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4. Clinical features and oncological outcomes of intestinal cancers associated with ulcerative colitis and Crohn’s disease

Author

Noguchi, Tatsuki, Ishihara, Soichiro, Uchino, Motoi, Ikeuchi, Hiroki, Okabayashi, Koji, Futami, Kitaro, Tanaka, Shinji, Ohge, Hiroki, Nagahara, Hisashi, Watanabe, Kazuhiro, Itabashi, Michio, Okamoto, Kinya, Okita, Yoshiki, Mizushima, Tsunekazu, Mizuuchi, Yusuke, Yamada, Kazutaka, Shimada, Yoshifumi, Sato, Yu, Kimura, Hideaki, Takahashi, Kenichi, Hida, Koya, Kinugasa, Yusuke, Okuda, Junji, Daito, Koji, Koyama, Fumikazu, Ueno, Hideki, Yamamoto, Takayuki, Hanai, Tsunekazu, Maemoto, Atsuo, Oba, Koji, Ajioka, Yoichi, and Sugihara, Kenichi

Published
2023
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5. Short-term clinical evaluation of teduglutide for patients with Crohn's disease on home parenteral support for postoperative short bowel syndrome with intestinal failure

Author

Sato, Toshiyuki, Uchino, Motoi, Takeuchi, Jiro, Fujihira, Yutaro, Shimizu, Kazuma, Yokoyama, Keiko, Yagi, Soichi, Kaku, Koji, Takashima, Yusuke, Ikenouchi, Maiko, Kojima, Kentaro, Kawai, Mikio, Nagase, Kazuko, Kamikozuru, Koji, Yokoyama, Yoko, Takagawa, Tetsuya, Ikeuchi, Hiroki, Watanabe, Kenji, and Shinzaki, Shinichiro

Published
2023
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10. Enhanced loading dose of teicoplanin for three days is required to achieve a target trough concentration of 20 μg/mL in patients receiving continuous venovenous haemodiafiltration with a low flow rate

Author

Ueda, Takashi, Takesue, Yoshio, Nakajima, Kazuhiko, Ichiki, Kaoru, Ishikawa, Kaori, Yamada, Kumiko, Tsuchida, Toshie, Otani, Naruhito, Ide, Takeshi, Takeda, Kenta, Nishi, Shinichi, Takahashi, Yoshiko, Ishihara, Mika, Takubo, Shingo, Ikeuchi, Hiroki, Uchino, Motoi, and Kimura, Takeshi

Published
2022
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11. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

Author

Nakase, Hiroshi, Uchino, Motoi, Shinzaki, Shinichiro, Matsuura, Minoru, Matsuoka, Katsuyoshi, Kobayashi, Taku, Saruta, Masayuki, Hirai, Fumihito, Hata, Keisuke, Hiraoka, Sakiko, Esaki, Motohiro, Sugimoto, Ken, Fuji, Toshimitsu, Watanabe, Kenji, Nakamura, Shiro, Inoue, Nagamu, Itoh, Toshiyuki, Naganuma, Makoto, Hisamatsu, Tadakazu, Watanabe, Mamoru, Miwa, Hiroto, Enomoto, Nobuyuki, Shimosegawa, Tooru, and Koike, Kazuhiko

Published
2021
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13. Possible poor prognosis in younger‐onset Crohn's disease‐associated anorectal cancer: A subanalysis of the Nationwide Japanese study.

Author

Okita, Yoshiki, Toiyama, Yuji, Ikeuchi, Hiroki, Uchino, Motoi, Futami, Kitaro, Okamoto, Kinya, Noguchi, Tatsuki, Sugihara, Kenichi, Ishihara, Soichiro, and Ajioka, Yoichi

Subjects
CROHN'S disease, CELIAC disease, INTESTINAL cancer, PROGNOSIS, JAPANESE people, PROGRESSION-free survival
Abstract

