39 results on '"Urticaria Pigmentosa etiology"'
Search Results
2. Multiple hyperpigmented papules and plaques.
- Author
-
Bray A and Sparling JD
- Subjects
- Biopsy, Child, Preschool, Female, Humans, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Urticaria Pigmentosa therapy, Skin pathology, Urticaria Pigmentosa diagnosis
- Abstract
We had our suspicions as to the diagnosis, but a particular sign was missing. The biopsy settled things.
- Published
- 2019
3. 12 Vertebral-Body Fractures and Simultaneous Skin Changes.
- Author
-
Gehlen M, Lazarescu AD, and Hinz C
- Subjects
- Female, Humans, Middle Aged, Osteoclasts chemistry, Osteoclasts physiology, Osteoporosis complications, Osteoporosis physiopathology, Radiography methods, Spinal Fractures complications, Spinal Fractures diagnostic imaging, Urticaria Pigmentosa physiopathology, Mastocytosis complications, Spinal Fractures diagnosis, Urticaria Pigmentosa etiology
- Published
- 2018
- Full Text
- View/download PDF
4. Paediatric mastocytosis: a systematic review of 1747 cases.
- Author
-
Méni C, Bruneau J, Georgin-Lavialle S, Le Saché de Peufeilhoux L, Damaj G, Hadj-Rabia S, Fraitag S, Dubreuil P, Hermine O, and Bodemer C
- Subjects
- Age of Onset, Biopsy methods, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Mastocytosis, Cutaneous genetics, Mutation genetics, Pregnancy, Prognosis, Proto-Oncogene Proteins c-kit genetics, Urticaria Pigmentosa etiology, Mastocytosis, Cutaneous pathology
- Abstract
Paediatric mastocytosis was previously considered to be a benign and spontaneously regressing disease. However, this evolution is impossible to predict. To clarify the characteristics and course of paediatric mastocytosis, we performed a literature review of 1747 cases published between 1950 and April 2014. Lesions occurred before the age of 2 years in 90% of cases, and presented as urticaria pigmentosa (75% of cases), mastocytoma (20%) or diffuse cutaneous mastocytosis (5%). The male-to-female ratio was 1·4. KIT D816V mutation was detected in 34% of 215 tested patients. Clinical regression (complete or partial) occurred in 67% of cases and stabilization in 27%. However, the outcome was fatal in 2·9% of patients., (© 2015 British Association of Dermatologists.)
- Published
- 2015
- Full Text
- View/download PDF
5. Two cases of dermatoses koebnerizing within fields of previous radiotherapy.
- Author
-
Hellen R, Kiely C, Murad A, Mulligan N, Coffey J, Lenane P, and Moloney FJ
- Subjects
- Adult, Breast Neoplasms radiotherapy, Female, Humans, Middle Aged, Radiation Injuries complications, Skin Diseases, Vesiculobullous etiology, Urticaria Pigmentosa etiology
- Abstract
We describe two patients with newly diagnosed dermatoses localizing to the radiotherapy field following treatment for breast cancer. Patient 1 was a 53-year-old woman who developed bullous morphoea on her left breast two years after radiotherapy. Patient 2 was a 43-year-old woman who developed urticaria pigmentosa on her right breast eight months after radiotherapy and similar lesions gradually developed beyond the radiotherapy field. Both patients experienced a significant delay in diagnosis due to diagnostic confusion and concern over breast cancer recurrence. Irradiated skin demonstrates gradual and sustained alterations in fibrosis due to the production of long-lived cytokines and chemokines. These changes can induce a koebnerizing response in conditions such as morphoea and urticaria pigmentosa. We explore the mechanisms behind radiotherapy-induced skin changes, and highlight the potential for radiotherapy to exacerbate or unmask underlying dermatoses and systemic disease in the months and years following treatment., (© 2014 British Association of Dermatologists.)
- Published
- 2014
- Full Text
- View/download PDF
6. Cutaneous mastocytosis extending beyond a radiotherapy site: a form of radiodermatitis or a neoplastic phenomenon?
- Author
-
Davidson SJ and Coates D
- Subjects
- Breast Neoplasms surgery, Carcinoma, Ductal, Breast surgery, Female, Histamine Antagonists therapeutic use, Humans, Middle Aged, Radiodermatitis drug therapy, Radiodermatitis etiology, Radiotherapy, Adjuvant adverse effects, Urticaria Pigmentosa drug therapy, Urticaria Pigmentosa etiology, Breast Neoplasms radiotherapy, Carcinoma, Ductal, Breast radiotherapy, Radiodermatitis pathology, Urticaria Pigmentosa pathology
- Abstract
Ionising radiation is often used as an adjuvant in the management of breast cancer. Acute and chronic skin changes are well recognised complications associated with its use. We demonstrate a rare clinical presentation of cutaneous mastocytosis that occurred at the site of radiotherapy and then extended beyond this boundary, and ask whether this can be treated as a localised side effect of radiotherapy or whether the potential for systemic mastocytosis needs to be excluded., (© 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.)
