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4. Interim management : an enquiry into praxis

Author

Tyrrell, J.

Subjects
658
Abstract

This paper contributes to the body of knowledge of interim management, through a process of interview, the development of an extended case study and reflection on practice. It develops a theory of interim management that conceptualises interim managers as process consultants working at an individual level in organisational development. It draws a distinction between instrumental stopgap contracting, functional consulting and consultancy. Interim managers largely operate as functional consultants, but bring to assignments the wider set of skills of process consulting. Their effectiveness is partially derived from their ability to bridge across organisational groups, and their ability to distinguish between organizational politics and the "back staging" required to deliver their assignments. Clients look for relevant sector experience in engaging interim managers and this constrains interim managers in offering cross sector services. Interim managers demonstrate value to organisations through the development of the staff they work with in the delivery of assignments. This paper report on the author’s first person action research into his practice as an interim manager which draws on the research described, on reflection on that research and the author’s practice as an interim manager. It has enabled the author to relate his practice to theory, to the practice of other interim managers, and provided an opportunity to think through issues of personal values and developmental needs. The paper also develops a viewpoint of the nature of knowledge, locates that viewpoint in the context of management education, and presents a conceptual argument that positions deficiencies in management education as a driver for the development of the interim management market.

Published
2014

6. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis.

Author

Quandt, Zoe, Kim, Stephanie, Villanueva-Meyer, Javier, Coupe, Catherine, Young, Arabella, Kang, Jee Hye, Yazdany, Jinoos, Schmajuk, Gabriela, Rush, Stephanie, Ziv, Elad, Perdigoto, Ana Luisa, Herold, Kevan, Lechner, Melissa G, Su, Maureen A, Tyrrell, J Blake, Bluestone, Jeffrey, Anderson, Mark, and Masharani, Umesh

Subjects
IMMUNE checkpoint proteins, SYMPTOMS, DRUG side effects, THYROID gland function tests, IMMUNE checkpoint inhibitors
Abstract

Context Hypophysitis is a known immune-related adverse event (irAE) of immune checkpoint inhibitors (CPIs), commonly associated with CTLA-4 inhibitors and less often with PD-1/PD-L1 inhibitors. Objective We aimed to determine clinical, imaging, and HLA characteristics of CPI-induced hypophysitis (CPI-hypophysitis). Methods We examined the clinical and biochemical characteristics, magnetic resonance imaging (MRI) of the pituitary, and association with HLA type in patients with CPI-hypophysitis. Results Forty-nine patients were identified. Mean age was 61.3 years, 61.2% were men, 81.6% were Caucasian, 38.8% had melanoma, and 44.5% received PD-1/PD-L1 inhibitor monotherapy while the remainder received CTLA-4 inhibitor monotherapy or CTLA-4/PD-1 inhibitor combination therapy. A comparison of CTLA-4 inhibitor exposure vs PD-1/PD-L1 inhibitor monotherapy revealed faster time to CPI-hypophysitis (median 84 vs 185 days, P <.01) and abnormal pituitary appearance on MRI (odds ratio 7.00, P =.03). We observed effect modification by sex in the association between CPI type and time to CPI-hypophysitis. In particular, anti-CTLA-4 exposed men had a shorter time to onset than women. MRI changes of the pituitary were most common at the time of hypophysitis diagnosis (55.6% enlarged, 37.0% normal, 7.4% empty or partially empty) but persisted in follow-up (23.8% enlarged, 57.1% normal, 19.1% empty or partially empty). HLA typing was done on 55 subjects; HLA type DQ0602 was over-represented in CPI-hypophysitis relative to the Caucasian American population (39.4% vs 21.5%, P = 0.01) and CPI population. Conclusion The association of CPI-hypophysitis with HLA DQ0602 suggests a genetic risk for its development. The clinical phenotype of hypophysitis appears heterogenous, with differences in timing of onset, changes in thyroid function tests, MRI changes, and possibly sex related to CPI type. These factors may play an important role in our mechanistic understanding of CPI-hypophysitis. [ABSTRACT FROM AUTHOR]

Published
2023
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8. The genetic architecture of depression in samples with East Asian ancestry

Author

Giannakopoulou, O., Lin, K., Meng, X., Su, M., Kuo, P., Peterson, R., Awasthi, S., Moscati, A., Coleman, J., Bass, N., Millwood, I., Chen, Y., Chen, Z., Li, L., Chen, H., Lu, M., Huang, M., Chen, C., Stahl, E., Loos, R., Mullins, N., Ursano, R., Kessler, R., Stein, M., Sen, S., Scott, L., Burmeister, M., Fang, Y., Tyrrell, J., Jiang, Y., Tian, C., McIntosh, A., Ripke, S., Dunn, E., Kendler, K., Walters, R., Lewis, C., Kuchenbaecker, K., Research Team, T, and Major Depressive Disorder Working Group of the PGC, T

