhoori, S, Borzio, M, Burra, P, Casadei Gardini, A, Carrai, P, Conti, F, Cozzolongo, R, Cucchetti, A, D'Ambrosio, R, Dell'Unto, C, De Matthaeis, N, Di Costanzo, Gg, Di Sandro, S, Famularo, S, Foschi, Fg, Fucilli, F, Galati, G, Gambato, M, Gasbarrini, A, Giuliante, F, Ghinolfi, D, Grieco, A, Gruttadauria, S, Guarino, M, Iavarone, M, Kostandini, A, Lai, Q, Lenci, I, Levi Sandri, Gv, Losito, F, Lupo, Lg, Marasco, G, Manzia, Tm, Mazzocato, S, Masarone, M, Melandro, F, Mescoli, C, Miele, L, Morisco, F, Muley, M, Nicolini, D, Pagano, D, Persico, M, Pompili, M, Ponziani, Fr, Pravisani, R, Rapaccini, Gl, Rendina, M, Renzulli, M, Romano, F, Rossi, M, Rreka, E, Russo, Fp, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Vigano, L, Vigano, M, Villa, E, Vincenzi, V, Violi, P, Azzaroli, F, Brunetto, Mr, Di Marco, A, Masotto, A, Mega, A, Nardone, G, Oliveri, F, Raimondo, G, Svegliati Baroni, G, Vidili, G, Zoli, M, Vitale A., Farinati F., Finotti M., Di Renzo C., Brancaccio G., Piscaglia F., Cabibbo G., Caturelli E., Missale G., Marra F., Sacco R., Giannini E.G., Trevisani F., Cillo U., Bhoori S., Borzio M., Burra P., Casadei Gardini A., Carrai P., Conti F., Cozzolongo R., Cucchetti A., D'ambrosio R., Dell'unto C., De Matthaeis N., Di Costanzo G.G., Di Sandro S., Famularo S., Foschi F.G., Fucilli F., Galati G., Gambato M., Gasbarrini A., Giuliante F., Ghinolfi D., Grieco A., Gruttadauria S., Guarino M., Iavarone M., Kostandini A., Lai Q., Lenci I., Levi Sandri G.V., Losito F., Lupo L.G., Marasco G., Manzia T.M., Mazzocato S., Masarone M., Melandro F., Mescoli C., Miele L., Morisco F., Muley M., Nicolini D., Pagano D., Persico M., Pompili M., Ponziani F.R., Pravisani R., Rapaccini G.L., Rendina M., Renzulli M., Romano F., Rossi M., Rreka E., Russo F.P., Sangiovanni A., Sessa A., Simonetti N., Sposito C., Tortora R., Vigano L., Vigano M., Villa E., Vincenzi V., Violi P., Azzaroli F., Brunetto M.R., Di Marco A., Masotto A., Mega A., Nardone G., Oliveri F., Raimondo G., Svegliati Baroni G., Vidili G., Zoli M., Vitale, A., Farinati, F., Finotti, M., Di Renzo, C., Brancaccio, G., Piscaglia, F., Cabibbo, G., Caturelli, E., Missale, G., Marra, F., Sacco, R., Giannini, E. G., Trevisani, F., Cillo, U., Bhoori, S., Borzio, M., Burra, P., Casadei Gardini, A., Carrai, P., Conti, F., Cozzolongo, R., Cucchetti, A., D'Ambrosio, R., Dell'Unto, C., De Matthaeis, N., Di Costanzo, G. G., Di Sandro, S., Famularo, S., Foschi, F. G., Fucilli, F., Galati, G., Gambato, M., Gasbarrini, A., Giuliante, F., Ghinolfi, D., Grieco, A., Gruttadauria, S., Guarino, M., Iavarone, M., Kostandini, A., Lai, Q., Lenci, I., Levi Sandri, G. V., Losito, F., Lupo, L. G., Marasco, G., Manzia, T. M., Mazzocato, S., Masarone, M., Melandro, F., Mescoli, C., Miele, L., Morisco, F., Muley, M., Nicolini, D., Pagano, D., Persico, M., Pompili, M., Ponziani, F. R., Pravisani, R., Rapaccini, G. L., Rendina, M., Renzulli, M., Romano, F., Rossi, M., Rreka, E., Russo, F. P., Sangiovanni, A., Sessa, A., Simonetti, N., Sposito, C., Tortora, R., Vigano, L., Vigano, M., Villa, E., Vincenzi, V., Violi, P., Azzaroli, F., Brunetto, M. R., Di Marco, A., Masotto, A., Mega, A., Nardone, G., Oliveri, F., Raimondo, G., Svegliati Baroni, G., Vidili, G., and Zoli, M.

