278 results on '"Tur-Sinai A"'
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2. Comparing the cross-national impact of the COVID-19 pandemic on care received by community-dwelling older adults in 2020 and 2021: restoring formal home care versus polarizing informal care?
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Tur-Sinai, Aviad, Bentur, Netta, Fabbietti, Paolo, and Lamura, Giovanni
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- 2024
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3. “I Would Consult a Doctor, But What the Rabbi Says Goes”: Ultra-Orthodox Jews’ Relationships with Rabbis and Doctors in Israel
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Neriya-Ben Shahar, Rivka, Yuval, Fany, and Tur-Sinai, Aviad
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- 2024
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4. The Role of Parents and Peers in Cyberbullying Perpetration: Comparison among Arab and Jewish and Youth in Israel
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Sasson, Hagit, Tur-Sinai, Aviad, Dvir, Keren, and Harel-Fisch, Yossi
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- 2023
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5. Patient-centeredness—a cultural targeted survey among junior medical managers
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Orna Tal, Royi Barnea, and Aviad Tur-Sinai
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Patient-centeredness ,Equity ,Junior medical managers ,Culture ,Standpoints ,Values ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Patient-centeredness is a core element in healthcare. However, there is a gap between the understanding of this term by healthcare professionals, and patients’ capability, self-efficacy, and willingness to take part in medical decisions. We aim to expose standpoints toward “patient centeredness” among junior medical managers (JMM), as they bridge between policy strategies and patients. We try to reveal cultural differences by comparing the views of the majority and the minority subpopulations of Israel (Arabic and Hebrew speakers). Methods A cross-sectional survey among JMM studying for an advanced degree in health-system management at three academic training colleges in Israel was conducted in February–March 2022. The respondents completed a structured questionnaire comprising four sections: a) perceptions of trust, accountability, insurance coverage, and economic status; b) perceptions regarding decision-making mechanisms; c) preferences toward achieving equity, and d) demographic details. Results A total of 192 respondents were included in the study—50% Hebrew speakers and 50% Arabic speakers. No differences were found between Arabic and Hebrew speakers regarding perception of trust, accountability, insurance coverage, and economic status. JMM from both subpopulations believed that patients’ gender and age do not influence physicians’ attitudes but Arabic-speaking respondents perceived that healthcare professionals prefer educated patients or those with supportive families. All respondents believed that patients would like to be more involved in medical decisions; yet Arabic-speakers perceived patients as tending to rely on physicians’ recommendations while Hebrew speakers believed that patients wish to lead the medical decision by themselves. Conclusions Patient-centeredness strategy needs to be implemented bottom-up as well as top-down, in a transparent nationwide manner. JMM are key actors in carrying out this strategy because they realize policy guidelines in the context of social disparities, enabling them to achieve a friendly personalized dialogue with their patients. We believe that empowering these JMM may create a ripple effect, yielding a bottom-up perception of equity and initiating change.
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- 2023
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6. Patient-centeredness—a cultural targeted survey among junior medical managers
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Tal, Orna, Barnea, Royi, and Tur-Sinai, Aviad
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- 2023
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7. Out-of-pocket expenditure on community healthcare services at end-of-life among decedents from cardiovascular disease in six European countries and Israel
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Tur-Sinai, Aviad and Bentur, Netta
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- 2023
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8. Out-of-pocket expenditure on community healthcare services at end-of-life among decedents from cardiovascular disease in six European countries and Israel
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Aviad Tur-Sinai and Netta Bentur
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Cardiovascular disease ,Out-of-pocket ,Economic capacity ,Welfare regime ,SHARE ,Medicine (General) ,R5-920 - Abstract
Abstract Objectives Most people who develop chronic diseases, including cardiovascular disease (CVD), live in their homes in the community in their last year of life. Since cost-sharing is common in most countries, including those with universal health insurance, these people incur out of pocket expenditure (OOPE). The study aims to identify the prevalence and measure the size of OOPE among CVD decedents at end-of-life (EOL) explore differences among countries in OOPE, and examine whether the decedents’ characteristics or their countries’ health policy affects OOPE more. Methods SHARE data among people aged 50 + from seven European countries (including Israel) who died from CVD are analyzed. Decedents’ family members are interviewed to learn about OOPE on their relatives’ account. Results We identified 1,335 individuals who had died from CVD (average age 80.8 years, 54% men). More than half of CVD-decedent people spend OOPE on community services at EOL and their expenditure varies widely among countries. About one-third of people in France and Spain had OOPE, rising to around two-thirds in Israel and Italy and almost all in Greece. The average OOPE is 391.9 PPT, with wide variance across countries. Significant odds of OOPE exist in the country variable only, and significant differences exist in the amount of OOPE among countries and duration of illness preceding death. Conclusions Since improving CVD care efficiency and effectiveness are key aims, healthcare policymakers should broaden the investigation into expanding public funding for community services in order to mitigate OOPE, alleviate the economic burden on households, mitigate forgoing of community services due to price, and reduce rehospitalization.
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- 2023
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9. Socioeconomic status and individual investors’ behavior during a financial crisis
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Galil, Koresh, Spivak, Avia, and Tur-Sinai, Aviad
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- 2023
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10. Inheritances and work for pay — will the expected wave of bequests undermine active ageing policies?
