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Children with a history of behaviorally inhibited (BI) temperament face a heightened risk for anxiety disorders and often use control strategies that are less planful. Although these relations have been observed concurrently in early childhood, middle childhood, and adolescence, few studies leverage longitudinal data to examine long-term prospective relations between cognitive control and anxiety. Using longitudinal data from 149 adolescents (55% female; from predominantly White middle-class families), we assessed temperament in toddlerhood and cognitive control and anxiety at 4, 12, 15, and 18 years of age. At age 4, separate measures of task switching and inhibitory control were obtained via the Dimensional Change Card Sort and Stroop tasks, respectively. At 12, 15, and 18 years of age, planful control was assessed with the AX-Continuous Performance Test, and anxiety symptoms were assessed via self-report. Growth curve models revealed that children with greater inhibitory control at age 4, regardless of BI status, experienced a sharper increase in anxiety symptoms across adolescence. Children with heightened BI during early childhood displayed lower levels of planful control at age 12, but experienced a more rapid improvement in these skills across adolescence. Children with greater task switching ability at age 4 displayed higher levels of planful control at age 12, but experienced a smaller increase in these skills across adolescence. Finally, children's growth rate for anxiety was unrelated to their growth rate for planful control. These findings reveal that early-life temperament, cognitive control, and anxiety remain interconnected across development, from toddlerhood to at least late adolescence. Public Significance Statement: This study indicates that temperament and executive function in early childhood predict the future development of anxiety and executive function across adolescence. However, changes in anxiety across adolescence did not relate to changes in executive function across the same period. Together, results suggest that early interventions may have the best chance of improving adolescents' anxiety trajectories. [ABSTRACT FROM AUTHOR]

Positive associations have been found between cortical thickness and measures of parasympathetic cardiac control (e.g., respiratory sinus arrhythmia, RSA) in adults, which may indicate mechanistic integration between neural and physiological indicators of stress regulation. However, it is unknown when in development this brain–body association arises and whether the direction of association and neuroanatomical localization vary across development. To investigate this, we collected structural magnetic resonance imaging and resting‐state respiratory sinus arrhythmia data from children in middle childhood (N = 62, Mage = 10.09, range: 8.28–12.14 years). Whole‐brain and exploratory ROI analyses revealed positive associations between RSA and cortical thickness in four frontal and parietal clusters in the left hemisphere and one cluster in the right. Exploratory ROI analyses revealed a similar positive association between cortical thickness and RSA, with two regions surviving multiple comparison correction, including the inferior frontal orbital gyrus and the Sylvian fissure. Prior work has identified these cortical areas as part of the central autonomic network that supports integrative regulation of stress response (e.g., autonomic, endocrine, and behavioral) and emotional expression. Our results suggest that the association between cortical thickness and resting RSA is present in middle childhood and is similar to the associations seen during adulthood. Future studies should investigate associations between RSA and cortical thickness among young children and adolescents. Positive correlations have been found between cortical thickness and parasympathetic nervous system functioning in adults. We show that these correlations between neural and physiological markers of emotional health may already be established during middle childhood, suggesting potential mechanistic pathways underlying emotional health development during middle childhood. [ABSTRACT FROM AUTHOR]

The ability to monitor performance during a goal‐directed behavior differs among children and adults in ways that can be measured with several tasks and techniques. As well, recent work has shown that individual differences in error monitoring moderate temperamental risk for anxiety and that this moderation changes with age. We investigated age differences in neural responses linked to performance monitoring using a multimodal approach. The approach combined functional MRI and source localization of event‐related potentials (ERPs) in 12‐year‐old, 15‐year‐old, and adult participants. Neural generators of two components related to performance and error monitoring, the N2 and ERN, lay within specific areas of fMRI clusters. Whereas correlates of the N2 component appeared similar across age groups, age‐related differences manifested in the location of the generators of the ERN component. The dorsal anterior cingulate cortex (dACC) was the predominant source location for the 12‐year‐old group; this area manifested posteriorly for the 15‐year‐old and adult groups. A fMRI‐based ROI analysis confirmed this pattern of activity. These results suggest that changes in the underlying neural mechanisms are related to developmental changes in performance monitoring. Our research shows that developmental differences occur in neural responses during performance monitoring, with more posterior brain areas showing activation in adults and anterior regions in 12‐ and 15‐year‐old subjects. The fMRI cluster of results showed large activation in the ACC across ages. Source localization of ERP responses identified the ACC as the generator of the N2 ERP in all age groups, whereas generators of the ERN component revealed that the ACC is active during error monitoring in adolescence, whereas more posterior areas (PCC) are active in adults. [ABSTRACT FROM AUTHOR]

