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4. Small area variations in non-affective first-episode psychosis: the role of socioeconomic and environmental factors

Author

Gutiérrez, Gerardo, Goicoa, Tomas, Ugarte, María Dolores, Aranguren, Lidia, Corrales, Asier, Gil-Berrozpe, Gustavo, Librero, Julián, Sánchez-Torres, Ana M., Peralta, Victor, García de Jalon, Elena, Cuesta, Manuel J., Martínez, Matilde, Otero, Maria, Azcarate, Leire, Pereda, Nahia, Monclús, Fernando, Moreno, Laura, Fernández, Alba, Ariz, Mari Cruz, Sabaté, Alba, Aquerreta, Ainhoa, Aguirre, Izaskun, Lizarbe, Tadea, and Begué, Maria Jose

Published
2024
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12. High increase of Nichols-like clade circulating Treponema pallidum subsp. pallidum in Barcelona from 2021 to 2023

Author

Patricia Nadal-Barón, Jesus Trejo-Zahinos, Maider Arando, Alicia Barberan-Masegosa, Marta Bernat-Sole, Arantxa Pérez-Ugarte, Ana Maria Villatoro, Pilar Alcubilla, Elena Sulleiro, Juan José Gonzalez-López, Andrés Antón, Mireia Alberny, Oriol Mitjà, Maria Nieves Larrosa, and Yannick Hoyos-Mallecot

Subjects
Molecular epidemiology, Multilocus sequence typing, Phylogeny, Syphilis, Treponema pallidum, Medicine, Science
Abstract

Abstract Worldwide, more than 90% of contemporary syphilis strains belong to SS14-like clade. This study aimed to describe the molecular profile of circulating Treponema pallidum subsp. pallidum (TPA) strains in Barcelona, Spain, from 2021 to 2023 building upon our report in 2015 which showed that 94.8% of typed strains belonged to the SS14 clade. Multilocus sequence typing (MLST) was conducted on TPA-positive samples obtained from swab samples by sequencing the tp0136, tp0548, and tp0705 loci. Strains were classified as Nichols-like or SS14-like clade. Macrolide and tetracycline resistance‑associated mutations were determined through analysis of 23S rDNA and 16S rRNA gene sequences. Of the 96 typeable samples, 47.9% belonged to SS14-like and 52.1% to the Nichols-like. Fourteen haplotypes were identified, with ST26 representing 43.8% of the samples, distributed across 11 haplotypes in the SS14-like and 3 haplotypes in the Nichols-like. All the samples showed macrolide resistance-associated mutations, while none exhibited tetracycline-associated mutations. Our findings revealed a substantial shift in the proportion of TPA clades within the Barcelona population from 2021 to 2023, characterized by a higher proportion of Nichols-like strains compared to 2015 and international trends. The varying temporal and geographical trends underscore the need for regular surveillance to understand regional variations in syphilis and strengthen control programs.

Published
2024
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13. Point-of-care biochemistry for primary healthcare in low-middle income countries: a qualitative inquiry

Author

Guillermo Z. Martínez-Pérez, Tajudin Adesegun Adetunji, Fátima Judith Leonela Salas Noriega, Olufemi Samuel Amoo, Cesar Ugarte-Gil, Abiodun Kofoworola Ajeigbe, Olufemi Adefehinti, Kingsley K. Akinroye, Babatope Kolawole, Kofoworola Odeyemi, Sonjelle Shilton, Beatrice Vetter, Elena Ivanova Reipold, and Morẹ́nikẹ Oluwátóyìn Foláyan

Subjects
Primary healthcare system, Low-middle income countries, Laboratory capacities, Primary care strengthening, Noncommunicable diseases, Clinical chemistry, Medicine (General), R5-920
Abstract