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Tur-Sinai, Aviad, Künemund, Harald, and Vogel, Claudia
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- 2022
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11. Perceived deterioration in health status among older adults in Europe and Israel following the first wave of the COVID-19 pandemic
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Tur-Sinai, Aviad, Bentur, Netta, and Lamura, Giovanni
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- 2022
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12. Patient preferences and choices as a reflection of trust—A cluster analysis comparing postsurgical perceptions in a private and a public hospital
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Royi Barnea, Aviad Tur‐Sinai, Osnat Levtzion‐Korach, Yossi Weiss, and Orna Tal
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cluster analysis ,commitment ,patient's empowerment ,patient's preferences ,patient's trust ,private hospital ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Active participation of patients in managing their medical treatment is a major component of the patient empowerment process and may contribute to better clinical outcomes. Patient perceptions and preferences affect the patient–physician encounter in a variety of dimensions, such as patient autonomy, freedom of choice and trust in the healthcare system. The Israeli healthcare system is mostly publicly funded, with additional private healthcare services for surgery and other medical treatments. The aim of this study was to compare the perceptions and preferences of patients in the public and private hospitals in Israel. Methods A cross‐sectional study among 545 individuals who had surgical procedures at two hospitals in Israel (one public and one private). A structured questionnaire comprising 23 items was used to collect perceptions via personal telephone interviews. The responses were categorized into five clusters and compared by type of health services provider (public vs. private) and sociodemographic characteristics (gender, age and education level). Results A hierarchical cluster analysis methodology identified five conceptual groups: trust, concern towards medical errors, dialogue between medical staff and the patient/patient's family, confidentiality and staff bias towards more informed patients, or those with supportive families. Four main themes that highlight patients' preferences were found: physical conditions, personal empowerment and perceived autonomy, patient experience and patient–provider encounter communication. Significant differences between the private and the public healthcare systems were found in four clusters: trust and patient care, patient's concerns, the extent of explanation and medical staff's commitment. Differences secondary to sociodemographic parameters were noticed: patients treated at the private hospital scored significantly higher items of trust, medical staff caring and the importance of choosing their treating surgeon, while patients treated at the public hospital scored higher staff commitment to the patient than those treated at the private hospital. Conclusions The study revealed the perceptions underlying the decisions of patients to undergo surgical procedures in public or private hospitals. Mutual learning could pave the way to better patient–physician encounters. Patient or Public Contribution Patients from the two hospitals were involved in this study by responding to the questionnaire. The data presented is based on the patient's responses.
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- 2022
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13. How Generous are Societies Toward Their Elderly? A European Comparative Study of Replacement Rates, Well-Being and Economic Adequacy
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Tur-Sinai, Aviad and Spivak, Avia
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- 2022
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14. Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
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Sarni, Dan, Barroso, Sonia, Shtrikman, Alon, Irony-Tur Sinai, Michal, Oren, Yifat S., Aguilera, Andrés, and Kerem, Batsheva
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- 2022
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15. The Older Sandwich Generation Across European Welfare Regimes: Demographic and Social Considerations
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Albertini, Marco, Tur-Sinai, Aviad, Lewin-Epstein, Noah, and Silverstein, Merril
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- 2022
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16. The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality
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Karlsen, Tom H, Sheron, Nick, Zelber-Sagi, Shira, Carrieri, Patrizia, Dusheiko, Geoffrey, Bugianesi, Elisabetta, Pryke, Rachel, Hutchinson, Sharon J, Sangro, Bruno, Martin, Natasha K, Cecchini, Michele, Dirac, Mae Ashworth, Belloni, Annalisa, Serra-Burriel, Miquel, Ponsioen, Cyriel Y, Sheena, Brittney, Lerouge, Alienor, Devaux, Marion, Scott, Nick, Hellard, Margaret, Verkade, Henkjan J, Sturm, Ekkehard, Marchesini, Giulio, Yki-Järvinen, Hannele, Byrne, Chris D, Targher, Giovanni, Tur-Sinai, Aviad, Barrett, Damon, Ninburg, Michael, Reic, Tatjana, Taylor, Alison, Rhodes, Tim, Treloar, Carla, Petersen, Claus, Schramm, Christoph, Flisiak, Robert, Simonova, Marieta Y, Pares, Albert, Johnson, Philip, Cucchetti, Alessandro, Graupera, Isabel, Lionis, Christos, Pose, Elisa, Fabrellas, Núria, Ma, Ann T, Mendive, Juan M, Mazzaferro, Vincenzo, Rutter, Harry, Cortez-Pinto, Helena, Kelly, Deirdre, Burton, Robyn, Lazarus, Jeffrey V, Ginès, Pere, Buti, Maria, Newsome, Philip N, Burra, Patrizia, and Manns, Michael P
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- 2022
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17. Understanding out-of-pocket spending and financial hardship among patients who succumb to cancer and their caregivers
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Aviad Tur-Sinai, Damien Urban, Daniel Azoulay, Gil Bar-Sela, and Netta Bentur
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Out-of-pocket spending ,Cancer ,Financial burden ,Private caregiver ,Medicines ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background In most countries, including those with national health insurance or comprehensive public insurance, some expenses for cancer treatment are borne by the ill and their families. Objectives This study aims to identify the areas of out-of-pocket (OOP) spending in the last half-year of the lives of cancer patients and examine the extent of that spending; to examine the probability of OOP spending according to patients’ characteristics; and to examine the financial burden on patients’ families. Methods 491 first-degree relatives of cancer patients (average age: 70) who died 3–6 months before the study were interviewed by telephone. They were asked about their OOP payments during the last-half year of the patient's life, the nature of each payment, and whether it had imposed a financial burden on them. A logistic regression and ordered logit models were used to estimate the probability of OOP expenditure and the probability of financial burden, respectively. Results Some 84% of cancer patients and their relatives incurred OOP expenses during the last half-year of the patient’s life. The average levels of expenditure were US$5800on medicines, $8000 on private caregivers, and $2800 on private nurses. The probability of paying OOP for medication was significantly higher among patients who were unable to remain alone at home and those who were less able to make ends meet. The probability of spending OOP on a private caregiver or private nurse was significantly higher among those who were incapacitated, unable to remain alone, had neither medical nor nursing-care insurance, and were older. The probability of a financial burden due to OOP was higher among those unable to remain alone, the incapacitated, and those without insurance, and lower among those with above-average income, those with better education, and patients who died at home. Conclusions The study yields three main insights. First, it is crucial that oncology services provide cancer patients with detailed information about their entitlements and refer them to the National Insurance Institute so that they can exercise those rights. Second, oncologists should relate to the financial burden associated with OOP care at end of life. Finally, it is important to sustain the annual increase in budgeting for technologies and pharmaceuticals in Israel and to allocate a significant proportion of those funds to the addition new cancer treatments to the benefits package; this can alleviate the financial burden on patients who need such treatments and their families.