Subjects
Cancer Research, medicine.medical_specialty, Review, lcsh:RC254-282, Prognostic score, 03 medical and health sciences, 0302 clinical medicine, medicine, In patient, Medical physics, Staging system, monotonicity of gradients, Settore MED/12 - Gastroenterologia, discrimination ability, hepatocellular carcinoma, homogeneity, prognostic performance, prognostic system, business.industry, External validation, Mono-tonicity of gradient, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Settore MED/18, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Population data, 030211 gastroenterology & hepatology, General health, Liver dysfunction, business
Abstract

Simple Summary This review proposes a comprehensive overview of the main prognostic systems for HCC classified as prognostic scores, staging systems, or combined systems. Prognostic systems for HCC are usually compared in terms of homogeneity, monotonicity of gradients, and discrimination ability. However, despite the great number of published studies comparing HCC prognostic systems, it is rather difficult to identify a system that could be universally accepted as the best prognostic scheme for all HCC patients encountered in clinical practice. In order to give a contribute in this topic, we conducted a study aimed at externally validate the MESH score and the CNLC classification using the ITA.LI.CA database. Abstract Prognostic assessment in patients with HCC remains an extremely difficult clinical task due to the complexity of this cancer where tumour characteristics interact with degree of liver dysfunction, patient general health status, and a large span of available treatment options. Several prognostic systems have been proposed in the last three decades, both from the Asian and European/North American countries. Prognostic scores, such as the CLIP score and the recent MESH score, have been generated on a solid statistical basis from real life population data, while staging systems, such as the BCLC scheme and the recent CNLC classification, have been created by experts according to recent HCC prognostic evidences from the literature. A third category includes combined prognostic systems that can be used both as prognostic scores and staging systems. A recent example is the ITA.LI.CA prognostic system including either a prognostic score and a simplified staging system. This review focuses first on an overview of the main prognostic systems for HCC classified according to the above three categories, and, second, on a comprehensive description of the methodology required for a correct comparison between different systems in terms of prognostic performance. In this second section the main studies in the literature comparing different prognostic systems are described in detail. Lastly, a formal comparison between the last prognostic systems proposed for each of the above three categories is performed using a large Italian database including 6882 HCC patients in order to concretely apply the comparison rules previously described.

Published
2021

7. Predictors of serious adverse events and non-response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid

Author

De Vincentis, A, D'Amato, D, Cristoferi, L, Gerussi, A, Malinverno, F, Lleo, A, Colapietro, F, Marra, F, Galli, A, Fiorini, C, Coco, B, Brunetto, M, Niro, Ga, Cotugno, R, Saitta, C, Cozzolongo, R, Losito, F, Giannini, Eg, Labanca, S, Marzioni, M, Marconi, G, Morgando, A, Pellicano, R, Vanni, E, Cazzagon, N, Floreani, A, Chessa, L, Morelli, O, Muratori, L, Pellicelli, A, Pompili, M, Ponziani, F, Tortora, A, Rosina, F, Russello, M, Cannavo, M, Simone, L, Storato, S, Vigano, M, Abenavoli, L, D'Anto, M, De Gasperi, E, Distefano, M, Scifo, G, Zolfino, T, Calvaruso, V, Cuccorese, G, Palitti, Vp, Sacco, R, Bertino, G, Frazzetto, E, Alvaro, D, Mulinacci, G, Palermo, A, Scaravaglio, M, Terracciani, F, Galati, G, Ronca, V, Zuin, M, Claar, E, Izzi, A, Picardi, A, Invernizzi, P, Vespasiani-Gentilucci, U, Carbone, M, Feletti, V, Mussetto, A, Venere, R, Bernaccioni, G, Graciella Pigozzi, M, Fagiuoli, S, Terreni, N, Pozzoni, P, Baiocchi, L, Grassi, G, Vinci, M, Bellia, V, Boldizzoni, R, Casella, S, Omazzi, B, Poggi, G, De Vincentis, A, D'Amato, D, Cristoferi, L, Gerussi, A, Malinverno, F, Lleo, A, Colapietro, F, Marra, F, Galli, A, Fiorini, C, Coco, B, Brunetto, M, Niro, G, Cotugno, R, Saitta, C, Cozzolongo, R, Losito, F, Giannini, E, Labanca, S, Marzioni, M, Marconi, G, Morgando, A, Pellicano, R, Vanni, E, Cazzagon, N, Floreani, A, Chessa, L, Morelli, O, Muratori, L, Pellicelli, A, Pompili, M, Ponziani, F, Tortora, A, Rosina, F, Russello, M, Cannavo, M, Simone, L, Storato, S, Vigano, M, Abenavoli, L, D'Anto, M, De Gasperi, E, Distefano, M, Scifo, G, Zolfino, T, Calvaruso, V, Cuccorese, G, Palitti, V, Sacco, R, Bertino, G, Frazzetto, E, Alvaro, D, Mulinacci, G, Palermo, A, Scaravaglio, M, Terracciani, F, Galati, G, Ronca, V, Zuin, M, Claar, E, Izzi, A, Picardi, A, Invernizzi, P, Vespasiani-Gentilucci, U, Carbone, M, Feletti, V, Mussetto, A, Venere, R, Bernaccioni, G, Graciella Pigozzi, M, Fagiuoli, S, Terreni, N, Pozzoni, P, Baiocchi, L, Grassi, G, Vinci, M, Bellia, V, Boldizzoni, R, Casella, S, Omazzi, B, Poggi, G, Niro, GA, Giannini, EG, and Palitti, VP