The Bucharest Early Intervention Project is the first randomized controlled trial of foster care as an alternative to institutional care. The authors synthesized data from nearly 20 years of assessments of the trial to determine the overall intervention effect size across time points and developmental domains. The goal was to quantify the overall effect of the foster care intervention on children's outcomes and examine sources of variation in this effect, including domain, age, and sex assigned at birth. An intent-to-treat approach was used to examine the causal effects of the randomized controlled trial for 136 children residing in institutions in Bucharest, Romania (baseline age, 6–31 months) who were randomly assigned to either foster care (N=68) or care as usual (N=68). At ages 30, 42, and 54 months and 8, 12, and 16–18 years, children were assessed for IQ, physical growth, brain electrical activity (EEG), and symptoms of five types of psychopathology. Participants provided 7,088 observations across follow-up waves. Children assigned to foster care had better cognitive and physical outcomes and less severe psychopathology than did those who received care as usual. The magnitude of these effect sizes remained stable across development. The foster care intervention most influenced IQ and disorders of attachment/social relatedness. Young children benefit from placement in families after institutional care. The benefits of foster care for previously institutionalized children were remarkably stable across development. [ABSTRACT FROM AUTHOR]

Behavioral Inhibition is a temperament identified in the first years of life that enhances the risk for development of anxiety during late childhood and adolescence. Amongst children characterized with this temperament, only around 40 percent go on to develop anxiety disorders, meaning that more than half of these children do not. Over the past 20 years, research has documented within‐child and socio‐contextual factors that support differing developmental pathways. This review provides a historical perspective on the research documenting the origins of this temperament, its biological correlates, and the factors that enhance or mitigate risk for development of anxiety. We review as well, research findings from two longitudinal cohorts that have identified moderators of behavioral inhibition in understanding pathways to anxiety. Research on these moderators has led us to develop the Detection and Dual Control (DDC) framework to understand differing developmental trajectories among behaviorally inhibited children. In this review, we use this framework to explain why and how specific cognitive and socio‐contextual factors influence differential pathways to anxiety versus resilience. Read the Commentary on this article at doi: 10.1111/jcpp.13771. [ABSTRACT FROM AUTHOR]

A variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08–12.14; M age = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children. [ABSTRACT FROM AUTHOR]

Objective: Data on the neurodevelopmental and associated behavioral effects of light to moderate in utero alcohol exposure are limited. This retrospective investigation tested for associations between reported maternal prenatal alcohol use and psychological, behavioral, and neurodevelopmental outcomes in substance-naive youths.Methods: Participants were 9,719 youths (ages 9.0 to 10.9 years) from the Adolescent Brain Cognitive Development Study. Based on parental reports, 2,518 (25.9%) had been exposed to alcohol in utero. Generalized additive mixed models and multilevel cross-sectional and longitudinal mediation models were used to test whether prenatal alcohol exposure was associated with psychological, behavioral, and cognitive outcomes, and whether differences in brain structure and resting-state functional connectivity partially explained these associations at baseline and 1-year follow-up, after controlling for possible confounding factors.Results: Prenatal alcohol exposure of any severity was associated with greater psychopathology, attention deficits, and impulsiveness, with some effects showing a dose-dependent response. Children with prenatal alcohol exposure, compared with those without, displayed greater cerebral and regional volume and greater regional surface area. Resting-state functional connectivity was largely unaltered in children with in utero exposure. Some of the psychological and behavioral outcomes at baseline and at the 1-year follow-up were partially explained by differences in brain structure among youths who had been exposed to alcohol in utero.Conclusions: Any alcohol use during pregnancy is associated with subtle yet significant psychological and behavioral effects in children. Women should continue to be advised to abstain from alcohol consumption from conception throughout pregnancy. [ABSTRACT FROM AUTHOR]