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- 2022
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18. Understanding out-of-pocket spending and financial hardship among patients who succumb to cancer and their caregivers
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Tur-Sinai, Aviad, Urban, Damien, Azoulay, Daniel, Bar-Sela, Gil, and Bentur, Netta
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- 2022
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19. Transitions in Giving and Receiving Intergenerational Financial Support in Middle and Old Age
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Tur-Sinai, Aviad and Lewin-Epstein, Noah
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- 2020
20. Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10 kb C-to-T splicing mutation
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Oren, Yifat S., Irony-Tur Sinai, Michal, Golec, Anita, Barchad-Avitzur, Ofra, Mutyam, Venkateshwar, Li, Yao, Hong, Jeong, Ozeri-Galai, Efrat, Hatton, Aurélie, Leibson, Chen, Carmel, Liran, Reiter, Joel, Sorscher, Eric J., Wilton, Steve D., Kerem, Eitan, Rowe, Steven M., Sermet-Gaudelus, Isabelle, and Kerem, Batsheva
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- 2021
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21. Facilitating open science without sacrificing IP rights: A novel tool for improving replicability of published research
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Cohen‐Sasson, Or and Tur‐Sinai, Ofer
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- 2022
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22. What drives older adults to continue working after official retirement age?
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Tur-Sinai, Aviad, Shahrabani, Shosh, Lowenstein, Ariela, Katz, Ruth, Halperin, Dafna, and Fogel-Grinvald, Haya
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WORK , *HEALTH status indicators , *ENDOWMENTS , *SATISFACTION , *RESEARCH funding , *GOVERNMENT policy , *RETIREMENT , *EMPLOYMENT of older people , *SOCIOECONOMIC factors , *AGE distribution , *MOTIVATION (Psychology) , *QUALITY of life , *SOCIODEMOGRAPHIC factors , *PUBLIC welfare , *EMPLOYEE attitudes , *WELL-being , *OLD age - Abstract
The need to ensure the economic wellbeing and quality of life of those who reach the official retirement age is a matter of concern in the world of social services and in social policy making. Since some working older adults may be forced to retire when they reach the official retirement age while others retire voluntarily, the study is based on a dedicated survey among 508 persons who retired both willingly and unwillingly for good after reaching the official retirement age and 437 persons who continued working uninterruptedly. The findings show that the odds of staying on the job after retirement age are contingent on the socio-demographic and health-related characteristics of the older adult. Furthermore, the economic predictors of remaining in the labour force after retirement age depend on how strongly the older adult wishes to retire. Those who continue working after retirement age and those who retire willingly are undifferentiated in the level of financial support that they give others. Comparing older adults who continue working uninterruptedly with those who retire unwillingly, the chances of being among the former are higher among those who are better off before reaching retirement age. These results emphasise the need to extend welfare and financial-support policies to older adults who are forced to retire, in order to minimise the economic blow that this path to retirement causes. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Out-of-Pocket Expenditure on Medical Services Among Older Adults: A Longitudinal Analysis
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Aviad Tur-Sinai
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health insurance ,out-of-pocket ,forgone medical care ,old age ,private funding ,SHARE ,Public aspects of medicine ,RA1-1270 - Abstract
The upturn in life expectancy and its consequence, population aging, are challenging labor, pension, and social-security systems throughout the developed world. The focal aim of this study is to measure the extent of out-of-pocket funding of healthcare services by the older adult population. The study has three objectives: to profile the healthcare services for which older adults pay out of pocket, profile the older adults who pay out of pocket for medical services and detect changes over the years, and identify predictors of out-of-pocket healthcare services funding by older adults. The study is predicated on the SHARE-Israel database (SHARE—Survey of Health, Ageing and Retirement in Europe). Relating to information yielded by the last two waves of SHARE-Israel (Wave 7 and Wave 8), it sheds light on the characteristics of those who reported having paid out-of-pocket for medical services. A large majority of the older-adult population in Israel that consumes healthcare services is asked to pay for services out of pocket. Having supplemental health insurance, personal state of health and changes in it, and economic resources are found to have the strongest effect on the probability of out-of-pocket funding. The motive of financial and/or social support that older adults receive from and/or give to their immediate surroundings makes it more likely that they will pay out of pocket for healthcare services. The probability of such funding varies between nationalities and immigration statuses. It is found with emphasis that the share of out-of-pocket funding of healthcare in older adult households' total annual income is trending upward. Furthermore, economic motives are central in determining whether such expenditure will stabilize over time. The findings stress the need to enhance the healthcare system's awareness of the profile of older adults who find it necessary to pay out of pocket for healthcare services.
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- 2022
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24. The accuracy of self-reported dwelling valuation
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Tur-Sinai, Aviad, Fleishman, Larisa, and Romanov, Dmitri
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- 2020
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25. Musculoskeletal Pain Medication Use in Middle Age and Older Adults in 15 European Countries and Israel
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Shuldiner, Jennifer, Tur-Sinai, Aviad, and Bentur, Netta
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- 2020
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26. Is a Municipal Boundary a Good Stratification Variable?