Subjects
Liver Cirrhosis, Male, liver decompensation, safety, Hepatology, Liver Cirrhosis, Biliary, decision curve analysis, efficacy, total bilirubin, Albumins, Ascites, Bilirubin, Chenodeoxycholic Acid, Humans, Biliary, decision curve analysi, Settore MED/12
Abstract

Background & Aims Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with "advanced cirrhosis" because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy. Methods Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs). Results One hundred PBC cirrhotics were included, 97 Child-Pugh class A and 3 class B. Thirty-one had oesophageal varices and 5 had a history of ascites. Thirty-three per cent and 32% of patients achieved a biochemical response at 6 and 12 months respectively. Male sex (adjusted-RR 1.75, 95%CI 1.42-2.12), INR (1.37, 1.00-1.87), Child-Pugh score (1.79, 1.28-2.50), MELD (1.17, 1.04-1.30) and bilirubin (1.83, 1.11-3.01) were independently associated with non-response to OCA. Twenty-two patients discontinued OCA within 12 months: 10 for pruritus, 9 for hepatic SAEs (5 for jaundice and/or ascitic decompensation; 4 for upper digestive bleeding). INR (adjusted-RR 1.91, 95%CI 1.10-3.36), lower albumin levels (0.18, 0.06-0.51), Child-Pugh score (2.43, 1.50-4.04), history of ascites (3.5, 1.85-6.5) and bilirubin (1.30, 1.05-1.56), were associated with hepatic SAEs. A total bilirubin >= 1.4 mg/dl at baseline was the most accurate biochemical predictor of hepatic SAEs under OCA. Conclusions An accurate baseline assessment is crucial to select cirrhotic patients who can benefit from OCA. Although OCA is effective in one third of cirrhotics, bilirubin level >= 1.4 mg/dl should discourage from its use.

Published
2022

15. First and further liver decompensation in patients with metabolic-dysfunction associated steatotic liver disease: what clinical impact?

Author

Pennisi, G., Viganò, M., Fracanzani, A.L., Miele, L., Bugianesi, E., D'Ambrosio, R., Ravaioli, F., Schepis, F., Marra, F., Aghemo, A., Svegliati-Baroni, G., Masarone, M., Valenti, L., Armandi, A., Ciccioli, C., Cerini, F., Colecchia, A., Gasbarrini, A., Infantino, G., Liguori, A., Pelusi, S., Saltini, D., Lampertico, P., Persico, M., Pugliese, N., Tulone, A., Marco, V. Di, Cammà, C., and Petta, S.

Published
2024
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18. Bulevirtide monotherapy prevents liver decompensation and reduces mortality in patients with HDV-related cirrhosis: a case control study with propensity score weighted analysis

Author

Degasperi, E., De Silvestri, A., Anolli, M.P., Sambarino, D., Borghi, M., Perbellini, R., Facchetti, F., Soffredini, R., Monico, S., De Ledinghen, V., Metivier, S., Jachs, M., Reiberger, T., D'Offizi, G., Dietz-Fricke, C., Papatheodoridis, G., Brunetto, M.R., Verucchi, G., Ciancio, A., Zoulim, F., Mangia, A., Hilleret, M.N., Santantonio, T. A, Coppola, N., Pellicelli, A., Roche, B., Causse, X., D'Alteroche, L., Dumortier, J., Ganne, N., Heluwaert, F., Ollivier, I., Loglio, A., Viganò, M., Federico, A., Pileri, F., Maracci, M., Tonnini, M., Arpurt, J.P., Barange, K., Billaud, E., Pol, S., Gervais, A., Minello, A., Rosa, I., Puoti, M., and Lampertico, P.

Published
2024
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20. Cholestasis impacts on performance of non invasive tests for ruling out high-risk esophageal varices in patients with primary biliary cholangitis and compensated advanced chronic liver disease

Author

Calvaruso, V., Celsa, C., Cristoferi, L., Scaravaglio, M., Capodicasa, L., Di Maria, G., Cadamuro, L., Gerussi, A., Malinverno, F., Lampertico, P., Cazzagon, N., Marzioni, M., Gentilucci, U. Vespasiani, Andreone, P., De Nalda, A. Lleo, Rigamonti, C., Viganò, M., Giannini, E.G., Russello, M., Vanni, E., Cerini, F., Missale, G., Brunetto, M., Niro, G., Vettori, G., Castellaneta, A., Cardinale, V., Alvaro, D., Mega, A., Palitti, V. Pace, Bellanti, F., Di Marco, V., Invernizzi, P., Cammà, C., and Carbone, M.