Abstract Background Access to essential diagnostics is crucial for primary healthcare (PHC) in low-and-middle income countries (LMICs). Many LMICs have invested in equipping PHC with point-of-care (PoC) diagnostics for infectious diseases, however there has been no similar investment to improve PHC capacities for clinical chemistry. The biochemistry gap is among the deterrents to universal health coverage. Methods A social sciences project was conducted with the aim to understand the key PHC stakeholders’ insights on the pertinence of PoC biochemistry for PHC in LMICs. Data generation was conducted between July-November 2023 in Mongolia, Nigeria and Peru. Decision-makers in healthcare delivery, healthcare professionals, and patient and community advocates were engaged using a combination of sampling techniques. Unstructured individual and group conversations, and non-participant observation were conducted. Analysis involved an inductive line-by-line coding on printed transcripts, followed by a deductive coding and theme-by-theme analysis on digitized transcripts. Results Fifteen, 51 and 20 informants from Mongolia, Nigeria and Peru, respectively, participated. Fifty-five of the 94 informants were female. Most informants considered that PoC biochemistry in PHC would be pertinent, from a clinical and a resources-saving perspective. Those households that currently bear the burden of referrals (i.e., the poor, the bedridden, the older adults) would benefit the most from the deployment of PoC biochemistry for essential biochemistry parameters. Improved access to PoC glycated hemoglobin (HbA1c), lipid, liver and kidney profile was perceived as helpful to inform clinicians’ decision-taking. The value of PoC biochemistry for the management of noncommunicable diseases (diabetes, hypertension) and infectious conditions (dengue, malaria, tuberculosis), to improve child health outcomes (severe dehydration in children with diarrhea and/or malnutrition) and to reduce preventable causes of death (dengue-related renal failure) was highlighted. Conclusions PoC biochemistry holds potential to revert the impact that the biochemistry gap has for patient care in some LMICs’ PHC settings. PoC equipment for parameters such as HbA1c, urea, creatinine or electrolytes could enhance community-level management of preventable causes of mortality, improve service delivery for patients affected by locally-prevalent infectious conditions, and improve the psychosocial and economic wellbeing of patients facing the burden of referrals to remote biochemistry-equipped centers. Trial Registration Not applicable.

Published
2024
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14. Binary progenitor systems for Type Ic supernovae

Author

Martín Solar, Michał J. Michałowski, Jakub Nadolny, Lluís Galbany, Jens Hjorth, Emmanouil Zapartas, Jesper Sollerman, Leslie Hunt, Sylvio Klose, Maciej Koprowski, Aleksandra Leśniewska, Michał Małkowski, Ana M. Nicuesa Guelbenzu, Oleh Ryzhov, Sandra Savaglio, Patricia Schady, Steve Schulze, Antonio de Ugarte Postigo, Susanna D. Vergani, Darach Watson, and Radosław Wróblewski

Subjects
Science
Abstract

Abstract Core-collapse supernovae are explosions of massive stars at the end of their evolution. They are responsible for metal production and for halting star formation, having a significant impact on galaxy evolution. The details of these processes depend on the nature of supernova progenitors, but it is unclear if Type Ic supernovae (without hydrogen or helium lines in their spectra) originate from core-collapses of very massive stars (>30 M⊙) or from less massive stars in binary systems. Here we show that Type II (with hydrogen lines) and Ic supernovae are located in environments with similar molecular gas densities, therefore their progenitors have comparable lifetimes and initial masses. This supports a binary interaction for most Type Ic supernova progenitors, which explains the lack of hydrogen and helium lines. This finding can be implemented in sub-grid prescriptions in numerical cosmological simulations to improve the feedback and chemical mixing.

Published
2024
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15. Design, develop, and implement the strategic information system on health, dependence, and healthy aging: an analysis of the Mexican experience

Author

Luis Miguel Gutierrez-Robledo, Rosa Estela García-Chanes, Emely Estefanía Max-Monroy, Liliana Giraldo-Rodríguez, Teresa Álvarez-Cisneros, Ana Cristina Gómez-Ugarte, José Antonio de la Rosa-Parra, Ángel Gabriel Estévez-Pedraza, Fernando Rebollar-Castelán, Víctor Montaño-Serrano, Francisco Gerson Cuero-Muciño, Roberto Carlos Rivera-González, Sara Gabriela Yeverino-Castro, Abigail Vanessa Rojas-Huerta, Luis Octavio Ramírez-Fernández, Cesar González-González, Santiago Yeomans-Almada, and Carmen García-Peña