Subjects
RC0321, BF, RC
Abstract

Importance: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European (EUR) descent. This limits our understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.\ud Objectives: to investigate the genetics of depression across East Asian and European cultural contexts and outcome definitions.\ud Design: Genome-wide association studies, followed by meta-analysis. \ud Setting: Nine cohort and case-control studies from China, Taiwan, USA and UK. \ud Participants: 15,771 depression cases and 178,777 controls of East Asian descent (EAS). \ud Exposures: Associations of genetic variants with depression risk were assessed using generalised linear mixed models and logistic regression. The results were combined across studies using fixed effects meta-analyses. These were subsequently also meta-analysed with the largest published GWAS for depression in EUR samples. Additional meta-analyses were carried out separately by outcome definition (clinical vs symptom-based) and region (East Asian countries vs Western countries). \ud Main outcomes and measures: Depression status was defined based on health records and self-report questionnaires.\ud Results: In total we identified five novel associations, including one in the EAS meta-analysis for broad depression: rs4656484 (beta=-0.018, SE=0.003, P=4.43x10-8) at 1q24.1. Another locus at 7p21.2 was associated in a meta-analysis restricted to geographically East Asian studies (P=5.03x10-9). Both associations were specific to EAS samples (P=0.53 and P=0.28 in EUR, respectively). Only 11% of depression loci previously identified in EUR reached nominal significance levels in the EAS samples. The trans-ancestry genetic correlation estimates with depression in EUR ranged from 0.223 to 0.558, depending on the outcome definition. Clinical depression risk was negatively genetically correlated with BMI in EAS (rg=-0.212), contrary to findings from EUR samples.\ud Conclusions and relevance: Our results suggest that cultural differences further add to the heterogeneity of depression and thereby impact on the genetic architecture. This cautions against generalising findings about depression risk factors across populations and highlights the need to increase the ancestral and geographic diversity of samples with consistent phenotyping.

Published
2021

11. Pediatric Project ECHO® for Pain: implementation and mixed methods evaluation of a virtual medical education program to support interprofessional pain management in children and youth.

Author

Lalloo, C., Mohabir, V., Campbell, F., Sun, N., Klein, S., Tyrrell, J., Mesaroli, G., Ataollahi-Eshqoor, S., Osei-Twum, J., and Stinson, J.

Subjects
MEDICAL education, INTERPROFESSIONAL education, PAIN management, MEDICAL personnel, COVID-19 pandemic, SIMULATED patients, CASE-based reasoning
Abstract

Background: Pediatric pain is a complex health challenge requiring a multi-modal management approach. It is critical that healthcare providers (HCPs) have access to ongoing, flexible education and mentorship specific to pediatric pain. However, there are significant gaps in available pain education and a need for more opportunities to support interprofessional training. Project Extension for Community Healthcare Outcomes (Project ECHO®) is a model for delivering online HCP education and cultivating a virtual community of practice. Within the pediatric pain setting, ECHO® has potential to improve local access to specialized pain knowledge, particularly among the physicians, nurses, and allied health providers who primarily manage these cases in community and hospital settings across rural and urban environments. The purpose of this study was three-fold. First, to evaluate the feasibility (participation levels, acceptability) of implementing Project ECHO® in the context of pediatric pain. Second, to measure preliminary program impacts on HCP knowledge, self-efficacy, and clinical practice. Third, to characterize HCP program engagement levels before and after onset of the COVID-19 pandemic. Methods: A needs assessment was conducted to identify interprofessional education gaps and inform the program curriculum. The no-cost Pediatric ECHO® for Pain program offered TeleECHO sessions (didactic and case-based learning) as well as foundational education. Surveys were distributed at baseline and 6 months to assess outcomes using 7-point Likert scales. Participant engagement was assessed for periods prior to and during the COVID-19 pandemic. Descriptive and inferential statistical analyses were conducted. Results: Eighty-five TeleECHO sessions were hosted, with a mean attendance of 34.1 ± 23.4 HCPs. Acceptability scores at 6 months (n = 33) ranged from 5.0 ± 1.4 to 6.5 ± 0.5. Participants reported statistically significant (p < 0.05) improvements in knowledge (7 out of 7 topics) and self-efficacy (8 out of 9 skills). Most participants reported positive practice impacts, including improved satisfaction with managing children with pain. Exploratory analyses showed a trend of greater engagement from ECHO® learners after onset of the COVID-19 pandemic. Conclusions: Project ECHO® is a feasible and impactful model for virtual education of interprofessional HCPs in managing pediatric pain. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Author