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Tur-Sinai, Aviad
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- 2019
27. Residential segregation, neighborhood violence and disorder, and inequalities in anxiety among Jewish and Palestinian-Arab perinatal women in Israel
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Nihaya Daoud, Samira Alfayumi-Zeadna, Aviad Tur-Sinai, Nabil Geraisy, and Ilan Talmud
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Residential segregation ,Neighborhood violence and disorder ,Anxiety ,Inequalities ,Women ,Perinatal ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Residential segregation can foster health inequality mechanisms by increasing stress related to neighborhood violence and disorder. Aims We studied the association between neighborhood violence and disorder and inequalities in anxiety between two groups of perinatal Israeli women (Jewish, Palestinian-Arab) living in ethno-nationally segregated neighborhoods, and explored the influence of neighborhood characteristics; social support and chronic stress to this inequality. Methods We linked survey data on neighborhood violence and disorder, neighborhood social characteristics (collective efficacy, social capital and social support) and aggregate discrimination to neighborhood SES census data. The survey data was obtained from the “Family Relations, Violence and Health” study (2014–2015) and included a stratified national sample of women (Palestinian-Arab = 436, Jewish = 965) residing in 63 segregated neighborhoods. We conducted multi-variable logistic regression analysis for anxiety (measured based on State-trait Anxiety Inventory) using generalized estimating equation (GEE) to estimate odds ratios of the association with neighborhood violence and disorder (total score for 10 problems) while considering neighborhood characteristics (SES; social characteristics; aggregate discrimination), social support and chronic stress in different models for the total sample, and separately for Palestinian-Arab and Jewish women. Results Palestinian-Arab women had higher anxiety (60.5% vs. 42.1%, respectively) and higher severity of neighborhood violence and disorder (49.5% vs. 16.2%, respectively) compared to Jewish women. After considering individual and neighborhood variables, adjusted odds ratio (AOR) and 95% confidence intervals (CI) = 1.63, 1.04–2.56. The association between neighborhood violence and disorder and anxiety was significant for low vs. no problems in the final model for the total sample (AOR, 95%CI = 1.28, 1.00–1.64). Similarly, significant association was found only for low severity vs. no problems for Jewish women (1.40, 1.07–1.86). While among Palestinian-Arab women the association between neighborhood violence and disorder and anxiety rendered insignificant in the final model. Neighborhood social cohesion and social support were protective factors from anxiety in both groups, high neighborhood SES was protective factor only among Jewish women, and neighborhood aggregate discrimination was a risk factor only in Palestinian-Arab women. Conclusions Inequalities in anxiety related to neighborhood violence and disorder in ethno-national perinatal groups of women likely reflect residential segregation. Policies entrenching segregation might have affected neighborhood mechanisms (SES inequalities, aggregate discrimination and low social cohesion) that lead to higher stress and ethno-national inequalities in anxiety among perinatal women.
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- 2020
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28. 3D genome organization contributes to genome instability at fragile sites
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Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, and Batsheva Kerem
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Science - Abstract
Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.
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- 2020
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29. Associations between socioeconomic and family determinants and weight-control behaviours among adolescents
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Tur-Sinai, Aviad, Kolobov, Tanya, Tesler, Riki, Baron-Epel, Orna, Dvir, Keren, and Harel-Fisch, Yossi
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- 2020
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30. The effect of terror and economic sector in early career years on future career path
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Tur-Sinai, Aviad
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- 2020
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31. Israeli Adults' Non-take-up of Social Benefits: A Study Using the Socio-ecological Model.
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Werner, Perla and Tur-Sinai, Aviad
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ISRAELIS , *CONVENIENCE sampling (Statistics) , *SOCIAL security , *SOCIAL services , *CITIZENS - Abstract
Even though welfare states aim to address citizens' social care needs, disparities in benefit distribution persist, leading to "non-take-up." Non-take-up is the phenomenon in which people who may be eligible for a benefit fail to apply for it or forgo it after applying. Based on a qualitative approach, this study explores reasons for the non-take-up of social-security benefits and services in a convenience sample of 34 Israeli adults. The findings show that the reasons for non-take-up of social benefits and services may be divided into several interrelated levels. Four of the levels identified were identical to those suggested by the socio-ecological model: intrapersonal, interpersonal, organizational, and cultural, with multiple subthemes included in most of them. The policy level, which is integral to the theoretical model, does not emerge in this study. Theoretically, the findings show that the economic "rational trade-off model" does not suffice to explain the non-take-up phenomenon. Future research should expand the study of non-take-up of social benefits and services to potential, rather than actual, claimants of particular benefits or services. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Vaccination uptake and income inequalities within a mass vaccination campaign
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Aviad Tur-Sinai, Rachel Gur-Arie, Nadav Davidovitch, Eran Kopel, Yael Glazer, Emilia Anis, and Itamar Grotto
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Socioeconomic status (SES) ,Gini inequality index ,Solidarity ,Mother-and-child clinic ,OPV vaccination ,IPV vaccination ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background In July 2013, Israel was swept with fear of a polio outbreak. In response to the importation of wild polio virus, the Ministry decided to take preventive action by administering oral poliovirus vaccine (OPV) to all children born after 1 January 2004 who had received at least one dose of inactivated poliovirus vaccine (IPV) in the past. This study analyzes the vaccination uptake rates resulting from the mass polio vaccination campaign on the basis of health inequality parameters of socioeconomic status (SES), principles of solidarity, and the Gini inequality index. The research explores understanding the value of the Gini inequality index within the context of SES and solidarity. Methods The study is based on data gathered from the Israeli Ministry of Health’s administrative records from mother-and-child clinics across Israel. The research population is comprised of resident infants and children whom the Ministry of Health defined as eligible for the OPV between August and December 2013 (the “campaign period”). The analysis was carried out at the municipality level as well as the statistical area level. Results The higher the SES level of the municipality where the mother-and-child clinic is located, the lower the OPV vaccination uptake is. The greater the income inequality is in the municipality where the mother-and-child clinic is situated, the lower the vaccination uptake. Conclusions Public health professionals promoting vaccine programs need to make specially-designed efforts both in localities with high average income and in localities with a high level of income diversity/inequality. Such practice will better utilize funds, resources, and manpower dedicated to increasing vaccination uptake across varying populations and communities.
