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1,138 results on '"URSANO, ROBERT J."'

1. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts

Author

Wani, Agaz H., Katrinli, Seyma, Zhao, Xiang, Daskalakis, Nikolaos P., Zannas, Anthony S., Aiello, Allison E., Baker, Dewleen G., Boks, Marco P., Brick, Leslie A., Chen, Chia-Yen, Dalvie, Shareefa, Fortier, Catherine, Geuze, Elbert, Hayes, Jasmeet P., Kessler, Ronald C., King, Anthony P., Koen, Nastassja, Liberzon, Israel, Lori, Adriana, Luykx, Jurjen J., Maihofer, Adam X., Milberg, William, Miller, Mark W., Mufford, Mary S., Nugent, Nicole R., Rauch, Sheila, Ressler, Kerry J., Risbrough, Victoria B., Rutten, Bart P. F., Stein, Dan J., Stein, Murray B., Ursano, Robert J., Verfaellie, Mieke H., Vermetten, Eric, Vinkers, Christiaan H., Ware, Erin B., Wildman, Derek E., Wolf, Erika J., Nievergelt, Caroline M., Logue, Mark W., Smith, Alicia K., and Uddin, Monica

Published
2024
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2. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Author

Nievergelt, Caroline M., Maihofer, Adam X., Atkinson, Elizabeth G., Chen, Chia-Yen, Choi, Karmel W., Coleman, Jonathan R. I., Daskalakis, Nikolaos P., Duncan, Laramie E., Polimanti, Renato, Aaronson, Cindy, Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegoviç, Esmina, Babić, Dragan, Bacanu, Silviu-Alin, Baker, Dewleen G., Batzler, Anthony, Beckham, Jean C., Belangero, Sintia, Benjet, Corina, Bergner, Carisa, Bierer, Linda M., Biernacka, Joanna M., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Brandolino, Amber, Breen, Gerome, Bressan, Rodrigo Affonseca, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Børglum, Anders D., Børte, Sigrid, Cahn, Leah, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chatzinakos, Chris, Cheema, Sheraz, Clouston, Sean A. P., Colodro-Conde, Lucía, Coombes, Brandon J., Cruz-Fuentes, Carlos S., Dale, Anders M., Dalvie, Shareefa, Davis, Lea K., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Desarnaud, Frank, DiPietro, Christopher P., Disner, Seth G., Docherty, Anna R., Domschke, Katharina, Dyb, Grete, Kulenović, Alma Džubur, Edenberg, Howard J., Evans, Alexandra, Fabbri, Chiara, Fani, Negar, Farrer, Lindsay A., Feder, Adriana, Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goleva, Slavina B., Gordon, Scott D., Goçi, Aferdita, Grasser, Lana Ruvolo, Guindalini, Camila, Haas, Magali, Hagenaars, Saskia, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M. J., Hesselbrock, Victor, Hickie, Ian B., Hogan, Kelleigh, Hougaard, David Michael, Huang, Hailiang, Huckins, Laura M., Hveem, Kristian, Jakovljević, Miro, Javanbakht, Arash, Jenkins, Gregory D., Johnson, Jessica, Jones, Ian, Jovanovic, Tanja, Karstoft, Karen-Inge, Kaufman, Milissa L., Kennedy, James L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kotov, Roman, Kranzler, Henry R., Krebs, Kristi, Kremen, William S., Kuan, Pei-Fen, Lawford, Bruce R., Lebois, Lauren A. M., Lehto, Kelli, Levey, Daniel F., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lu, Yi, Luft, Benjamin J., Lupton, Michelle K., Luykx, Jurjen J., Makotkine, Iouri, Maples-Keller, Jessica L., Marchese, Shelby, Marmar, Charles, Martin, Nicholas G., Martínez-Levy, Gabriela A., McAloney, Kerrie, McFarlane, Alexander, McLaughlin, Katie A., McLean, Samuel A., Medland, Sarah E., Mehta, Divya, Meyers, Jacquelyn, Michopoulos, Vasiliki, Mikita, Elizabeth A., Milani, Lili, Milberg, William, Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Mufford, Mary S., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., Nugent, Nicole R., O’Donnell, Meaghan, Orcutt, Holly K., Pan, Pedro M., Panizzon, Matthew S., Pathak, Gita A., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Porjesz, Bernice, Powers, Abigail, Qin, Xue-Jun, Ratanatharathorn, Andrew, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Runz, Heiko, Rutten, Bart P. F., de Viteri, Stacey Saenz, Salum, Giovanni Abrahão, Sampson, Laura, Sanchez, Sixto E., Santoro, Marcos, Seah, Carina, Seedat, Soraya, Seng, Julia S., Shabalin, Andrey, Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stensland, Synne, Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Tiwari, Arun K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Valdimarsdóttir, Unnur, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Waszczuk, Monika, Weber, Heike, Wendt, Frank R., Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winsvold, Bendik S., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Xia, Yan, Xiong, Ying, Yehuda, Rachel, Young, Keith A., Young, Ross McD, Zai, Clement C., Zai, Gwyneth C., Zervas, Mark, Zhao, Hongyu, Zoellner, Lori A., Zwart, John-Anker, deRoon-Cassini, Terri, van Rooij, Sanne J. H., van den Heuvel, Leigh L., Stein, Murray B., Ressler, Kerry J., and Koenen, Karestan C.