Erzurumluoglu, AM, Liu, M, Jackson, VE, Barnes, DR, Datta, G, Melbourne, CA, Young, R, Batini, C, Surendran, P, Jiang, T, Adnan, SD, Afaq, S, Agrawal, A, Altmaier, E, Antoniou, AC, Asselbergs, FW, Baumbach, C, Beirut, L, Bertelsen, S, Boehnke, M, Bots, ML, Brazel, DM, Chambers, JC, Chang-Claude, J, Chen, C, Corley, J, Chou, Y-L, David, SP, de Boer, RA, de Leeuw, CA, Dennis, JG, Dominiczak, AF, Dunning, AM, Easton, DF, Eaton, C, Elliott, P, Evangelou, E, Faul, JD, Foroud, T, Goate, A, Gong, J, Grabe, HJ, Haessler, J, Haiman, C, Hallmans, G, Hammerschlag, AR, Harris, SE, Hattersley, A, Heath, A, Hsu, C, Iacono, WG, Kanoni, S, Kapoor, M, Kaprio, J, Kardia, SL, Karpe, F, Kontto, J, Kooner, JS, Kooperberg, C, Kuulasmaa, K, Laakso, M, Lai, D, Langenberg, C, Le, N, Lettre, G, Loukola, A, Luan, J, Madden, PAF, Mangino, M, Marioni, RE, Marouli, E, Marten, J, Martin, NG, McGue, M, Michailidou, K, Mihailov, E, Moayyeri, A, Moitry, M, Müller-Nurasyid, M, Naheed, A, Nauck, M, Neville, MJ, Nielsen, SF, North, K, Perola, M, Pharoah, PDP, Pistis, G, Polderman, TJ, Posthuma, D, Poulter, N, Qaiser, B, Rasheed, A, Reiner, A, Renström, F, Rice, J, Rohde, R, Rolandsson, O, Samani, NJ, Samuel, M, Schlessinger, D, Scholte, SH, Scott, RA, Sever, P, Shao, Y, Shrine, N, Smith, JA, Starr, JM, Stirrups, K, Stram, D, Stringham, HM, Tachmazidou, I, Tardif, J-C, Thompson, DJ, Tindle, HA, Tragante, V, Trompet, S, Turcot, V, Tyrrell, J, Vaartjes, I, van der Leij, AR, van der Meer, P, Varga, TV, Verweij, N, Völzke, H, Wareham, NJ, Warren, HR, Weir, DR, Weiss, S, Wetherill, L, Yaghootkar, H, Yavas, E, Jiang, Y, Chen, F, Zhan, X, Zhang, W, Zhao, W, Zhou, K, Amouyel, P, Blankenberg, S, Caulfield, MJ, Chowdhury, R, Cucca, F, Deary, IJ, Deloukas, P, Di Angelantonio, E, Ferrario, M, Ferrières, J, Franks, PW, Frayling, TM, Frossard, P, Hall, IP, Hayward, C, Jansson, J-H, Jukema, JW, Kee, F, Männistö, S, Metspalu, A, Munroe, PB, Nordestgaard, BG, Palmer, CNA, Salomaa, V, Sattar, N, Spector, T, Strachan, DP, Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ Consortium, van der Harst, P, Zeggini, E, Saleheen, D, Butterworth, AS, Wain, LV, Abecasis, GR, Danesh, J, Tobin, MD, Vrieze, S, Liu, DJ, and Howson, JMM

Abstract

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P

Published
2020

25. Across the sub-Arctics of Canada : a journey of 3,200 miles by canoe and snowshoe through the barren lands

Author

Tyrrell, J. W. (James Williams), 1863-1945, Heming, Arthur, 1871-1940, Tyrrell, Joseph Burr, 1858-1957, University of Toronto - Thomas Fisher Rare Book Library, Tyrrell, J. W. (James Williams), 1863-1945, Heming, Arthur, 1871-1940, and Tyrrell, Joseph Burr, 1858-1957

Subjects
Botany, Description and travel, Eskimo languages, Glossaries, vocabularies, etc, Northwest Territories, Prairie Provinces
Published
1897

26. Report on the Doobaunt, Kazan and Ferguson Rivers and the north-west coast of Hudson Bay and on two overland routes from Hudson Bay to Lake Winnipeg /