- Published
- 2013
- Full Text
- View/download PDF
7. A 39-year-old woman with spots covering her body.
- Author
-
Cowart D, Cowart KA, and Hougeir FG
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Urticaria Pigmentosa etiology, Mast Cells pathology, Skin pathology, Skin Pigmentation, Urticaria Pigmentosa diagnosis
- Published
- 2013
- Full Text
- View/download PDF
8. Urticaria pigmentosa in a female patient with celiac disease: response to a gluten-free diet.
- Author
-
Rodrigo L, Pérez-Martínez I, and Lucendo AJ
- Subjects
- Adult, Celiac Disease complications, Celiac Disease diet therapy, Cell Movement, DNA Mutational Analysis, Female, Humans, Lymphocytes pathology, Mast Cells pathology, Mastocytosis, Systemic etiology, Mutation genetics, Proto-Oncogene Proteins c-kit genetics, Urticaria Pigmentosa etiology, Vitamin B 12 blood, Young Adult, Celiac Disease diagnosis, Diet, Gluten-Free, Lymphocytes immunology, Mast Cells immunology, Mastocytosis, Systemic prevention & control, Urticaria Pigmentosa prevention & control
- Published
- 2013
- Full Text
- View/download PDF
9. Anaphylactic shock in a patient with mastocytosis.
- Author
-
Lee SS, Unglik GA, and Mar AW
- Subjects
- Adult, Female, Humans, Mastocytosis diagnosis, Anaphylaxis etiology, Bites and Stings complications, Mastocytosis complications, Urticaria Pigmentosa etiology
- Published
- 2012
- Full Text
- View/download PDF
10. Neurologic symptoms and diagnosis in adults with mast cell disease.
- Author
-
Smith JH, Butterfield JH, Pardanani A, DeLuca GC, and Cutrer FM
- Subjects
- Adolescent, Adult, Aged, Back Pain etiology, Cohort Studies, Female, Headache etiology, Humans, Male, Middle Aged, Retrospective Studies, Spinal Cord Compression etiology, Syncope etiology, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Young Adult, Mastocytosis complications, Mastocytosis diagnosis, Nervous System Diseases diagnosis, Nervous System Diseases etiology
- Abstract
Objective: To identify complications of mastocytosis that impact the nervous system across a large cohort., Patients and Methods: In this retrospective series, we reviewed the electronic medical records of adult patients with a diagnosis of mastocytosis who were referred to a Neurologist at Mayo Clinic in Rochester, MN from January 1, 1999 to December 31, 2008., Results: Thirty patients were identified who presented to a Neurologist with symptoms potentially related to the mast cell disease. Twelve of these patients presented with complex spells involving syncope, which frequently preceded a formal diagnosis of mastocytosis. Nine individuals presented with acute back pain which was ultimately deemed symptomatic of vertebral compression fractures. One individual experienced spinal cord compression from a vertebral mast cell infiltrate. Headaches were reported in 78/223 (35%) total patients with mastocytosis. Although details of headaches were insufficiently ascertained to diagnose most, the five individuals in our referral cohort met International Headache Society (IHS) criteria for migraine. Finally, three individuals (1.3%) were identified with multiple sclerosis occurring at variable times after the mast cell diagnosis., Conclusion: Symptoms related to mastocytosis may be encountered by neurologists and mimic many common, often idiopathic syndromes including, syncopal spells, back pain, and headache. In our cohort, multiple sclerosis may be over-represented. Mastocytosis should be considered in patients with these presentations, especially when also accompanied by flushing, abdominal cramping or diarrhea., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
11. Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1.
- Author
-
Theoharides TC, Kempuraj D, Marchand J, Tzianoumis L, Vasiadi M, Katsarou-Katsari A, Makris M, and Kalogeromitros D
- Subjects
- Acute Disease, Adult, Female, Humans, Urticaria Pigmentosa metabolism, Urticaria Pigmentosa pathology, Mast Cells metabolism, Receptors, Corticotropin-Releasing Hormone metabolism, Skin metabolism, Stress, Psychological complications, Urticaria Pigmentosa etiology
- Abstract
A 38-year-old woman presented with a pronounced increase in symptoms and proliferation of urticaria pigmentosa (UP) after acute psychological stress, which was quantified using the Spielberger's State-Trait Anxiety Inventory. Immunohistochemical examination of a skin biopsy from a new UP lesion showed a large number of activated mast cells expressing corticotrophin-releasing factor receptor-1 (CRF-R1) and there was high serum CRF. This is the first documented report to our knowledge of UP worsening associated with acute stress, possibly through activation of skin mast-cell CRF-R1.