Published
2024
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3. Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Author

Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Rentería, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen, Liu, Yu-Li, Kendler, Kenneth S., Peterson, Roseann E., Cai, Na, Fang, Yu, Sen, Srijan, Scott, Laura J., Burmeister, Margit, Loos, Ruth J. F., Preuss, Michael H., Actkins, Ky’Era V., Davis, Lea K., Uddin, Monica, Wani, Agaz H., Wildman, Derek E., Aiello, Allison E., Ursano, Robert J., Kessler, Ronald C., Kanai, Masahiro, Okada, Yukinori, Sakaue, Saori, Rabinowitz, Jill A., Maher, Brion S., Uhl, George, Eaton, William, Cruz-Fuentes, Carlos S., Martinez-Levy, Gabriela A., Campos, Adrian I., Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wassertheil-Smoller, Sylvia, Jiang, Yunxuan, Tian, Chao, Martin, Nicholas G., Mitchell, Brittany L., Byrne, Enda M., Awasthi, Swapnil, Coleman, Jonathan R. I., Ripke, Stephan, Sofer, Tamar, Walters, Robin G., McIntosh, Andrew M., Polimanti, Renato, Dunn, Erin C., Stein, Murray B., Gelernter, Joel, Lewis, Cathryn M., and Kuchenbaecker, Karoline

Published
2024
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8. Predicting Homelessness Among Transitioning U.S. Army Soldiers

Author

Tsai, Jack, Szymkowiak, Dorota, Hooshyar, Dina, Gildea, Sarah M., Hwang, Irving, Kennedy, Chris J., King, Andrew J., Koh, Katherine A., Luedtke, Alex, Marx, Brian P., Montgomery, Ann E., O'Brien, Robert W., Petukhova, Maria V., Sampson, Nancy A., Stein, Murray B., Ursano, Robert J., and Kessler, Ronald C.

Published
2024
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11. Rare copy number variation in posttraumatic stress disorder