Subjects
Aging, Information systems, Functional Dependence, Healthy aging, Big Data, Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The Decade of Healthy Aging (2021–2030) emerges as a 10 years strategy to improve the lives of older adults, their families, and the communities in which they live. One of the actions defined in this framework is related to improving the measurement, monitoring, and understanding of characteristics, factors, and needs related to aging and health. The aim was to analyze and assess the process of construction and development of the Strategic Information System on Health, Funcional Dependence and Aging (SIESDE, for its acronym in Spanish). SIESDE will provide strategic information in Mexico at the municipal, state, and national levels that support the public policies on healthy aging. Methods The system processes and analyzes the data sources of the Health Information Systems and the National System of Statistical and Geographical Information. SIESDE comprises three components: (1) Design, construction, and evaluation of the indicators; (2) storage, management, and visualization, and (3) diffusion and translation of information. Results A total of 135 indicators were built on seven themes: (1) demographic, socioeconomic, and aging conditions, (2) health, (3) functional dependence, (4) healthy aging, (5) health services, (6) social and physical environments, and (7) complex indicators. Conclusions SIESDE is an effective system for providing an overall view of health, aging, and functional dependence.

Published
2024
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16. Effects of space allowance on patterns of activity in group-housed dairy calves

Author

M.B. Ugarte Marin, K.N. Gingerich, J. Wang, H. Yu, and E.K. Miller-Cushon

Subjects
Dairy processing. Dairy products, SF250.5-275
Abstract

With increasing use of social housing for dairy calves, there is a need to refine housing management practices that influence animal behavior and may affect welfare. Our aim was to assess the effect of pen space allowance on activity patterns and pen space use. Holstein heifer calves were group-housed (n = 6 pens; 5 calves/pen) at 14 d ± 2.8 d of age (mean ± SD). After a 7-d adaptation, each pen was exposed to 3 different space allowances (3.7, 4.6, and 5.6 m2/calf) in a random order, according to a replicated Latin square design with three 7-d periods (period 1, d 22–28; period 2, d 29–35; and period 3, d 36–42). Calves were provided milk replacer (12 L/d) ad libitum via an automated milk feeder and gradually weaned over 10 d, beginning at 48 ± 3 d of age. Using leg-based accelerometers (HOBO Pendant G data logger, Onset Computer Corp., Pocasset, MA), we obtained data describing standing time, standing bout frequency, and standing bout duration. Daily pen-level average standing time (6.5 h/d; SE = 0.27) did not differ between treatments. However, with greater space allowance, calves had more frequent standing bouts (22.6 vs. 20.3 bouts/d; 5.6 vs. 3.7 m2/calf; SE = 0.96) of shorter duration. To assess effects of space allowance on within-pen individual variability, we calculated the coefficient of variation for daily activity outcomes at the pen level and intra-class correlation coefficients for hourly standing time, by pen and day. The coefficient of variation for standing behavior outcomes decreased with increasing space allowance, and the intraclass correlation for hourly standing time increased, suggesting that increasing space allowance reduced individual variability and may promote more synchronous rest. Finally, we qualitatively assessed use of pen space using motion heat maps generated using computer vision from video recorded of each pen from 0800 to 1200 h on d 6 and 7 of each experimental period for each pen. These images suggest that calves preferentially used space near the perimeter of the pen, but space was used more uniformly when space allowance is restricted. Overall, these results suggest that lower space allowances may restrict patterns of activity at the pen level and reduce behavioral synchrony.

Published
2024
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17. Assessing Departmental Readiness to Support Minoritized Faculty

Author

Wendy Y. Carter-Veale, Robin H. Cresiski, Gwen Sharp, Jordan D. Lankford, and Fadel Ugarte

Abstract

Though increasing numbers of racially and ethnically minoritized (REM) individuals earn PhDs and national initiatives focus on faculty diversity, challenges persist in recruiting, hiring, and retaining REM faculty. While a pervasive issue nationally, the literature predominantly focuses on faculty diversity at research-intensive institutions. This exploratory case study pilots a readiness instrument to evaluate the commitment and willingness of a biomedical department at a primarily undergraduate institution to embrace faculty diversity before initiating a postdoctoral faculty conversion program. We introduce the Community Readiness Model (CRM) into an academic context, offering academic departments a robust framework and tool to evaluate readiness and capacity to recruit, retain, and support REM faculty.