- Published
- 2009
- Full Text
- View/download PDF
12. Urticaria and urticaria related skin condition/disease in children.
- Author
-
Novembre E, Cianferoni A, Mori F, Calogero C, Bernardini R, Di Grande L, Pucci N, Azzari C, and Vierucci A
- Subjects
- Angioedemas, Hereditary etiology, Angioedemas, Hereditary immunology, Angioedemas, Hereditary physiopathology, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Autoimmunity, Child, Child, Preschool, Food Hypersensitivity, Humans, Infant, Insect Bites and Stings immunology, Urticaria Pigmentosa etiology, Urticaria Pigmentosa immunology, Urticaria Pigmentosa physiopathology, Skin Diseases complications, Skin Diseases immunology, Skin Diseases physiopathology, Urticaria classification, Urticaria etiology, Urticaria immunology, Urticaria physiopathology, Urticaria therapy
- Published
- 2007
13. UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States.
- Author
-
Tuchinda C, Kerr HA, Taylor CR, Jacobe H, Bergamo BM, Elmets C, Rivard J, and Lim HW
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Dermatitis, Atopic epidemiology, Dermatitis, Atopic etiology, Dermatitis, Atopic pathology, Dermatitis, Atopic radiotherapy, Female, Foot Dermatoses epidemiology, Foot Dermatoses etiology, Foot Dermatoses pathology, Foot Dermatoses radiotherapy, Hand Dermatoses epidemiology, Hand Dermatoses etiology, Hand Dermatoses pathology, Hand Dermatoses radiotherapy, Humans, Male, Medical Records, Middle Aged, Retrospective Studies, Scleredema Adultorum epidemiology, Scleredema Adultorum etiology, Scleredema Adultorum pathology, Scleredema Adultorum radiotherapy, Severity of Illness Index, Skin Diseases etiology, Skin Diseases pathology, Treatment Outcome, Ultraviolet Therapy adverse effects, United States epidemiology, Urticaria Pigmentosa epidemiology, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Urticaria Pigmentosa radiotherapy, Skin Diseases epidemiology, Skin Diseases radiotherapy, Ultraviolet Therapy statistics & numerical data
- Abstract
Background: The efficacy and safety of UVA1 (340-400 nm) phototherapy were established by studies from European countries., Purpose: Evaluate experience with UVA1 phototherapy for patients with cutaneous diseases in the United States., Methods: A retrospective analysis of 92 cases of UVA1-treated cutaneous conditions from four medical centers in the United States was performed., Results: Two-third of the patients showed a fair to good response (26-100% improvement) and one-third of the patients showed a poor response (0-25% improvement). Diseases with a moderate to good response (51-100% improvement) included scleredema adultorum, hand or foot dermatitis, atopic dermatitis, morphea (medium or medium- to high-dose UVA1), systemic sclerosis, and urticaria pigmentosa. Besides tanning, other adverse effects were found in 15% of patients, which include pruritus, erythema, tenderness, and burning sensation. Patients with skin types I-III responded better that those with a darker skin type., Conclusion: UVA1 phototherapy is a useful and well-tolerated treatment option for a variety of skin conditions.
- Published
- 2006
- Full Text
- View/download PDF
14. Recurrent syncope and anaphylaxis as presentation of systemic mastocytosis in a pediatric patient: case report and literature review.
- Author
-
Shaffer HC, Parsons DJ, Peden DB, and Morrell D
- Subjects
- Cetirizine therapeutic use, Child, Preschool, Histamine H1 Antagonists, Non-Sedating therapeutic use, Humans, Male, Mastocytosis, Systemic diagnosis, Mastocytosis, Systemic drug therapy, Ranitidine therapeutic use, Recurrence, Anaphylaxis etiology, Histamine H2 Antagonists therapeutic use, Mastocytosis, Systemic complications, Syncope etiology, Urticaria Pigmentosa etiology
- Abstract
Mastocytosis refers to a rare collection of disorders, both cutaneous and systemic, that are characterized by increased numbers of mast cells. Depending on the extent of the disease, these disorders may present with symptoms resulting from mast cell degranulation including flushing, diarrhea, vomiting, cramping, syncope, or anaphylaxis. In pediatric patients, cutaneous involvement is most prevalent in the form of urticaria pigmentosa, which is typically asymptomatic or minimally so with resolution by adolescence. In this case report and review of literature, we review a case of a 3-year-old child with uritcaria pigmentosa displaying recurrent syncope and anaphylaxis as the first presentation of systemic mastocytosis. We found data to be limited on this topic, and concluded that pediatric patients with prior diagnoses of cutaneous mastocytosis could benefit from either more aggressive screening for systemic disease or prophylactic treatment with antihistamines and rescue subcutaneous epinephrine.