Published
2024
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21. Hepatic sarcoidosis:an Italian multicenter study

Author

Della Corte, C., Malinverno, F., D'Amato, D., Reati, R., Arena, I., Campigotto, M., Cardinale, V., Cespiati, A., Degasperi, E., Del Poggio, P., Durante, E., Federico, A., Galati, G., Germani, G., Giannini, G., Marin, R., Martini, A., Mazzarelli, C., Mirici, F., Missale, G., Morana, E., Morelli, M., Pasulo, L., Piras, M., Perricone, G., Pieri, G., Pugliese, N., Rapetti, R., Rendina, M., Sciarrone, S., Simone, L., Surace, L., Strona, S., B, G. Svegliati, Terracciani, F., Viganò, M., Manes, G., and Carbone, M.

Published
2024
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22. Biochemical response to obeticholic acid drives liver stiffness variation over time and the risk of liver-related events in patients with primary biliary cholangitis

Author

De Vincentis, A., Terracciani, F., D'Amato, D., Scaravaglio, M., Invernizzi, P., Vanni, E., Campion, D., Floreani, A., Cazzagon, N., Alvaro, D., Venere, R., Giannini, E.G., Labanca, S., Lleo, A., Colapietro, F., Degasperi, E., Viganò, M., Pesatori, E., Fagiuoli, S., Marzioni, M., Buzzanca, V., Viganò, R., D'Amico, F., Galli, A., Curto, A., Marra, F., Begini, P., Baiocchi, L., Carnì, P., Muratori, L., Coco, B., Brunetto, M., Pizzolante, F., De Matthaeis, N., Falbo, E., Surace, L., Mattalia, A., Ieluzzi, D., Salomone, F., Delle Monache, G., Tatonetti, R., Cavalli, I., Cossiga, V., Morisco, F., Valiani, V., Gatti, P., Boccaccio, V., Angrisani, D., Vettori, G., Cuffari, B., Moretti, A., Rocco, A., Nardone, G., Scivetti, P., Costanzo, M., Boano, V., Manfredi, G.F., Simone, L., Palitti, V. Pace, Russello, M., Cannavò, M., Frazzetto, E., Bertino, G., Di Stefano, M., Izzi, A., Cerini, F., Chessa, L., Miglianti, M., Feletti, V., Mussetto, A., Cozzolongo, R., Losito, F., Niro, G.A., Cotugno, R., Sacco, R., Ricci, C., Poise, P., Cadamuro, L., Castellaneta, A., Squeo, F., Terreni, N., Bina, N., Pozzoni, P., Casella, S., Zani, F., Morelli, O., Cuccorese, G., Saitta, C., Zolfino, T., Rigamonti, C., Calvaruso, V., Carbone, M., and Vespasiani-Gentilucci, U.

Published
2024
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23. Burden of Hepatitis D Virus infection in Italy: interim results from a prospective multicentre nationwide study

Author

Caviglia, G.P., Colombatto, P., Coco, B., Loglio, A., Viganò, M., Fagiuoli, S., Olivero, A., Dileo, E., Troshina, G., Ciancio, A., Milella, M., Saracino, A., Magni, C.F., Antinori, S., Rizzardini, G., Quaranta, M., Taurian, S., Cariti, G., Cossiga, V., Morisco, F., Cretella, S., Verucchi, G., Cologni, G., Rizzi, M., Costanzo, G.G. Di, Anolli, M.P., Lampertico, P., Di Marco, V., Cosentino, C., Marrone, A., Santantonio, T.A., Biliotti, E., Garbuglia, A.R., D'Offizi, G., Capoluongo, N., Cuomo, N., Perrella, A., Izzi, A., Fornasiere, E., Toniutto, P., Cotugno, R., Barone, M., Cozzolongo, R., Cela, E.M., Niro, G.A., Rapetti, R., Pirisi, M., Viganò, R., Belli, L.S., Puoti, M., Teti, E., Andreoni, M., Coppola, N., Feasi, M., Pontali, E., Cipullo, M., Federico, A., Rapisarda, L., Siciliano, E., Bracciamà, E., Risicato, A., Bertino, G., Distefano, M., Brunetto, M.R., and Rizzetto, M.

Published
2024
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24. Virological and clinical outcomes of patients with HDV-related compensated cirrhosis treated with Bulevirtide monotherapy for 96 weeks: a retrospective multicenter european study (SAVE-D)

Author

Anolli, M.P., Degasperi, E., Jachs, M., Reiberger, T., De Ledinghen, V., Metivier, S., D'Offizi, G., di Maria, F., Schramm, C., Schmidt, H., Zöllner, C., Tacke, F., Dietz-Fricke, C., Wedemeyer, H., Papatheodoridi, M., Papatheodoridis, G., Van Bömmel, F., Brunetto, M.R., Verucchi, G., Ciancio, A., Zoulim, F., Mangia, A., Hilleret, M.N., Merle, U., Santantonio, T.A., Coppola, N., Pellicelli, A., Roche, B., Causse, X., D'Alteroche, L., Dumortier, J., Ganne, N., Heluwaert, F., Ollivier, I., Loglio, A., Viganò, M., Federico, A., Pileri, F., Maracci, M., Tonnini, M., Arpurt, J.P., Barange, K.l., Billaud, E., Pol, S., Gervais, A., Minello, A., Rosa, I., Puoti, M., and Lampertico, P.