Author

Tyrrell, J. B. (Joseph Burr), 1858-1957, Geological Survey of Canada, Canadiana.org (archive.org), Tyrrell, J. B. (Joseph Burr), 1858-1957, and Geological Survey of Canada

Subjects
Botany, Chipewyan language, Decouverte et explor, Description and trave, Descriptions et voyage, Discovery and exploratio, Dubawnt River Region (N.W.T.), Dubawnt River, Region (Territoires du Nord-Ouest), Geology, Glossaries, vocabularies, etc, Inuit language, Kazan River Region (N.W.T.), Keewatin District, Keewatin District (N.W.T.), Keewatin District (Territoires du Nord-Ouest), Northwest Territories, Zoology
Published
1897

27. The mammalia of Canada by J.B. Tyrrell.

Author

Tyrrell, J. B. (Joseph Burr), 1858-1957, Canadian Institute, Canadiana.org (archive.org), Tyrrell, J. B. (Joseph Burr), 1858-1957, and Canadian Institute

Subjects
Canada, Mammals
Published
1888

29. Across the sub-Arctics of Canada : a journey of 3,200 miles by canoe and snowshoe through the barren lands

Author

Tyrrell, J. W. (James Williams), 1863-1945, Heming, Arthur, 1871-1940, Tyrrell, Joseph Burr, 1858-1957, University of Toronto - Thomas Fisher Rare Book Library, Tyrrell, J. W. (James Williams), 1863-1945, Heming, Arthur, 1871-1940, and Tyrrell, Joseph Burr, 1858-1957

Subjects
Botany, Description and travel, Eskimo languages, Glossaries, vocabularies, etc, Northwest Territories, Prairie Provinces

31. Across the sub-Artics of Canada, a journey of 3,200 miles by canoe and snow-shoe through the barren lands, including a list of plants collected on the expedition, a vocabulary of Eskimo words, a route map and full classified index

Author

Tyrrell, J. W. (James Williams), 1863-1945, Smithsonian Libraries, and Tyrrell, J. W. (James Williams), 1863-1945

Subjects
Botany, Description and travel, Eskimo languages, Glossaries, vocabularies, etc, Mackenzie, Northwest Territories, Northwest, Canadian

44. Profiling interactions of vaborbactam with metallo-β-lactamases

Author

Langley, G, Cain, R, Tyrrell, J, Hinchliffe, P, Calvopiña, K, Tooke, C, Widlake, E, Dowson, C, Spencer, J, Walsh, T, Schofield, C, and Brem, J

Subjects
RM, serine- and metallo-β-lactamase, antibiotic resistance, Transition state analogue, β-Lactamase induction, Vaborbactam, boronate inhibitor, QR, RS
Abstract

β-Lactams are the most successful antibacterials, yet their use is threatened by resistance, importantly as caused by β-lactamases. β-Lactamases fall into two mechanistic groups: the serine β-lactamases that utilise a covalent acyl-enzyme mechanism and the metallo β-lactamases that utilise a zinc-bound water nucleophile. Achieving simultaneous inhibition of both β-lactamase classes remains a challenge in the field. Vaborbactam is a boronate-based inhibitor that reacts with serine-β-lactamases to form covalent complexes that mimic tetrahedral intermediates in catalysis. Vaborbactam has recently been approved for clinical use in combination with the carbapenem meropenem. Here we show that vaborbactam moderately inhibits metallo-β-lactamases from all 3 subclasses (B1, B2 and B3), with a potency of around 20–100 fold below that by which it inhibits its current clinical targets, the Class A serine β-lactamases. This result contrasts with recent investigations of bicyclic boronate inhibitors, which potently inhibit subclass B1 MBLs but which presently lack activity against B2 and B3 enzymes. These findings indicate that cyclic boronate scaffolds have the potential to inhibit the full range of β-lactamases and justify further work on the development of boronates as broad-spectrum β-lactamase inhibitors.\ud \ud