Background and aims: Crohn's disease (CD)‐associated intestinal cancers are characterized by their high incidence, particularly at the anorectal site in the Japanese population. Accumulating evidence revealed that younger‐onset sporadic colorectal cancer may exhibit unique biological features. To the best of our knowledge, few previous articles reported clinicopathological features in patients with CD‐associated anorectal cancer (CDAAC). Therefore, we aimed to clarify the relationship between the younger onset of cancer and clinicopathological characteristics and prognosis, and the efficacy of cancer surveillance in patients with CDAAC. Methods: CD patients who had been diagnosed with intestinal cancers from 1983 to 2020 were collected from 39 Japanese institutions in this study. Of 316 patients with CD‐associated intestinal cancers, we analyzed 211 patients with CDAAC. We divided the patients into two groups according to the median age at cancer diagnosis (45 years old). Results: Younger‐onset CDAAC (YO‐CDAAC) patients were significantly more likely to have a poor outcome than those with older‐onset CDAAC (OO‐CDAAC) in terms of both disease‐free survival (DFS) (p = 0.0014) and overall survival (OS) (p = 0.023). Multivariate analysis showed that age under 45 years old at diagnosis of cancer was one of the independent factors for poor DFS and OS (hazard ratios: 2.15, 95% confidence interval: 1.09–4.26, p = 0.028, hazard ratios: 1.95, 95% confidence interval: 1.05–3.60, p = 0.033, respectively). Patients detected via surveillance showed significantly better DFS and OS rates than symptomatic patients in YO‐CDAAC (p = 0.012 and 0.0031, respectively). Conclusions: YO‐CDAAC may have a poorer prognosis compared with OO‐CDAAC. Surveillance could be important to improve cancer prognosis, especially in young CD patients with anorectal disease. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Association between the hypokalaemia index based on area over the serum potassium concentration curve and occurrence of acute kidney injury in patients administered liposomal amphotericin B.

Author

Ueda, Takashi, Nakajima, Kazuhiko, Ichiki, Kaoru, Ishikawa, Kaori, Yamada, Kumiko, Tsuchida, Toshie, Otani, Naruhito, Takubo, Shingo, Iijima, Kosuke, Uchino, Motoi, Horio, Yuki, Kuwahara, Ryuichi, Kimura, Takeshi, Murakami, Yasushi, Nozaki, Yasuhiro, Nakama, Soichiro, Miyazaki, Yoshitsugu, and Takesue, Yoshio

Subjects
ACUTE kidney failure, AMPHOTERICIN B, HYPOKALEMIA, KIDNEYS, POTASSIUM
Abstract

Background: Acute kidney injury (AKI) and hypokalaemia are common adverse events after treatment with liposomal amphotericin B (L‐AMB). Objectives: Because excess potassium (K) leakage occurs during renal tubular injury caused by L‐AMB, measuring the decrease in rate of serum K concentration might be more useful to assess the renal impact of L‐AMB than hypokalaemia identified from a one‐point measurement. The effects of a decrease in K concentration and duration of hypokalaemia on AKI were investigated. Methods: A ≥ 10% decrease in K concentration from the reference concentration within a 7‐day timeframe was evaluated. The hypokalaemia index, which combines the duration of K concentration lower than the reference and a marked low K concentration, was calculated from the area over the concentration curve. Results: Eighty‐six patients were included in the study. The incidences of AKI and decrease in K concentration were 36.0% and 63.9%, respectively. Of patients who developed both adverse events, a decrease in K concentration occurred first in 22 of 26 patients, followed by AKI 7 days later. Hypokalaemia did not increase AKI risk whereas a decrease in K concentration was an independent risk factor for AKI. The hypokalaemia index in patients with AKI was significantly higher than those without AKI (5.35 vs. 2.50 points, p = 0.002), and ≥3.45 points was a significant predictor for AKI. Conclusion: A ≥ 10% decrease in the K concentration was a significant factor for AKI in patients receiving L‐AMB therapy. In such patients, dose reduction or alternative antifungals could be considered based on the hypokalaemia index. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Association between preoperative tumor necrosis factor alpha inhibitor and surgical site infection after surgery for inflammatory bowel disease: a systematic review and meta-analysis

Author

Uchino, Motoi, Ikeuchi, Hiroki, Shimizu, Junzo, Ohge, Hiroki, Haji, Seiji, Mizuguchi, Toru, Mohri, Yasuhiko, Yamashita, Chizuru, Kitagawa, Yuichi, Suzuki, Katsunori, Kobayashi, Motomu, Kobayashi, Masahiro, Sakamoto, Fumie, Yoshida, Masahiro, Mayumi, Toshihiko, Hirata, Koichi, and Takesue, Yoshio

Published
2021
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22. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Author

Kakiuchi, Nobuyuki, Yoshida, Kenichi, Uchino, Motoi, Kihara, Takako, Akaki, Kotaro, Inoue, Yoshikage, and Kawada, Kenji

