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The aim is to compare the cumulative incidence of Hodgkin's lymphoma and non-Hodgkin's lymphomas between conditionally clean and polluted regions of the Cherkasy region in 2001, 2014. Materials and methods. The incidence of Hodgkin's lymphoma and non-Hodgkin's lymphomas in conditionally clean, radioactive, chemical and radioactively and chemically contaminated regions of the Cherkasy region per 100 thousand population according to the All-Ukrainian census conducted in 2001 and published by the State Statistical Service of Ukraine in 2014. Results. According to the results of our study, in 2001, in the chemically contaminated region of the Cherkasy region, there was an increase in the incidence of mainly diffuse large B-cell lymphoma by 3.781 (p = 0.043) times compared to its conditionally clean territory (1.076; 0.022-2.130 versus 4.070; 0.082-8.058 per 100 thousand population, respectively). In the chemically contaminated area in 2014, a 3.314 times (p = 0.035) higher level of cumulative incidence of unspecified lymphomas was also revealed (1.793; 0.358-3.228 versus 5.945; 0.734-11.156 per 100 thousand population, respectively) compared to clean areas of the Cherkasy region. Conclusions. Thus, the results of our study showed that in 2001, living in a chemically contaminated area increased the growth of the cumulative incidence of diffuse B-cell lymphoma, and in 2014 - lymphomas of an unspecified type.

The purpose - to carry out comparison of the cumulative morbidity on the lymphoid and myeloid leukemia on relatively clean and contaminated regions of the Cherkassy region for 2001 and 2014. Materials and methods. The incidence was determined in regions A (relatively clean), B (radioactive contaminated), C (chemically contaminated) and D (radioactive and chemical contaminated) per 100 thousand population, which was registered during the All-Ukrainian census conducted in 2001, and in 2014 according to the published data of the State Statistical Service of Ukraine. Results. In 2001, in the radioactive contaminated region of Cherkassy oblast, there was a 2.46-fold (p = 0.024) higher incidence of myeloid leukemias alone (5.30; 3.03-8.33 vs. 2.15; 0.66-3.64 per 100 thousand population, respectively). Instead, in the area contaminated with chemical factors, the prevalence of lymphoid (acute and chronic) was determined (7.12; 1.84 - 12.39 vs. 2.69; 1.02 - 4.35 per 100 thousand population, respectively) and myeloid (6.10; 1.22 - 10.99 vs. 2.15; 0.66 - 3.64 per 100 thousand population, respectively) leukemia, compared with relatively clean regions. According to 2001 data, who living in a chemical contaminated region, the risk of cumulative morbidity for acute and chronic lymphoid and myeloid leukemias is 3.30 (p = 0.014) and 2.83 (p = 0.043), respectively. In 2014, no increase in the level of cumulative incidence of these hematological neoplasms was detected between the clean and contaminated regions of Cherkassy oblast. Conclusions. It was proved that the radiation factor in 2001 increased the probability of growth the cumulative incidence only for myeloid leukemias, and chemical contamination - for both myeloid and lymphoid leukemias. In 2014, there was no increase in the level of cumulative incidence of certain hematological diseases between clean and contaminated regions of Cherkasy oblast.

The purpose of the study was to analyze the cumulative incidence of hematological neoplasia and evaluate the dynamics of this in different regions of Cherkasy oblast in 1980, 1989, 2001, 2014 yy. Materials and methods. The epidemiological parameters of hematological neoplasms in the radiation-contaminated (RC), chemically contaminated (CC), radiation and chemically contaminated (RCC), conditionally clean (CNC) regions of Cherkassy oblast (CO) in 1980, 1989, 2001, 2014 yy. were analyzed. Classification of CO territories to the RC, CC, RCC, CNC regions was conducted based on reports of the dosimetry certification of all settlements of Ukraine after the Chernobyl accident and the results of determination of the level of chemical contamination by the sanitary and epidemiological service during 1980-2014 yy. Results. It was determined, that, at the limit of statistical significant (p = 0.057), on the RC territory of CO in 2001 year the relative risk for the cumulative incidence of hematologic neoplasia was on 1.41 times higher (18,682 (95 % confidence interval (CI) = 14,426 – 16,879) against 13,187 (95 % CI = 9,495 – 16,879)), compared with CNC region. In addition, in the RC territory from 1989 to 2001 year the increasing at 9,342 times (1,999 (95% CI = 0.69–3.305) versus 18,682 (95% CI = 14.426 – 16.879)) of cumulative incidence of the hematopoietic and lymphoid systems neoplasm was detected. It is proved, that in the CNC region from 2001 to 2014 year at 1,791 times (13,187 (95% CI = 9.495 – 16.879) versus 23,619 (95% CI = 18.412 – 28.826)) higher level of the cumulative incidence of hematologic neoplasia was observed. Conclusions. In the CO, which was polluted by the radiation factor because of the Chernobyl nuclear power plant accident, 5 years after that, in 2001 was detected the increasing of the relative risk of hematologic neoplasia, compared to that on the CNC region. In addition, on the RC territory from 1989 to 2001 year the increasing at 9,342 times of the incidence of hematopoietic and lymphoid system tumors was observed. This is evidence of pro-leukemic effects of ionization radiation and, probably, the increase in the diagnostic potential of the hematological service of the CO.