Author

Maihofer, Adam X., Engchuan, Worrawat, Huguet, Guillaume, Klein, Marieke, MacDonald, Jeffrey R., Shanta, Omar, Thiruvahindrapuram, Bhooma, Jean-louis, Martineau, Saci, Zohra, Jacquemont, Sebastien, Scherer, Stephen W., Ketema, Elizabeth, Aiello, Allison E., Amstadter, Ananda B., Avdibegović, Esmina, Babic, Dragan, Baker, Dewleen G., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bryant, Richard A., Bustamante, Angela C., Caldas-de-Almeida, Jose Miguel, Cardoso, Graça, Deckert, Jurgen, Delahanty, Douglas L., Domschke, Katharina, Dunlop, Boadie W., Dzubur-Kulenovic, Alma, Evans, Alexandra, Feeny, Norah C., Franz, Carol E., Gautam, Aarti, Geuze, Elbert, Goci, Aferdita, Hammamieh, Rasha, Jakovljevic, Miro, Jett, Marti, Jones, Ian, Kaufman, Milissa L., Kessler, Ronald C., King, Anthony P., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A. M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Mavissakalian, Matig R., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Morris, Charles Phillip, Muhie, Seid, Orcutt, Holly K., Peverill, Matthew, Ratanatharathorn, Andrew, Risbrough, Victoria B., Rizzo, Albert, Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rutten, Bart P. F., Schijven, Dick, Seng, Julia S., Sheerin, Christina M., Sorenson, Michael A., Teicher, Martin H., Uddin, Monica, Ursano, Robert J., Vinkers, Christiaan H., Voisey, Joanne, Weber, Heike, Winternitz, Sherry, Xavier, Miguel, Yang, Ruoting, McD Young, Ross, Zoellner, Lori A., Salem, Rany M., Shaffer, Richard A., Wu, Tianying, Ressler, Kerry J., Stein, Murray B., Koenen, Karestan C., Sebat, Jonathan, and Nievergelt, Caroline M.

Published
2022
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13. The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Author

Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Borglum, Anders D., Babic, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chen, Chia-Yen, Dale, Anders M., Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Kulenovic, Alma Dzubur, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Miller, Mark W., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Luella van den Heuvel, Leigh, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan, Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Yehuda, Rachel, Young, Keith A., Young, Ross McD., Zhao, Hongyu, Zoellner, Lori A., Haas, Magali, Lasseter, Heather, Provost, Allison C., Salem, Rany M., Sebat, Jonathan, Shaffer, Richard, Wu, Tianying, Ripke, Stephan, Daly, Mark J., Ressler, Kerry J., Koenen, Karestan C., Stein, Murray B., Nievergelt, Caroline M., Wendt, Frank R., Garcia-Argibay, Miguel, Cabrera-Mendoza, Brenda, Valdimarsdóttir, Unnur A., Nivard, Michel G., Larsson, Henrik, Mattheisen, Manuel, and Meier, Sandra M.

Published
2023
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16. Predicting suicide attempts among U.S. Army soldiers after leaving active duty using information available before leaving active duty: results from the Study to Assess Risk and Resilience in Servicemembers-Longitudinal Study (STARRS-LS)

Author

Stanley, Ian H., Chu, Carol, Gildea, Sarah M., Hwang, Irving H., King, Andrew J., Kennedy, Chris J., Luedtke, Alex, Marx, Brian P., O’Brien, Robert, Petukhova, Maria V., Sampson, Nancy A., Vogt, Dawne, Stein, Murray B., Ursano, Robert J., and Kessler, Ronald C.

Published
2022
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17. Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress

Author

Katrinli, Seyma, Maihofer, Adam X., Wani, Agaz H., Pfeiffer, John R., Ketema, Elizabeth, Ratanatharathorn, Andrew, Baker, Dewleen G., Boks, Marco P., Geuze, Elbert, Kessler, Ronald C., Risbrough, Victoria B., Rutten, Bart P. F., Stein, Murray B., Ursano, Robert J., Vermetten, Eric, Logue, Mark W., Nievergelt, Caroline M., Smith, Alicia K., and Uddin, Monica

Published
2022
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18. Attachment Style, Social Support Network, and Lifetime Suicide Ideation and Suicide Attempts Among New Soldiers in the U.S. Army.

Author

Wang, Jing, Naifeh, James A., Herberman Mash, Holly B., Thomas, Jeffrey L., Hooke, Joseph, Morganstein, Joshua C., Fullerton, Carol S., Cozza, Stephen J., Stein, Murray B., and Ursano, Robert J.