Subjects
Gene mutations -- Forecasts and trends, Ulcerative colitis -- Genetic aspects, Transcription factors -- Analysis, Market trend/market analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer.sup.1-3. However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer development, remains unknown. Here we show that in patients with ulcerative colitis, the inflamed intestine undergoes widespread remodelling by pervasive clones, many of which are positively selected by acquiring mutations that commonly involve the NFKBIZ, TRAF3IP2, ZC3H12A, PIGR and HNRNPF genes and are implicated in the downregulation of IL-17 and other pro-inflammatory signals. Mutational profiles vary substantially between colitis-associated cancer and non-dysplastic tissues in ulcerative colitis, which indicates that there are distinct mechanisms of positive selection in both tissues. In particular, mutations in NFKBIZ are highly prevalent in the epithelium of patients with ulcerative colitis but rarely found in both sporadic and colitis-associated cancer, indicating that NFKBIZ-mutant cells are selected against during colorectal carcinogenesis. In further support of this negative selection, we found that tumour formation was significantly attenuated in Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells. Our results highlight common and discrete mechanisms of clonal selection in inflammatory tissues, which reveal unexpected cancer vulnerabilities that could potentially be exploited for therapeutics in colorectal cancer. In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis., Author(s): Nobuyuki Kakiuchi [sup.1] [sup.2] [sup.3] , Kenichi Yoshida [sup.1] , Motoi Uchino [sup.4] , Takako Kihara [sup.5] , Kotaro Akaki [sup.6] , Yoshikage Inoue [sup.1] [sup.2] [sup.7] , Kenji [...]

Published
2020
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23. Evidence-based diagnosis and clinical practice guidelines for intestinal Behçet’s disease 2020 edited by Intractable Diseases, the Health and Labour Sciences Research Grants

Author

Watanabe, Kenji, Tanida, Satoshi, Inoue, Nagamu, Kunisaki, Reiko, Kobayashi, Kiyonori, Nagahori, Masakazu, Arai, Katsuhiro, Uchino, Motoi, Koganei, Kazutaka, Kobayashi, Taku, Takeno, Mitsuhiro, Ueno, Fumiaki, Matsumoto, Takayuki, Mizuki, Nobuhisa, Suzuki, Yasuo, and Hisamatsu, Tadakazu

Published
2020
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25. Changes in the rate of and trends in colectomy for ulcerative colitis during the era of biologics and calcineurin inhibitors based on a Japanese nationwide cohort study

Author

Uchino, Motoi, Ikeuchi, Hiroki, Hata, Keisuke, Okada, Satoshi, Ishihara, Soichiro, Morimoto, Koji, Sahara, Rikisaburo, Watanabe, Kazuhiro, Fukushima, Kouhei, Takahashi, Kenichi, Kimura, Hideaki, Hirata, Keiji, Mizushima, Tsunekazu, Araki, Toshimitsu, Kusunoki, Masato, Nezu, Riichiro, Nakao, Sayumi, Itabashi, Michio, Hirata, Akira, Ozawa, Heita, Ishida, Takashi, Okabayashi, Koji, Yamamoto, Takayuki, Noake, Toshihiro, Arakaki, Junya, Watadani, Yusuke, Ohge, Hiroki, Futatsuki, Ryo, Koganei, Kazutaka, Sugita, Akira, Higashi, Daijiro, and Futami, Kitaro

Published
2019
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27. Histological differentiation between sporadic and colitis‐associated intestinal cancer in a nationwide study: A propensity‐score‐matched analysis.

Author

Uchino, Motoi, Ikeuchi, Hiroki, Noguchi, Tatsuki, Okabayashi, Koji, Futami, Kitaro, Tanaka, Shinji, Ohge, Hiroki, Watanabe, Kazuhiro, Itabashi, Michio, Okamoto, Kinya, Okita, Yoshiki, Mizushima, Tsunekazu, Mizuuchi, Yusuke, Yamada, Kazutaka, Shimada, Yoshifumi, Sato, Yu, Kimura, Hideaki, Takahashi, Kenichi, Hida, Koya, and Kinugasa, Yusuke

Subjects
*INTESTINAL cancer, *CROHN'S disease, *INFLAMMATORY bowel diseases, *MUCINOUS adenocarcinoma, *ULCERATIVE colitis
Abstract