Published
2019

45. National Scientific Medical Meeting 1994 Abstracts

Author

Carson, K. D., Grimes, S. B., McGinley, J. M., Thornton, M. T., Mulhall, J., Bourke, A. M., McCrory, C., Marsh, B., Hone, R., Phelan, D., White, M., Fabry, J., Hughes, D., Carson, K., Donnelly, M., Shanahan, E., Fitzpatrick, G. J., Bourke, M., Warde, D., Buggy, D., Hughes, N., Taylor, A., Dowd, N., Markham, T., Blunnie, W., Nicholson, G., O’Leary, E., Cunningham, A. J., Dwyer, R., McMechan, S., Cullen, C., Dempsey, G., Wright, G., MacKenzie, G., Anderson, J., Adgey, J., Walsh, M., O’Callaghan, P., Graham, I., O’Hare, J. A., Geoghegan, M., Iman, N., Shah, P., Chander, R., Lavin, F., Daly, K., Johnston, P. W., Imam, Z., Adgey, A. A. J., Rusk, R. A., Richardson, S. G., Hale, A., Kinsella, B. M., FitzGerald, G. A., King, G., Crean, P., Gearty, G., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Upton, J., D’Arcy, G., Stinson, J., Cooke, T., Colgan, M. P., Hall, M., Tyrrell, J., Gaffney, K., Grouden, M., Moore, D. J., Shanik, G., Feely, J., Delanty, N., Reilly, M., Lawson, J. A., Fitzgerald, D. J., Reilly, M. P., McAdam, B. F., Bergin, C., Walshe, M. J., Herity, N. A., Allen, J. D., Silke, B., Singh, H. P., O’Neill, S., Hargrove, M., Coleman, E., Shorten, E., Aherne, T., Kelly, B. E., Hill, D. H., McIlrath, E., Morrow, B. C., Lavery, G. G., Blackwood, B., Fee, J. P. H., Kevin, L., Doran, M., Tansey, D., Boylan, I., McShane, A. J., O’Reilly, G., Tuohy, B., Grainger, P., Larkin, T., Mahady, J., Malone, J., Condon, C., Donoghue, T., O’Leary, J., Lyons, J. F., Tay, Y. K., Tham, S. N., Khoo Tan, H. S., Gibson, G., O’Grady, A., Leader, M., Walshe, J., Carmody, M., Donohoe, J., Murphy, G. M., O’Connor, W., Barnes, L., Watson, R., Darby, C., O’Moore, R., Mulcahy, F., O’Toole, E., O’Briain, D. S., Young, M. M., Buckley, D., Healy, E., Rogers, S., Ni Scannlain, N., McKenna, M. J., McBrinn, Y., Murray, B., Freaney, R., Barrett, E., Razza, Q., Abuaisha, F., Powell, D., Murray, T. M., Powell, A. M., O’Mongain, E., O’Neill, J., Kernan, R. P., O’Connor, P., Clarke, D., Fearon, U., Cunningham, S. K., McKenna, T. J., Hayes, F., Heffernan, A., Sheahan, K., Harper, R., Johnston, G. D., Atkinson, A. B., Sheridan, B., Bell, P. M., Heaney, A. P., Loughrey, G., McCance, D. R., Hadden, D. R., Kennedy, A. L., McNamara, P., O’Shaughnessy, C., Loughrey, H. C., Reid, I., Teahan, S., Caldwell, M., Walsh, T. N., McSweeney, J., Hennessy, T. P., Caldwell, M. T. P., Byrne, P. J., Hennessy, T. P. J., El-Magbri, A. A., Stevens, F. M., O’Sullivan, R., McCarthy, C. F., Laundon, J., Heneghan, M. A., Kearns, M., Goulding, J., Egan, E. L., McMahon, B. P., Hegarty, F., Malone, J. F., Merriman, R., MacMathuna, P., Crowe, J., Lennon, J., White, P., Clarke, E., Prabhakar, M. C., Ryan, E., Graham, D., Yeoh, P. L., Kelly, P., McKeogh, D., O’Keane, C., Kitching, A., Mulligan, E., Gorey, T. F., Mahmud, N., O’Connell, M., Goggins, M., Keeling, P. W. N., Weir, D. G., Kelleher, D., McDonald, G. S. A., Maguire, D., O’Sullivan, G., Harvey, B., Cherukuri, A., McGrath, J. P., Timon, C., Lawlor, P., O’Shea, J., Buckley, M., English, L., Walsh, T., O’Morain, C., Lavelle, S. M., Kanagaratnam, B., Harding, B., Murphy, B., Kavanagh, J., Kerr, D., Lavelle, E., O’Gorman, T., Liston, S., Fitzpatrick, C., Fitzpatrick, P., Turner, M., Murphy, A. W., Cafferty, D., Dowling, J., Bury, G., Kaf Al-Ghazal, S., Zimmermann, E., O’Donoghue, J., McCann, J., Sheehan, C., Boissel, L., Lynch, M., Cryan, B., Fanning, S., O’Meara, D., Fennell, J., Byrne, P. M., Lyons, D., Mulcahy, R., Pooransingh, A., Walsh, J. B., Coakley, D., O’Neill, D., Ryall, N., Connolly, P., Namushi, R., Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., McCann, S. R., Pamphilon, D., Reidy, M., Madden, M., Finch, T., Borton, M., Barnes, C. A., Lawlor, S. E., Gardiner, N., Egan, L. J., Orren, A., Doherty, J., Curran, C., O’Hanlon, D., Kent, P., Kerin, M., Maher, D., Given, H. F., Lynch, S., McManus, R., O’Farrelly, C., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., Morris, T. C. M., Maguire, H., Davidson, F., Kaminski, G. Z., Butler, K., Hillary, I. B., Parfrey, N. A., Crowley, B., McCreary, C., Keane, C., O’Reilly, M., Goh, J., Kennedy, M., Fitzgerald, M., Scott, T., Murphy, S., Hildebrand, J., Holliman, R., Smith, C., Kengasu, K., Riain, U. Ni, Cormican, M., Flynn, J., Glennon, M., Smith, T., Whyte, D., Keane, C. T., Barry, T., Noone, D., Maher, M., Dawson, M., Gilmartin, J. J., Gannon, F., Eljamel, M. S., Allcut, D., Pidgeon, C. N., Phillips, J., Rawluk, D., Young, S., Toland, J., Deveney, A. M., Waddington, J. L., O’Brien, D. P., Hickey, A., Maguire, E., Phillips, J. P., Al-Ansari, N., Cunney, R., Smyth, E., Sharif, S., Eljamel, M., Pidgeon, C., Maguire, E. A., Burke, E. T., Staunton, H., O’Riordan, J. I., Hutchinson, M., Norton, M., McGeeney, B., O’Connor, M., Redmond, J. M. T., Feely, S., Boyle, G., McAuliffe, F., Foley, M., Kelehan, P., Murphy, J., Greene, R. A., Higgins, J., Darling, M., Byrne, P., Kondaveeti, U., Gordon, A. C., Hennelly, B., Woods, T., Harrison, R. F., Geary, M., Sutherst, J. R., Turner, M. J., DeLancey, J. O. L, Donnelly, V. S., O’Connell, P. R., O’Herlihy, C., Barry-Kinsella, C., Sharma, S. C., Drury, L., Lewis, S., Stratton, J., Ni Scanaill, S., Stuart, B., Hickey, K., Coulter-Smith, S., Moloney, A., Robson, M. S., Murphy, M., Keane, D., Stronge, J., Boylan, P., Gonsalves, R., Blankson, S., McGuinness, E., Sheppard, B., Bonnar, J., MacDonagh-White, C. M., Kelleher, C. C., Newell, J., White, O., Young, Y., Hallahan, C., Carroll, K., Tipton, K., McDermott, E. W., Reynolds, J. V., Nolan, N., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Grimes, H., Gallagher, S., O’Hanlon, D. M., Strattan, J., Lenehan, P., Robson, M., Cusack, Y. A., O’Riordain, D., Mercer, P. M., Smyth, P. P. A., Gallagher, H. J., Moule, B., Cooke, T. G., McArdle, C. S., Burke, C., Vance, A., Saidtéar, C., Early, A., Eustace, P., Maguire, L., Cullinane, A. B. P., Prosser, E. S., Coca-Prados, M., Harvey, B. J., Saidléar, C., Orwa, S., Fitzsimons, R. B., Bradley, O., Hogan, M., Zimmerman, L., Wang, J., Kuliszewski, M., Liu, J., Post, M., Premkumar, Conran, M. J., Nolan, G., Duff, D., Oslizlok, P., Denham, B., O’Connell, P. A, Birthistle, K., Hitchcock, R., Carrington, D., Calvert, S., Holmes, K., Smith, D. F., Hetherton, A. M., Mott, M. G., Oakhill, A., Foreman, N., Foot, A., Dixon, J., Walsh, S., Mortimer, G., O’Sullivan, C., Kilgallen, C. M., Sweeney, E. C., Brayden, D. J., Kelly, J. G., McCormack, P. M. E., Hayes, C., Johnson, Z., Dack, P., Hosseini, J., O’Connell, T., Hemeryck, L., Condren, L., McCormack, P., McAdam, B., Lawson, J., Keimowitz, R., O’Leary, A., Pilkington, R., Adebayo, G. I., Gaffney, P., McGettigan, P., McManus, J., O’Shea, B., Wen, Y., Killalea, S., Golden, J., Swanwick, G., Clare, A. W., Mulvany, F., Byrne, M., O’Callaghan, E., Byrne, H., Cannon, N., Kinsella, T., Cassidy, B., Shepard, N., Horgan, R., Larkin, C., Cotter, D., Coffey, V. P., Sham, P. C., Murray, L. H., Lane, A., Kinsella, A., Murphy, P., Colgan, K., Sloan, D., Gilligan, P., McEnri, J., Ennis, J. T., Stack, J., Corcoran, E., Walsh, D., Thornton, L., Temperley, I., Lawlor, E., Tobin, A., Hillary, I., Nelson, H. G., Martin, M., Ryan, F. M., Christie, M. A., Murray, D., Keane, E., Holmes, E., Hollyer, J., Strangeways, J., Foster, P., Stanwell-Smith, R., Griffin, E., Conlon, T., Hayes, E., Clarke, T., Fogarty, J., Moloney, A. C., Killeen, P., Farrell, S., Clancy, L., Hynes, M., Conlon, C., Foley-Nolan, C., Shelley, E., Collins, C., McNamara, E., Hayes, B., Creamer, E., LaFoy, M., Costigan, P., Al fnAnsari, N., Cunney, R. J., Smyth, E. G., Johnson, H., McQuoid, G., Gilmer, B., Browne, G., Keogh, J. A. B., Jefferson, A, Smith, M., Hennessy, S., Burke, C. M., Sreenan, S., Power, C. K., Pathmakanthan, S., Poulter, L. W., Chan, A., Sheehan, M., Maguire, M., O’Connor, C. M., FitzGerald, M. X., Southey, A., Costello, C. M., McQuaid, K., Urbach, V., Thomas, S., Horwitz, E. R., Mulherin, D., FitzGerald, O., Bresnihan, B., Kirk, G., Veale, D. J., Belch, J. J. F., Mofidi, A., Mofidi, R., Quigley, C., McLaren, M., Veale, D., D’Arrigo, C., Couto, J. Candal, Woof, J., Greer, M., Cree, I., Belch, J., Hone, S., Fenton, J., Hamilton, S., and McShane, D.