Subjects
SUICIDE risk factors, RISK assessment, FEAR, SOCIAL security, SELF-injurious behavior, SUICIDAL ideation, RESEARCH funding, ATTACHMENT behavior, SEX distribution, MENTAL illness, PSYCHOLOGY of military personnel, DESCRIPTIVE statistics, AGE distribution, ODDS ratio, RACE, SOCIAL networks, MARITAL status, SOCIAL support, PSYCHOANALYTIC theory, EDUCATIONAL attainment
Abstract

Objective: Attachment style and social support networks (SSN) are associated with suicide ideation (SI) and suicide attempt (SA). How these two factors interact is important to understanding the mechanisms of risk for suicidal behaviors and identifying interventions. Method: Using the Army Study to Assess Risk and Resilience in Servicemembers New Soldier Study (N = 38,507 soldiers), we examined how three attachment styles (preoccupied, fearful, and secure) and SSN (smaller vs larger) were associated with lifetime SI, SA, and SA among soldiers with SI. The interaction of each attachment style by SSN was examined. Results: All three attachment styles were associated with SI and SA in the total sample (for SA: preoccupied OR = 2.82, fearful OR = 2.84, and secure OR = 0.76). Preoccupied and fearful attachment were associated with SA among suicide ideators. Smaller SSN was associated with a higher risk for all three outcomes (range of ORs = 1.23–1.52). The association of SSN with SI and with SA among suicide ideators was significantly modified by the presence or absence of preoccupied attachment style. Among soldiers without preoccupied attachment, larger SSN was associated with lower risk of SI. Among suicide ideators with preoccupied attachment, a larger SSN was associated with lower risk of SA. Conclusion: This study highlights the need for increased understanding of the role of attachment style and social networks in suicide risk, in particular preoccupied attachment among soldiers with SI. A critical next step is to explore these relationships prospectively to guide intervention development. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Optimism, Sociability, and the Risk of Future Suicide Attempt among U.S. Army Soldiers.

Author

Naifeh, James A, Ursano, Robert J, Stein, Murray B, Mash, Holly B. Herberman, Aliaga, Pablo A, Fullerton, Carol S, Shor, Rachel, Kao, Tzu-Cheg, Sampson, Nancy A, and Kessler, Ronald C

Subjects
*ATTEMPTED suicide, *SUICIDE risk factors, *SOCIABILITY, *PERSONALITY assessment, *OPTIMISM, *MENTAL illness
Abstract

Introduction Most research on suicide attempts among U.S. service members has been focused on risk factors that occur during service. There is an important gap in our understanding of premilitary factors, such as personality characteristics, that may be associated with future suicide attempt risk during service. Of particular importance is identifying risk factors for the 1/3 of suicide attempters who never receive a mental health diagnosis (MH-Dx)–and therefore are not identified as having a mental health problem in the military healthcare system–prior to their suicide attempt. Materials and Methods Using two components of the Army Study to Assess Risk and Resilience in Servicemembers, we examined the association of personality facets from the Tailored Adaptive Personality Assessment System, a computerized instrument administered prior to entering service, with medically documented suicide attempts during service. A 2010–2016 sample of historical administrative records from U.S. Regular Army enlisted soldiers with complete data on 11 commonly administered Tailored Adaptive Personality Assessment System facets was examined using a series of logistic regression analyses to identify the facets associated with future suicide attempt. Significant facets were then applied to data from a longitudinal cohort study of 11,288 soldiers surveyed upon entering basic combat training and followed via administrative records for their first 48 months of service. This research was approved by the Institutional Review Boards at the collaborating institutions. Results Analysis of the historical administrative data (87.0% male, 61.6% White non-Hispanic), found that low Optimism (odds ratio (OR) = 1.2 [95% CI = 1.0-1.4]) and high/low (vs. moderate) Sociability (OR = 1.3 [95%CI = 1.1-1.6]) were associated with suicide attempt after adjusting for other univariable-significant facets and socio-demographic and service-related variables. When examined in the longitudinal survey cohort, low Optimism (OR = 1.7 [95% CI = 1.1-2.4]) and high/low (vs. moderate) Sociability (OR = 1.7 [95% CI = 1.1-2.5]) were still associated with increased odds of documented suicide attempt during service, even after adjusting for each other, socio-demographic and service-related variables, and medically documented MH-Dx. Mental health diagnosis had a significant two-way interaction with Optimism (F  = 5.27, p  = 0.0236) but not Sociability. Stratified analyses indicated that low Optimism was associated with suicide attempt among soldiers without, but not among those with, a MH-Dx. Interactions of Optimism and Sociability with gender were nonsignificant. In the full model, population attributable risk proportions for Optimism and Sociability were 15.0% and 18.9%, respectively. Optimism and Sociability were differentially associated with suicide attempt risk across time in service. Conclusions Optimism and Sociability, assessed prior to entering U.S. Army service, are consistently associated with future suicide attempt during service, even after adjusting for other important risk factors. While Sociability is equally associated with suicide attempt among those with and without a MH-Dx, Optimism is specifically associated with suicide attempt among soldiers not identified in the mental healthcare system. Risk differences across time in service suggest that Optimism and Sociability interact with stressors and contextual factors in particular developmental and Army career phases. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Overview and Design of the Child Maltreatment in Military Families Life Course Study.