Published
2024
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18. Point-of-care biochemistry for primary healthcare in low-middle income countries: a qualitative inquiry

Author

Martínez-Pérez, Guillermo Z., Adetunji, Tajudin Adesegun, Salas Noriega, Fátima Judith Leonela, Amoo, Olufemi Samuel, Ugarte-Gil, Cesar, Ajeigbe, Abiodun Kofoworola, Adefehinti, Olufemi, Akinroye, Kingsley K., Kolawole, Babatope, Odeyemi, Kofoworola, Shilton, Sonjelle, Vetter, Beatrice, Reipold, Elena Ivanova, and Foláyan, Morẹ́nikẹ Oluwátóyìn

Published
2024
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21. Binary progenitor systems for Type Ic supernovae

Author

Solar, Martín, Michałowski, Michał J., Nadolny, Jakub, Galbany, Lluís, Hjorth, Jens, Zapartas, Emmanouil, Sollerman, Jesper, Hunt, Leslie, Klose, Sylvio, Koprowski, Maciej, Leśniewska, Aleksandra, Małkowski, Michał, Nicuesa Guelbenzu, Ana M., Ryzhov, Oleh, Savaglio, Sandra, Schady, Patricia, Schulze, Steve, de Ugarte Postigo, Antonio, Vergani, Susanna D., Watson, Darach, and Wróblewski, Radosław

Published
2024
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22. Design, develop, and implement the strategic information system on health, dependence, and healthy aging: an analysis of the Mexican experience

Author

Gutierrez-Robledo, Luis Miguel, García-Chanes, Rosa Estela, Max-Monroy, Emely Estefanía, Giraldo-Rodríguez, Liliana, Álvarez-Cisneros, Teresa, Gómez-Ugarte, Ana Cristina, de la Rosa-Parra, José Antonio, Estévez-Pedraza, Ángel Gabriel, Rebollar-Castelán, Fernando, Montaño-Serrano, Víctor, Cuero-Muciño, Francisco Gerson, Rivera-González, Roberto Carlos, Yeverino-Castro, Sara Gabriela, Rojas-Huerta, Abigail Vanessa, Ramírez-Fernández, Luis Octavio, González-González, Cesar, Yeomans-Almada, Santiago, and García-Peña, Carmen

Published
2024
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26. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
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28. An artificial intelligence approach of feature engineering and ensemble methods depicts the rumen microbiome contribution to feed efficiency in dairy cows

Author

Monteiro, Hugo F., Figueiredo, Caio C., Mion, Bruna, Santos, José Eduardo P., Bisinotto, Rafael S., Peñagaricano, Francisco, Ribeiro, Eduardo S., Marinho, Mariana N., Zimpel, Roney, da Silva, Ana Carolina, Oyebade, Adeoye, Lobo, Richard R., Coelho Jr, Wilson M., Peixoto, Phillip M. G., Ugarte Marin, Maria B., Umaña-Sedó, Sebastian G., Rojas, Tomás D. G., Elvir-Hernandez, Modesto, Schenkel, Flávio S., Weimer, Bart C., Brown, C. Titus, Kebreab, Ermias, and Lima, Fábio S.

Published
2024
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30. Development of a novel clinimetric tool: PAtient Reported Disease Activity Index in Rheumatoid Arthritis (PARDAI-RA) by PANLAR, for the assessment of patients living with rheumatoid arthritis

Author

Fernández-Ávila, Daniel G., Patiño-Hernández, Daniela, Moreno-Luna, Socorro, Brance, Lorena, Arbeláez, Álvaro, Vilar, Antonio Cachafeiro, Lozada, Carlos, Ríos, Carlos, Toro, Carlos, Ramírez, Claudia, Pons-Estel, Guillermo, Ugarte-Gil, Manuel, Narváez, María, Albanese, Miguel, Roa, Orlando, Ruiz, Oscar, Burgos, Paula, Xavier, Ricardo, Fuentes, Yurilis, and Soriano, Enrique

Published
2024
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32. Olfactory repellents as perceptual traps for mesocarnivores immersed in livestock systems