Published
1994
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46. Irish gerontological society: Proceedings of annual scientific and general meeting on friday & saturday 2nd/3rd October 1992 in court hotel, Killiney, co. Dublin

Author

Khaw, K-T., Compston, J. E., Murphy, S., Lawlor, R., McGee, C., Hegarty, V., Scott, T., MacMahon, M., Healy, M., O’Moore, R. R., Keane, C. T., Mulvihill, E., Taggart, H., Crawford, V. L. S., Tracey, F., Crawford, V., O’Mahory, D., Coffey, J., Hamilton, D., Freyne, P., Keane, E. M., Wilson, H., Maher, A., McGrane, D., Walsh, J. B., Coakley, D., Coen, R. F., O’Mahony, D., O’Boyle, C. A., Browne, J., Joyce, C. R. B., O’Neill, D., Wilcock, G. K., Crossin, Jane, Mills, J. O. M, Collins, J. C., Gilmore, D. H., Beringer, T. R. O., Miller, M., Hyland, C. M., Twomey, C., Corcoran, E. M., Guerandel, A., Wrigley, M., Lee, H., Walsh, P. J., Hickey, G., Tyrrell, J., McCabe, C., Kelly, E., Swanwick, G., Ward, F., Lawlor, B. A., Moraes, D., McCormack, P. M. E., Feely, J., Jassal, S. V., Coulshed, S. C., Douglas, J. F., Stout, R. W., Kane, Nuala, Keane, N., Brennan, B., Denholm, S., Fox, J., Herlihey, E., O’Keeffe, S., Noel, J., Lavan, J., Mclntosh, S., Kenny, R. A., Lawson, J., da Costa, D., Ford, G., Mulkerin, E., Rice, K., Freeman, E. A., Keyes, C. B., Hickey, A., Clinch, D., Liston, R., Passmore, A. P., Passmore, C. M., Copeland, S., tout, R. W., and Johnston, G. D.

Published
1993
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48. Royal academy of medicine in Ireland section of biomedical sciences: Proceedings of meeting held 23rd and 24th June, 1992