Author

Ogle, Christin M., Zhou, Jing, Fisher, Joscelyn E., Aliaga, Pablo A., Rose, Valija C., Huleatt, William J., Chiarantona, Kathleen H., Naifeh, James A., Herberman Mash, Holly B., Fullerton, Carol S., Ursano, Robert J., and Cozza, Stephen J.

Subjects
RISK assessment, HUMAN services programs, MENTAL health, CHILD abuse, RETROSPECTIVE studies, FAMILIES, FAMILIES of military personnel, LIFE course approach, CASE-control method, CONCEPTUAL structures, DEMOGRAPHY, MILITARY personnel
Abstract

This report presents an overview of the objectives, design, and analytic strategy of the Child Maltreatment in Military Families Life Course Study, an investigation of factors associated with child maltreatment in active duty military families. The study uses a case-control retrospective research design and discrete-time survival methodology to examine service member demographic characteristics, family characteristics, military-related characteristics, and military family life events associated with child maltreatment incidents that meet the Department of Defense definition of child abuse or neglect. The sample includes all active duty families with a first occurrence of child maltreatment anytime between Fiscal Year (FY) 2009 and FY 2018 (n = 28,684), and a representative sample of control families with children under age of 18 during the same period (n = 589,417). Analyses include child maltreatment and domestic abuse data from the Family Advocacy Program Central Registry; sponsor socio-demographic, military-related, and family data from the Active Duty Military Personnel Master and Defense Enrollment Eligibility Reporting System data files; deployment data from the Contingency Tracking System; and mental health data from the Medical Data Repository. Study results identify risk and protective factors associated with child maltreatment in military families, subgroups at elevated risk of child maltreatment, and periods of heightened risk during the military family life course. These results are expected to improve the ability to identify families most at-risk for particular types of child maltreatment and inform prevention strategies that promote the health and safety of military families. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Perspectives of suicide loss survivors: Qualitative analysis of data from a psychological autopsy study of U.S. Army soldiers.

Author

Zuromski, Kelly L., Wilks, Chelsey R., Al‐Suwaidi, Maha, Wittler, Ellen, Scherban, Lilly, Hite, Blake, Raymond, LaTashia, Dempsey, Catherine L., Stein, Murray B., Ursano, Robert J., Benedek, David, and Nock, Matthew K.

Subjects
SUICIDE, MENTAL health services, SUICIDE prevention, AUTOPSY, DATA analysis, SUICIDE risk factors, SUICIDAL behavior in youth
Abstract

Introduction: Suicide loss survivors can provide information not otherwise available about the circumstances preceding a suicide. In this study, we analyzed interview data from suicide loss survivors collected as part of a psychological autopsy study of U.S. Army soldiers. Methods: Next‐of‐kin (NOK) (n = 61) and Army supervisors (SUP) (n = 107) of suicide decedents (n = 135) who had died in the last 2–3 months answered open‐ended questions about suicide risk factors, ideas for improving suicide prevention, and the impact of the suicide. Responses were coded using conventional content analysis methods to identify common themes. Results: Many NOK (30%) and SUP (50%) did not observe any signs of risk preceding the soldier's suicide. The most common idea regarding suicide prevention from SUP was that the suicide was inevitable, whereas NOK were more likely to emphasize the importance of increasing mental health treatment and reducing stigma. Both NOK and SUP reported negative effects of the suicide, but SUP reported some positive effects (e.g., increased unit connectedness). Conclusions: Results underscore the challenges of using informants to identify soldiers at high risk of suicide, given many respondents did not observe any warning signs. Findings also highlight attitudinal barriers present in the military that, if targeted, may increase soldiers' help‐seeking and willingness to disclose their risk. [ABSTRACT FROM AUTHOR]

Published
2024
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22. The Combat Path: Sustaining Mental Readiness in Ukrainian Soldiers.