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- 2019
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33. Health policy regulations pertaining to advanced surgical devices—their socio-economic effects on ophthalmology practice
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Dana Barequet, Aviad Tur-Sinai, and Irit Barequet
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Astigmatism ,Toric intraocular lenses ,Cataract surgery ,Out-of-pocket ,Insurance coverage ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract The Israel Ministry of Health enacted regulations that aim to reduce private expenditure on healthcare services and mitigate social inequality. According to the modified rules, which went into effect in the second half of 2016, patients who undergo surgery in a private hospital and are covered by their healthcare provider’s supplemental insurance (SI) make only a basic co-payment. The modified regulations limited the option of self-payment for advanced devices not covered by national health basket, meaning that patients for whom such devices are indicated had to pay privately for the entire procedure. These regulations applied to all medical and surgical devices not covered by national health insurance (NHI). Toric intraocular lenses (IOLs) are a case in point. These advanced lenses are implanted during cataract surgery to correct corneal astigmatism and, in indicated cases, obviate the need for complex eyeglasses postoperatively. Toric IOL implantation has been shown to be highly cost-effective in both economic and quality-of-life terms. Limitations of the use of these advanced IOLs threatened to increase social inequality. In 2017, further adjustments of the regulations were made which enabled supplemental charges for these advanced IOLs, performed through the SI programs of the healthcare medical organizations (HMOs). Allowing additional payment for these lenses at a fixed pre-set price made it possible to apply a supplemental part of the insurance package to the surgery itself. In mid 2018 these IOLs were included without budget in the national health basket, allowing for self-payment for the additional cost in addition to the basic coverage for all patients with NHI. This case study suggests that, in their efforts to enhance health care equity, policymakers may benefit if exercising due caution when limiting the extent to which SI programs can charge co-payments. This is because, when a service or product is not available via the basic NHI benefits package, limiting SI co-payments can sometimes result in a boomerang effect - leading to an increase in inequality rather than the sought-after decrease in inequality.
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- 2019
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34. PATENTS AND CLIMATE CHANGE: A SKEPTIC'S VIEW
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Tur-Sinai, Ofer
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- 2018
35. Analyzing patient trust through the lens of hospitals managers-The other side of the coin.
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Aviad Tur-Sinai, Royi Barnea, and Orna Tal
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Medicine ,Science - Abstract
Trust is an essential element in patient-physician relationships, yet trust is perceived differently among providers and customers exist. During January-February 2020 we examined the standpoints of medical managers and administrative directors from the private and public health hospitals on patient-physician trust, using a structured questionnaire. Thirty-six managers in public and private hospitals (24 from the public sector and 12 from the private sector) responded to the survey. Managers in the private sector rated trust higher in comparison to managers in the public sector, including trust related to patient satisfaction, professionalism and accountability. Managers from public hospitals gave higher scores to the need for patient education and shared responsibility prior to medical procedures. Administrative directors gave higher scores to various dimensions of trust and autonomy while medical managers gave higher scores to economic considerations. Trust is a fundamental component of the healthcare system and may be used to improve the provision and quality of care by analyzing standpoints and comparable continuous monitoring. Differences in position, education and training influence the perception of trust among managers in the health system. This survey may allow policy makers and opinion leaders to continue building and maintaining trust between patients and care providers.
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- 2021
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36. Prevalence and correlates of forgone care among adult Israeli Jews: A survey conducted during the COVID-19 outbreak.
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Perla Werner and Aviad Tur-Sinai
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Medicine ,Science - Abstract
Efforts to control the spread of the novel Coronavirus (COVID-19) pandemic include drastic measures such as isolation, social distancing, and lockdown. These restrictions are accompanied by serious adverse consequences such as forgoing of healthcare. The study aimed to assess the prevalence and correlates of forgone care for a variety of healthcare services during a two-month COVID-19 lockdown, using Andersen's Behavioral Model of Healthcare Utilization. A cross-sectional study using computerized phone interviews was conducted with 302 Israeli Jewish participants aged 40 and above. Almost half of the participants (49%) reported a delay in seeking help for at least one needed healthcare service during the COVID-19 lockdown period. Among the predisposing factors, we found that participants aged 60+, being more religious, and reporting higher levels of COVID-19 fear were more likely to report forgone care than younger, less religious and less concerned participants. Among need factors, a statistically significant association was found with a reported diagnosis of diabetes, with participants with the disease having a considerably higher likelihood of forgone care. The findings stress the importance of developing interventions aimed at mitigating the phenomenon of forgoing care while creating nonconventional ways of consuming healthcare services. In the short term, healthcare services need to adapt to the social distancing and isolation measures required to stanch the epidemic. In the long term, policymakers should consider alternative ways of delivering healthcare services to the public regularly and during crisis without losing sight of their budgetary consequences. They must recognize the possibility of having to align medical staff to the changing demand for healthcare services under conditions of health uncertainty.
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- 2021
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37. DNA replication stress drives fragile site instability
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Irony-Tur Sinai, Michal and Kerem, Batsheva
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- 2018
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38. Assessing the determinants of healthcare expenditures in single-person households
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Aviad Tur-Sinai, Racheli Magnezi, and Haya Grinvald-Fogel
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Healthcare expenditure ,Health self-assessment ,Socioeconomic level ,Single-person ,Social survey ,Propensity score matching ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The study documents a direct relationship between individuals’ health and patterns of healthcare expenditure by isolating single-person households and creating a new reference group in which household healthcare expenditure is based on one person’s expenditure patterns in accordance with his or her own state of health. Method The study matched two surveys using Propensity Score Matching based on single-person household, age, and gender. Structural Equation Modeling (SEM) explores paths of relation between the population’s income and socioeconomic level and its health self-assessment and expenditure. Results Single-person households’ health expenditure increases with age and the differences in most expenditure categories are significant. The current study looks into the direct and indirect effects of income, gender, and SES on health insurance and other out-of-pocket health expenses among single-person households. A direct link exists between income, gender, and socioeconomic status (SES) and several aspects of health expenditure, depending on the specific age group. The indirect effects are attested via health status assessment, in which a negative correlation is found between self-assessed health status and various health-expenditure categories. Conclusions The last-mentioned result may support the general perception that single-person households who feel that they are doing better than their near-equals enjoy better health. This line of inquiry yields a better examination of how a single-person household’s state of health affects expenditure patterns without assuming ab initio that expenditure patterns attest to state of health.
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- 2018
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39. 3D genome organization contributes to genome instability at fragile sites
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Sarni, Dan, Sasaki, Takayo, Irony Tur-Sinai, Michal, Miron, Karin, Rivera-Mulia, Juan Carlos, Magnuson, Brian, Ljungman, Mats, Gilbert, David M., and Kerem, Batsheva
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- 2020
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40. Residential segregation, neighborhood violence and disorder, and inequalities in anxiety among Jewish and Palestinian-Arab perinatal women in Israel
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Daoud, Nihaya, Alfayumi-Zeadna, Samira, Tur-Sinai, Aviad, Geraisy, Nabil, and Talmud, Ilan
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- 2020
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41. Becoming Sandwiched in Later Life: Consequences for Individuals' Well-Being and Variation Across Welfare Regimes.