- Published
- 2006
- Full Text
- View/download PDF
15. Anaphylaxis to insect sting associated with urticaria pigmentosa.
- Author
-
Kim DC and Horan R
- Subjects
- Humans, Hypersensitivity complications, Hypersensitivity diagnosis, Hypersensitivity etiology, Hypersensitivity therapy, Immunotherapy, Male, Mastocytosis complications, Middle Aged, Skin Tests, Anaphylaxis etiology, Insect Bites and Stings complications, Urticaria Pigmentosa etiology
- Abstract
Anaphylaxis associated with insect stings has been reported to cause approximately 40 deaths per year in the United States. Immunotherapy with venom extracts is a well-established method of treatment of allergy to insect stings. The duration of therapy is based mainly on the initial symptoms and the presence or absence of systemic symptoms during therapy. Evaluation of immunoglobulin E and immunoglobulin G levels as well as repeat skin tests and sting challenges may also provide some additional benefit but are not as useful as the former two criteria. Patients with mastocytosis have a particularly increased risk for anaphylaxis after insect stings. There are many case reports of individuals first diagnosed with mastocytosis after an episode of anaphylaxis after an insect sting, in addition these patients tend to have more severe reactions as well as repeated episodes of systemic reactions during immunotherapy. Early diagnosis of mastocytosis and proper treatment can contribute greatly to the outcome in patients who present with venom allergy.
- Published
- 2003
16. Severe human urticaria produced by ant (Odontomachus bauri, Emery 1892) (Hymenoptera: Formicidae) venom.
- Author
-
Rodriguez-Acosta A and Reyes-Lugo M
- Subjects
- Animals, Bites and Stings drug therapy, Child, Female, Hand Dermatoses drug therapy, Hand Dermatoses etiology, Histamine H1 Antagonists, Non-Sedating therapeutic use, Humans, Loratadine therapeutic use, Urticaria Pigmentosa drug therapy, Ant Venoms adverse effects, Ants, Bites and Stings complications, Urticaria Pigmentosa etiology
- Abstract
Background: Ant sting reactions are becoming an increasing problem in tropical countries. It is important for physicians to be aware of their possible cutaneous and systemic manifestations., Methods: A child with a severe allergic reaction to an ant sting was examined and is discussed. This is the first case described in the literature caused by the ant Odontomachus bauri, and the biology of the ant and the clinical signs in the patient are described., Results: A child developed a strong allergic reaction to an ant sting. The case was not associated with a previous ant sting. Treatment with the systemic antihistamine loratadine (Clarityn) was favorable in this patient., Conclusions: In tropical areas, ant stings are usually benign, self-limited pathologic processes. In some cases, however, severe allergic reactions can develop, including urticaria and anaphylactic shock. Physicians should be aware of the possible complications of ant stings.
- Published
- 2002
- Full Text
- View/download PDF
17. Oral hyposensitization with celery juice.
- Author
-
Ruëff F, Eberlein-König B, and Przybilla B
- Subjects
- Administration, Oral, Allergens administration & dosage, Allergens therapeutic use, Anaphylaxis etiology, Apiaceae adverse effects, Female, Humans, Middle Aged, Plant Proteins administration & dosage, Plant Proteins therapeutic use, Urticaria Pigmentosa etiology, Anaphylaxis therapy, Apiaceae therapeutic use, Desensitization, Immunologic, Food Hypersensitivity complications, Phytotherapy
- Published
- 2001
- Full Text
- View/download PDF
18. Urticaria developing into mastocytosis.
- Author
-
Martin-Muñoz F, Vilchez MA, Garcia PG, Sepulveda CM, and Esteban MM
- Subjects
- Child, Preschool, Chronic Disease, Humans, Urticaria pathology, Urticaria complications, Urticaria Pigmentosa etiology
- Published
- 2000
- Full Text
- View/download PDF
19. Urticaria pigmentosa.
- Author
-
Allison MA and Schmidt CP
- Subjects
- Humans, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Urticaria Pigmentosa therapy