Author

Carolina S. Ugarte, Carolina Saavedra, and Javier A. Simonetti

Subjects
Carnivore-livestock conflict, Perceptual traps, The landscape of fear, Fox behavior, Olfactory repellents, Carnivore conservation, Ecology, QH540-549.5, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Predation risk is perceived by prey and mesocarnivores through risk signals given by large carnivores. These signals can be manipulated without exposing mesocarnivores to real risk, creating landscapes of fear through perceptual traps, altering behavior. Olfactory signals like urine and feces have been used to deter carnivores that predate on livestock, but a more biologically meaningful cue could be more effective. Livestock guardian dogs (LGD) deter carnivores and reduce predation, so using their whole-body odor as a risk signal in a livestock system could contribute to reduce livestock-carnivore conflict. We tested LGD whole-body odor effect on Patagonian foxes (Lycalopex culpaeus and Lycalopex griseus) present in sheep production in three different habitats—forest, scrubland and pastureland—and analyzed behavioral changes. The presence of LGD whole-body odor reduce the presence of foxes in scrubland habitats and could increase fear behavior and reduced food consumption compared to non-scented places. This technique could act as a complement to LGD, amplifying its effect, but the habitat characteristics must be considered to make it effective. LGD whole-body odor, a more realistic risk signal, representing the presence of LGD without exposing mesocarnivores to a real encounter, i.e. a perceptual trap, could contribute to reduce livestock losses and carnivore threats from livestock owners, aiming to facilitate coexistence between livestock production and native carnivores.

Published
2024
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34. RNA-guided RNA silencing by an Asgard archaeal Argonaute

Author

Carolien Bastiaanssen, Pilar Bobadilla Ugarte, Kijun Kim, Giada Finocchio, Yanlei Feng, Todd A. Anzelon, Stephan Köstlbacher, Daniel Tamarit, Thijs J. G. Ettema, Martin Jinek, Ian J. MacRae, Chirlmin Joo, Daan C. Swarts, and Fabai Wu

Subjects
Science
Abstract

Abstract Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into two clades: AGOs generally facilitate miRNA- or siRNA-mediated silencing, while PIWIs generally facilitate piRNA-mediated silencing. It is currently unclear when and how Argonaute-based RNA silencing mechanisms arose and diverged during the emergence and early evolution of eukaryotes. Here, we show that in Asgard archaea, the closest prokaryotic relatives of eukaryotes, an evolutionary expansion of Argonaute proteins took place. In particular, a deep-branching PIWI protein (HrAgo1) encoded by the genome of the Lokiarchaeon ‘Candidatus Harpocratesius repetitus’ shares a common origin with eukaryotic PIWI proteins. Contrasting known prokaryotic Argonautes that use single-stranded DNA as guides and/or targets, HrAgo1 mediates RNA-guided RNA cleavage, and facilitates gene silencing when expressed in human cells and supplied with miRNA precursors. A cryo-EM structure of HrAgo1, combined with quantitative single-molecule experiments, reveals that the protein displays structural features and target-binding modes that are a mix of those of eukaryotic AGO and PIWI proteins. Thus, this deep-branching archaeal PIWI may have retained an ancestral molecular architecture that preceded the functional and mechanistic divergence of eukaryotic AGOs and PIWIs.

Published
2024
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35. Transcranial electrical stimulation modulates emotional experience and metabolites in the prefrontal cortex in a donation task

Author

Luiza Mugnol-Ugarte, Tiago Bortolini, Bo Yao, Mark Mikkelsen, Marina Carneiro Monteiro, Ana Carolina Andorinho de Freitas Ferreira, Ivanei Bramatti, Bruno Melo, Sebastian Hoefle, Fernanda Meireles, Jorge Moll, and Gorana Pobric

Subjects
Medicine, Science
Abstract

Abstract Understanding the neural, metabolic, and psychological mechanisms underlying human altruism and decision-making is a complex and important topic both for science and society. Here, we investigated whether transcranial Direct Current Stimulation (tDCS) applied to two prefrontal cortex regions, the ventromedial prefrontal cortex (vmPFC, anode) and the right dorsolateral prefrontal cortex (DLPFC, cathode) can induce changes in self-reported emotions and to modulate local metabolite concentrations. We employed in vivo quantitative MR Spectroscopy in healthy adult participants and quantified changes in GABA and Glx (glutamate + glutamine) before and after five sessions of tDCS delivered at 2 mA for 20 min (active group) and 1 min (sham group) while participants were engaged in a charitable donation task. In the active group, we observed increased levels of GABA in vmPFC. Glx levels decreased in both prefrontal regions and self-reported happiness increased significantly over time in the active group. Self-reported guiltiness in both active and sham groups tended to decrease. The results indicate that self-reported happiness can be modulated, possibly due to changes in Glx concentrations following repeated stimulation. Therefore, local changes may induce remote changes in the reward network through interactions with other metabolites, previously thought to be unreachable with noninvasive stimulation techniques.

