4 results on '"Ulrich Wesselmann"'
Number of results to display per page
Search Results
2. CLAUDIUS Study: Risk of materno-fetal transmission of melanoma cells in pregnant women with high grade melanoma – A retrospective multicenter study and literature review
- Author
-
Svenja Vanessa Wiedemann, Verena Müller, Bettina Toth, Michael Erdmann, Bodo Bühler, Susanne Dugas-Breit, Kerstin Schatton, Lydia Reinhardt, Markus Meissner, Marion Mickler, Claudia Pföhler, Carsten Weishaupt, Rudolf Herbst, Dirk Debus, Laura Susok, Julia Katharina Tietze, Julia Welzel, Andreas Arnold, Evelyn Dabrowski, Andrea Forschner, Steven Goetze, Kinan Hayani, Céleste Lebbe, Florian Löhr, Miriam Mengoni, Barbara Hermes, Wiebke Katharina Peitsch, Gabriela Poch, Michael Max Sachse, Anca Sindrilaru, Saskia Wenk, Mirjana Ziemer, Kjell Kaune, Lisette Meier-Naust, Georgios Nikolakis, Florian Oberndörfer, Ulrich Wesselmann, Jochen Sven Utikal, and Maria Rita Gaiser
- Subjects
Melanoma ,Multicentre ,Pregnancy ,Retrospective ,Transplacental metastases ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Vertical transmission of maternal cancer cells to the child is extremely rare, but melanoma represents the most common culprit. The aim of this study is to determine individual risks for materno-fetal transmission of melanoma cells and to establish standardized procedures for pregnant melanoma patients and their offspring. Patients and methods: In this retrospective multicenter study, data on women with stage III or IV melanoma that had been diagnosed before, during or up to 12 months after pregnancy, were analyzed for the occurrence of metastases in the placenta or the infant. In addition, a literature search for previously described materno-fetal transmission in case of maternal melanoma was conducted. A historical patient group was established from these cases and a statistical analysis was performed (SAS, p < 0.05 significant). Results: In total, 67 children born to women with stage III or IV melanoma were included. No placental or infant metastases were detected in any of the cases. The additional literature search revealed 37 cases with placental metastases and 14 cases with infant metastases (6 of them overlapping). Of the affected children, 10 (71.43%) died from their disease. Maternal death shortly after birth seems to be an unfavorable factor for transmission to the infant. Conclusion: The risk of materno-fetal transmission of maternal melanoma metastases seems to be much lower than anticipated based on former studies. However, thorough placental screening and systematic follow-up of the children resulting from pregnancies of high-risk melanoma patients should be performed.
- Published
- 2023
- Full Text
- View/download PDF
3. Surveillance of patients with conjunctival melanoma in German-speaking countries: a multinational survey of the German dermatologic cooperative oncology group
- Author
-
Anja Wessely, Theresa Steeb, Carola Berking, Max Schlaak, Markus V. Heppt, Mareike Alter, Christiane Bayerl, Armin Bender, Guido Bruning, Evelyn Dabrowski, Dirk Debus, Nina Devereux, Edgar Dippel, Konstantin Drexler, Pia Dücker, Reinhard Dummer, Steffen Emmert, Peter Elsner, Alexander Enk, Christoffer Gebhardt, Anja Gesierich, Matthias Goebeler, Sergij Goerdt, Steven Goetze, Ralf Gutzmer, Sebastian Haferkamp, Gesina Hansel, Jessica C. Hassel, Lucie Heinzerling, Katharina C. Kähler, Kjell M. Kaume, Wolfgang Krapf, Nicole Kreuzberg, Percy Lehmann, Elisabeth Livingstone, Harald Löffler, Carmen Loquai, Cornelia Mauch, Johanna Mangana, Friedegund Meier, Markus Meissner, Rose K.C. Moritz, Lara Valeska Maul, Verena Müller, Peter Mohr, Alexander Navarini, Ahn Van Nguyen, Christiane Pfeiffer, Claudia Pföhler, Christian Posch, Erika Richtig, Rainer Rompel, Michael M. Sachse, Stefanie Sauder, Dirk Schadendorf, Kerstin Schatton, Hans-Joachim Schulze, Erwin Schultz, Bastian Schilling, Matthias Schmuth, Jan C. Simon, Markus Streit, Patrick Terheyden, Alexander Thiem, Thomas Tüting, Julia Welzel, Gerhard Weyandt, Ulrich Wesselmann, Uwe Wollina, Mirjana Ziemer, Lisa Zimmer, and Markus Zutt