- Published
- 1997
- Full Text
- View/download PDF
20. Severe osteoporosis due to systemic mast cell disease: successful treatment with interferon alpha-2B.
- Author
-
Lehmann T, Beyeler C, Lämmle B, Hunziker T, Vock P, Olah AJ, Dahinden C, and Gerber NJ
- Subjects
- Adult, Clodronic Acid therapeutic use, Follow-Up Studies, Humans, Interferon alpha-2, Interferon-alpha adverse effects, Male, Palliative Care, Recombinant Proteins, Urticaria Pigmentosa etiology, Interferon-alpha therapeutic use, Mastocytosis etiology, Osteoporosis etiology, Osteoporosis therapy, Spinal Diseases etiology, Spinal Diseases therapy
- Abstract
We describe a 33-year old man suffering from severe vertebral osteoporosis and urticaria pigmentosa due to systemic mast cell disease (SMCD). Because i.v. clodronate therapy could not prevent further vertebral fractures, an additional treatment with interferon alpha-2b was initiated. During 24 months of treatment, our patient had no further pain episodes, no new vertebral fractures were discovered, trabecular bone mineral density (BMD) increased significantly and urticarial symptoms improved. Nevertheless, the extent of skin lesions remained unchanged. On histological examination, a remarkable decrease of mast cells was observed in the bone marrow, but not in the skin. Five months after discontinuation of interferon alpha-2b, trabecular BMD decreased and urticarial symptoms deteriorated. These findings illustrate a beneficial effect of interferon alpha-2b on SMCD-induced osteoporosis as well as urticarial symptoms, and raise the question whether this treatment may have a diverse impact on mast cell population in different tissues.
- Published
- 1996
- Full Text
- View/download PDF
21. Cutaneous mastocytosis complicating pregnancy.
- Author
-
Donahue JG, Lupton JB, and Golichowski AM
- Subjects
- Adult, Apgar Score, Biopsy, Cesarean Section, Female, Humans, Infant, Newborn, Magnesium Sulfate therapeutic use, Obstetric Labor, Premature drug therapy, Pregnancy, Pregnancy Trimester, Second, Skin pathology, Urticaria Pigmentosa drug therapy, Urticaria Pigmentosa pathology, Pregnancy Complications diagnosis, Pregnancy Complications pathology, Urticaria Pigmentosa etiology
- Abstract
Background: Telangiectasia macularis eruptiva perstans, a rare form of cutaneous mastocytosis associated with elevated histamine excretion, has not previously been reported to complicate pregnancy., Case: A woman presented in the late second trimester with an anaphylactoid reaction, rash, uterine contractions, and vaginal bleeding. Skin biopsy revealed perivascular mast-cell infiltration. Her urinary histamine excretion was markedly elevated. She was treated successfully with tocolytics and antihistamines., Conclusion: Elevated histamine excretion in biopsy-proven cutaneous mastocytosis may be associated with preterm labor.
- Published
- 1995
- Full Text
- View/download PDF
22. Biology, diagnosis and therapy of mastocytosis.
- Author
-
Marone G, Spadaro G, and Genovese A
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Child, Female, Histamine Antagonists therapeutic use, Histamine Release, Humans, Infant, Male, Mastocytosis diagnosis, Mastocytosis therapy, PUVA Therapy, Urticaria Pigmentosa etiology, Mastocytosis etiology
- Published
- 1995
23. Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis.
- Author
-
Kors JW, van Doormaal JJ, and de Monchy JG
- Subjects
- Adult, Aged, Anaphylaxis immunology, Anaphylaxis therapy, Animals, Bee Venoms immunology, Epinephrine therapeutic use, Female, Humans, Immunoglobulin E immunology, Insect Bites and Stings therapy, Male, Mastocytosis immunology, Mastocytosis therapy, Middle Aged, Prednisolone therapeutic use, Skin Tests, Urticaria Pigmentosa etiology, Urticaria Pigmentosa immunology, Urticaria Pigmentosa therapy, Wasp Venoms immunology, Wasps, Anaphylaxis etiology, Hymenoptera, Insect Bites and Stings complications, Mastocytosis etiology
- Abstract
Systemic mastocytosis is a rare and chronic disorder characterized by a pathologically increased number of mast cells in various tissues and overproduction of mast cell mediators. From a group of 15 patients (10 females, 5 males) with systemic mastocytosis five female patients presented with a history of an anaphylactoid shock reaction to wasp sting. Three of them had no demonstrable specific IgE against wasp or bee venom in serum, and a skin test that was only weakly positive for wasp venom. One patient had specific IgE against wasp venom and a clearly positive skin test to wasp venom. The other patient had specific IgE against both wasp and bee venom and a skin test that was only weakly positive to wasp venom. Two patients had to stop a hyposensitization procedure because of systemic side effects. The five patients did not differ from the other patients with systemic mastocytosis with regard to either clinical symptoms and signs or urinary excretion of histamine metabolites. From the latter group two female and three male patients said they had been stung by a wasp in the past. Thus, anaphylactoid shock after Hymenoptera sting can be a presenting symptom of systemic mastocytosis and may be caused by an IgE- as well as a non-IgE-mediated mechanism. In cases of anaphylactoid reaction to Hymenoptera sting, especially when there is no IgE demonstrable in serum or in cases of intolerance of hyposensitization, the diagnosis of systemic mastocytosis should be considered, also in the absence of the clinical hallmarks of urticaria pigmentosa.