Author

Barniville, G., Hartigan, P. J., Lydon, A., Rawas, O., Andrews, J. F., Donne, B., Kelly, M., Brady, C., McNamara, B., Taylor, D., Ishtiaq, A., Glacken, P., O’brien, M., Moraes, D., Tyrrell, J., McCormack, P. M. E., Feely, J., Stinson, J., Hemeryck, L., Feely, J., Chan, R., Hemeryck, L., Clancy, L., Feely, J., Sharma, S. C., Barry-Kinsella, C., Cortell, E., Harrison, R. F., O’connor, J. J., Trout, S. J., Kruk, Z. L., Sharma, S. C., Barry-Kinsella, C., Foran, K., Han, B., Kelly, J. P., O’donnell, J. M., Hollywood, M. A., McHale, N. G., Kearns, J. B., Hardiman, O., Harris, A. M., Harris, C. S., O’halloran, K. D., Bradford, A., McKeogh, D., Nolan, P., O’regan, R. G., McDermott, M., Maddineni, V. R., Mirakhur, R. K., Cooper, A. R., Clarke, R. S. J., O’brien, W., Tarpey, J., Cooney, C., Blunnie, W. P., Moriarty, D. C., Niveditha, Y., O’donovan, D. J., Manning, B., Furlong, E., Martin, F., Brazil, D. P., Smyth, E. M., Keenan, A. K., Nunan, N., Faustman, D., Li, X., Sklar, R. M., Brown, R. H., O’gorman, S., Bannigan, J., Moynihan, J. B., Staunton, H. P., Breathnach, C. S., Lynch, L., Bowen, M., Malone, L., Cunningham, A. J., Armstrong, N. C., Allen, J. M., Strain, J. J., McDermott, B. M., Strain, J. J., Bailey, C. J., Flatt, P. R., Megaw, D. P., Murphy, F. J., Reen, D. J., D’arcy, G., Cooke, T., Sheahan, R., Foley, D., Reilly, M., Jauch, W., Gibney, M., Crean, P., Gearty, G., Walsh, M., McGinley, J., Hurley, J., Phelan, D., Neligan, M., Luckwill, R. G., O’connor, J. J., Rowan, M. J., Anwyll, R., Wall, M., Houghton, J. A., Heatley, M., Whiteside, C., Maxwell, P., Toner, P., Walsh, D. M., Lowe, A. S., Baxter, G. D., Allen, J. M., Bell, A. J., Lee, T. C., McNamara, B. P., Prendergast, P. J., Taylor, D., Campion, D. P., and Leek, B. F.

Published
1992
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49. Royal academy of medicine in ireland section of biological sciences: Proceedings of winter meeting held friday, 3rd January, 1992 in R.C.S.I.

Author

Bourke, W., O’Connor, C., Fitzgerald, M. X., McConnell, T. J., Kent, A., Redmond, E. M., Keenan, A. K., Smyth, E. M., Shanahan, R., O’Donnell, N., O’Connor, C. M., Kelly, V., Barry-Kinsella, C., Sharma, S. C., Cottrell, E., Harrison, R. F., Sheppard, B. L., Bonnar, J., McNally, O., Hannigan, B., Allen, J. M., Feely, J., Buggy, D., Barry, M., Keeling, P. W. N., Weir, D. G., Breathnach, A., Keogh, B., Cooke, T., Murphy, J., O’Sullivan, C., Walsh, M., Tyrrell, J., Bergin, C., Colgan, M., Moore, D., Shanik, D. G., Cooke, T., Southey, A., Costello, E., Jehn, B., Marti, R., Deane, R., Thornton, F., Jaggi, R., Martin, F., Armstrong, C., Mannion, D., Feely, T., Fitzpatrick, G., McCormack, P. M. E., O’Reilly, E., Walsh, J. B., Coakley, D., Stinson, J. C., Murphy, C. M., Andrews, J. F., Tomkin, G. H., Howe, J. P., Fogarty, D. J., Manahan-Vaughan, D., Rowan, M. J., Anwyl, R., Thornbury, K. D., Ward, S. M., Sanders, K. M., Murnin, M., Guthrie, D. J. S., Irvine, G. B., Doyle, E., Regan, C. M., Bannigan, J., Giles, J., Adebayo, G. I., Deasy, P. B., Omara, A. A. M., Lambert, M. B., Shields, T. D., O’Kane, S., Leckey, D., Gilmore, W. S., Hannigan, B. M., McKeogh, D., Bradford, A., O’Regan, R. G., Nolan, P., McEvoy, F., Edgell, T., Webbon, P., Creighton-Kempsford, L., Gaffney, P. J., O’Donnell, M. D., McGeeney, K. F., Breslin, E., Smith, K., Docherty, J. R., Adams, N., Ravey, J., Bell, A. J., Tong, K. K., Strain, J. J., Walsh, D. M., Baxter, G. D., Mokhtar, B., Victory, R., Bergin, D., Cooney, C., Staunton, M., Fitzgerald, J., Gardiner, J., Blunnie, W., Smith, J., Magee, O., Lowe, D., Robinson, R., Magner, J., Eustace, P., Martyn, C. J., Cooney, C. M., Adams, H., Lyons, J. B., Blunnie, W. P., and Moriarty, D. C.

Published
1992
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