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Albertini, Marco, Lewin-Epstein, Noah, Silverstein, Merril, and Tur-Sinai, Aviad
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WELL-being ,SOCIAL support ,MENTAL health ,REGRESSION analysis ,EXPERIENCE ,HUMANITY ,SOCIOECONOMIC factors ,SURVEYS ,SEX distribution ,ADULT children ,AGING ,MENTAL depression ,AUTONOMY (Psychology) ,RESEARCH funding ,PUBLIC welfare ,PARENTS ,SOCIAL responsibility - Abstract
Objectives The experience of being sandwiched between support obligations towards both aging parents and adult offspring is likely to become more common and more relevant. We aim at assessing the effect of demographic and social sandwiching on the psychological health and subjective well-being of individuals experiencing these transitions, and to what extent, these effects vary across welfare regimes. Methods Data are from 63,585 individuals aged 50–75 participating in the Survey of Health, Ageing and Retirement in Europe (SHARE). We estimate within- and between-individual effects using hybrid regression models to predict depressive symptoms (EURO-D) and subjective well-being (control, autonomy, self-realization, and pleasure [CASP]). Results Among demographically sandwiched women, transitioning into social sandwiching and into supporting only parents was associated with a moderate but statistically significant increase in EURO-D and decline in CASP scores. The same association is not observed for male respondents. The pattern of variation among women living in countries characterized by different welfare regimes suggests that social sandwiching is less detrimental in Nordic regimes than in other welfare contexts. Discussion Results from the between-individuals part of the model indicate that there is a selection into social sandwiching of more healthy individuals into support roles. However, the within-individuals part of the model indicates that the transition into social sandwiching has a detrimental effect on women's (but not men's) psychological health and well-being. The explanations for this gendered effect of social sandwiching may be found in the "invisible" support provided by women and the gendered division of specific care tasks. [ABSTRACT FROM AUTHOR]
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- 2024
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42. BRACING SCARCITY: CAN NFTS SAVE DIGITAL ART?
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HELMAN, LITAL and TUR-SINAI, OFER
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NON-fungible tokens ,COPYRIGHT infringement ,COMPUTER art ,CULTURAL pluralism ,TECHNOLOGICAL innovations - Abstract
Rebecca creates artwork. David mints an NFT that links to Rebecca's work. Is David making a copyright infringement? This question--probably the most fundamental one at the intersection between copyright and the technology of non-fungible tokens (NFTs)--is the focus of this Article. As surprising as this may sound, the answer is not at all obvious under extant copyright law. This Article argues that from a policy standpoint, the answer must be positive. Expounding this issue is imperative in order for NFT technology to fulfill its potential for creative works markets. In this Article, we analyze the markets for digital artworks and show that NFTs could potentially address the most pressing and long-lasting dilemma of art and the digital world: how to maintain the incentive to create digital art without overshadowing the big promise of the Internet--to maximize access to content. This incentive-access friction was so far perceived as a necessary tradeoff in copyright theory, and the Internet presented a powerful manifestation of it. It has become a truism: the more enhanced the access to works has become online, the less likely artists were to benefit from their works. Everyone had to pick a side or draw the line somewhere on this incentive-access continuum. NFTs may open a way to move past the incentive-access paradigm. NFT transactions occur on the blockchain--a separate, parallel platform--and they do not affect the availability of the work outside of the platform. Thus, NFTs can revive scarcity and authenticity in the digital sphere without harming access to the underlying works. While this could feature a dramatic improvement, this potential can only be realized if copyright law awards exclusive minting rights to rightsholders. If all can mint NFTs, scarcity is lost again, and artists cannot benefit from art sales. This Article offers at least three novel contributions to the literature. First, it establishes the case for exclusive minting rights to authors based on an analysis of art markets and the attributes of NFT technology. It also shows that exclusive minting rights to authors can promote other crucial objectives such as distributive justice and cultural diversity in art markets. Second, it analyzes the legal mechanisms that can effectuate the desired result of exclusive minting rights. Third, this Article's analysis of NFTs illustrates more generally different approaches to the design of copyright law amid emerging technologies, which is a contentious and hotly debated issue. [ABSTRACT FROM AUTHOR]
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- 2024
43. Determining the optimal allocation of time among work, sports, internet use, and sleep
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Ben David, Nissim and Tur-Sinai, Aviad
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- 2017
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44. Health policy regulations pertaining to advanced surgical devices—their socio-economic effects on ophthalmology practice
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Barequet, Dana, Tur-Sinai, Aviad, and Barequet, Irit
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- 2019
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45. Vaccination uptake and income inequalities within a mass vaccination campaign
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Tur-Sinai, Aviad, Gur-Arie, Rachel, Davidovitch, Nadav, Kopel, Eran, Glazer, Yael, Anis, Emilia, and Grotto, Itamar
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- 2019
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46. Ageism towards older and younger people in the wake of the COVID-19 outbreak
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Hanan AboJabel, Aviad Tur-Sinai, and Perla Werner
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Gerontology ,Male ,2019-20 coronavirus outbreak ,Aging ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Younger people ,General Biochemistry, Genetics and Molecular Biology ,Ageism ,Pandemic ,Medicine ,Humans ,Pandemics ,Aged ,business.industry ,SARS-CoV-2 ,Obstetrics and Gynecology ,Outbreak ,COVID-19 ,Mean age ,Cross-Sectional Studies ,Female ,Original Article ,Stereotypes ,business ,Older people - Abstract
Objectives The COVID-19 pandemic has provided a rich environment for ageist attitudes towards both older and younger people. However, publications on ageism during the outbreak have been mostly non-empirical and have concentrated on ageist beliefs directed towards older people. To overcome these limitations, we examined empirically the prevalence and the determinants of ageism towards older and younger people in the wake of COVID-19. Study design A cross-sectional study using an online survey was conducted with 503 Israeli adults (51.9% male, 79.5% Jews, mean age 47 years). Main measures We used a structured questionnaire that measured the following: COVID-19 ageism towards older people, COVID-19 ageism towards younger people, stereotyping, the experience of discrimination, perceived fears about contracting COVID-19, subjective knowledge about COVID-19, and sociodemographic characteristics. Results Overall, participants reported a relatively low level of COVID-19 ageism towards older people but a significantly higher level of COVID-19 ageism towards younger people. Hierarchical regressions revealed that negative age stereotypes were the most important determinants of both types of ageism. Sociodemographic variables (including age and majority/minority) were significant determinants only for COVID-19 ageism towards older people. That is, older and Jewish participants reported lower levels of this type of ageism. Conclusions Our findings demonstrate that negative age-related stereotypes have played a central role in ageist beliefs towards both older and younger people during the COVID-19 crisis. It is recommended that the public and scientific media start disseminating messages aimed at reducing rather than increasing negative stereotypes directed towards younger and older people.