Published
2024
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38. Exposing postdocs to multiple institutional types: a PROMISE-ing intervention to prepare biomedical faculty

Author

Robin H. Cresiski, Fadel Ugarte, LaKeisha Harris, and Jessica K. Clark

Subjects
postdoctoral, faculty, diversity, AGEP, university system, Education (General), L7-991
Abstract

Biomedical faculty positions require experience as a postdoctoral scholar (or “postdoc”). However, there is a current misalignment with postdoctoral training and workforce needs within higher education. The majority of postdocs are trained to be research faculty while completing fellowships at research-intensive universities, despite the fact that the majority of US higher educational institutions (where these postdocs may be employed) focus on undergraduate education. This leads to postdoctoral scholars not having the opportunity to gain exposure to different institutional types where they could be employed. Importantly, they also lack the opportunity to build a network or receive mentorship from faculty at non-R1 institutions. This may be particularly true of underrepresented scholars. In this brief report, we describe the practice of the NSF-funded PROMISE Academy Alliance to bridge this training gap and support greater preparation for faculty careers at an array of institutional types by leveraging collaboration within a state university system. A survey of PROMISE Academy Fellows about their structured experiences engaging with other campuses (e.g., campus tours, workshops, speaking opportunities) reveals that visits to other campuses within the state system are informative and impactful, both on their research and their employment interests. The positive findings can hopefully inspire easy-to-implement changes in postdoctoral support across other university systems or regional consortia.

Published
2024
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40. Heavy-element production in a compact object merger observed by JWST

Author

Levan, Andrew J., Gompertz, Benjamin P., Salafia, Om Sharan, Bulla, Mattia, Burns, Eric, Hotokezaka, Kenta, Izzo, Luca, Lamb, Gavin P., Malesani, Daniele B., Oates, Samantha R., Ravasio, Maria Edvige, Rouco Escorial, Alicia, Schneider, Benjamin, Sarin, Nikhil, Schulze, Steve, Tanvir, Nial R., Ackley, Kendall, Anderson, Gemma, Brammer, Gabriel B., Christensen, Lise, Dhillon, Vikram S., Evans, Phil A., Fausnaugh, Michael, Fong, Wen-fai, Fruchter, Andrew S., Fryer, Chris, Fynbo, Johan P. U., Gaspari, Nicola, Heintz, Kasper E., Hjorth, Jens, Kennea, Jamie A., Kennedy, Mark R., Laskar, Tanmoy, Leloudas, Giorgos, Mandel, Ilya, Martin-Carrillo, Antonio, Metzger, Brian D., Nicholl, Matt, Nugent, Anya, Palmerio, Jesse T., Pugliese, Giovanna, Rastinejad, Jillian, Rhodes, Lauren, Rossi, Andrea, Saccardi, Andrea, Smartt, Stephen J., Stevance, Heloise F., Tohuvavohu, Aaron, van der Horst, Alexander, Vergani, Susanna D., Watson, Darach, Barclay, Thomas, Bhirombhakdi, Kornpob, Breedt, Elmé, Breeveld, Alice A., Brown, Alexander J., Campana, Sergio, Chrimes, Ashley A., D’Avanzo, Paolo, D’Elia, Valerio, De Pasquale, Massimiliano, Dyer, Martin J., Galloway, Duncan K., Garbutt, James A., Green, Matthew J., Hartmann, Dieter H., Jakobsson, Páll, Kerry, Paul, Kouveliotou, Chryssa, Langeroodi, Danial, Le Floc’h, Emeric, Leung, James K., Littlefair, Stuart P., Munday, James, O’Brien, Paul, Parsons, Steven G., Pelisoli, Ingrid, Sahman, David I., Salvaterra, Ruben, Sbarufatti, Boris, Steeghs, Danny, Tagliaferri, Gianpiero, Thöne, Christina C., de Ugarte Postigo, Antonio, and Kann, David Alexander