- Subjects
Cancer Research ,medicine.medical_specialty ,business.industry ,MEDLINE ,Medizin ,language.human_language ,German ,Cross-Sectional Studies ,Oncology ,Multinational corporation ,Germany ,Surveys and Questionnaires ,Family medicine ,medicine ,language ,Humans ,business ,Conjunctiva ,Melanoma ,Conjunctival Melanoma - Published
- 2021
4. Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases
- Author
-
Ulrich Wesselmann, Daniela Massi, Christiane Bailly, Apollon Karlseladze, Arnaud de la Fouchardière, Thomas Jouary, Lorenzo Cerroni, Béatrice Vergier, Vincenzo De Giorgi, Marie-Françoise Avril, Jean-Philippe Merlio, and Martina Prochazkova-Carlotti
- Subjects
Adult ,Male ,FISH, melanoma ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Biology ,Malignancy ,Diagnostic aid ,Pathology and Forensic Medicine ,Young Adult ,Predictive Value of Tests ,medicine ,Humans ,Child ,Melanoma diagnosis ,Melanoma ,Nevus ,In Situ Hybridization, Fluorescence ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Chromosome Aberrations ,medicine.diagnostic_test ,Reproducibility of Results ,Benign lesion ,DNA, Neoplasm ,Middle Aged ,medicine.disease ,Predictive value of tests ,Child, Preschool ,%22">Fish ,Melanocytes ,Female ,Lymph Nodes ,Fluorescence in situ hybridization - Abstract
Some melanocytic tumors are ambiguous, so the reproducible histopathological diagnosis of benign or malignant lesion is difficult. This study evaluated the contribution of fluorescence in situ hybridization (FISH) first in 43 non-equivocal melanomas and nevi, and then in 113 ambiguous melanocytic tumors selected by expert pathologists from six different European institutions. We included two groups of ambiguous tumors: patients without recurrence (5-year minimal follow-up) and with metastases. An independent triple-blind histopathological review was performed to classify tumors as 'favor benign' (A-) or 'favor malignant' (A+). A four-color probe set targeting 6p25, 6q23, 11q13 and CEP6 was used for FISH. In the 43 non-equivocal melanomas and nevi, sensitivity was 85% and specificity 90%. Ninety out of 95 ambiguous melanocytic tumors included were FISH interpretable (67 FISH negative and 23 FISH positive). Of the 90 patients, 69 presented no recurrence and 21/90 exhibited metastases. These ambiguous tumors were mostly spitzoid tumors (45/90). Histopathological reviewers classified these tumors as favor malignant (49/90) and favor benign (32/90), whereas nine cases had a discordant diagnosis. By comparison with outcome, the sensitivity and specificity of histopathological review were 95 and 52%, and the sensitivity and specificity of FISH were 43 and 80%. Compared with histopathological review, the sensitivity and specificity of FISH were 34.5 and 91%. Interestingly, by combining the histopathological diagnosis with FISH results, the diagnosis was optimized, especially by increasing specificity (76% instead of 52% for expert diagnosis alone) and by improving sensitivity compared with FISH alone (90 vs 43% for FISH result alone). The value of this FISH test is to add a reproducible demonstration of malignancy to the histopathological diagnosis, especially in doubtful/ambiguous melanocytic tumors. A positive FISH test reinforces the diagnosis of melanoma, allowing such tumors (particularly thick tumors) to be managed as melanomas.
- Published
- 2011
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.