Published
2024
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25. Treatment with tenofovir disoproxil fumarate or entecavir in chronic hepatitis B virus-infected patients with renal impairment: results from a 7-year, multicentre retrospective cohort study

Author

Lampertico P., Berg T., Buti M., Pathil A., Petersen J., Ryder S. D., Zoulim F., Botros I., Flaherty J. F., Jump B., Op den Brouw M. L., van Troostenburg A., Ramroth H., Bourliere M., De Ledinghen V., Riachi G., Loustaud-Ratti V., Tran A., Larrey D., Dumortier J., Leroy V., Metivier S., Sellier P., Mauss S., Peterson J., Schiefke I., Niederau C., Teuber G., Goeser T., Jung M. C., Grambihler A., Pathil-Warth A., Sprinzl K., Von der Ohe M., Antoni C., Weigand K., Andreone P., Di Marco V., Madonia S., Puoti M., Santantonio T., Vigano M., Ciancio A., D'Offizi G., Pirisi M., Suarez Garcia E., Pascasio Acevedo J. M., Andrade R., Gea F., Serra Desfilis M. A., Molina Perez E., Manzano Alonso M., Carrion J. A., Aoufi Rabih S., Planas M. M., Ryder S., Agarwal K., Ustianowski A., Aspinall R., Kennedy P., Geretti A. M., McCorry R., Foxton M., Healy B., Lampertico P., Berg T., Buti M., Pathil A., Petersen J., Ryder S.D., Zoulim F., Botros I., Flaherty J.F., Jump B., Op den Brouw M.L., van Troostenburg A., Ramroth H., Bourliere M., De Ledinghen V., Riachi G., Loustaud-Ratti V., Tran A., Larrey D., Dumortier J., Leroy V., Metivier S., Sellier P., Mauss S., Peterson J., Schiefke I., Niederau C., Teuber G., Goeser T., Jung M.C., Grambihler A., Pathil-Warth A., Sprinzl K., Von der Ohe M., Antoni C., Weigand K., Andreone P., Di Marco V., Madonia S., Puoti M., Santantonio T., Vigano M., Ciancio A., D'Offizi G., Pirisi M., Suarez Garcia E., Pascasio Acevedo J.M., Andrade R., Gea F., Serra Desfilis M.A., Molina Perez E., Manzano Alonso M., Carrion J.A., Aoufi Rabih S., Planas M.M., Ryder S., Agarwal K., Ustianowski A., Aspinall R., Kennedy P., Geretti A.M., McCorry R., Foxton M., Healy B., Lampertico, P, Berg, T, Buti, M, Pathil, A, Petersen, J, Ryder, S, Zoulim, F, Botros, I, Flaherty, J, Jump, B, Op den Brouw, M, van Troostenburg, A, Ramroth, H, Bourliere, M, De Ledinghen, V, Riachi, G, Loustaud-Ratti, V, Tran, A, Larrey, D, Dumortier, J, Leroy, V, Metivier, S, Sellier, P, Mauss, S, Peterson, J, Schiefke, I, Niederau, C, Teuber, G, Goeser, T, Jung, M, Grambihler, A, Pathil-Warth, A, Sprinzl, K, Von der Ohe, M, Antoni, C, Weigand, K, Andreone, P, Di Marco, V, Madonia, S, Puoti, M, Santantonio, T, Vigano, M, Ciancio, A, D'Offizi, G, Pirisi, M, Suarez Garcia, E, Pascasio Acevedo, J, Andrade, R, Gea, F, Serra Desfilis, M, Molina Perez, E, Manzano Alonso, M, Carrion, J, Aoufi Rabih, S, Planas, M, Agarwal, K, Ustianowski, A, Aspinall, R, Kennedy, P, Geretti, A, Mccorry, R, Foxton, M, and Healy, B

Subjects
Male, Adult, medicine.medical_specialty, Guanine, Tenofovir, MEDLINE, Antiviral Agents, Virus, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Hepatitis B, Chronic, Retrospective Studie, Internal medicine, 80 and over, HBV, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Renal Insufficiency, Young adult, Aged, Aged, 80 and over, Female, Middle Aged, Retrospective Studies, Treatment Outcome, Chronic, Antiviral Agent, Hepatology, business.industry, Gastroenterology, virus diseases, Retrospective cohort study, Entecavir, Hepatitis B, medicine.disease, Cohort, 030211 gastroenterology & hepatology, business, medicine.drug, Human
Abstract