- Published
- 1993
- Full Text
- View/download PDF
24. Urticaria-pigmentosa-like lesions in acute lymphoblastic leukaemia (2 cases).
- Author
-
Raj S, Khopkar U, Wadhwa SL, and Kapasi A
- Subjects
- Adult, Child, Humans, Leukemic Infiltration pathology, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Skin pathology, Urticaria Pigmentosa pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Urticaria Pigmentosa etiology
- Abstract
Two males aged 12 and 38 years presented with widespread severely pruritic blackish spots for 15 days. Widespread slate-grey patches and erythematous hyperpigmented plaques were observed with a positive Darier's sign. There were associated neck swellings, abdominal pain, anorexia, weight loss and bleeding gums in both. Peripheral blood and bone marrow showed blast cells, anaemia and thrombocytopenia. Cell surface markers confirmed the presence of acute lymphoblastic leukaemia. Skin biopsy showed an infiltrate of lymphoblasts as well as mast cells. Partial response was noted with cytotoxic therapy in 1 patient. Thus lesions mimicking urticaria pigmentosa may be the presenting sign of acute lymphoblastic leukaemia.
- Published
- 1993
- Full Text
- View/download PDF
25. Urticaria pigmentosum: nature's experiment in mast cell biology.
- Author
-
Lazarus GS, Guzzo C, Lavker RM, Murphy GF, and Schechter NM
- Subjects
- Animals, Endopeptidases metabolism, Humans, Mast Cells pathology, Peptide Hydrolases metabolism, Urticaria Pigmentosa pathology, Urticaria Pigmentosa physiopathology, Mast Cells physiology, Urticaria Pigmentosa etiology
- Published
- 1991
- Full Text
- View/download PDF
26. Cutaneous mastocytosis after autologous bone marrow transplantation.
- Author
-
Van Hoof A, Criel A, Louwagie A, and Vanvuchelen J
- Subjects
- Adult, Humans, Lymphoma, Non-Hodgkin surgery, Male, Mast Cells pathology, Transplantation, Autologous, Urticaria Pigmentosa pathology, Bone Marrow Transplantation adverse effects, Urticaria Pigmentosa etiology
- Abstract
A 41-year-old male patient developed cutaneous mastocytosis 3 months after autologous bone marrow transplantation (ABMT). The ABMT was performed as part of consolidation treatment for a high-grade malignant non-Hodgkin's lymphoma. There was no evidence for systemic mastocytosis. Recurrence of the lymphoma could not be shown. Mast cell proliferation frequently coexists with dysplastic and neoplastic disorders of myeloid and, more rarely, of lymphoid cells. Mast cells are growth factor responsive and ultimately originate from the pluripotent hematopoietic stem cell. After autologous bone marrow transplantation, hematological reconstitution may in rare cases lead to an abnormal proliferation of mast cells possibly due to unbalanced production of growth factors.
- Published
- 1991
27. Leukemia-associated skin infiltrates.
- Author
-
Dreizen S, McCredie KB, Keating MJ, Andersson BS, and Schachner JR
- Subjects
- Acute Disease, Chronic Disease, Diagnosis, Differential, Ecchymosis etiology, Humans, Purpura etiology, Skin Diseases diagnosis, Skin Neoplasms diagnosis, Urticaria Pigmentosa etiology, Vasculitis etiology, Leukemia complications, Skin Diseases etiology, Skin Neoplasms complications
- Published
- 1989
- Full Text
- View/download PDF
28. External expressions of internal malignancy.
- Author
-
Dreizen S, McCredie KB, Bodey GP, and Keating MJ
- Subjects
- Acanthosis Nigricans etiology, Adolescent, Adult, Cachexia etiology, Calcinosis etiology, Child, Dermatomyositis etiology, Female, Humans, Ichthyosis etiology, Male, Neurofibromatosis 1 etiology, Osteoarthropathy, Primary Hypertrophic etiology, Osteoarthropathy, Secondary Hypertrophic diagnosis, Osteoarthropathy, Secondary Hypertrophic etiology, Porphyrias etiology, Priapism etiology, Skin Diseases etiology, Skin Neoplasms etiology, Urticaria Pigmentosa etiology, Paraneoplastic Syndromes diagnosis
- Abstract
Paraneoplastic conditions are cancer-connected but are not produced as a direct effect of the tumor or metastasis. Some antedate the appearance of the internal malignancy; some run a course parallel to the tumor; some follow a pattern independent of the neoplasm. They occur in a small minority of patients with cancer and are, for the most part, of unknown cause. When an external disorder is present, it may act as a marker of hidden malignancy and thus contribute to its detection, or it may serve as an indicator of successful treatment. Many of the conditions described occur commonly without any underlying malignancy, but an unusual frequency of association with cancer makes their presence significant.