Objective: Early adversity is correlated with increased risk for negative outcomes, including psychopathology and atypical neurodevelopment. The authors aimed to test the causal impact of an early parenting intervention (Attachment and Biobehavioral Catch-Up; ABC) on children's neural processing of parent cues and on psychosocial functioning in a longitudinal randomized clinical trial.Methods: Participants (N=68, mean age, 10.0 years [SD=0.8 years]) were 46 high-risk children whose parents were randomly assigned to receive either the ABC intervention (N=22) or a control intervention (N=24) while the children were infants, in addition to a comparison sample of low-risk children (N=22). During functional MRI scanning, children viewed pictures of their own mothers and of a stranger.Results: Children in the ABC condition showed greater maternal cue-related activation than children in the control condition in clusters of brain regions, including the precuneus, the cingulate gyrus, and the hippocampus, regions commonly associated with social cognition. Additionally, greater activity in these regions was associated with fewer total behavior problems. There was an indirect effect of early intervention on middle childhood psychosocial functioning mediated through increased activity in brain regions in response to maternal cues.Conclusions: These results suggest that early parenting intervention (in this case the ABC intervention) can enhance brain regions supporting children's social cognitive development. In addition, the findings highlight these brain effects as a possible neural pathway through which ABC may prevent future behavior problems among high-risk children, yielding psychosocial benefits that endure through at least middle childhood without the need to intervene with the child directly. [ABSTRACT FROM AUTHOR]

Human social decision-making is significantly modulated by previous decision outcomes. Using event-related potentials (ERPs), we examined whether ERP components evoked by outcome feedback could serve as electrophysiological indices to examine the influence of current outcome evaluation on subsequent cooperative or aggressive decision-making. Thirty-four adult volunteers participated in a social game task, in which they were asked to choose between cooperation and aggression with an opponent player.Conventionally-averaged ERPs and temporospatial principal components analysis (PCA) factors were tested for their associations with subsequent decision-making. Results revealed that a central-parietal late positive potential (LPP) and central-parietal PCA factor approximating the classic LPP were related to changes of decision-making strategies on subsequent trials; however, the effect was significant only when the opponent selected 'cooperate' in the initial trial. The decision to cooperate in subsequent trials induced a larger LPP relative to the decision to aggress following opponent cooperation in the initial trial. Furthermore, we found that larger LPP amplitudes for an opponent's cooperative decision on the initial trial were associated with a higher probability of choosing cooperation on the subsequent trial. The results suggest that the amplitude of the central-parietal LPP is an electrophysiological index of the influence of initial outcome on subsequent social decision-making. [ABSTRACT FROM AUTHOR]

Abstract: Past studies utilizing cognitive control tasks have noted that trials following errors are characterized by slowed reaction time. Despite the assumption long held by researchers that this slowing is compensatory (in the service of post‐error performance recovery), studies consistently show that post‐error trials are no more accurate than post‐correct trials. As a result, it has recently been proposed that post‐error slowing (PES) is merely part of an orienting response that serves no task‐relevant cognitive control purpose. Frontal midline theta (FMθ) oscillations represent another potential compensatory mechanism serving cognitive control processes, yet past studies relying on ERPs have failed to find an association between FMθ and post‐error accuracy. The present study investigated the potentially adaptive role of PES and FMθ oscillations during a flanker task using trial‐by‐trial comparisons. Results indicated that error‐related FMθ oscillations signal the need for enhanced top‐down cognitive control and that PES supports cognitive control by providing the added time needed to achieve greater confidence in judgment. Overall, findings provide convergent evidence that both error‐related FMθ and PES predict performance recovery following errors. [ABSTRACT FROM AUTHOR]

This study investigates the brain correlates of decisionmaking and outcome evaluation of generalized trust (i.e. trust in unfamiliar social agents)--a core component of social capital which facilitates civic cooperation and economic exchange. We measured 18 (9male) Chinese participants' event-related potentials while they played the role of the trustor in a one-shot trust game with unspecified social agents (trustees) allegedly selected from a large representative sample. At the decisionmaking phase, greater N2 amplitudes were found for trustors' distrusting decisions compared to trusting decisions, which may reflect greater cognitive control exerted to distrust. Source localization identified the precentral gyrus as one possible neuronal generator of this N2 component. At the outcome evaluation phase, principal components analysis revealed that the so called feedback-related negativity was in fact driven by a reward positivity, which was greater in response to gain feedback compared to loss feedback. This reduced reward positivity following loss feedbackmay indicate that the absence of reward for trusting decisions was unexpected by the trustor. In addition, we found preliminary evidence suggesting that the decisionmaking processesmay differ between high trustors and low trustors. [ABSTRACT FROM AUTHOR]