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- 2021
47. Legal reform to enhance global text and data mining research: Outdated copyright laws around the world hinder research
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Fiil-Flynn, S.M., Butler, B., Carroll, M., Cohen-Sasson, O., Craig, C., Guibault, L., Jaszi, P., Jütte, B.J., Katz, A., Quintais, J.P., Margoni, T., Rocha de Souza, A., Sag, M., Samberg, R., Schirru, L., Senftleben, M., Tur-Sinai, O., Contreras, J.L., FdR overig onderzoek, and IViR (FdR)
- Abstract
Researchers engaged in text and data mining (TDM) research collect vast amounts of digitized material and use software to analyze and extract information from it. TDM is a crucial first step to many machine learning, digital humanities, and social science applications, addressing some of the world’s greatest scientific and societal challenges, from predicting and tracking COVID-19 to battling hate speech and disinformation. Although applications of TDM often occur across borders, with researchers, subjects, and materials in more than one country, a patchwork of copyright laws across jurisdictions limits where and how TDM research can occur. With the World Intellectual Property Organization (WIPO) Standing Committee on Copyright and Related Rights, and legislatures around the world, deliberating the harmonization of copyright exceptions for various research uses, we discuss policy measures that can ensure that TDM research is unambiguously authorized under copyright law.
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- 2022
48. The EASL–Lancet Liver Commission:protecting the next generation of Europeans against liver disease complications and premature mortality
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Tom H Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J Hutchinson, Bruno Sangro, Natasha K Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Järvinen, Chris D Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Núria Fabrellas, Ann T Ma, Juan M Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey V Lazarus, Pere Ginès, Maria Buti, Philip N Newsome, Patrizia Burra, Michael P Manns, Karlsen T.H., Sheron N., Zelber-Sagi S., Carrieri P., Dusheiko G., Bugianesi E., Pryke R., Hutchinson S.J., Sangro B., Martin N.K., Cecchini M., Dirac M.A., Belloni A., Serra-Burriel M., Ponsioen C.Y., Sheena B., Lerouge A., Devaux M., Scott N., Hellard M., Verkade H.J., Sturm E., Marchesini G., Yki-Jarvinen H., Byrne C.D., Targher G., Tur-Sinai A., Barrett D., Ninburg M., Reic T., Taylor A., Rhodes T., Treloar C., Petersen C., Schramm C., Flisiak R., Simonova M.Y., Pares A., Johnson P., Cucchetti A., Graupera I., Lionis C., Pose E., Fabrellas N., Ma A.T., Mendive J.M., Mazzaferro V., Rutter H., Cortez-Pinto H., Kelly D., Burton R., Lazarus J.V., Gines P., Buti M., Newsome P.N., Burra P., Manns M.P., Repositório da Universidade de Lisboa, University of Oslo (UiO), King‘s College London, Tel Aviv Sourasky Medical Center [Te Aviv], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), University College of London [London] (UCL), Università degli studi di Torino = University of Turin (UNITO), Bewdley Medical Centre [Bewdley, UK] (BMC), Glasgow Caledonian University (GCU), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Liver Unit, Clínica Universitaria, CIBER-EHD, University of Bristol [Bristol], Organisation de Coopération et de Développement Economiques = Organisation for Economic Co-operation and Development (OCDE), University of Washington [Seattle], Public Health England [London], Universität Zürich [Zürich] = University of Zurich (UZH), Amsterdam UMC - Amsterdam University Medical Center, Burnet Institute [Melbourne, Victoria], Royal Prince Alfred Hospital [Sydney, Australia], University of Melbourne, University of Groningen [Groningen], University Children's Hospital of Tübingen, Partenaires INRAE, University hospital - Policlinico S.Orsola-Malpighi [Bologna, Italy], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University Hospital Southampton NHS Foundation Trust, Università degli studi di Verona = University of Verona (UNIVR), Max Stern Yezreel Valley college (YVC), University of Gothenburg (GU), World Hepatitis Alliance [London, UK] (WHA), European Liver Patients Organization [Brussels, Belgium] (ELPO), Croatian Society for Liver Diseases-Hepatos [Split, Croatia] (CSLDH), Children's Liver Disease Foundation [Birmingham, UK] (CLDF), London School of Hygiene and Tropical Medicine (LSHTM), University of New South Wales [Sydney] (UNSW), Hannover Medical School [Hannover] (MHH), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Medical University of Białystok (MUB), Medical Military Academy [Sofia, Bulgaria] (2MA), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Liverpool, University of Bologna/Università di Bologna, University of Crete [Heraklion] (UOC), University of Barcelona, Institute of Health Carlos III, Università degli Studi di Milano = University of Milan (UNIMI), University of Bath [Bath], Universidade de Lisboa = University of Lisbon (ULISBOA), University of Birmingham [Birmingham], Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Instituto de Salud Carlos III [Madrid] (ISC), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), and Malbec, Odile
- Subjects
Medicine(all) ,Mortality, Premature ,[SDV]Life Sciences [q-bio] ,Liver Diseases ,Health Policy ,Liver Disease ,Alcoholic liver diseases ,General Medicine ,Lancet commission ,[SDV] Life Sciences [q-bio] ,Europe ,SDG 3 - Good Health and Well-being ,NAFLD ,Liver diseases, NAFLD, Alcoholic liver diseases, Liver hepatitis, Lancet commission ,Humans ,Liver hepatitis ,ComputingMilieux_MISCELLANEOUS ,Human - Abstract