- Published
- 1987
- Full Text
- View/download PDF
29. Urticaria and angioedema.
- Author
-
Burrall BA and Huntley AC
- Subjects
- Histamine H1 Antagonists therapeutic use, Histamine Release, Humans, Urticaria therapy, Urticaria Pigmentosa etiology, Vasculitis etiology, Angioedema etiology, Urticaria etiology
- Published
- 1985
- Full Text
- View/download PDF
30. Generalized mastocytosis, relapsing herpes zoster and polyradiculoneuritis.
- Author
-
Kalz F
- Subjects
- Aged, Female, Herpes Zoster etiology, Herpes Zoster immunology, Humans, Immunologic Deficiency Syndromes complications, Polyradiculopathy immunology, Recurrence, Urticaria Pigmentosa etiology, Urticaria Pigmentosa immunology, Herpes Zoster complications, Polyradiculopathy etiology, Urticaria Pigmentosa complications
- Abstract
A 68-year-old woman suffering from a longstanding urticaria pigmentosa with mast cell infiltrations in bones had two attacks of herpes zoster. The second herpes zoster attack was followed by a severe polyradiculoneuritis (Guillain-Barré syndrome). The sequence of events suggests an immunological deficiency.
- Published
- 1975
- Full Text
- View/download PDF
31. Systemic mastocytosis in a patient with polycythemia vera treated with radioactive phosphorus.
- Author
-
Eagan JW Jr, Baughman KL, Miller S, Conley CL, and Eggleston JC
- Subjects
- Biopsy, Gastrointestinal Hemorrhage etiology, Humans, Liver pathology, Male, Middle Aged, Polycythemia Vera radiotherapy, Postoperative Complications, Psoriasis etiology, Splenectomy, Splenomegaly etiology, Phosphorus Radioisotopes therapeutic use, Polycythemia Vera complications, Urticaria Pigmentosa etiology
- Abstract
Systemic mastocytosis occurred as a fatal event in a patient with long-standing polycythemia vera. The patient had been treated over the course of 21 yr with radioactive phosphorus. Possible relationships between mastocytosis and polycythemia vera, and also between mastocytosis and treatment with ionizing radiation, are discussed. Histopathologic and electron microscopic findings are illustrated. Difficulties in establishing the diagnosis of mast cell disease in this setting are also described.
- Published
- 1977
32. The spectrum of mastocytosis.
- Author
-
Tharp MD
- Subjects
- Adult, Bone Diseases pathology, Bone Marrow pathology, Child, Preschool, Cromolyn Sodium therapeutic use, Epinephrine therapeutic use, Female, Gastrointestinal Diseases pathology, Glucocorticoids therapeutic use, Hepatomegaly pathology, Histamine metabolism, Histamine urine, Histamine Antagonists therapeutic use, Histamine Release drug effects, Humans, Lymphatic Diseases pathology, Male, Mast Cells metabolism, Mast Cells pathology, Mast Cells physiology, Mast Cells ultrastructure, PUVA Therapy, Preleukemia, Prognosis, Prostaglandin Antagonists therapeutic use, Skin pathology, Splenomegaly pathology, Urticaria Pigmentosa diagnosis, Urticaria Pigmentosa drug therapy, Urticaria Pigmentosa epidemiology, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology
- Abstract
Mastocytosis represents a spectrum of clinical disorders that results from an aberrant proliferation of tissue mast cells. This disease process may be confined to the skin (cutaneous mastocytosis) or may involve multiple organs (systemic mastocytosis). Parameters that are useful in differentiating cutaneous from systemic disorders include patient age, symptom complex, and clinical signs. A wide range of clinical symptoms may be encountered in patients with mastocytosis which result from the release of pharmacologically potent mast cell mediators. Distinct cutaneous patterns resulting from skin mast cell infiltrates can be helpful in identifying patients with systemic involvement. The diagnosis of mastocytosis is confirmed by demonstrating increased tissue mast cells in involved organs. The overall prognosis for patients with proliferative mast cell disease is relatively good, although a small percentage are at risk for developing a fatal neoplastic disorder (malignant mastocytosis). Treatment of mastocytosis is directed at both inhibiting mast cell degranulation and blocking the potential systemic effects of released secretory products. Future therapeutic advances depend upon an improved understanding of the basic mechanisms involved in mast cell mediator release and the forces that govern mast cell growth and development.