Author

Hukovskyy, Oleh, West, James C., Morganstein, Joshua C., Augusterfer, Eugene F., Benedek, David M., Boyko, Oleg, Ursano, Robert J., and Adler, Amy B.

Subjects
PSYCHOLOGICAL resilience, MILITARY personnel, MILITARY life, ARMED Forces, PREPAREDNESS, MENTAL health
Abstract

In Ukraine, soldiers' psychological resilience is of paramount concern. Therefore, the Armed Forces of Ukraine have developed a new intervention, Combat Path Debriefing, designed to address combat stress and promote unit readiness for soldiers returning to combat. This article outlines the components of Combat Path Debriefing and discusses how it is rooted in principles of combat and operational stress control and the unique characteristics of Ukrainian military life. This perspective offers US and allied leaders real-world experience that can inform future efforts to support soldiers' mental health and combat performance. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Pre-deployment predictors of suicide attempt during and after combat deployment: Results from the Army Study to Assess Risk and Resilience in Servicemembers

Author

Steven Heeringa, Wagner, James, Kessler, Ronald C., Cox, Kenneth, Aliaga, Pablo A., Benedek, David M., Campbell-Sills, Laura, Fullerton, Carol S., Gebler, Nancy, Gifford, Robert K., House, Meredith, Hurwitz, Paul E., Jain, Sonia, Kao, Tzu-Cheg, Lewandowski-Romps, Lisa, Mash, Holly Herberman, McCarroll, James E., Naifeh, James A., Hinz Ng, Tsz Hin, Nock, Matthew K., Sampson, Nancy A., Santiago, Patcho, Wynn, Gary H., Zaslavsky, Alan M., Zuromski, Kelly L., Bernecker, Samantha L., Chu, Carol, Wilks, Chelsey R., Gutierrez, Peter M., Joiner, Thomas E., Liu, Howard, Stein, Murray B., and Ursano, Robert J.

Published
2020
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32. Association of 5-HTTLPR With Post-Traumatic Stress Disorder in US Service Members.

Author

Hu, Xian-Zhang, Ursano, Robert J., Benedek, David, Li, Xiaoxia, and Zhang, Lei

Subjects
POST-traumatic stress disorder, RISK assessment, MATHEMATICAL variables, GENOMICS, RESEARCH funding, T-test (Statistics), PSYCHOLOGY of military personnel, DNA, CHI-squared test, RESEARCH, COMPARATIVE studies, DATA analysis software, MEMBRANE proteins, SINGLE nucleotide polymorphisms, GENOTYPES
Abstract

