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2 results on '"Urszula Siekiera"'

1. Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?

Author

Grazyna Deja, Przemyslawa Jarosz-Chobot, Joanna Polanska, Urszula Siekiera, and Ewa Malecka-Tendera

Subjects
Pathology, RB1-214
Abstract

The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic children, their 78 siblings, and 85 persons from healthy control group were followed up. The highest risk of DMT1 was connected with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41), DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR = 4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles.

Published
2006
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2. The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease

Author

Grazyna Deja, Przemysława Jarosz-Chobot, Anna Myrda, and Urszula Siekiera

Subjects
Male, medicine.medical_specialty, Thyroiditis, Adolescent, endocrine system diseases, Article Subject, Immunology, Disease, Comorbidity, Gastroenterology, Coeliac disease, Sex Factors, Risk Factors, immune system diseases, Immunopathology, Diabetes mellitus, Internal medicine, Epidemiology, medicine, Prevalence, lcsh:Pathology, Humans, Child, Autoantibodies, Retrospective Studies, Type 1 diabetes, business.industry, Age Factors, nutritional and metabolic diseases, Cell Biology, medicine.disease, Celiac Disease, Diabetes Mellitus, Type 1, Female, Poland, business, Research Article, lcsh:RB1-214
Abstract

This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group comprises 27 patients at the mean age of 12.30 years (±SD3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35,p<.05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset.

Published
2008
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