Published
2024
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41. Surgical site occurrence after prophylactic use of mesh for prevention of incisional hernia in midline laparotomy: systematic review and meta-analysis of randomized clinical trials

Author

Lozada Hernández, Edgard Efrén, Maldonado Barrios, Irma Lisseth, Amador Ramírez, Sebastián, Rodríguez Casillas, Jonathan Lennie, Hinojosa Ugarte, Diego, Smolinski Kurek, Rafal Ludwik, Crocco Quirós, Bruno, Cethorth Fonseca, Roland Kevin, Sánchez Téran, Alfonso, and Macias Grageda, Michelle

Published
2024
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44. Ventilación con liberación de presión en la vía aérea y posición prono en el síndrome de distrés respiratorio agudo grave por SARS-CoV-2: reporte de caso

Author

Rita Pino-Pino, Emilia Guajardo-Moyano, Felipe Castillo-Merino, and Sebastián Ugarte-Ubiergo

Subjects
APRV, COVID-19, síndrome de distrés respiratorio agudo (SDRA), Medicine
Abstract

Resumen: COVID-19 tuvo un amplio espectro de manifestaciones clínicas, desde formas asintomáticas hasta graves. Un porcentaje significativo de sujetos infectados desarrolla el síndrome de distrés respiratorio agudo (SDRA). Objetivo: uso de posición prono y ventilación con liberación de presión de las vías respiratorias (APRV), para mejorar la oxigenación en un paciente con SDRA por COVID-19. Caso clínico: paciente de 73 años, con diabetes e hipertensión arterial, presenta diagnóstico de neumonía por COVID-19 grave, que requirió uso de ventilación mecánica invasiva (VMI). En contexto de oxigenación deficiente, difícil sedación y deterioro gasométrico, se inicia APRV. Con el avance del compromiso pulmonar, las estrategias ventilatorias fueron poco fructíferas por lo que se decide utilizar prono + APRV. Resultados: un total de 574 horas en VMI y 274 horas en prono divididos en 3 ciclos de duración. Los primeros ciclos de prono + APRV fueron relevantes en cuanto mejoras en PaO2/FiO2 (PaFi), sin embargo, a partir del tercer evento en prono, no hubo cambios significativos. Conclusiones: prono + APRV fue adecuada a los requerimientos del paciente, sin embargo, el curso clínico de la enfermedad produjo un deterioro irreversible. Abstract: COVID-19 had a wide spectrum of clinical manifestations, from asymptomatic to severe forms. A significant percentage of infected subjects develop acute respiratory distress syndrome (ARDS). Objective: Use of prone position and airway pressure release ventilation (APRV) to improve oxygenation in a patient with COVID-19 ARDS. Clinical case: 73-year-old patient, with diabetes and high blood pressure, presented with a diagnosis of severe COVID-19 pneumonia, which required the use of invasive mechanical ventilation (IMV). In the context of poor oxygenation, difficult sedation and blood gas deterioration, APRV is started. With the progression of pulmonary involvement, ventilatory strategies were not very fruitful, so it was decided to use prone + APRV. Results: a total of 574 hours in IMV and 274 hours in prone divided into 3 cycles of duration. The first cycles of prone + APRV were relevant in terms of improvements in PaO2/FiO2 (PaFi), however, from the third prone event, there were no significant changes. Conclusions: prone + APRV was adequate to the patient's requirements, however, the clinical course of the disease produced irreversible deterioration.

Published
2024
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45. Protein sequence analysis in the context of drug repurposing

Author

Natalia García Sánchez, Esther Ugarte Carro, Lucía Prieto-Santamaría, and Alejandro Rodríguez-González

Subjects
Drug repurposing, Sequence analysis, Protein sequences, Embedding vectors, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Motivation Drug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery. There are numerous biological elements that contribute to the development of diseases and, as a result, to the repurposing of drugs. Methods In this article, we analysed the potential role of protein sequences in drug repurposing scenarios. For this purpose, we embedded the protein sequences by performing four state of the art methods and validated their capacity to encapsulate essential biological information through visualization. Then, we compared the differences in sequence distance between protein-drug target pairs of drug repurposing and non - drug repurposing data. Thus, we were able to uncover patterns that define protein sequences in repurposing cases. Results We found statistically significant sequence distance differences between protein pairs in the repurposing data and the rest of protein pairs in non-repurposing data. In this manner, we verified the potential of using numerical representations of sequences to generate repurposing hypotheses in the future.