Objective: Post-traumatic stress disorder (PTSD) is a mental disorder that manifests after exposure to a stressful traumatic event, such as combat experience. Accumulated evidence indicates an important genetic influence in the development of PTSD. The serotonin transporter (5-HTT) gene has been identified as a candidate for PTSD and a polymorphism of the serotonin transporter-linked promoter region (5-HTTLPR) is associated with the disorder in the general population. However, whether it is associated with PTSD in active military service members has not been investigated. This study aimed to investigate the relationship between 5-HTTLPR and PTSD in service members. Methods: Leucocyte genomic DNA was extracted from service members, including those with PTSD (n = 134) or without PTSD (n = 639). The 5-HTTLPR polymorphism was detected by means of 2 stages of TaqMan fluorescent PCR assay. PTSD symptoms and symptom severity were assessed using the PTSD Checklist (PCL), a 17-item, DSM-based, self-report questionnaire with well-established validity and reliability. PTSD was determined based on endorsement of DSM-IV criteria and a PCL total score ≥ 44. Results: Significant differences in biallele distribution were observed between PTSD and controls (χ2 = 7.497, P =.024). The frequency of SS, SL, and LL genotypes in the PTSD group was 0.17, 0.56, and 0.27 respectively, compared to the frequencies of 0.27, 0.43, and 0.29 in non-PTSD controls. Carriers of the L allele had higher scores for reexperiencing and arousal symptoms on the PCL, compared to SS homozygote carriers (P <.05). The triallele genotypes showed no significant differences in distribution between the PTSD and control groups (P >.05) and no relationship with PTSD symptom severity. The interaction of triallelic genotypes of 5-HTTLPR and traumatic life events was associated with re-experiencing, avoidance, and arousal (P <.05 for all). Multiple regression analysis revealed significant correlations between both biallelic and triallelic genotypes of 5-HTTLPR, the interaction of the number of stressful lifetime events, and 5-HTTLPR genotypes with PCL total score (P <.001). Conclusion: Our findings suggested that 5-HTT might play a minor role in PTSD, and the interaction between 5-HTTLPR and the environment had effects on PCL score, complementing and emphasizing 5-HTT for PTSD, especially in the military population. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Prospective association of attachment style with suicide attempts among US Army soldiers.

Author

Naifeh, James A., Ursano, Robert J., Stein, Murray B., Wang, Jing, Mash, Holly B. Herberman, Aliaga, Pablo A., Fullerton, Carol S., Dinh, Hieu M., Kao, Tzu-Cheg, Sampson, Nancy A., and Kessler, Ronald C.

Subjects
*SUICIDE risk factors, *RISK assessment, *MENTAL health, *RESEARCH funding, *ATTACHMENT behavior, *QUESTIONNAIRES, *LOGISTIC regression analysis, *PSYCHOLOGY of military personnel, *DESCRIPTIVE statistics, *RETROSPECTIVE studies, *CHI-squared test, *ODDS ratio, *LONGITUDINAL method, *STATISTICS, *DATA analysis software, *CONFIDENCE intervals
Abstract

Background: Insecure attachment styles are associated with retrospectively reported suicide attempts (SAs). It is not known if attachment styles are prospectively associated with medically documented SAs. Methods: A representative sample of US Army soldiers entering service (n = 21 772) was surveyed and followed via administrative records for their first 48 months of service. Attachment style (secure, preoccupied, fearful, dismissing) was assessed at baseline. Administrative medical records identified SAs. Discrete-time survival analysis examined associations of attachment style with future SA during service, adjusting for time in service, socio-demographics, service-related variables, and mental health diagnosis (MH-Dx). We examined whether associations of attachment style with SA differed based on sex and MH-Dx. Results: In total, 253 respondents attempted suicide. Endorsed attachment styles included secure (46.8%), preoccupied (9.1%), fearful (15.7%), and dismissing (19.2%). Examined separately, insecure attachment styles were associated with increased odds of SA: preoccupied [OR 2.5 (95% CI 1.7–3.4)], fearful [OR 1.6 (95% CI 1.1–2.3)], dismissing [OR 1.8 (95% CI 1.3–2.6)]. Examining attachment styles simultaneously along with other covariates, preoccupied [OR 1.9 (95% CI 1.4–2.7)] and dismissing [OR 1.7 (95% CI 1.2–2.4)] remained significant. The dismissing attachment and MH-Dx interaction was significant. In stratified analyses, dismissing attachment was associated with SA only among soldiers without MH-Dx. Other interactions were non-significant. Soldiers endorsing any insecure attachment style had elevated SA risk across the first 48 months in service, particularly during the first 12 months. Conclusions: Insecure attachment styles, particularly preoccupied and dismissing, are associated with increased future SA risk among soldiers. Elevated risk is most substantial during first year of service but persists through the first 48 months. Dismissing attachment may indicate risk specifically among soldiers not identified by the mental healthcare system. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Traumatic stress and accelerated DNA methylation age: A meta-analysis