Aperiodic activity contains important and meaningful physiological information that has been shown to dynamically change with age. However, no longitudinal studies have examined its development during early-to-mid adolescence. The current study closes this gap by investigating age- and sex-related longitudinal change in aperiodic activity across early-to-mid adolescence (N = 186; 54.3% female). Participants completed a resting state task and a Flanker task while EEG was record at age 13 years and again at age 15 years. Across different tasks and two time points, we observed significant age-related reductions in aperiodic offset and exponent. In addition, we observed significant sex-related differences in the aperiodic offset and exponent over time. We did not find any significant correlation between aperiodic activity and behavioral measures, nor did we find any significant condition-dependent change in aperiodic activity during the Flanker task. However, we did observe significant correlations between aperiodic activity across tasks and over time, suggesting that aperiodic activity may demonstrate stable trait-like characteristics. Collectively, these results may suggest a developmental parallelism between decreases in aperiodic components alongside adolescent brain development during this period; changes to cortical and subcortical brain structure and organization during early adolescence may have been responsible for the observed sex-related effects. • Early adolescence is associated with changes in the aperiodic signal. • We observed significant sex-related differences in the aperiodic signal over time. • Aperiodic activity is significantly correlated within/between tasks and over time. [ABSTRACT FROM AUTHOR]

Early adversity such as maltreatment is associated with increased risk for psychopathology and atypical neurological development in children. The present study examined associations between depressive symptoms and error‐related brain activity (the error‐related negativity, or ERN) among children involved with Child Protective Services (CPS) and among comparison children. Results indicate that the relation between depressive symptoms and ERN amplitude depends on CPS involvement, such that depressive symptoms were associated with blunted ERNs only for CPS‐referred children. The present study can inform future research investigating the mechanisms by which experiences of adversity affect the association between symptoms and error‐related brain activity. [ABSTRACT FROM AUTHOR]

Behavioral inhibition (BI) is a temperament characterized in early childhood by distress to novelty and avoidance of unfamiliar people, and it is one of the best-known risk factors for the development of social anxiety. However, nearly 60% of children with BI do not go on to meet criteria for social anxiety disorder. In this review we present an approach to understanding differential developmental trajectories among children with BI. We review research using laboratory-based tasks that isolate specific attention processes that enhance versus mitigate risk for social anxiety among behaviorally inhibited children and studies that suggest that BI is associated with heightened detection of novelty or threat. Moreover, stimulus-driven control processes, which we term "automatic control," increase the probability that behaviorally inhibited children display socially reticent behavior and develop social anxiety. In contrast, goal-driven control processes, which we term "planful control," decrease risk for anxiety. We suggest that these three categories of processes (detection, automatic control, and planful control) function together to determine whether behaviorally inhibited children are able to flexibly regulate their initial reactions to novelty, and in turn, decrease risk for social anxiety. Although laboratory-based tasks have identified these processes underlying risk and resilience, the challenge is linking them to the emotions, thoughts, and behaviors of behaviorally inhibited children in real-world contexts. [ABSTRACT FROM AUTHOR]

Trust is a risky social decision because betrayal may occur. It's not clear how individual differences in social risk-seeking propensity modulate brain processes of trusting strangers. We examined event-related potentials and time-frequency power to investigate this question while 40 participants played the one-shot trust game. Twenty high social risk-seekers (HSR) and 20 low social risk-seekers (LSR) made trusting or distrusting decisions regarding unknown trustees while their electroencephalogram activity was recorded. At the decision-making stage, HSR participants exhibited a larger N2 and increased ß power following distrusting decisions than trusting decisions, suggesting greater cognitive control exerted to distrust. By contrast, no such N2 and ß differences were found for LSR participants. At the outcome evaluation stage, LSR participants exhibited a more negative-going difference wave between loss feedback-related negativity (FRN) and gain FRN (dFRN) and increased β power (following losses compared to gains) than did HSR participants, indicating enhanced risk sensitivity of LSR people. Our findings provide insights into the mechanism by which social risk-taking facilitates trusting strangers. The results also shed light on the temporal course of brain activity involved in trust decision-making and outcome evaluation, as well as how individual differences modulate brain dynamics of trusting strangers. [ABSTRACT FROM AUTHOR]

We examined the long-term causal effects of an evidence-based parenting program delivered in infancy on children's emotion regulation and resting-state functional connectivity (rs-fc) during middle childhood. Families were referred to the study by Child Protective Services (CPS) as part of a diversion from a foster care program. A low-risk group of families was also recruited. CPS-involved families were randomly assigned to receive the target (Attachment and Biobehavioral Catch-up, ABC) or a control intervention (Developmental Education for Families, DEF) before infants turned 2. Both interventions were home-based, manualized, and 10-sessions long. During middle childhood, children underwent a 6-min resting-state functional MRI scan. Amygdala seed-based rs-fc analysis was completed with intervention group as the group-level predictor of interest. Fifty-seven children ( N ABC = 21; N DEF = 17; N COMP = 19; M age = 10.02 years, range = 8.08-12.14) were scanned successfully. The DEF group evidenced negative left amygdala↔OFC connectivity, whereas connectivity was near zero in the ABC and comparison groups (ABCvsDEF: Cohen's d = 1.17). ABC may enhance high-risk children's regulatory neurobiology outcomes ∼8 years after the intervention was completed.