Published
2024
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46. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K. Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O’Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K. Abdoun, Hytham K. S. Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D. Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M. Bardes, Sirivan Suon Seng, Lauren S. Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M. Napolitano, Naveen F. Sangji, Mark Hemmila, Jacob A. Quick, Tyler R. Austin, Theodore S. Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L. Biffl, Hung P. Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, and Fausto Catena

Subjects
Hartmann’s procedure, Ostomy, Emergency surgery, Resection, Primary anastomosis, Left side, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P

Published
2024
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47. Esti Vivancoren Egun gorriak (2019) eleberriaren azterketa: futbol-literatura eta hezkuntza

Author

Oihane Calvo Ugarte

Subjects
football literature, primary education, emotions, values, Education (General), L7-991
Abstract

The main objective of this research is to establish a relationship between football literature and education, analysing the pedagogical value of football literature. For this purpose, based on the novel Egun gorriak (2019) by Esti Vivanco, a narratological analysis of the novel has been carried out, following the model of Gérard Genette (1989), and subsequently, based on the classification models of Rafael Bisquerra (2009) and Ricardo Marín Ibáñez (1976), the emotions and values displayed in the novel have been studied. Hence, it has been concluded that football literature can be a potential tool for education, since it not only awakens their motivation and interest, but when football is turned into words, it provides the opportunity to work on emotions and values.

Published
2024
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48. Numerical performance of CO2 accumulation and droplet dispersion from a cough inside a hospital lift under different ventilation strategies

Author

Sergio A. Chillón, Unai Fernandez-Gamiz, Ekaitz Zulueta, Ainara Ugarte-Anero, and Jesus Maria Blanco

Subjects
CFD, COVID-19, Interior ventilation, Droplet contagious, Airborne transmission, Cough, Medicine, Science
Abstract

Abstract The impact of mechanical ventilation on airborne diseases is not completely known. The recent pandemic of COVID-19 clearly showed that additional investigations are necessary. The use of computational tools is an advantage that needs to be included in the study of designing safe places. The current study focused on a hospital lift where two subjects were included: a healthy passenger and an infected one. The elevator was modelled with a fan placed on the middle of the ceiling and racks for supplying air at the bottom of the lateral wall. Three ventilation strategies were evaluated: a without ventilation case, an upwards-blowing exhausting fan case and a downwards-blowing fan case. Five seconds after the elevator journey began, the infected person coughed. For the risk assessment, the CO2 concentration, droplet removal performance and dispersion were examined and compared among the three cases. The results revealed some discrepancies in the selection of an optimal ventilation strategy. Depending on the evaluated parameter, downward-ventilation fan or no ventilation strategy could be the most appropriate approach.

Published
2024
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49. Bankers are afraid of technology now: explaining perceived vulnerability to technological change among the higher-educated

Author

Carlo Knotz, Andrey Ugarte Montero, Maude Lavanchy, and Joël Wagner

Subjects
Labour markets, technological change, artificial intelligence, perceived vulnerability, Political science
Abstract

The higher-educated are typically seen as winners of technological change and automation, but recent evidence shows that many higher-educated workers are, in fact, concerned about losing their jobs to technology. The reasons why higher-educated workers are worried about technological change are not yet clear, however. We analyse survey data from 25 countries to resolve this puzzle. Our results indicate, in a nutshell, that many higher-educated workers are concerned about being replaced by ‘artificial intelligence’ (AI) and related technologies. Specifically, we find that perceived technological vulnerability among the higher-educated is strongly linked to working in the finance and IT sectors – which are known to be particularly heavily exposed to advances in AI technology. We discuss the implications of technological vulnerability among the higher-educated for social solidarity and political conflict in digitalizing economies.

Published
2024
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