BackgroundLimited data exist regarding tenofovir disoproxil fumarate (TDF) safety and effectiveness in chronic hepatitis B virus-infected (CHB) patients with renal impairment (RI).AimsTo compare real-world data on renal safety and effectiveness of TDF vs entecavir (ETV) in CHB patients with moderate-to-severe RI.MethodsRetrospective, non-interventional, cohort study analysing medical records for TDF/ETV-treated CHB patients (54 European centres). Included patients experienced moderate-to-severe RI (creatinine clearance 20-60 mL/min [Cockcroft-Gault]) either before TDF/ETV initiation ('before' subgroup [baseline = treatment initiation]) or after TDF/ETV initiation ('after' subgroup [baseline = first RI occurrence]). The primary objective was TDF safety, particularly renal-related adverse events of special interest (AESI). TDF and ETV safety and effectiveness were compared and multivariate analyses were performed using inverse probability treatment weighting.Results'Before' subgroup included 107 TDF- and 91 ETV-treated patients; 'after' subgroup included 212 TDF- and 77 ETV-treated patients. Mean baseline creatinine clearance was higher for TDF- vs ETV-treated patients (both subgroups). Median follow-up was 3.1 years (both treatments). AESI were more frequent with TDF vs ETV ('before': 18.7% vs 8.8%; 'after': 9.9% vs 3.9%); however, differences were not significant by multivariate analysis. Only TDF-treated patients experienced renal tubular dysfunction (6.5% 'before'; 1.9% 'after') as well as renal adverse events leading to treatment discontinuation (8.4% 'before'; 7.1% 'after'). Effectiveness was similar between treatments.ConclusionsOverall safety was similar for TDF vs ETV (both subgroups). Given that renal tubular dysfunction occurred with TDF and not with ETV, renal safety concerns may be greater with TDF in CHB patients with RI.

Published
2020

26. Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units

Author

Zanella, A., Florio, G., Antonelli, M., Bellani, G., Berselli, A., Bove, T., Cabrini, L., Carlesso, E., Castelli, G. P., Cecconi, M., Citerio, G., Coloretti, I., Corti, D., Dalla Corte, F., De Robertis, E., Foti, G., Fumagalli, R., Girardis, M., Giudici, R., Guiotto, L., Langer, T., Mirabella, L., Pasero, D., Protti, A., Ranieri, M. V., Rona, R., Scudeller, L., Severgnini, P., Spadaro, S., Stocchetti, N., Vigano, M., Pesenti, A., Grasselli, G., Aspesi, M., Baccanelli, F., Bassi, F., Bet, A., Biagioni, E., Biondo, A., Bonenti, C., Bottino, N., Brazzi, L., Buquicchio, I., Busani, S., Calini, A., Calligaro, P., Cantatore, L. P., Carelli, S., Carsetti, A., Cavallini, S., Cimicchi, G., Coppadoro, A., Dall'Ara, L., Di Gravio, V., Erba, M., Evasi, G., Facchini, A., Fanelli, V., Feliciotti, G., Fusarini, C. F., Ferraro, G., Garberi, R., Gay, H., Giacche, L., Grieco, D., Guzzardella, A., Longhini, F., Manzan, A., Maraggia, D., Milani, A., Mischi, A., Montalto, C., Mormina, S., Noseda, V., Paleari, C., Pedeferri, M., Pezzi, A., Pizzilli, G., Pozzi, M., Properzi, P., Rauseo, M., Russotto, V., Saccarelli, L., Servillo, G., Spano, S., Tagliabue, P., Tonetti, T., Tullo, L., Vetrugno, L., Vivona, L., Volta, C. A., Zambelli, V., Zanoni, A, Brazzi, L, Gagliardi, G., Zanella A., Florio G., Antonelli M., Bellani G., Berselli A., Bove T., Cabrini L., Carlesso E., Castelli G.P., Cecconi M., Citerio G., Coloretti I., Corti D., Dalla Corte F., De Robertis E., Foti G., Fumagalli R., Girardis M., Giudici R., Guiotto L., Langer T., Mirabella L., Pasero D., Protti A., Ranieri M.V., Rona R., Scudeller L., Severgnini P., Spadaro S., Stocchetti N., Vigano M., Pesenti A., Grasselli G., Aspesi M., Baccanelli F., Bassi F., Bet A., Biagioni E., Biondo A., Bonenti C., Bottino N., Brazzi L., Buquicchio I., Busani S., Calini A., Calligaro P., Cantatore L.P., Carelli S., Carsetti A., Cavallini S., Cimicchi G., Coppadoro A., Dall'Ara L., Di Gravio V., Erba M., Evasi G., Facchini A., Fanelli V., Feliciotti G., Fusarini C.F., Ferraro G., Gagliardi G., Garberi R., Gay H., Giacche L., Grieco D., Guzzardella A., Longhini F., Manzan A., Maraggia D., Milani A., Mischi A., Montalto C., Mormina S., Noseda V., Paleari C., Pedeferri M., Pezzi A., Pizzilli G., Pozzi M., Properzi P., Rauseo M., Russotto V., Saccarelli L., Servillo G., Spano S., Tagliabue P., Tonetti T., Tullo L., Vetrugno L., Vivona L., Volta C.A., Zambelli V., Zanoni A., Zanella, A, Florio, G, Antonelli, M, Bellani, G, Berselli, A, Bove, T, Cabrini, L, Carlesso, E, Castelli, G, Cecconi, M, Citerio, G, Coloretti, I, Corti, D, Dalla Corte, F, De Robertis, E, Foti, G, Fumagalli, R, Girardis, M, Giudici, R, Guiotto, L, Langer, T, Mirabella, L, Pasero, D, Protti, A, Ranieri, M, Rona, R, Scudeller, L, Severgnini, P, Spadaro, S, Stocchetti, N, Viganò, M, Pesenti, A, and Grasselli, G