Author

Wolf, Erika J., Maniates, Hannah, Nugent, Nicole, Maihofer, Adam X., Armstrong, Don, Ratanatharathorn, Andrew, Ashley-Koch, Allison E., Garrett, Melanie, Kimbrel, Nathan A., Lori, Adriana, VA Mid-Atlantic MIRECC Workgroup, Aiello, Allison E., Baker, Dewleen G., Beckham, Jean C., Boks, Marco P., Galea, Sandro, Geuze, Elbert, Hauser, Michael A., Kessler, Ronald C., Koenen, Karestan C., Miller, Mark W., Ressler, Kerry J., Risbrough, Victoria, Rutten, Bart P.F., Stein, Murray B., Ursano, Robert J., Vermetten, Eric, Vinkers, Christiaan H., Uddin, Monica, Smith, Alicia K., Nievergelt, Caroline M., and Logue, Mark W.

Published
2018
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40. Genomic influences on self-reported childhood maltreatment

Author

Dalvie, Shareefa, Maihofer, Adam X., Coleman, Jonathan R. I., Bradley, Bekh, Breen, Gerome, Brick, Leslie A., Chen, Chia-Yen, Choi, Karmel W., Duncan, Laramie E., Guffanti, Guia, Haas, Magali, Harnal, Supriya, Liberzon, Israel, Nugent, Nicole R., Provost, Allison C., Ressler, Kerry J., Torres, Katy, Amstadter, Ananda B., Bryn Austin, S., Baker, Dewleen G., Bolger, Elizabeth A., Bryant, Richard A., Calabrese, Joseph R., Delahanty, Douglas L., Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Galea, Sandro, Gautam, Aarti, Gelernter, Joel, Hammamieh, Rasha, Jett, Marti, Junglen, Angela G., Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kranzler, Henry R., Lebois, Lauren A. M., Marmar, Charles, Mavissakalian, Matig R., McFarlane, Alexander, Donnell, Meaghan O’, Orcutt, Holly K., Pietrzak, Robert H., Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Roy-Byrne, Peter, Ruggiero, Ken, Seligowski, Antonia V., Sheerin, Christina M., Silove, Derrick, Smoller, Jordan W., Stein, Murray B., Teicher, Martin H., Ursano, Robert J., Van Hooff, Miranda, Winternitz, Sherry, Wolff, Jonathan D., Yehuda, Rachel, Zhao, Hongyu, Zoellner, Lori A., Stein, Dan J., Koenen, Karestan C., and Nievergelt, Caroline M.

Published
2020
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47. Genome-wide analysis of insomnia disorder

Author

Stein, Murray B., McCarthy, Michael J., Chen, Chia-Yen, Jain, Sonia, Gelernter, Joel, He, Feng, Heeringa, Steven G., Kessler, Ronald C., Nock, Matthew K., Ripke, Stephan, Sun, Xiaoying, Wynn, Gary H., Smoller, Jordan W., and Ursano, Robert J.

Published
2018
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50. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Author

Nievergelt, Caroline M., Maihofer, Adam X., Klengel, Torsten, Atkinson, Elizabeth G., Chen, Chia-Yen, Choi, Karmel W., Coleman, Jonathan R. I., Dalvie, Shareefa, Duncan, Laramie E., Gelernter, Joel, Levey, Daniel F., Logue, Mark W., Polimanti, Renato, Provost, Allison C., Ratanatharathorn, Andrew, Stein, Murray B., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Børglum, Anders D., Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas- de- Almeida, José M., Dale, Anders M., Daly, Mark J., Daskalakis, Nikolaos P., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Geuze, Elbert, Gillespie, Charles, Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M. J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Junglen, Angela G., Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A. M., Lewis, Catrin E., Linnstaedt, Sarah D., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica, Marmar, Charles, Martin, Alicia R., Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., McLeay, Sarah, Mehta, Divya, Milberg, William P., Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben B., Neale, Benjamin M., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Ripke, Stephan, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Ken, Rung, Ariane, Rutten, Bart P. F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., van den Heuvel, Leigh Luella, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Wolff, Jonathan D., Yehuda, Rachel, Young, Ross McD., Young, Keith A., Zhao, Hongyu, Zoellner, Lori A., Liberzon, Israel, Ressler, Kerry J., Haas, Magali, and Koenen, Karestan C.

Published
2019
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