Behavioral inhibition (BI), an infant temperament characterized by distress to novelty, is amongst the strongest early risk markers for future anxiety. In this review, we highlight three ways that recent research elucidates key details about the pathophysiology of anxiety in individuals with BI. First, atypical amygdala connectivity during infancy may be related to BI. Second, developmental shifts in cognitive control may portend risk for anxiety for children with BI. Lastly, distinct cognitive control processes moderate the BI-anxiety relation in different ways. Studying the intersection of these three streams of work may inform prevention or intervention work., Competing Interests: Conflict of interest statement Nothing declared.

Background: Behavioral inhibition (BI) is a temperament style characterized by heightened reactivity and negative affect in response to novel people and situations, and it predicts anxiety problems later in life. However, not all BI children develop anxiety problems, and mounting evidence suggests that how one manages their cognitive resources (cognitive control) influences anxiety risk. The present study tests whether more (proactive control) or less (reactive control) planful cognitive strategies moderate relations between early BI and later anxiety., Methods: Participants included 112 adolescents (55% female; M age = 15.4 years) whose temperament was assessed during toddlerhood. In adolescence, participants completed an AX Continuous Performance Test while electroencephalography was recorded to disentangle neural activity related to proactive (cue-locked P3b) and reactive (probe-locked N2) control., Results: Greater BI was associated with greater total anxiety scores only among adolescents with smaller ΔP3bs and larger ΔN2s-a pattern consistent with decreased reliance on proactive strategies and increased reliance on reactive strategies. Additionally, a larger ΔP3b was associated with greater total anxiety scores; however, this effect was largely explained by the fact that females tended to have larger ΔP3bs and greater anxiety than males., Conclusions: Early BI relates to risk for later anxiety specifically among adolescents who rely less on proactive strategies and more on reactive control strategies. Thus, cognitive control strategy moderates the association between developmental context (i.e., temperament) and later anxiety. The present study is the first to characterize how proactive and reactive control uniquely relate to pathways toward anxiety risk., Competing Interests: CONFLICT OF INTEREST The authors have declared that they have no competing or potential conflicts of interest.

Trust is a risky social decision because betrayal may occur. It's not clear how individual differences in social risk-seeking propensity modulate brain processes of trusting strangers. We examined event-related potentials and time-frequency power to investigate this question while 40 participants played the one-shot trust game. Twenty high social risk-seekers (HSR) and 20 low social risk-seekers (LSR) made trusting or distrusting decisions regarding unknown trustees while their electroencephalogram activity was recorded. At the decision-making stage, HSR participants exhibited a larger N2 and increased β power following distrusting decisions than trusting decisions, suggesting greater cognitive control exerted to distrust. By contrast, no such N2 and β differences were found for LSR participants. At the outcome evaluation stage, LSR participants exhibited a more negative-going difference wave between loss feedback-related negativity (FRN) and gain FRN (dFRN) and increased θ power (following losses compared to gains) than did HSR participants, indicating enhanced risk sensitivity of LSR people. Our findings provide insights into the mechanism by which social risk-taking facilitates trusting strangers. The results also shed light on the temporal course of brain activity involved in trust decision-making and outcome evaluation, as well as how individual differences modulate brain dynamics of trusting strangers. (PsycINFO Database Record, ((c) 2017 APA, all rights reserved).)

This study investigates the brain correlates of decision making and outcome evaluation of generalized trust (i.e. trust in unfamiliar social agents)-a core component of social capital which facilitates civic cooperation and economic exchange. We measured 18 (9 male) Chinese participants' event-related potentials while they played the role of the trustor in a one-shot trust game with unspecified social agents (trustees) allegedly selected from a large representative sample. At the decision-making phase, greater N2 amplitudes were found for trustors' distrusting decisions compared to trusting decisions, which may reflect greater cognitive control exerted to distrust. Source localization identified the precentral gyrus as one possible neuronal generator of this N2 component. At the outcome evaluation phase, principal components analysis revealed that the so called feedback-related negativity was in fact driven by a reward positivity, which was greater in response to gain feedback compared to loss feedback. This reduced reward positivity following loss feedback may indicate that the absence of reward for trusting decisions was unexpected by the trustor. In addition, we found preliminary evidence suggesting that the decision-making processes may differ between high trustors and low trustors., (© The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.)