Subjects
Male, Original, Critical Illness, Socio-culturale, Retrospective Studie, Risk Factors, Humans, Intensive care unit, Prospective Studies, Mortality, Aged, Retrospective Studies, COVID-19, Longitudinal models, Predictors, Time course, SARS-CoV-2, Risk Factor, Respiration, Intensive Care Units, Italy, Middle Aged, Respiration, Artificial, Prospective Studie, Longitudinal model, Artificial, Predictor, Human
Abstract

Purpose To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill patients with coronavirus disease 19 (COVID-19). Methods In this retrospective–prospective multicentric study, we enrolled COVID-19 patients admitted to Italian ICUs from February 22 to May 31, 2020. Clinical data were daily recorded. The time course of 18 clinical parameters was evaluated by a polynomial maximum likelihood multilevel linear regression model, while a full joint modeling was fit to study the association with ICU outcome. Results 1260 consecutive critically ill patients with COVID-19 admitted in 24 ICUs were enrolled. 78% were male with a median age of 63 [55–69] years. At ICU admission, the median ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) was 122 [89–175] mmHg. 79% of patients underwent invasive mechanical ventilation. The overall mortality was 34%. Both the daily values and trends of respiratory system compliance, PaO2/FiO2, driving pressure, arterial carbon dioxide partial pressure, creatinine, C-reactive protein, ferritin, neutrophil, neutrophil–lymphocyte ratio, and platelets were associated with survival, while for lactate, pH, bilirubin, lymphocyte, and urea only the daily values were associated with survival. The trends of PaO2/FiO2, respiratory system compliance, driving pressure, creatinine, ferritin, and C-reactive protein showed a higher association with survival compared to the daily values. Conclusion Daily values or trends over time of parameters associated with acute organ dysfunction, acid–base derangement, coagulation impairment, or systemic inflammation were associated with patient survival. Supplementary Information The online version contains supplementary material available at 10.1007/s00134-021-06495-y.

Published
2021

27. Correction to: Treat all COVID 19‑positive patients, but do not forget those negative with chronic diseases (Internal and Emergency Medicine, (2020), 15, 5, (787-790), 10.1007/s11739-020-02395-z)

Author

Vigano M., Mantovani L., Cozzolino P., Harari S., Vigano, M, Mantovani, L, Cozzolino, P, and Harari, S

Subjects
COVID-19
Abstract

In the original publication of the article, the given name and family name of all the author were swapped. The correct author name is given in this erratum.

Published
2021

37. Survey on hepatic sarcoidosis in Italy

Author

Corte, C. Della, Reati, R., Malinverno, F., Arena, I., Campigotto, M., Cardinale, V., Cespiati, A., Degasperi, E., Del Poggio, P., Durante, E., Federico, A., Galati, G., Germani, G., Giannini, G., Marin, R., Martini, A., Mazzarelli, C., Mirici, F., Missale, G., Morana, E., Morelli, M., Pasulo, L., Piras, M., Perricone, G., Pugliese, N., Rapetti, R., Rendina, M., Sciarrone, S., Simone, L., Surace, L., Strona, S., Svegliati B, G., Viganò, M., Manes, G., and Carbone, M.

Published
2023
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40. Long-term results from the Italian real-world experience on obeticholic acid treatment in primary biliary cholangitis: The RECAPITULATE study

