1,604 results on '"Van Den Berg, Leonard"'
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2. ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons
3. ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
4. Author Correction: The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
5. IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
6. Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
7. Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
8. Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
9. Genetic characterization of primary lateral sclerosis
10. Remote monitoring of amyotrophic lateral sclerosis using wearable sensors detects differences in disease progression and survival: a prospective cohort study
11. Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
12. Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3
13. Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease
14. A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial
15. Multifocal motor neuropathy is not associated with altered innate immune responses to endotoxin
16. Frequency of euthanasia, factors associated with end-of-life practices, and quality of end-of-life care in patients with amyotrophic lateral sclerosis in the Netherlands: a population-based cohort study
17. The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases
18. Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey
19. Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis
20. Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy
21. Home-monitoring of vital capacity in people with a motor neuron disease
22. Joint modeling of endpoints can be used to answer various research questions in randomized clinical trials
23. Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS
24. Genetic variants associated with longitudinal changes in brain structure across the lifespan
25. REVEALS—a longitudinal cohort study of multifaceted respiratory assessment in ALS.
26. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
27. Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
28. The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
29. Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial
30. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
31. Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
32. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
33. High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy
34. Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study
35. Impact of stimulus duration on motor unit thresholds and alternation in compound muscle action potential scans
36. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
37. Portable fixed dynamometry: towards remote muscle strength measurements in patients with motor neuron disease
38. Association Between Hypothalamic Volume and Metabolism, Cognition, and Behavior in Patients With Amyotrophic Lateral Sclerosis.
39. Cultivating Patient Preferences in ALS Clinical Trials: Reliability and Prognostic Value of the Patient-Ranked Order of Function.
40. Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis.
41. Excitability of motor and sensory axons in multifocal motor neuropathy
42. Assessment of motor unit loss in patients with spinal muscular atrophy
43. Quantitative assessment of brachial plexus MRI for the diagnosis of chronic inflammatory neuropathies
44. Improving clinical trial outcomes in amyotrophic lateral sclerosis
45. Occupation and motor neuron disease : a New Zealand case–control study
46. Validated inference of smoking habits from blood with a finite DNA methylation marker set
47. Using patient-reported symptoms of dyspnea for screening reduced respiratory function in patients with motor neuron diseases
48. Pharmacogenetic interactions in amyotrophic lateral sclerosis: a step closer to a cure?
49. KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia
50. Validating biomarkers and models for epigenetic inference of alcohol consumption from blood
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