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Your search keyword '"Udisti, R."' showing total 239 results
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239 results on '"Udisti, R."'

2. Prominent features in isotopic, chemical and dust stratigraphies from coastal East Antarctic ice sheet (Eastern Wilkes Land)

Author

Caiazzo, L., Baccolo, G., Barbante, C., Becagli, S., Bertò, M., Ciardini, V., Crotti, I., Delmonte, B., Dreossi, G., Frezzotti, M., Gabrieli, J., Giardi, F., Han, Y., Hong, S.-B., Hur, S.D., Hwang, H., Kang, J.-H., Narcisi, B., Proposito, M., Scarchilli, C., Selmo, E., Severi, M., Spolaor, A., Stenni, B., Traversi, R., and Udisti, R.

Published
2017
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23. Changes in environment over the last 800,000 years from chemical analysis of the EPICA Dome C ice core

Author

Wolff, E.W., Barbante, C., Becagli, S., Bigler, M., Boutron, C.F., Castellano, E., de Angelis, M., Federer, U., Fischer, H., Fundel, F., Hansson, M., Hutterli, M., Jonsell, U., Karlin, T., Kaufmann, P., Lambert, F., Littot, G.C., Mulvaney, R., Röthlisberger, R., Ruth, U., Severi, M., Siggaard-Andersen, M.L., Sime, L.C., Steffensen, J.P., Stocker, T.F., Traversi, R., Twarloh, B., Udisti, R., Wagenbach, D., and Wegner, A.

Published
2010
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31. One-to-one coupling of glacial climate variability in Greenland and Antarctica

Author

Barbante, C., Barnola, J.-M., Becagli, S., Beer, J., Bigler, M., Boutron, C., Blunier, T., Castellano, E., Cattani, O., Chappellaz, J., Dahl-Jensen, D., Debret, M., Delmonte, B., Dick, D., Falourd, S., Faria, S., Federer, U., Fischer, H., Freitag, J., Frenzel, A., Fritzsche, D., Fundel, F., Gabrielli, P., Gaspari, V., Gersonde, R., Graf, W., Grigoriev, D., Hamann, I., Hansson, M., Hoffmann, G., Hutterli, M. A., Huybrechts, P., Isaksson, E., Johnsen, S., Jouzel, J., Kaczmarska, M., Karlin, T., Kaufmann, P., Kipfstuhl, S., Kohno, M., Lambert, F., Lambrecht, Anja, Lambrecht, Astrid, Landais, A., Lawer, G., Leuenberger, M., Littot, G., Loulergue, L., Luthi, D., Maggi, V., Marino, F., Masson-Delmotte, V., Meyer, H., Miller, H., Mulvaney, R., Narcisi, B., Oerlemans, J., Oerter, H., Parrenin, F., Petit, J.-R., Raisbeck, G., Raynaud, D., Rothlisberger, R., Ruth, U., Rybak, O., Severi, M., Schmitt, J., Schwander, J., Siegenthaler, U., Siggaard-Andersen, M.-L., Spahni, R., Steffensen, J. P., Stenni, B., Stocker, T. F., Tison, J.-L., Traversi, R., Udisti, R., Valero-Delgado, F., van den Broeke, M. R., van de Wal, R. S. W., Wagenbach, D., Wegner, A., Weiler, K., Wilhelms, F., Winther, J.-G., and Wolff, E.

Abstract

Author(s): EPICA Community Members; EPICA Community Members; C. Barbante [1, 2]; J.-M. Barnola [3]; S. Becagli [4]; J. Beer [5]; M. Bigler [6, 7]; C. Boutron [3]; T. Blunier [6]; [...]

Published
2006
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32. Southern Ocean sea-ice extent, productivity and iron flux over the past eight glacial cycles

Author

Wolff, E. W., Fischer, H., Fundel, F., Ruth, U., Twarloh, B., Littot, G. C., Mulvaney, R., Rothlisberger, R., de Angelis, M., Boutron, C. F., Hansson, M., Jonsell, U., Hutterli, M. A., Lambert, F., Kaufmann, P., Stauffer, B., Stocker, T. F., Steffensen, J. P., Bigler, M., Siggaard-Andersen, M. L., Udisti, R., Becagli, S., Castellano, E., Severi, M., Wagenbach, D., Barbante, C., Gabrielli, P., and Gaspari, V.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): E. W. Wolff (corresponding author) [1]; H. Fischer [2]; F. Fundel [2]; U. Ruth [2]; B. Twarloh [2]; G. C. Littot [1]; R. Mulvaney [1]; R. Rothlisberger [1]; M. [...]