Background and Aim: Colitis‐associated intestinal cancer (CAC) can develop in patients with inflammatory bowel disease; however, the malignant grade of CAC may differ from that of sporadic colorectal cancer (CRC). Therefore, we compared histological findings distinct from cancer stage between CAC and sporadic CRC to evaluate the features of CAC. Methods: We reviewed the clinical and histological data collected from a nationwide database in Japan between 1983 and 2020. Patient characteristics were compared to distinguish ulcerative colitis (UC), Crohn's disease (CD), and sporadic CRC. Comparisons were performed by using all collected data and propensity score‐matched data. Results: A total of 1077 patients with UC‐CAC, 297 with CD‐CAC, and 136 927 with sporadic CRC were included. Although the prevalence of well or moderately differentiated adenocarcinoma (Tub1 and Tub2) decreased according to tumor progression for all diseases (P < 0.01), the prevalence of other histological findings, including signet ring cell carcinoma, mucinous carcinoma, poorly differentiated adenocarcinoma, or squamous cell carcinoma, was significantly higher in CAC than in sporadic CRC. Based on propensity score‐matched data for 982 patients with UC and 268 with CD, the prevalence of histological findings other than Tub1 and Tub2 was also significantly higher in those with CAC. At pT4, mucinous carcinoma occurred at a significantly higher rate in patients with CD (45/86 [52.3%]) than in those with sporadic CRC (13/88 [14.8%]) (P < 0.01). Conclusion: CAC, including early‐stage CAC, has a higher malignant grade than sporadic CRC, and this difference increases in significance with tumor progression. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan

Author

Takesue, Yoshio, Kusachi, Shinya, Mikamo, Hiroshige, Sato, Junko, Watanabe, Akira, Kiyota, Hiroshi, Iwata, Satoshi, Kaku, Mitsuo, Hanaki, Hideaki, Sumiyama, Yoshinobu, Kitagawa, Yuko, Nakajima, Kazuhiko, Ueda, Takashi, Uchino, Motoi, Mizuguchi, Toru, Ambo, Yoshiyasu, Konosu, Masafumi, Ishibashi, Keiichiro, Matsuda, Akihisa, Hase, Kazuo, Harihara, Yasushi, Okabayashi, Koji, Seki, Shiko, Hara, Takuo, Matsui, Koshi, Matsuo, Yoichi, Kobayashi, Minako, Kubo, Shoji, Uchiyama, Kazuhisa, Shimizu, Junzo, Kawabata, Ryohei, Ohge, Hiroki, Akagi, Shinji, Oka, Masaaki, Wakatsuki, Toshiro, Suzuki, Katsunori, Okamoto, Kohji, and Yanagihara, Katsunori

Published
2018
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33. Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn’s disease patients versus mucus

Author

Sekido, Yuki, Nishimura, Junichi, Nakano, Kazuhiro, Osu, Takeaki, Chow, Cheryl-Emiliane T., Matsuno, Hiroshi, Ogino, Takayuki, Fujino, Shiki, Miyoshi, Norikatsu, Takahashi, Hidekazu, Uemura, Mamoru, Matsuda, Chu, Kayama, Hisako, Mori, Masaki, Doki, Yuichiro, Takeda, Kiyoshi, Uchino, Motoi, Ikeuchi, Hiroki, and Mizushima, Tsunekazu

Published
2020
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36. Prognostic impact of tumour location in stage II/III ulcerative colitis-associated colon cancer: subgroup analysis of a nationwide multicentre retrospective study in Japan.

Author

Mizuuchi, Yusuke, Nagayoshi, Kinuko, Nakamura, Masafumi, Ikeuchi, Hiroki, Uchino, Motoi, Futami, Kitaro, Okamoto, Kinya, Mizushima, Tsunekazu, Nagahara, Hisashi, Watanabe, Kazuhiro, Okabayashi, Koji, Yamada, Kazutaka, Ohge, Hiroki, Tanaka, Shinji, Okita, Yoshiki, Sato, Yu, Ueno, Hideki, Maemoto, Atsuo, Itabashi, Michio, and Kimura, Hideaki

Subjects
COLON cancer, SUBGROUP analysis (Experimental design), RETROSPECTIVE studies, TUMORS
Published
2024
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38. Correction to: Long-term clinical outcomes and follow-up status in Japanese patients with familial adenomatous polyposis after radical surgery: a descriptive, retrospective cohort study from a single institute

Author

Babaya, Akihito, Yamano, Tomoki, Matsubara, Takaaki, Takenaka, Yuya, Song, Jihyung, Kimura, Kei, Yasuhara, Michiko, Kataoka, Kozo, Beppu, Naohito, Uchino, Motoi, Ikeda, Masataka, Ikeuchi, Hiroki, Matsubara, Nagahide, Tamura, Kazuo, and Tomita, Naohiro