© 2021 Elsevier Ltd. All rights reserved., Liver diseases have become a major health threat across Europe, and the face of European hepatology is changing due to the cure of viral hepatitis C and the control of chronic viral hepatitis B, the increasingly widespread unhealthy use of alcohol, the epidemic of obesity, and undiagnosed or untreated liver disease in migrant populations. Consequently, Europe is facing a looming syndemic, in which socioeconomic and health inequities combine to adversely affect liver disease prevalence, outcomes, and opportunities to receive care. In addition, the COVID-19 pandemic has magnified pre-existing challenges to uniform implementation of policies and equity of access to care in Europe, arising from national borders and the cultural and historical heterogeneity of European societies. In following up on work from the Lancet Commission on liver disease in the UK and epidemiological studies led by the European Association for the Study of the Liver (EASL), our multidisciplinary Commission, comprising a wide range of public health, medical, and nursing specialty groups, along with patient representatives, set out to provide a snapshot of the European landscape on liver diseases and to propose a framework for the principal actions required to improve liver health in Europe. We believe that a joint European process of thinking, and construction of uniform policies and action, implementation, and evaluation can serve as a powerful mechanism to improve liver care in Europe and set the way for similar changes globally., The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193; COMPARE: CIT5-CT-2005-028857; SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N°211909; SHARE-LEAP: GA N°227822; SHARE M4: GA N°261982; DASISH: GA N°283646), and Horizon 2020 (SHARE-DEV3: GA N°676536; SHARE-COHESION: GA N°870628; SERISS: GA N°654221; SSHOC: GA N°823782) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2; P01_AG005842; P01_AG08291; P30_AG12815; R21_AG025169; Y1-AG-4553-01; IAG_BSR06-11; OGHA_04-064; HHSN271201300071C), and from various national funding sources is gratefully acknowledged. PC acknowledges support by the French National Agency for HIV, hepatitis and emerging infectious diseases research (ANRS / EMERGING INFECTIOUS DISEASES).
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- 2022
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49. The Older Sandwich Generation Across European Welfare Regimes: Demographic and Social Considerations
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Marco Albertini, Aviad Tur-Sinai, Noah Lewin-Epstein, Merril Silverstein, Albertini, Marco, Tur-Sinai, Aviad, Lewin-Epstein, Noah, and Silverstein, Merril
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Family solidarity ,Intergenerational support ,SHARE ,Sandwich generation ,Article ,Demography ,Population aging - Abstract
The lengthening of the amount of time adult children depend on their parents' support and rising longevity have pushed scholars to devote increasing attention to the phenomenon of older sandwich family generations. This brief report develops a descriptive portrait of the prevalence of being demographically and socially sandwiched in the population aged 50 or more years, in Europe. It is shown that the prevalence of social sandwiching is highly sensitive to the types of support utilized to operationalize the concept; also, differences between welfare and transfer regimes are significantly affected by different operationalizations. Next, the analyses highlight the dynamic nature of social sandwiching over the adult life cycle, and show that demographic events and the changing needs of older parents are the main drivers of moving in/out the status of socially sandwiched. Support to adult children is ubiquitous in all European societies. Among the pivot generation family solidarity prevails over competition, but children enjoy a strategic advantage when older parents are in good health.
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- 2022
50. Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849 + 10 kb C-to-T splicing mutation
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Ofra Barchad-Avitzur, Yifat S. Oren, Liran Carmel, Venkateshwar Mutyam, Steve D. Wilton, Eric J. Sorscher, Isabelle Sermet-Gaudelus, A. Hatton, Efrat Ozeri-Galai, Steven M. Rowe, Yao Li, Batsheva Kerem, Joel Reiter, A. Golec, Eitan Kerem, Chen Leibson, Michal Irony-Tur Sinai, and Jeong S. Hong
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Pulmonary and Respiratory Medicine ,Cystic Fibrosis ,RNA Splicing ,medicine.disease_cause ,Cystic fibrosis ,Article ,Drug Development ,medicine ,Humans ,Allele ,Protein maturation ,Cells, Cultured ,Mutation ,Messenger RNA ,Antisense oligonucleotides ,business.industry ,Wild type ,Heterozygote advantage ,Oligonucleotides, Antisense ,medicine.disease ,Splicing modulation ,3849 + 10 kb C-to-T mutation ,Pediatrics, Perinatology and Child Health ,RNA splicing ,Cancer research ,business - Abstract
Background Antisense oligonucleotide (ASO)-based drugs for splicing modulation were recently approved for various genetic diseases with unmet need. Here we aimed to develop an ASO-based splicing modulation therapy for Cystic Fibrosis (CF) patients carrying the 3849+10 kb C-to-T splicing mutation in the CFTR gene. Methods We have screened, in FRT cells expressing the 3849+10 kb C-to-T splicing mutation, ~30 2′-O-Methyl-modified phosphorothioate ASOs, targeted to prevent the recognition and inclusion of a cryptic exon generated due to the mutation. The effect of highly potent ASO candidates on the splicing pattern, protein maturation and CFTR function was further analyzed in well differentiated primary human nasal and bronchial epithelial cells, derived from patients carrying at least one 3849+10 kb C-to-T allele. Results A highly potent lead ASO, efficiently delivered by free uptake, was able to significantly increase the level of correctly spliced mRNA and completely restore the CFTR function to wild type levels in cells from a homozygote patient. This ASO led to CFTR function with an average of 43% of wild type levels in cells from various heterozygote patients. Optimized efficiency of the lead ASO was further obtained with 2′-Methoxy Ethyl modification (2′MOE). Conclusion The highly efficient splicing modulation and functional correction, achieved by free uptake of the selected lead ASO in various patients, demonstrate the ASO therapeutic potential benefit for CF patients carrying splicing mutations and is aimed to serve as the basis for our current clinical development.
- Published
- 2021
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