- Published
- 1985
- Full Text
- View/download PDF
33. Cutaneous and systemic porcine mastocytosis.
- Author
-
Bundza A and Dukes TW
- Subjects
- Animals, Mycoplasma Infections complications, Mycoplasma Infections pathology, Skin Diseases etiology, Skin Diseases pathology, Swine, Swine Diseases etiology, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Anaplasmataceae Infections veterinary, Mycoplasma Infections veterinary, Skin Diseases veterinary, Swine Diseases pathology, Urticaria Pigmentosa veterinary
- Published
- 1982
- Full Text
- View/download PDF
34. Fever, hemorrhagic bullae and gastritis in a 20-month-old male.
- Author
-
Frieri M, Claus M, Martinez S, Annunziato D, Kosuri S, and Lin J
- Subjects
- Diagnosis, Differential, Humans, Infant, Male, Mast Cells pathology, Physical Examination, Urticaria Pigmentosa etiology, Urticaria Pigmentosa pathology, Urticaria Pigmentosa diagnosis
- Published
- 1989
35. Urticaria pigmentosa in patients closely related by birth.
- Author
-
Aoki K and Suzuki H
- Subjects
- Adolescent, Child, Female, Histamine blood, Humans, Measles complications, Urticaria Pigmentosa etiology, Urticaria Pigmentosa genetics
- Published
- 1981
- Full Text
- View/download PDF
36. Immunologically mediated intestinal mastocytosis in Nippostrongylus brasiliensis-infected rats.
- Author
-
Befus AD and Bienenstock J
- Subjects
- Animals, Antigens immunology, Immune Sera immunology, Immunization, Passive, Intestinal Diseases etiology, Intestinal Diseases radiotherapy, Lymphocytes immunology, Nippostrongylus immunology, Rats, Rats, Inbred Lew, Urticaria Pigmentosa etiology, Urticaria Pigmentosa radiotherapy, Intestinal Diseases immunology, Nematode Infections complications, Urticaria Pigmentosa immunology
- Abstract
To investigate mechanisms of mast-cell proliferation, we have utilized infection of Lewis rats with the intestinal nematode, Nippostrongylus brasiliensis, which induces a pronounced intestinal mast-cell hyperplasia. Adoptive transfer of 2 x 10(8) immune mesenteric lymph node cells (IMLN), collected 14 days post infection with 3000 third stage larvae (L3), into rats concurrently given 3000 L3 hastened the expected intestinal mastocytosis by up to 4-5 days. IMLN exhibited this mastopoietic activity in the presence but not in the absence of concurrent infection. Normal mesenteric lymph node cells did not show similar mastopoietic activity. Intestinal mastocytosis was delayed by sub-lethal irradiation (400 rad) but IMLN reconstituted the mast-cell response of such animals. The mastopoietic activity could not be attributed to worm antigen as antigen administered intravenously had no significant effect on mastocytosis and furthermore, antigen could not be detected in mastopoietically active IMLN suspensions used as a possible antigen source in passive cutaneous anaphylaxis tests. Immune serum (14 days post primary infection with 3000 L3) also hastened mastocytosis in infected rats, whereas normal serum did not. The IMLN may be an enriched source of intestinal mast cell precursors and, in addition, may contain a cell type(s) which regulates the differentiation and proliferation of such precursors.
- Published
- 1979
37. Erythema gyratum repens and undifferentiated carcinoma.
- Author
-
Leavell UW Jr, Winternitz WW, and Black JH
- Subjects
- Aged, Humans, Male, Neoplasm Metastasis, Brain Neoplasms complications, Carcinoma, Squamous Cell complications, Cauda Equina, Erythema etiology, Mediastinal Neoplasms complications, Urticaria Pigmentosa etiology
- Published
- 1967
38. Solitary mast cell tumor. Progression to disseminated urticaria pigmentosa in a negro infant.
- Author
-
Lantis SH and Koblenzer PJ
- Subjects
- Biopsy, Black People, Female, Humans, Infant, Mast-Cell Sarcoma pathology, Skin Neoplasms pathology, Urticaria Pigmentosa pathology, Mast-Cell Sarcoma complications, Skin Neoplasms complications, Urticaria Pigmentosa etiology
- Published
- 1969
- Full Text
- View/download PDF
39. Cutaneous mastocytosis: an unusual radiation dermatitis.
- Author
-
Macdonald A and Feiwel M
- Subjects
- Breast Neoplasms radiotherapy, Carcinoma radiotherapy, Female, Humans, Middle Aged, Radiotherapy adverse effects, Urticaria Pigmentosa pathology, Radiodermatitis, Urticaria Pigmentosa etiology
- Published
- 1971
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.