Published
2021
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39. The Efficacy of Antimicrobial-Coated Sutures for Preventing Incisional Surgical Site Infections in Digestive Surgery: a Systematic Review and Meta-analysis

Author

Uchino, Motoi, Mizuguchi, Toru, Ohge, Hiroki, Haji, Seiji, Shimizu, Junzo, Mohri, Yasuhiko, Yamashita, Chizuru, Kitagawa, Yuichi, Suzuki, Katsunori, Kobayashi, Motomu, Kobayashi, Masahiro, Sakamoto, Fumie, Yoshida, Masahiro, Mayumi, Toshihiko, Hirata, Koichi, and On behalf of the SSI Prevention Guideline Committee of the Japan Society for Surgical Infection

Published
2018
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41. Pouch functional outcomes after restorative proctocolectomy with ileal-pouch reconstruction in patients with ulcerative colitis: Japanese multi-center nationwide cohort study

Author

Uchino, Motoi, Ikeuchi, Hiroki, Sugita, Akira, Futami, Kitaro, Watanabe, Toshiaki, Fukushima, Kouhei, Tatsumi, Kenji, Koganei, Kazutaka, Kimura, Hideaki, Hata, Keisuke, Takahashi, Kenichi, Watanabe, Kazuhiro, Mizushima, Tsunekazu, Funayama, Yuji, Higashi, Daijiro, Araki, Toshimitsu, Kusunoki, Masato, Ueda, Takeshi, Koyama, Fumikazu, Itabashi, Michio, Nezu, Riichiro, Suzuki, Yasuo, and On behalf of a research grant on intractable disease affiliated with the Japan Ministry of Health Labor Welfare

Published
2018
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42. Crohn's Disease-Associated Anorectal Cancer Has a Poor Prognosis With High Local Recurrence: A Subanalysis of the Nationwide Japanese Study.

Author

Takayuki Ogino, Tsunekazu Mizushima, Makoto Fujii, Yuki Sekido, Hidetoshi Eguchi, Riichiro Nezu, Hiroki Ikeuchi, Uchino Motoi, Kitaro Futami, Kinya Okamoto, Hisashi Nagahara, Kazuhiro Watanabe, Koji Okabayashi, Kazutaka Yamada, Hiroki Ohge, Shinji Tanaka, Yusuke Mizuuchi, Yoshiki Ohkita, Yu Sato, and Hideki Ueno

Published
2023
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46. Oncological outcomes of Crohn's disease‐associated cancers focusing on disease behavior.

Author

Yamamoto, Akira, Toiyama, Yuji, Ikeuchi, Hiroki, Uchino, Motoi, Futami, Kitaro, Okamoto, Kinya, Ogino, Takayuki, Ishihara, Soichiro, Ajioka, Yoichi, and Sugihara, Kenichi

Subjects
CROHN'S disease, CANCER patients, OVERALL survival, DISEASE risk factors
Abstract

Background: The overall risk of colorectal cancer in Crohn's disease (CD) is higher than in the general population, and CD‐associated cancer (CDAC) has poorer prognosis than sporadic cancer. Developing treatment strategies for improving the prognosis of CDAC, we evaluated the characteristics of CDAC according to the underlying disease behavior, namely stricturing and penetrating. Methods: This multicenter retrospective study comprises 316 CDAC patients who underwent surgery between 1985 and 2019. Clinicopathological findings including disease behavior and oncological outcomes were investigated. Results: There was no association between the preoperative course of CDAC patients and disease behavior; however, postoperative information revealed distinctly different characteristics between CDAC patients with stricturing behavior and those with penetrating behavior (stricturing with lymphatic invasion and peritoneal dissemination recurrence, and penetrating with histologically poorly differentiated and local recurrence). Oncological outcome of patients with CDAC was distinctly different according to disease behavior, as penetrating provided a poor outcome (overall survival [OS]: p = 0.02; relapse‐free survival [RFS]: p = 0.002) whereas stricturing had no effect. Furthermore, penetrating behavior was identified as one of the independent risk factors for poor OS and RFS (OS: hazard ratio [HR] 1.89, 95% confidence interval [CI] 1.16–3.09, p = 0.01; RFS: HR 2.15, 95% CI 1.28–3.63, p = 0.004). Conclusions: Our study highlights the different characteristics of CDAC according to the underlying disease behavior and substantiates the poor prognosis of CDAC patients with penetrating behavior. Treatment planning including screening, surgical procedures, and postoperative treatment, with awareness of these findings, may contribute to improved prognosis for CDAC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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