Author

Terracciani, F., De Vincentis, A., D'Amato, D., Invernizzi, P., Morgando, A., Vanni, E., Viganò, M., Alvaro, D., Venere, R., Lleo, A., Colapietro, F., Degasperi, E., Viganò, R., Giannini, E.G., Labanca, S., Feletti, V., Mussetto, A., Cozzolongo, R., Losito, F., Pompili, M., Ponziani, F.R., Niro, G.A., Cotugno, R., Pozzoni, P., Chessa, L., Cuccorese, G., Palitti, V. Pace, Russello, M., Cannavò, M., Frazzetto, E., Bertino, G., Marzioni, M., Terreni, N., Zolfino, T., Saitta, C., Pellicelli, A., Coco, B., Brunetto, M., Cazzagon, N., Floreani, A., Muratori, L., Rosina, F., Di Stefano, M., Scifo, G., Baiocchi, L., Grassi, G., Sacco, R., Izzi, A., Crocè, S. Lory, Fiorini, C., Marra, F., Simone, L., Morelli, O., Abenavoli, L., Pizzolante, F., De Matthaeis, N., Scaravaglio, M., Gimignani, G., Boano, V., Manfredi, G.F., Marignani, M., Fanella, S., Giacchetto, M., Castellaneta, A., Poggi, G., Buzzanca, V., Scivetti, P., Tortora, A., Casella, S., Bellia, V., Omazzi, B.F., Alagna, G., Ricci, C., Poisa, P., Rigamonti, C., Calvaruso, V., Carbone, M., and Vespasiani-Gentilucci, U.

Published
2023
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41. Presence and severity of esophageal varices drives portal hypertension-related complications in compensated advanced nonalcoholic fatty liver disease

Author

Pennisi, G., Enea, M., Viganò, M., Schepis, F., de Ledinghen, V., Berzigotti, A., Wong, V., Fracanzani, A.L., Sebastiani, G., Romero-Gomez, M., Bugianesi, E., Svegliati-Baroni, G., Marra, F., Aghemo, A., Valenti, L., Calvaruso, V., Colecchia, A., Di Maria, G., La Mantia, C., Lin, H., Mendoza, Y., Pugliese, N., Ravaioli, F., Lara-Romero, C., Saltini, D., Craxì, A., Di Marco, V., Cammà, C., and Petta, S.

Published
2023
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43. Prediction of response to obeticholic acid in primary biliary cholangitis: Development and validation of the OCA response score (ORS)

Author

De Vincentis, A., Terracciani, F., D'Amato, D., Invernizzi, P., Morgando, A., Vanni, E., Viganò, M., Alvaro, D., Venere, R., Lleo, A., Colapietro, F., Degasperi, E., Viganò, R., Giannini, E.G., Labanca, S., Feletti, V., Mussetto, A., Cozzolongo, R., Losito, F., Pompili, M., Ponziani, F.R., Niro, G.A., Cotugno, R., Pozzoni, P., Chessa, L., Cuccorese, G., Palitti, V. Pace, Russello, M., Cannavò, M., Frazzetto, E., Bertino, G., Marzioni, M., Terreni, N., Zolfino, T., Saitta, C., Pellicelli, A., Coco, B., Brunetto, M., Cazzagon, N., Floreani, A., Muratori, L., Rosina, F., Di Stefano, M., Scifo, G., Baiocchi, L., Grassi, G., Sacco, R., Izzi, A., Crocè, Saveria Lory, Fiorini, Cecilia, Marra, Fabio, Simone, Loredana, Morelli, Olivia, Abenavoli, L., Pizzolante, F., De Matthaeis, N., Scaravaglio, M., Gimignani, G., Boano, V., Manfredi, G.F., Marignani, M., Fanella, S., Giacchetto, M., Castellaneta, A., Poggi, G., Buzzanca, V., Scivetti, P., Tortora, A., Casella, S., Bellia, V., Omazzi, B.F., Alagna, G., Ricci, C., Poisa, P., Rigamonti, C., Calvaruso, V., Vespasiani-Gentilucci, U., and Carbone, M.

Published
2023
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47. Plaque composition in plexogenic and thromboembolic pulmonary hypertension: the critical role of thrombotic material in pultaceous core formation. (Basic Research)

Author

Arbustini, E., Morbini, P., D'Armini, A.M., Repetto, A., Minzioni, G., Piovella, F., Vigano, M., and Tavazzi, L.

Subjects
Atherosclerotic plaque -- Physiological aspects, Pulmonary hypertension -- Physiological aspects, Health, Physiological aspects
Abstract

Background: Patients with pulmonary hypertension develop intimal plaques in large pulmonary arteries. Objective: To test the hypothesis that the composition of such plaques differs depending an whether the aetiology of [...]

Published
2002

48. Mid term effects of pulmonary thromboendarterectomy on clinical and cardiopulmonary function status. (Original Article)

Author

Zoia, M.C., D'Armini, A.M., Beccaria, M., Corsico, A., Fulgoni, P., Klersy, C., Piovella, F., Vigano, M., and Cerveri, I.

Subjects
Endarterectomy -- Physiological aspects, Pulmonary hypertension -- Physiological aspects, Surgery -- Physiological aspects, Health, Physiological aspects
Abstract

on behalf of the Pavia Thromboendarterectomy Group * Background: Chronic thromboembolic pulmonary hypertension (CTEPH) can be successfully treated surgically by pulmonary thromboendarterectomy (PTE) but there are few data on mid-term [...]

Published
2002

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