Published
2006
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34. A Combined Observational and Modeling Approach to Study Modern Dust Transport from the Patagonia Desert to East Antarctica

Author

Gasso, S, Stein, A, Marino, F, Castellano, E, Udisti, R, and Ceratto, J

Subjects
Geophysics
Abstract

The understanding of present atmospheric transport processes from Southern Hemisphere (SH) landmasses to Antarctica can improve the interpretation of stratigraphic data in Antarctic ice cores. In addition, long range transport can deliver key nutrients normally not available to marine ecosystems in the Southern Ocean and may trigger or enhance primary productivity. However, there is a dearth of observational based studies of dust transport in the SH. This work aims to improve current understanding of dust transport in the SH by showing a characterization of two dust events originating in the Patagonia desert (south end of South America). The approach is based on a combined and complementary use of satellite retrievals (detectors MISR, MODIS, GLAS ,POLDER, OMI,), transport model simulation (HYSPLIT) and surface observations near the sources and aerosol measurements in Antarctica (Neumayer and Concordia sites). Satellite imagery and visibility observations confirm dust emission in a stretch of dry lakes along the coast of the Tierra del Fuego (TdF) island (approx.54deg S) and from the shores of the Colihue Huapi lake in Central Patagonia (approx.46deg S) in February 2005. Model simulations initialized by these observations reproduce the timing of an observed increase in dust concentration at the Concordia Station and some of the observed increases in atmospheric aerosol absorption (here used as a dust proxy) in the Neumayer station. The TdF sources were the largest contributors of dust at both sites. The transit times from TdF to the Neumayer and Concordia sites are 6-7 and 9-10 days respectively. Lidar observations and model outputs coincide in placing most of the dust cloud in the boundary layer and suggest significant de- position over the ocean immediately downwind. Boundary layer dust was detected as far as 1800 km from the source and approx.800 km north of the South Georgia Island over the central sub-Antarctic Atlantic Ocean. Although the analysis suggests the presence of dust at approx.1500 km SW of South Africa five days after, the limited capabilities of existing satellite platforms to differentiate between aerosol types do not permit a definitive conclusion. In addition, the model simulations show dust lifting to the free troposphere as it travels south but it could not be confirmed by the satellite observations due to cloudiness. This work demonstrates that complementary information from existing transport models, satellite and surface data can yield a consistent picture of the dust transport from the Patagonia desert to Antarctica. It also illustrates the limitation of using any of these approaches individually to characterize the transport of dust in a heavily cloudy area.

Published
2010
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40. The combined activation of K Ca 3.1 and inhibition of K v 11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells

Author

Pillozzi, S, D'Amico, M, Bartoli, G, Gasparoli, L, Petroni, G, Crociani, O, Marzo, T, Guerriero, A, Messori, L, Severi, M, Udisti, R, Wulff, H, Chandy, KG, Becchetti, A, and Arcangeli, A

Subjects
preclinical mouse models, Riluzole, Cisplatin uptake, SKA-31, E4031
Abstract

Background:Platinum-based drugs such as Cisplatin are commonly employed for cancer treatment. Despite an initial therapeutic response, Cisplatin treatment often results in the development of chemoresistance. To identify novel approaches to overcome Cisplatin resistance, we tested Cisplatin in combination with K + channel modulators on colorectal cancer (CRC) cells.Methods:The functional expression of Ca 2+ -activated (K Ca 3.1, also known as KCNN4) and voltage-dependent (K v 11.1, also known as KCNH2 or hERG1) K + channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. Cisplatin and several K + channel modulators were tested in vitro for their action on K + currents, cell vitality, apoptosis, cell cycle, proliferation, intracellular signalling and Platinum uptake. These effects were also analysed in a mouse model mimicking Cisplatin resistance.Results:Cisplatin-resistant CRC cells expressed higher levels of K Ca 3.1 and K v 11.1 channels, compared with Cisplatin-sensitive CRC cells. In resistant cells, K Ca 3.1 activators (SKA-31) and K v 11.1 inhibitors (E4031) had a synergistic action with Cisplatin in triggering apoptosis and inhibiting proliferation. The effect was maximal when K Ca 3.1 activation and K v 11.1 inhibition were combined. In fact, similar results were produced by Riluzole, which is able to both activate K Ca 3.1 and inhibit K v 11.1. Cisplatin uptake into resistant cells depended on K Ca 3.1 channel activity, as it was potentiated by K Ca 3.1 activators. K v 11.1 blockade led to increased K Ca 3.1 expression and thereby stimulated Cisplatin uptake. Finally, the combined administration of a K Ca 3.1 activator and a K v 11.1 inhibitor also overcame Cisplatin resistance in vivo.Conclusions:As Riluzole, an activator of K Ca 3.1 and inhibitor of K v 11.1 channels, is in clinical use, our results suggest that this compound may be useful in the clinic to improve Cisplatin efficacy and overcome Cisplatin resistance in CRC.

Published
2018
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